KEGG   PATHWAY: dre04150
Entry
dre04150                    Pathway                                
Name
mTOR signaling pathway - Danio rerio (zebrafish)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
dre04150  mTOR signaling pathway
dre04150

Organism
Danio rerio (zebrafish) [GN:dre]
Gene
100000252  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
100000325  rragcb; Ras-related GTP binding Cb [KO:K16186]
100001198  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100002225  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
100002263  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100003514  prkcg; protein kinase C alpha type isoform X1 [KO:K19663] [EC:2.7.11.13]
100003877  lrp6; low-density lipoprotein receptor-related protein 6 precursor [KO:K03068]
100006041  rhoab; rho-related GTP-binding protein RhoA-B isoform X1 [KO:K04513]
100006675  prkcba; protein kinase C, beta A [KO:K19662] [EC:2.7.11.13]
100009657  rps6ka3b; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
100148840  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
100149082  dvl3b; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100149745  sesn2; sestrin-2 [KO:K20394]
100149794  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100151344  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
100170793  ulk1a; serine/threonine-protein kinase ULK1a [KO:K21357] [EC:2.7.11.1]
100329656  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
100329702  ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
100330617  tsc1b; TSC complex subunit 1b [KO:K07206]
100332722  wnt6a; protein Wnt-6 [KO:K00445]
100333504  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
100333967  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100534937  [KO:K04526]
100536950  stradb; STE20-related kinase adapter protein beta [KO:K17532]
100537196  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 [KO:K20410]
100537790  clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
100537865  prr5b; proline-rich protein 5 isoform X3 [KO:K20411]
100538220  atp6v1c2; V-type proton ATPase subunit C 1-B [KO:K02148]
101910198  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103909113  wdr59; GATOR2 complex protein WDR59 isoform X1 [KO:K20409]
108179059  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
114433  igf1; insulin-like growth factor I precursor [KO:K05459]
192335  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
245699  insra; insulin receptor a precursor [KO:K04527] [EC:2.7.10.1]
245700  insrb; insulin receptor b precursor [KO:K04527] [EC:2.7.10.1]
245701  igf1ra; insulin-like growth factor 1a receptor precursor [KO:K05087] [EC:2.7.10.1]
245702  igf1rb; insulin-like growth factor 1b receptor precursor [KO:K05087] [EC:2.7.10.1]
286779  atp6v1h; V-type proton ATPase subunit H isoform 1 [KO:K02144]
30105  wnt5b; protein Wnt-5b precursor [KO:K00444]
30122  wnt8a; protein Wnt-8a ORF1 precursor [KO:K00714]
30123  wnt4; protein Wnt-4a precursor [KO:K00408]
30127  wnt2; protein Wnt-2 precursor [KO:K00182]
30128  wnt1; protein Wnt-1 precursor [KO:K03209]
30144  wnt8b; protein Wnt-8b precursor [KO:K00714]
30171  wnt10a; protein Wnt-10a [KO:K01357]
30262  ins; insulin preproprotein [KO:K04526]
30283  wnt11; protein Wnt-11 precursor [KO:K01384]
30308  wnt10b; protein Wnt-10b precursor [KO:K01357]
30363  fzd4; frizzled-4 precursor [KO:K02354]
30364  fzd5; frizzled-5 precursor [KO:K02375]
30366  fzd10; frizzled-10 precursor [KO:K02842]
30369  fzd7a; frizzled-7a precursor [KO:K02432]
30370  fzd2; frizzled-2 precursor [KO:K02235]
30380  nraS; GTPase NRas [KO:K07828]
30412  fzd7b; frizzled-7b precursor [KO:K02432]
30654  gsk3ba; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
30716  raf1a; Raf-1 proto-oncogene, serine/threonine kinase A [KO:K04366] [EC:2.7.11.1]
30738  eif4e1b; eukaryotic translation initiation factor 4E-1B [KO:K03259]
323630  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
324140  sgk1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
324254  mtoR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
324863  fnip1; folliculin-interacting protein 1 [KO:K20400]
325358  rraga; ras-related GTP-binding protein A isoform X1 [KO:K16185]
327294  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
334550  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
334749  seh1l; nucleoporin SEH1 [KO:K14299]
335025  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
336619  eif4bb; eukaryotic translation initiation factor 4Bb [KO:K03258]
337167  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
337583  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
337670  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
338219  rps6ka3a; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
359837  wnt2ba; wingless-type MMTV integration site family, member 2Ba precursor [KO:K00182]
359839  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
359840  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
360144  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
368415  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
368907  atp6v1c1a; V-type proton ATPase subunit C 1-A [KO:K02148]
378866  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
378972  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
393208  mioS; GATOR2 complex protein MIOS [KO:K20407]
393228  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
393287  chuK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
393533  fzd6; frizzled-6 precursor [KO:K02376]
393702  rheB; GTP-binding protein Rheb [KO:K07208]
393732  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 isoform X2 [KO:K03259]
393750  tbc1d7; TBC1 domain family member 7 isoform X1 [KO:K20396]
393935  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
393953  prkcbb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
394110  atp6v1aa; ATPase H+ transporting V1 subunit Aa [KO:K02145] [EC:7.1.2.2]
394125  rhoca; ras homolog family member Ca [KO:K04513]
394174  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
399480  mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
399488  slc3a2b; solute carrier family 3 member 2b isoform X1 [KO:K06519]
403000  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
403065  braF; serine/threonine-protein kinase B-raf isoform 1 [KO:K04365] [EC:2.7.11.1]
403146  akt2l; v-akt murine thymoma viral oncogene homolog 2, like isoform X1 [KO:K04456] [EC:2.7.11.1]
404211  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
405785  tnfA; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
406308  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
406336  wdr24; GATOR2 complex protein WDR24 isoform X2 [KO:K20408]
406349  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
406411  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
406471  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
406659  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
406728  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
406822  cab39l1; calcium binding protein 39, like 1 isoform X1 [KO:K08272]
415235  cab39; calcium-binding protein 39 [KO:K08272]
436718  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
436799  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
445028  rps6; small ribosomal subunit protein eS6 [KO:K02991]
445155  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
445289  kraS; GTPase KRas isoform 2 [KO:K07827]
446167  grb10a; growth factor receptor-bound protein 10A [KO:K20064]
449655  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
449937  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
492361  cab39l; calcium-binding protein 39-like isoform X1 [KO:K08272]
493609  grb2a; growth factor receptor-bound protein 2A [KO:K04364]
493617  eif4eb; eukaryotic translation initiation factor 4eb [KO:K03259]
497384  prkcaa; protein kinase C, alpha, A [KO:K02677] [EC:2.7.11.13]
541523  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
541544  rnf152; E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
550286  hrasa; HRas proto-oncogene, GTPase A [KO:K02833]
550537  stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
550549  eif4e1c; eukaryotic translation initiation factor 4E family member 1c [KO:K03259]
553214  eif4ba; eukaryotic translation initiation factor 4Ba [KO:K03258]
553597  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
553656  hrasb; HRas proto-oncogene, GTPase B [KO:K02833]
553976  wnt8-2; protein Wnt-8a ORF2 precursor [KO:K00714]
555584  prr5a; proline-rich protein 5A [KO:K20411]
556087  wnt2bb; wingless-type MMTV integration site family, member 2Bb [KO:K00182]
556286  sos1; son of sevenless homolog 1 [KO:K03099]
557109  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
557176  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
557384  fzd1; frizzled-1 precursor [KO:K02432]
557447  fzd9a; frizzled-9 [KO:K02842]
557634  prr5l; proline-rich protein 5-like isoform X2 [KO:K20411]
557882  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate B [KO:K03083] [EC:2.7.11.26]
558422  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
558848  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
559050  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
559281  irs1; insulin receptor substrate 1 [KO:K16172]
559391  nprl2; GATOR1 complex protein NPRL2 [KO:K20405]
560032  dvl1b; segment polarity protein dishevelled homolog DVL-1b [KO:K02353]
560455  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
560549  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
560638  lpin1b; phosphatidate phosphatase LPIN1 isoform X2 [KO:K15728] [EC:3.1.3.4]
561019  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
561670  sos2; son of sevenless homolog 2 [KO:K03099]
561703  [KO:K08267]
561737  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
561831  wnt6b; protein Wnt-6 [KO:K00445]
561835  [KO:K08267]
562032  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
562137  slc38a9; neutral amino acid transporter 9 [KO:K14995]
562242  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
562995  depdc5; GATOR1 complex protein DEPDC5 isoform X1 [KO:K20404]
563181  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
563427  wnt7ba; protein Wnt-7b isoform X1 [KO:K00572]
563560  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
563708  skp2; S-phase kinase-associated protein 2 [KO:K03875]
564989  nprl3; GATOR1 complex protein NPRL3 [KO:K20406]
565677  wnt9b; protein Wnt-9b precursor [KO:K01064]
565714  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
565921  fzd3a; frizzled-3a precursor [KO:K02329]
566559  akt1s1; proline-rich AKT1 substrate 1 [KO:K16184]
566735  insB; preproinsulin b precursor [KO:K04526]
567524  tsc2; tuberin [KO:K07207]
567746  fzd3b; frizzled-3b precursor [KO:K02329]
568110  wnt7ab; protein Wnt-7a [KO:K00572]
568191  wnt5a; protein Wnt-5a [KO:K00444]
568518  lrp5; low-density lipoprotein receptor-related protein 5 isoform 1 precursor [KO:K03068]
569420  wnt3; proto-oncogene Wnt-3 precursor [KO:K00312]
569863  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X5 [KO:K02353]
570077  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
570568  rragd; ras-related GTP-binding protein D [KO:K16186]
571285  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
572074  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
573492  rragca; Ras-related GTP binding Ca [KO:K16186]
58023  fzd9b; frizzled-9b precursor [KO:K02842]
58072  fzd8b; frizzled-8b precursor [KO:K02375]
58073  fzd8a; frizzled-8a precursor [KO:K02375]
60632  wnt3a; protein Wnt-3a precursor [KO:K00312]
641489  [KO:K15728] [EC:3.1.3.4]
678628  flcN; folliculin isoform X1 [KO:K09594]
751630  zgc:153713; RhoA_like domain-containing protein [KO:K04513]
751644  wnt9a; protein Wnt-9a precursor [KO:K01064]
767781  rhebl1; Ras homolog, mTORC1 binding like 1 [KO:K07208]
768159  [KO:K13302] [EC:2.7.11.1]
768177  deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
768202  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a precursor [KO:K06276] [EC:2.7.11.1]
777634  telo2; telomere length regulation protein TEL2 homolog isoform 1 [KO:K11137]
777728  rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
790938  zgc:158423; uncharacterized protein LOC790938 [KO:K06519]
791141  zgc:158659; uncharacterized protein isoform X1 [KO:K00922] [EC:2.7.1.153]
791563  wnt16; protein Wnt-16 precursor [KO:K01558]
791595  wnt11f2; protein Wnt-11 precursor [KO:K01384]
791993  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
792689  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
79380  eif4ea; eukaryotic translation initiation factor 4E-1A [KO:K03259]
794088  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
796322  slc3a2a; solute carrier family 3 member 2a [KO:K06519]
797213  fnip2; folliculin-interacting protein 2 [KO:K20401]
797250  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
797680  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
798071  sec13; protein SEC13 homolog [KO:K14004]
799099  lpin1a; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
799566  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
80972  dvl3a; segment polarity protein dishevelled homolog DVL-3a [KO:K02353]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
dre00561  Glycerolipid metabolism
dre04010  MAPK signaling pathway
dre04140  Autophagy - animal
dre04810  Regulation of actin cytoskeleton
dre04910  Insulin signaling pathway
KO pathway
ko04150   

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