KEGG   PATHWAY: ggo04115
Entry
ggo04115                    Pathway                                
Name
p53 signaling pathway - Gorilla gorilla gorilla (western lowland gorilla)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
ggo04115  p53 signaling pathway
ggo04115

Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101123696  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
101123850  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
101123855  CCNG1; cyclin-G1 [KO:K10145]
101124618  CHEK2; serine/threonine-protein kinase Chk2 isoform X3 [KO:K06641] [EC:2.7.11.1]
101124773  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
101124847  SESN1; sestrin-1 isoform X3 [KO:K10141]
101125453  BBC3; bcl-2-binding component 3 isoform X2 [KO:K10132]
101125787  SIVA1; apoptosis regulatory protein Siva isoform X1 [KO:K22744]
101126640  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
101126742  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101128036  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
101128993  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
101129170  [KO:K08738]
101129439  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
101129964  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X3 [KO:K06643] [EC:2.3.2.27]
101130414  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101130447  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101130628  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101131389  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101131508  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101131522  CD82; CD82 antigen [KO:K06509]
101131799  CCNG2; cyclin-G2 isoform X1 [KO:K10146]
101131973  SFN; 14-3-3 protein sigma [KO:K06644]
101131993  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
101133309  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
101133524  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
101133824  MDM4; protein Mdm4 isoform X1 [KO:K10127]
101134279  EI24; etoposide-induced protein 2.4 homolog isoform X3 [KO:K10134]
101134470  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101134769  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
101135431  [KO:K08738]
101135507  THBS1; thrombospondin-1 [KO:K16857]
101135688  AIFM2; ferroptosis suppressor protein 1 [KO:K22745]
101135722  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
101136123  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101137835  SERPINB5; serpin B5 [KO:K10139]
101137934  TSC2; tuberin isoform X1 [KO:K07207]
101138252  TP73; tumor protein p73 isoform X1 [KO:K10148]
101138854  [KO:K04506] [EC:2.3.2.27]
101138898  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101139749  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101140085  TP53I3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
101140270  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X2 [KO:K04402]
101140934  ADGRB1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
101141415  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B [KO:K04722]
101141452  SESN3; sestrin-3 isoform X2 [KO:K10141]
101142025  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101142032  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
101142111  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X2 [KO:K10144] [EC:2.3.2.27]
101143160  PIDD1; p53-induced death domain-containing protein 1 isoform X4 [KO:K10130]
101143199  ZMAT3; zinc finger matrin-type protein 3 isoform X2 [KO:K10137]
101143801  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
101144525  RPRM; protein reprimo [KO:K10128]
101144860  [KO:K04503]
101145463  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
101145779  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
101146129  [KO:K08738]
101146659  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
101146783  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101147065  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
101147526  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101148099  SESN2; sestrin-2 isoform X1 [KO:K20394]
101148147  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
101148205  GTSE1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
101149013  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X2 [KO:K04506] [EC:2.3.2.27]
101149162  SERPINE1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
101151027  TP53AIP1; p53-regulated apoptosis-inducing protein 1 [KO:K13773]
101151684  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
101152154  [KO:K10131]
101152221  STEAP3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
101152441  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
101152462  [KO:K08738]
101152769  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
101153109  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
101153263  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101154256  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
101154397  IGF1; insulin-like growth factor I isoform X4 [KO:K05459]
109023121  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
109023149  [KO:K08738]
109025064  PPP1R13L; RelA-associated inhibitor isoform X1 [KO:K27356]
109025909  [KO:K08738]
109027916  [KO:K08738]
115931433  [KO:K10134]
115932158  [KO:K08738]
115933428  [KO:K08738]
129524120  [KO:K08738]
129526136  [KO:K08738]
129526436  [KO:K08738]
129527250  [KO:K08738]
134756931  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
ggo04110  Cell cycle
ggo04210  Apoptosis
ggo04218  Cellular senescence
KO pathway
ko04115   

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