KEGG   PATHWAY: esp04010
Entry
esp04010                    Pathway                                
Name
MAPK signaling pathway - Etheostoma spectabile (orangethroat darter)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
esp04010  MAPK signaling pathway
esp04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116669567  [KO:K02187] [EC:3.4.22.56]
116669677  rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
116669684  [KO:K04373] [EC:2.7.11.1]
116669702  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116669704  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
116669778  [KO:K04427] [EC:2.7.11.25]
116669797  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
116670013  [KO:K04410] [EC:2.7.11.1]
116670022  [KO:K04402]
116670053  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
116670054  [KO:K04379]
116670100  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
116670120  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116670256  [KO:K05462]
116670481  [KO:K04453]
116670486  [KO:K16859]
116670546  [KO:K04445] [EC:2.7.11.1]
116670566  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116670573  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
116670583  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
116670894  [KO:K04467] [EC:2.7.11.10]
116670942  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116671081  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
116671100  [KO:K04430] [EC:2.7.12.2]
116671107  mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
116671117  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
116671244  [KO:K04433] [EC:2.7.12.2]
116671255  [KO:K22429]
116671269  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
116671270  taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
116671304  [KO:K02583]
116671539  [KO:K04440] [EC:2.7.11.24]
116671546  [KO:K07861]
116671738  [KO:K04461] [EC:3.1.3.16]
116671912  map3k8; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
116671913  [KO:K05093] [EC:2.7.10.1]
116672012  vegfd; vascular endothelial growth factor D [KO:K05449]
116672056  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
116672244  [KO:K04674] [EC:2.7.11.30]
116672351  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
116672376  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
116672482  [KO:K04421] [EC:2.7.11.25]
116672533  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
116672539  flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
116672606  [KO:K04373] [EC:2.7.11.1]
116672836  [KO:K04850]
116672841  [KO:K04861]
116672986  [KO:K05461]
116673091  [KO:K04858]
116673128  [KO:K04441] [EC:2.7.11.24]
116673142  [KO:K04456] [EC:2.7.11.1]
116673193  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116673224  [KO:K04441] [EC:2.7.11.24]
116673226  [KO:K05460]
116673300  fgf23; fibroblast growth factor 23 [KO:K22428]
116673308  fgf6; fibroblast growth factor 6 isoform X1 [KO:K04358]
116673342  [KO:K04456] [EC:2.7.11.1]
116673369  igf1; insulin-like growth factor I [KO:K05459]
116673427  ntf3; neurotrophin-3 [KO:K04356]
116673735  [KO:K05449]
116673752  [KO:K04865]
116673862  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
116673914  map4k4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
116673917  erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
116674182  nf1; neurofibromin isoform X1 [KO:K08052]
116674205  nlk; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
116674771  crk; adapter molecule crk [KO:K04438]
116676102  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116677434  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
116677596  [KO:K09253]
116677748  [KO:K04448]
116678184  [KO:K04350]
116678414  [KO:K05090] [EC:2.7.10.1]
116678606  [KO:K04457] [EC:3.1.3.16]
116678806  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
116678819  [KO:K03099]
116679342  [KO:K04439]
116679431  [KO:K04429] [EC:2.7.11.1]
116679543  [KO:K04375]
116679810  [KO:K04465]
116681957  [KO:K04429] [EC:2.7.11.1]
116682771  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116682862  [KO:K13375]
116683329  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116683575  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
116685041  [KO:K04409] [EC:2.7.11.1]
116685911  [KO:K04407] [EC:2.7.11.1]
116685972  [KO:K04348] [EC:3.1.3.16]
116686128  [KO:K05866] [EC:3.1.3.48]
116686339  [KO:K04451]
116686512  [KO:K04358]
116686525  [KO:K17333]
116686565  ppp3ca; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
116686746  [KO:K04388] [EC:2.7.11.30]
116686864  [KO:K04861]
116686956  rasa2; ras GTPase-activating protein 2 [KO:K08053]
116687015  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
116687052  [KO:K04362] [EC:2.7.10.1]
116687277  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
116687375  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
116687431  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116687621  [KO:K04851]
116687726  [KO:K04443] [EC:2.7.11.1]
116687813  [KO:K04444] [EC:2.7.11.1]
116687835  [KO:K04441] [EC:2.7.11.24]
116687866  [KO:K04859]
116688024  [KO:K08774]
116688229  [KO:K04860]
116688288  [KO:K04393]
116688304  [KO:K05465]
116688344  [KO:K04353]
116688351  [KO:K02582]
116688361  erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
116688394  [KO:K04444] [EC:2.7.11.1]
116688446  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
116688464  [KO:K05103] [EC:2.7.10.1]
116688504  [KO:K04465]
116688656  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
116688848  ereg; proepiregulin isoform X1 [KO:K09784]
116688894  ntrk2; LOW QUALITY PROTEIN: BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
116688937  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
116689192  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
116689195  [KO:K04849]
116689221  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
116689286  rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
116689519  [KO:K04348] [EC:3.1.3.16]
116689557  efna5; ephrin-A5 isoform X1 [KO:K05462]
116689559  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116689662  fgf10; fibroblast growth factor 10 [KO:K04358]
116689682  il1b; interleukin-1 beta [KO:K04519]
116689928  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
116690056  rras2; ras-related protein R-Ras2 [KO:K07830]
116690095  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
116690100  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116690145  [KO:K03173] [EC:2.3.2.27]
116690250  [KO:K05452]
116690260  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116690278  taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
116690302  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
116690322  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116690326  fgf5; fibroblast growth factor 5 [KO:K04358]
116690381  [KO:K04362] [EC:2.7.10.1]
116690444  [KO:K04426] [EC:2.7.11.25]
116690518  efna1; ephrin-A1 [KO:K05462]
116690550  [KO:K04349]
116690679  [KO:K02583]
116691017  [KO:K03283]
116691144  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116691264  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
116691327  [KO:K04393]
116691362  [KO:K19663] [EC:2.7.11.13]
116691363  [KO:K04872]
116691375  [KO:K04873]
116691376  [KO:K04871]
116691522  [KO:K05462]
116691523  [KO:K04446]
116691701  [KO:K04381]
116691705  [KO:K05462]
116691890  [KO:K04441] [EC:2.7.11.24]
116691938  [KO:K05459]
116692046  [KO:K04423] [EC:2.7.11.25]
116692062  [KO:K04465]
116692093  [KO:K04353]
116692170  [KO:K04393]
116692201  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116692206  [KO:K04441] [EC:2.7.11.24]
116692230  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116692233  [KO:K05084] [EC:2.7.10.1]
116692310  [KO:K04864]
116692451  [KO:K02582]
116692510  [KO:K04864]
116692552  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116692688  [KO:K05103] [EC:2.7.10.1]
116692861  [KO:K03283]
116692878  [KO:K04853]
116692928  [KO:K04851]
116693019  [KO:K04860]
116693071  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116693173  [KO:K04443] [EC:2.7.11.1]
116693198  [KO:K04441] [EC:2.7.11.24]
116693200  [KO:K04437]
116693209  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
116693572  [KO:K04441] [EC:2.7.11.24]
116693658  srf; serum response factor isoform X1 [KO:K04378]
116693711  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
116693768  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
116693783  kitlg; kit ligand [KO:K05461]
116693948  [KO:K04434]
116693976  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116694007  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116694009  [KO:K05087] [EC:2.7.10.1]
116694034  [KO:K04434]
116694099  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
116694119  igf2; insulin-like growth factor II [KO:K13769]
116694238  [KO:K04349]
116694245  hras; GTPase HRas [KO:K02833]
116694286  [KO:K18018] [EC:3.1.3.48]
116694484  kras; GTPase KRas isoform X1 [KO:K07827]
116694654  [KO:K05087] [EC:2.7.10.1]
116694676  mapk8ip2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
116694689  hgf; hepatocyte growth factor isoform X1 [KO:K05460]
116694723  [KO:K04858]
116694773  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116694957  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
116694968  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
116695172  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116695201  [KO:K04448]
116695203  [KO:K04389]
116695425  [KO:K04852]
116695589  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116695590  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
116695596  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116695614  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116695686  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116695713  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116695847  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
116695922  artn; LOW QUALITY PROTEIN: artemin [KO:K25415]
116695992  [KO:K04527] [EC:2.7.10.1]
116696006  jund; transcription factor jun-D [KO:K04449]
116696019  [KO:K04402]
116696132  [KO:K04358]
116696380  [KO:K04358]
116696408  [KO:K04358]
116696412  fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
116696435  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
116696497  [KO:K04358]
116696510  egf; pro-epidermal growth factor [KO:K04357]
116696522  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
116696607  [KO:K04358]
116696793  rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
116696858  [KO:K04358]
116696869  ins; insulin [KO:K04526]
116696884  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116696885  csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
116696921  fgf16; fibroblast growth factor 16 [KO:K04358]
116696922  [KO:K18496]
116697037  [KO:K13376]
116697062  [KO:K04389]
116697073  [KO:K02187] [EC:3.4.22.56]
116697226  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116697230  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
116697253  [KO:K05096] [EC:2.7.10.1]
116697380  vegfb; vascular endothelial growth factor B [KO:K05448]
116697416  [KO:K04440] [EC:2.7.11.24]
116697605  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
116697624  atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
116697676  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
116697881  [KO:K04407] [EC:2.7.11.1]
116697890  [KO:K04386]
116697891  [KO:K04865]
116698104  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116698137  [KO:K04358]
116698140  mras; ras-related protein M-Ras [KO:K07831]
116698166  [KO:K05085] [EC:2.7.10.1]
116698585  [KO:K04358]
116698669  [KO:K04345] [EC:2.7.11.11]
116698703  [KO:K04527] [EC:2.7.10.1]
116698745  [KO:K04448]
116698815  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116698837  [KO:K04424] [EC:2.7.11.25]
116698956  [KO:K04852]
116698971  [KO:K25415]
116698982  [KO:K04402]
116698983  [KO:K04347]
116699327  [KO:K05448]
116699426  [KO:K04369] [EC:2.7.12.2]
116699428  [KO:K04369] [EC:2.7.12.2]
116699436  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
116699518  [KO:K25414]
116699845  [KO:K04449]
116699944  hspb1; heat shock protein beta-1 [KO:K04455]
116699951  [KO:K16510] [EC:2.7.11.1]
116700138  [KO:K03283]
116700286  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116700400  [KO:K04359]
116700479  [KO:K04348] [EC:3.1.3.16]
116700613  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
116700716  [KO:K04457] [EC:3.1.3.16]
116700737  [KO:K04438]
116700921  [KO:K04429] [EC:2.7.11.1]
116700940  [KO:K17386]
116700966  atf4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
116701103  [KO:K05095] [EC:2.7.10.1]
116701356  stk3; serine/threonine-protein kinase 3 [KO:K04412]
116701461  daxx; death domain-associated protein 6 [KO:K02308]
116701499  [KO:K05466]
116701500  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
116701514  [KO:K04871]
116701671  [KO:K04867]
116701685  [KO:K05462]
116701687  [KO:K05462]
116701720  [KO:K04388] [EC:2.7.11.30]
116701768  [KO:K04872]
116701783  [KO:K04446]
116701822  [KO:K04873]
116701833  [KO:K04393]
116702065  [KO:K03156]
116702117  [KO:K04381]
116702284  vegfc; vascular endothelial growth factor C [KO:K05449]
116702364  [KO:K17333]
116702397  grb2; growth factor receptor-bound protein 2 [KO:K04364]
116702472  [KO:K04855]
116702478  [KO:K02677] [EC:2.7.11.13]
116702491  [KO:K04392]
116702641  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
116702675  [KO:K02583]
116702706  [KO:K04867]
116702724  [KO:K04433] [EC:2.7.12.2]
116702769  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
116702985  [KO:K03283]
116702998  [KO:K04468] [EC:2.7.11.24]
116703002  [KO:K04429] [EC:2.7.11.1]
116703027  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
116703070  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116703076  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
116703151  pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116703189  map3k14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
116703304  fgf3; fibroblast growth factor 3 [KO:K04358]
116703305  fgf4; fibroblast growth factor 4 [KO:K04358]
116703362  [KO:K04344]
116703372  [KO:K04869]
116703389  fgf19; fibroblast growth factor 19 [KO:K22603]
116703408  pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
116703423  [KO:K04866]
116703434  [KO:K04856]
116703458  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
116703473  [KO:K04870]
116703532  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116703555  rras; ras-related protein R-Ras [KO:K07830]
116703632  [KO:K04347]
116703683  [KO:K04345] [EC:2.7.11.11]
116703729  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
116703753  [KO:K04371] [EC:2.7.11.24]
116703772  [KO:K07827]
116703876  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116703898  crkl; crk-like protein [KO:K04438]
116703984  [KO:K03173] [EC:2.3.2.27]
116704058  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
116704060  [KO:K04448]
116704166  [KO:K05462]
116704170  [KO:K04402]
116704319  [KO:K12326]
116704489  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
116704504  [KO:K07860]
116704545  [KO:K04358]
116704577  [KO:K03173] [EC:2.3.2.27]
116704619  [KO:K07861]
116704672  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116704759  [KO:K04849]
116704792  [KO:K04360] [EC:2.7.10.1]
116704848  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
116704886  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
116705038  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
116705087  [KO:K17534] [EC:2.7.11.25]
116705099  [KO:K04456] [EC:2.7.11.1]
116705198  [KO:K04467] [EC:2.7.11.10]
116705361  fgf7; fibroblast growth factor 7 [KO:K04358]
116705380  angpt2; angiopoietin-2 isoform X1 [KO:K05466]
116705432  [KO:K04440] [EC:2.7.11.24]
116705456  [KO:K19662] [EC:2.7.11.13]
116705506  [KO:K04430] [EC:2.7.12.2]
116705519  [KO:K04390]
116705548  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116705613  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
116705632  [KO:K16342] [EC:3.1.1.4]
116705636  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
116705728  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
116705828  gna12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
116705943  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
116706070  max; protein max isoform X1 [KO:K04453]
116706210  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
116706222  [KO:K13377]
116706224  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
116706347  dusp10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
116706488  [KO:K04379]
116706489  [KO:K04379]
116706644  [KO:K16859]
116706745  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
116706861  [KO:K05091] [EC:2.7.10.1]
116707059  [KO:K12361]
116707140  [KO:K12361]
116707169  [KO:K04419] [EC:2.7.11.25]
116707177  [KO:K04868]
116707180  [KO:K04735]
116707193  arrb2; beta-arrestin-2 [KO:K04439]
116707290  [KO:K04414] [EC:2.7.11.1]
116707297  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
esp04070  Phosphatidylinositol signaling system
esp04110  Cell cycle
esp04115  p53 signaling pathway
esp04210  Apoptosis
esp04310  Wnt signaling pathway
KO pathway
ko04010   

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