KEGG   PATHWAY: ggo04664
Entry
ggo04664                    Pathway                                
Name
Fc epsilon RI signaling pathway - Gorilla gorilla gorilla (western lowland gorilla)
Description
Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses.
Class
Organismal Systems; Immune system
Pathway map
ggo04664  Fc epsilon RI signaling pathway
ggo04664

Other DBs
GO: 0045576
Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
115930559  uncharacterized protein LOC115930559 [KO:K06856]
101133851  putative V-set and immunoglobulin domain-containing-like protein IGHV1OR21-1 [KO:K06856]
109023154  Ig heavy chain Mem5-like isoform X1 [KO:K06856]
101126100  FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089]
101139625  MS4A2; high affinity immunoglobulin epsilon receptor subunit beta isoform X1 [KO:K08090]
101125858  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
101138129  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101145340  LYN; tyrosine-protein kinase Lyn isoform X3 [KO:K05854] [EC:2.7.10.2]
101141049  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
101142949  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1 [KO:K03084] [EC:3.1.3.86]
101135199  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101133643  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
101124828  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101143811  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101146434  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101152123  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101130978  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101135298  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101129336  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101147096  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101147811  LOW QUALITY PROTEIN: putative 3-phosphoinositide-dependent protein kinase 2 [KO:K06276] [EC:2.7.11.1]
101137723  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101138019  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101135430  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101141534  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101154090  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101143954  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101124339  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X4 [KO:K04431] [EC:2.7.12.2]
101145420  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101142374  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
101152026  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
101124033  MAPK8; mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101133141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101134492  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101134843  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101148438  MAPK13; mitogen-activated protein kinase 13 isoform X3 [KO:K04441] [EC:2.7.11.24]
101152640  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
101140015  IL4; interleukin-4 isoform X1 [KO:K05430]
101132913  IL3; interleukin-3 [KO:K04736]
101138467  IL5; interleukin-5 [KO:K05428]
101133274  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
101135535  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
101124128  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101142265  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101139851  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101143006  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
101148004  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
101138805  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
101133976  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101130824  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101137539  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
101136425  HRAS; GTPase HRas isoform X1 [KO:K02833]
101144039  KRAS; GTPase KRas isoform X2 [KO:K07827]
101146562  NRAS; GTPase NRas [KO:K07828]
101136454  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101132391  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101126885  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101140164  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101135988  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109025233  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101137812  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101138793  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101147399  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
101135686  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
101146015  ALOX5AP; arachidonate 5-lipoxygenase-activating protein [KO:K20735]
101139192  IL13; interleukin-13 isoform X1 [KO:K05435]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00374  Heparin
C00388  Histamine
C00696  Prostaglandin D2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02166  Leukotriene C4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12360215
  Authors
Kawakami T, Galli SJ.
  Title
Regulation of mast-cell and basophil function and survival by IgE.
  Journal
Nat Rev Immunol 2:773-86 (2002)
DOI:10.1038/nri914
Reference
PMID:14630197
  Authors
Siraganian RP.
  Title
Mast cell signal transduction from the high-affinity IgE receptor.
  Journal
Curr Opin Immunol 15:639-46 (2003)
DOI:10.1016/j.coi.2003.09.010
Reference
  Authors
Janeway CA, Travers P, Walport M, Shlomchik MJ.
  Title
Immunobiology 6th edition
  Journal
Garland Science Publishing (2005)
Reference
PMID:10586892
  Authors
Turner H, Kinet JP.
  Title
Signalling through the high-affinity IgE receptor Fc epsilonRI.
  Journal
Nature 402:B24-30 (1999)
DOI:10.1038/35037021
Reference
PMID:16470226
  Authors
Gilfillan AM, Tkaczyk C.
  Title
Integrated signalling pathways for mast-cell activation.
  Journal
Nat Rev Immunol 6:218-30 (2006)
DOI:10.1038/nri1782
Reference
PMID:11079101
  Authors
Nadler MJ, Matthews SA, Turner H, Kinet JP.
  Title
Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
  Journal
Adv Immunol 76:325-55 (2000)
DOI:10.1016/S0065-2776(01)76022-1
Reference
PMID:11449275
  Authors
Gu H, Saito K, Klaman LD, Shen J, Fleming T, Wang Y, Pratt JC, Lin G, Lim B, Kinet JP, Neel BG.
  Title
Essential role for Gab2 in the allergic response.
  Journal
Nature 412:186-90 (2001)
DOI:10.1038/35084076
Reference
PMID:12145654
  Authors
Nadler MJ, Kinet JP.
  Title
Uncovering new complexities in mast cell signaling.
  Journal
Nat Immunol 3:707-8 (2002)
DOI:10.1038/ni0802-707
Related
pathway
ggo00590  Arachidonic acid metabolism
ggo04010  MAPK signaling pathway
ggo04070  Phosphatidylinositol signaling system
KO pathway
ko04664   
LinkDB

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