KEGG   PATHWAY: hhv04820
Entry
hhv04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Hyaena hyaena (striped hyena)
Class
Cellular Processes; Cell motility
Pathway map
hhv04820  Cytoskeleton in muscle cells
hhv04820

Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120219799  COL11A1; LOW QUALITY PROTEIN: collagen alpha-1(XI) chain [KO:K19721]
120219825  DES; desmin [KO:K07610]
120219862  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
120219960  ITGA7; integrin alpha-7 [KO:K06583]
120220031  ITGA5; integrin alpha-5 [KO:K06484]
120220147  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
120220209  ANK2; ankyrin-2 isoform X1 [KO:K09255]
120220334  FMN2; formin-2 isoform X1 [KO:K02184]
120220447  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
120220700  ITGA10; integrin alpha-10 [KO:K06586]
120220753  MYOT; myotilin [KO:K19875]
120220847  FBN1; LOW QUALITY PROTEIN: fibrillin-1 [KO:K06825]
120221272  ITGA11; integrin alpha-11 [KO:K06587]
120221286  TLN1; talin-1 isoform X1 [KO:K06271]
120221291  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
120221358  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
120221389  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
120221524  TLN2; talin-2 isoform X1 [KO:K06271]
120221531  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
120221730  BGN; biglycan [KO:K08118]
120221821  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
120222174  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
120222277  ITGA2B; integrin alpha-IIb [KO:K06476]
120222283  FMNL1; formin-like protein 1 isoform X1 [KO:K23957]
120222311  SYNE1; LOW QUALITY PROTEIN: nesprin-1 [KO:K19326]
120222387  SDC1; syndecan-1 [KO:K06257]
120222434  OBSCN; LOW QUALITY PROTEIN: obscurin [KO:K17531] [EC:2.7.11.1]
120222517  MYL5; myosin light chain 5 [KO:K12753]
120222633  ITGB1; integrin beta-1 [KO:K05719]
120222730  NEB; nebulin [KO:K18267]
120222978  THBS2; thrombospondin-2 [KO:K04659]
120223110  SGCZ; zeta-sarcoglycan [KO:K27062]
120223311  SNTB2; beta-2-syntrophin [KO:K24064]
120223385  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
120223827  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
120224177  TTN; LOW QUALITY PROTEIN: titin [KO:K12567] [EC:2.7.11.1]
120224348  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
120224971  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
120225509  TNNI2; troponin I, fast skeletal muscle isoform X1 [KO:K12043]
120225515  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
120225714  COL5A2; collagen alpha-2(V) chain [KO:K19721]
120225731  [KO:K18267]
120226842  [KO:K05637]
120227471  EMD; emerin isoform X1 [KO:K12569]
120227950  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
120228024  ACTB; actin, cytoplasmic 1 [KO:K05692]
120228176  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
120228303  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120228347  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
120228350  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
120228481  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
120228602  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
120228676  SNTB1; beta-1-syntrophin [KO:K24064]
120228897  TNNI1; LOW QUALITY PROTEIN: troponin I, slow skeletal muscle [KO:K10371]
120228898  LMOD1; leiomodin-1 [KO:K22030]
120228900  MYBPH; myosin-binding protein H [KO:K24494]
120228905  CSRP1; cysteine and glycine-rich protein 1 isoform X1 [KO:K09377]
120228936  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
120229011  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
120229050  [KO:K19879]
120229071  COL1A1; collagen alpha-1(I) chain [KO:K06236]
120229121  SGCA; alpha-sarcoglycan [KO:K12565]
120229185  [KO:K04659]
120229269  DAG1; dystroglycan [KO:K06265]
120229352  MYL3; myosin light chain 3 [KO:K12749]
120229528  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
120229791  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
120230086  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
120230625  ANKRD2; LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 2 [KO:K21434]
120230628  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
120230925  SDC3; syndecan-3 [KO:K16337]
120231353  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
120231384  MYH10; myosin-10 isoform X1 [KO:K10352]
120231448  [KO:K24220]
120231449  [KO:K24220]
120231450  [KO:K24220]
120231451  [KO:K24220]
120231456  [KO:K24220]
120231459  [KO:K24220]
120232016  ANKRD23; ankyrin repeat domain-containing protein 23 [KO:K21438]
120232021  MYOM3; LOW QUALITY PROTEIN: myomesin-3 [KO:K24495]
120232066  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
120232111  FHL2; four and a half LIM domains protein 2 [KO:K14380]
120232213  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
120232220  SPTBN5; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 5 [KO:K06115]
120232244  THBS1; thrombospondin-1 [KO:K16857]
120232375  NEBL; nebulette isoform X1 [KO:K25865]
120232421  FN1; fibronectin isoform X1 [KO:K05717]
120232508  MYPN; myopalladin isoform X1 [KO:K22028]
120232677  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
120232682  [KO:K06237]
120232697  MYH11; myosin-11 [KO:K10352]
120232789  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
120232821  CUNH10orf71; cardiac-enriched FHL2-interacting protein [KO:K28413]
120233495  TMOD1; tropomodulin-1 [KO:K10370]
120233614  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
120233629  FBLN1; fibulin-1 isoform X1 [KO:K17307]
120233724  MYOZ1; myozenin-1 [KO:K26050]
120233762  VCL; vinculin isoform X1 [KO:K05700]
120234125  LBR; delta(14)-sterol reductase LBR [KO:K19532] [EC:1.3.1.70]
120234375  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
120234406  COL1A2; collagen alpha-2(I) chain [KO:K06236]
120234440  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
120234731  FBN2; fibrillin-2 [KO:K23342]
120234734  LMNB1; lamin-B1 [KO:K07611]
120234802  CSRP3; cysteine and glycine-rich protein 3 isoform X1 [KO:K09377]
120234938  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
120235031  TMOD3; tropomodulin-3 [KO:K10370]
120235038  TMOD2; tropomodulin-2 isoform X1 [KO:K10370]
120235085  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
120235088  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
120235312  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
120235359  [KO:K24421]
120235891  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
120236225  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
120236244  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
120236401  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
120236603  MYOZ3; myozenin-3 [KO:K26050]
120236690  ITGA4; integrin alpha-4 [KO:K06483]
120236714  LMOD2; leiomodin-2 [KO:K22030]
120236771  PDLIM7; PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
120236917  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
120237006  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
120237080  DCN; decorin [KO:K04660]
120237465  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
120237491  SSPN; sarcospan isoform X1 [KO:K22194]
120237655  VCAN; versican core protein [KO:K06793]
120237712  SGCB; beta-sarcoglycan [KO:K12566]
120237718  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
120237786  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
120237834  ACTA1; actin, alpha skeletal muscle [KO:K10354]
120237850  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
120237918  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
120238196  COL11A2; collagen alpha-2(XI) chain [KO:K19721]
120238233  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
120238415  SYNE2; nesprin-2 isoform X1 [KO:K19346]
120238460  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
120238480  [KO:K06238]
120238481  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
120238724  FLNC; filamin-C isoform X1 [KO:K27393]
120238762  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
120238920  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
120238972  ZYX; zyxin [KO:K06273]
120239092  MYOM1; myomesin-1 [KO:K24495]
120239171  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
120239441  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
120239475  PDLIM2; PDZ and LIM domain protein 2 isoform X1 [KO:K23353]
120239760  TNNI3; troponin I, cardiac muscle [KO:K12044]
120239770  TNNT1; troponin T, slow skeletal muscle [KO:K10372]
120239934  FHL3; four and a half LIM domains protein 3 [KO:K24414]
120240023  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
120240091  ACTN3; alpha-actinin-3 [KO:K21073]
120240128  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
120240268  MYH15; myosin-15 [KO:K24220]
120240927  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
120240973  VIM; vimentin [KO:K07606]
120241159  SUN2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
120241162  MYH9; myosin-9 [KO:K10352]
120241297  TMOD4; tropomodulin-4 [KO:K10370]
120241370  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
120241371  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
120241461  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
120241465  COL3A1; collagen alpha-1(III) chain [KO:K19720]
120241647  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
120241683  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
120241792  MYH14; myosin-14 [KO:K10352]
120241814  NID1; nidogen-1 [KO:K06826]
120241830  ACTN2; alpha-actinin-2 isoform X1 [KO:K21073]
120241888  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
120241900  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
120242026  THBS4; thrombospondin-4 [KO:K04659]
120242157  PKP2; plakophilin-2 [KO:K12642]
120242286  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
120242316  LMNB2; lamin-B2 isoform X1 [KO:K07611]
120242413  CKM; creatine kinase M-type [KO:K27382]
120242559  AGRN; agrin isoform X1 [KO:K06254]
120242576  SPTBN4; spectrin beta chain, non-erythrocytic 4 [KO:K06115]
120242616  SDC4; syndecan-4 [KO:K16338]
120242657  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
120242770  MYH7B; myosin-7B isoform X1 [KO:K24220]
120242811  SNTA1; alpha-1-syntrophin [KO:K24063]
120242821  DMD; dystrophin isoform X1 [KO:K10366]
120242861  MYBPC2; myosin-binding protein C, fast-type isoform X1 [KO:K12558]
120242874  LMOD3; leiomodin-3 [KO:K22030]
120243008  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
120243087  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
120243159  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
120243296  TNNC2; troponin C, skeletal muscle [KO:K12042]
120243322  SGCD; delta-sarcoglycan [KO:K12563]
120243678  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
120243689  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
120243750  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
120243917  XIRP2; xin actin-binding repeat-containing protein 2 isoform X1 [KO:K27381]
120244136  ANK3; ankyrin-3 isoform X1 [KO:K09259]
120244252  MYL4; myosin light chain 4 isoform X1 [KO:K12750]
120244266  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
120244450  COL5A3; collagen alpha-3(V) chain isoform X1 [KO:K19721]
120244504  MYBPHL; myosin-binding protein H-like [KO:K24494]
120244519  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
120244686  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
120244719  LMNA; lamin [KO:K12641]
120244836  FBN3; fibrillin-3 [KO:K23342]
120245445  MYBPC1; myosin-binding protein C, slow-type [KO:K12557]
120245479  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
120245869  ITGB5; integrin beta-5 [KO:K06588]
120246124  SDC2; syndecan-2 [KO:K16336]
120246353  SYNPO2; synaptopodin-2 [KO:K24066]
120246355  MYOZ2; myozenin-2 [KO:K26050]
120246388  [KO:K10366]
120246538  [KO:K10388]
120246789  [KO:K10381]
120246824  DSC2; desmocollin-2 isoform X1 [KO:K07601]
120246834  DSG2; desmoglein-2 [KO:K07597]
120246889  ENO3; beta-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
120246911  SYNE3; nesprin-3 isoform X1 [KO:K21761]
120247001  [KO:K17751]
120247013  [KO:K17751]
120247132  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
120247157  TMEM43; transmembrane protein 43 [KO:K27488]
120247159  FBLN2; fibulin-2 isoform X1 [KO:K17307]
120247227  ITGB7; integrin beta-7 [KO:K06590]
120247305  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
120247341  ELN; elastin isoform X1 [KO:K14211]
120247408  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
120247433  SGCG; gamma-sarcoglycan [KO:K12564]
120247749  MYOM2; myomesin-2 isoform X1 [KO:K24495]
120247766  INF2; inverted formin-2 isoform X1 [KO:K23958]
120247870  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
120247983  NID2; nidogen-2 isoform X1 [KO:K06826]
120248041  ITGA1; integrin alpha-1 [KO:K06480]
120248043  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
120248435  [KO:K10056]
120248554  [KO:K05637]
120248667  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
120248672  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
120249144  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
120249150  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
hhv04512  ECM-receptor interaction
hhv04814  Motor proteins
KO pathway
ko04820   

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