KEGG   PATHWAY: gga00230
Entry
gga00230                    Pathway                                
Name
Purine metabolism - Gallus gallus (chicken)
Class
Metabolism; Nucleotide metabolism
Pathway map
gga00230  Purine metabolism
gga00230

Module
gga_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:gga00230]
gga_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:gga00230]
gga_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:gga00230]
gga_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:gga00230]
gga_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:gga00230]
gga_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:gga00230]
gga_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:gga00230]
Other DBs
GO: 0006163 0042278
Organism
Gallus gallus (chicken) [GN:gga]
Gene
100857155  APRT; adenine phosphoribosyltransferase isoform 1 [KO:K00759] [EC:2.4.2.7]
100858145  NME7; nucleoside diphosphate kinase 7 isoform X2 [KO:K00940] [EC:2.7.4.6]
100858603  ADCY10L8; adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
100858617  NT5DC4; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
100859339  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
101747367  [KO:K00365] [EC:1.7.3.3]
101749972  ADCY10L11; adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
101751749  [KO:K01952] [EC:6.3.5.3]
101752207  ADCY10L6; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
107050028  [KO:K08046] [EC:4.6.1.1]
107054975  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
107055115  [KO:K12323] [EC:4.6.1.2]
107056801  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
112530034  [KO:K00940] [EC:2.7.4.6]
112530327  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
374095  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
378929  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
395091  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
395092  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
395315  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
395339  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
395340  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
395653  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
395797  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 precursor [KO:K01509] [EC:3.6.1.-]
395834  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
395915  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
395916  NME2; nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
396002  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
396025  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
396091  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
396534  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
396540  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
415455  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
415732  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
415859  URAH; 5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
416058  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
416071  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
416399  NME3; nucleoside diphosphate kinase 3 precursor [KO:K00940] [EC:2.7.4.6]
416505  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
416708  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
417281  ENTPD8L; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
417968  GUCY2C; heat-stable enterotoxin receptor isoform X2 [KO:K12320] [EC:4.6.1.2]
418160  ADA2; adenosine deaminase 2 precursor [KO:K19572] [EC:3.5.4.4]
418185  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
418538  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2 [KO:K13761] [EC:3.1.4.35]
418639  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
418840  LACC1; laccase domain-containing protein 1 isoform X2 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
419081  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
419089  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
419194  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
419531  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
419675  NT5C1A; cytosolic 5'-nucleotidase 1A isoform X4 [KO:K01081] [EC:3.1.3.5]
420253  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
420328  ADCY8; adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
420752  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
420788  ADCY1; adenylate cyclase type 1 isoform X2 [KO:K08041] [EC:4.6.1.1]
420842  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
420935  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
421574  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
421692  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
421719  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
421833  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
421936  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
421954  NT5C1B; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
422013  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
422055  ENPP4; ectonucleotide pyrophosphatase/phosphodiesterase family member 4 precursor [KO:K18424] [EC:3.6.1.29]
422094  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
422185  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
422407  GUCY1A3; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
422408  GUCY1B3; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
422530  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
422587  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X3 [KO:K13988] [EC:3.6.1.13]
422648  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
422677  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
422743  PPAT; amidophosphoribosyltransferase precursor [KO:K00764] [EC:2.4.2.14]
423041  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
423064  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
423343  ENTPD5; LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
423678  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X3 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
423735  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
423826  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
423871  NT5C2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
424116  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
424133  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
424390  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
424555  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
424691  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
424697  AK4; LOW QUALITY PROTEIN: adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
424700  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
424932  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
425028  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
425199  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X4 [KO:K18436] [EC:3.1.4.53]
425215  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
426368  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
426435  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
426534  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
426866  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
426928  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
426929  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
427053  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
427253  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
427399  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
427645  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
427778  [KO:K01510] [EC:3.6.1.5]
427977  GART-B; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
428227  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
428399  GUK1; guanylate kinase isoform X2 [KO:K00942] [EC:2.7.4.8]
428447  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
428579  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
428588  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
428907  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
429128  GUCY1B4; guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
430103  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
430522  AK8; adenylate kinase 8 isoform X2 [KO:K00939] [EC:2.7.4.3]
431640  NPR1; atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
768578  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
769469  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2 [KO:K13293] [EC:3.1.4.53]
769860  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
769866  HPRTL; hypoxanthine-guanine phosphoribosyltransferase isoform X2 [KO:K00760] [EC:2.4.2.8]
769958  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
770187  ADCY10L3; adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
770392  C5NT1AL; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
770922  DGUOK; deoxyguanosine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
771077  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
771678  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
772125  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
776127  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
777528  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
gga00030  Pentose phosphate pathway
gga00220  Arginine biosynthesis
gga00250  Alanine, aspartate and glutamate metabolism
gga00260  Glycine, serine and threonine metabolism
gga00340  Histidine metabolism
gga00630  Glyoxylate and dicarboxylate metabolism
gga00730  Thiamine metabolism
gga00740  Riboflavin metabolism
gga00790  Folate biosynthesis
KO pathway
ko00230   

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