KEGG   PATHWAY: hsa00250
Entry
hsa00250                    Pathway                                
Name
Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
Class
Metabolism; Amino acid metabolism
Pathway map
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00250

Module
hsa_M00027  GABA (gamma-Aminobutyrate) shunt [PATH:hsa00250]
Drug
D07130  Carglumic acid (JAN/USAN/INN)
Other DBs
GO: 0006522 0006531 0006536
Organism
Homo sapiens (human) [GN:hsa]
Gene
122622  ADSS1; adenylosuccinate synthetase isozyme 1 isoform 2 [KO:K01939] [EC:6.3.4.4]
1373  CPS1; carbamoyl-phosphate synthase [ammonia], mitochondrial isoform b precursor [KO:K01948] [EC:6.3.4.16]
137362  GOT1L1; putative aspartate aminotransferase, cytoplasmic 2 [KO:K14454] [EC:2.6.1.1]
158  ADSL; adenylosuccinate lyase isoform a [KO:K01756] [EC:4.3.2.2]
159  ADSS2; adenylosuccinate synthetase isozyme 2 isoform 1 [KO:K01939] [EC:6.3.4.4]
18  ABAT; 4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor [KO:K13524] [EC:2.6.1.19 2.6.1.22]
189  AGXT; alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
2346  FOLH1; glutamate carboxypeptidase 2 isoform 1 [KO:K14592] [EC:3.4.17.21]
2571  GAD1; glutamate decarboxylase 1 isoform GAD67 [KO:K01580] [EC:4.1.1.15]
2572  GAD2; glutamate decarboxylase 2 [KO:K01580] [EC:4.1.1.15]
259307  IL4I1; L-amino-acid oxidase isoform 1 precursor [KO:K03334] [EC:1.4.3.2]
2673  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform 1 [KO:K00820] [EC:2.6.1.16]
27165  GLS2; glutaminase liver isoform, mitochondrial isoform 1 precursor [KO:K01425] [EC:3.5.1.2]
2744  GLS; glutaminase kidney isoform, mitochondrial isoform 1 precursor [KO:K01425] [EC:3.5.1.2]
2746  GLUD1; glutamate dehydrogenase 1, mitochondrial isoform a precursor [KO:K00261] [EC:1.4.1.3]
2747  GLUD2; glutamate dehydrogenase 2, mitochondrial precursor [KO:K00261] [EC:1.4.1.3]
2752  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
2805  GOT1; aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
2806  GOT2; aspartate aminotransferase, mitochondrial isoform 1 precursor [KO:K14455] [EC:2.6.1.1]
284716  RIMKLA; N-acetylaspartylglutamate synthase A [KO:K18311] [EC:6.3.2.41 6.3.2.42]
2875  GPT; alanine aminotransferase 1 [KO:K00814] [EC:2.6.1.2]
339983  NAT8L; N-acetylaspartate synthetase [KO:K18309] [EC:2.3.1.17]
435  ASL; argininosuccinate lyase isoform 1 [KO:K01755] [EC:4.3.2.1]
440  ASNS; asparagine synthetase [glutamine-hydrolyzing] isoform a [KO:K01953] [EC:6.3.5.4]
443  ASPA; aspartoacylase [KO:K01437] [EC:3.5.1.15]
445  ASS1; argininosuccinate synthase [KO:K01940] [EC:6.3.4.5]
5471  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
56954  NIT2; omega-amidase NIT2 [KO:K13566] [EC:3.5.1.3]
57494  RIMKLB; beta-citrylglutamate synthase B [KO:K18310] [EC:6.3.1.17 6.3.2.41]
64902  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform a precursor [KO:K00827] [EC:2.6.1.44 2.6.1.40]
790  CAD; multifunctional protein CAD isoform 1 [KO:K11540] [EC:6.3.5.5 2.1.3.2 3.5.2.3]
7915  ALDH5A1; succinate-semialdehyde dehydrogenase, mitochondrial isoform 2 precursor [KO:K00139] [EC:1.2.1.24]
80150  ASRGL1; isoaspartyl peptidase/L-asparaginase isoform 1 [KO:K13051] [EC:3.5.1.1 3.4.19.5]
84706  GPT2; alanine aminotransferase 2 isoform 1 [KO:K00814] [EC:2.6.1.2]
8528  DDO; D-aspartate oxidase isoform h [KO:K00272] [EC:1.4.3.1]
8659  ALDH4A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial isoform a precursor [KO:K00294] [EC:1.2.1.88]
9945  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
Compound
C00014  Ammonia
C00022  Pyruvate
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00041  L-Alanine
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00122  Fumarate
C00152  L-Asparagine
C00158  Citrate
C00169  Carbamoyl phosphate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00352  D-Glucosamine 6-phosphate
C00402  D-Aspartate
C00438  N-Carbamoyl-L-aspartate
C00940  2-Oxoglutaramate
C01042  N-Acetyl-L-aspartate
C02362  2-Oxosuccinamate
C03090  5-Phosphoribosylamine
C03406  N-(L-Arginino)succinate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03912  (S)-1-Pyrroline-5-carboxylate
C12270  N-Acetylaspartylglutamate
C20775  beta-Citryl-L-glutamate
C20776  N-Acetylaspartylglutamylglutamate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:9687539
  Authors
Wu G
  Title
Intestinal mucosal amino acid catabolism.
  Journal
J Nutr 128:1249-52 (1998)
DOI:10.1093/jn/128.8.1249
Related
pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00020  Citrate cycle (TCA cycle)
hsa00220  Arginine biosynthesis
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
hsa00260  Glycine, serine and threonine metabolism
hsa00330  Arginine and proline metabolism
hsa00340  Histidine metabolism
hsa00410  beta-Alanine metabolism
hsa00470  D-Amino acid metabolism
hsa00480  Glutathione metabolism
hsa00520  Amino sugar and nucleotide sugar metabolism
hsa00620  Pyruvate metabolism
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa00650  Butanoate metabolism
hsa00660  C5-Branched dibasic acid metabolism
hsa00760  Nicotinate and nicotinamide metabolism
hsa00770  Pantothenate and CoA biosynthesis
hsa00860  Porphyrin metabolism
hsa00910  Nitrogen metabolism
KO pathway
ko00250   

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