KEGG PATHWAY: esp04540

KEGG

PATHWAY: esp04540

Entry

esp04540                    Pathway

Name

Gap junction - Etheostoma spectabile (orangethroat darter)

Description

Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.

Class

Cellular Processes; Cellular community - eukaryotes

Pathway map

Gap junction

Other DBs

GO:

Organism

Etheostoma spectabile (orangethroat darter) [GN:esp]

Gene

sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]

prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]

plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]

gjd2; gap junction delta-2 protein [KO:K07373]

mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]

adrb1; beta-1 adrenergic receptor [KO:K04141]

[KO:K12319] [EC:4.6.1.2]

map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]

grm5; metabotropic glutamate receptor 5 [KO:K04604]

drd2; D(2) dopamine receptor [KO:K04145]

pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]

[KO:K08045] [EC:4.6.1.1]

[KO:K08043] [EC:4.6.1.1]

cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]

[KO:K05858] [EC:3.1.4.11]

gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]

htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]

[KO:K05704] [EC:2.7.10.2]

prkg2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]

mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]

[KO:K08042] [EC:4.6.1.1]

[KO:K19663] [EC:2.7.11.13]

[KO:K08046] [EC:4.6.1.1]

[KO:K05704] [EC:2.7.10.2]

adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]

gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]

raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]

adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]

hras; GTPase HRas [KO:K02833]

itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]

kras; GTPase KRas isoform X1 [KO:K07827]

map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]

map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]

htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]

[KO:K08041] [EC:4.6.1.1]

pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]

prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]

egf; pro-epidermal growth factor [KO:K04357]

pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]

pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]

[KO:K08045] [EC:4.6.1.1]

[KO:K04345] [EC:2.7.11.11]

egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]

adcy8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]

[KO:K08041] [EC:4.6.1.1]

gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]

gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]

[KO:K04369] [EC:2.7.12.2]

[KO:K04369] [EC:2.7.12.2]

[KO:K08043] [EC:4.6.1.1]

adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]

grb2; growth factor receptor-bound protein 2 [KO:K04364]

[KO:K02677] [EC:2.7.11.13]

adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]

csnk1d; casein kinase I [KO:K08959] [EC:2.7.11.1]

prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]

pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]

[KO:K04345] [EC:2.7.11.11]

[KO:K04371] [EC:2.7.11.24]

tubb4b; tubulin beta-4B chain [KO:K07375]

map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]

lpar1; lysophosphatidic acid receptor 1 [KO:K04289]

[KO:K05858] [EC:3.1.4.11]

prkg1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]

[KO:K19662] [EC:2.7.11.13]

[KO:K19477] [EC:2.7.11.12]

[KO:K08048] [EC:4.6.1.1]

grm1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]

plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]

plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]

[KO:K08043] [EC:4.6.1.1]

[KO:K08049] [EC:4.6.1.1]

[KO:K19477] [EC:2.7.11.12]

Compound

L-Glutamate

Calcium cation

Diacylglycerol

Nitric oxide

L-Noradrenaline

3',5'-Cyclic AMP

1-Acyl-sn-glycerol 3-phosphate

Serotonin

3',5'-Cyclic GMP

D-myo-Inositol 1,4,5-trisphosphate

Dopamine

Reference

Authors

Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.

Title

Plasma membrane channels formed by connexins: their regulation and functions.

Journal

Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003

Reference

Authors

Warn-Cramer BJ, Lau AF.

Title

Regulation of gap junctions by tyrosine protein kinases.

Journal

Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018

Reference

Authors

Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.

Title

Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.

Journal

J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188

Reference

Authors

Roerig B, Feller MB.

Title

Neurotransmitters and gap junctions in developing neural circuits.

Journal

Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7

Reference

Authors

Hatton GI.

Title

Synaptic modulation of neuronal coupling.

Journal

Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386

Reference

Authors

Cruciani V, Mikalsen SO.

Title

Connexins, gap junctional intercellular communication and kinases.

Journal

Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X

Reference

Authors

Giepmans BN.

Title

Gap junctions and connexin-interacting proteins.

Journal

Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009

Reference

Authors

Laird DW.

Title

Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.

Journal

Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009

Reference

Authors

Peracchia C.

Title

Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.

Journal

Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020

Reference

Authors

Bukauskas FF, Verselis VK.

Title

Gap junction channel gating.

Journal

Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008

Related
pathway

MAPK signaling pathway

Calcium signaling pathway

Cytokine-cytokine receptor interaction

Phosphatidylinositol signaling system

Neuroactive ligand-receptor interaction

KO pathway

DBGET integrated database retrieval system