KEGG   PATHWAY: jcu03013
Entry
jcu03013                    Pathway                                
Name
Nucleocytoplasmic transport - Jatropha curcas (Barbados nut)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
jcu03013  Nucleocytoplasmic transport
jcu03013

Other DBs
GO: 0050658
Organism
Jatropha curcas (Barbados nut) [GN:jcu]
Gene
105643389  aladin isoform X1 [KO:K14320]
105643716  zinc finger CCCH domain-containing protein 16 isoform X2 [KO:K14321]
105644675  protein GLE1 isoform X1 [KO:K18723]
105642304  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:5.6.2.7]
105630341  LOW QUALITY PROTEIN: protein RAE1 [KO:K14298]
105630339  nuclear pore complex protein NUP96 isoform X1 [KO:K14297]
105645557  nuclear pore complex protein NUP98A isoform X1 [KO:K14297]
105641002  nuclear pore complex protein NUP214 [KO:K14317]
105646334  nuclear pore complex protein NUP88 [KO:K14318]
105631951  RAN GTPase-activating protein 2 [KO:K14319]
105649995  RAN GTPase-activating protein 1 [KO:K14319]
105639748  SUMO-conjugating enzyme SCE1 [KO:K10577]
105635903  nuclear pore complex protein NUP160 isoform X1 [KO:K14303]
105638205  nuclear pore complex protein NUP85 [KO:K14304]
105628400  protein transport protein SEC13 homolog B [KO:K14004]
105631556  protein transport protein SEC13 homolog B [KO:K14004]
105631364  LOW QUALITY PROTEIN: nuclear pore complex protein NUP107 [KO:K14301]
105641494  nuclear pore complex protein NUP133 isoform X1 [KO:K14300]
105645695  protein SEH1 [KO:K14299]
105633561  nuclear pore complex protein NUP43 [KO:K14305]
105630579  nuclear pore complex protein NUP62 [KO:K14306]
105639643  nuclear pore complex protein NUP58 [KO:K14307]
105644794  nuclear pore complex protein NUP54 [KO:K14308]
105639358  nuclear pore complex protein NUP205 isoform X1 [KO:K14310]
105643779  uncharacterized protein LOC105643779 [KO:K14311]
105634120  nuclear pore complex protein NUP155 [KO:K14312]
105630329  nuclear pore complex protein NUP93A isoform X1 [KO:K14309]
105631560  nuclear pore complex protein NUP35 [KO:K14313]
105646857  uncharacterized protein LOC105646857 [KO:K14315]
105633954  nuclear pore complex protein GP210 [KO:K14314]
105646820  transmembrane protein 33 homolog [KO:K20724]
105634597  nuclear-pore anchor [KO:K09291]
105645887  nucleoporin NUP152 isoform X1 [KO:K14295]
105643500  importin subunit alpha-2 isoform X1 [KO:K15042]
105643571  importin subunit alpha-4 [KO:K15042]
105647451  importin subunit alpha-2 [KO:K15042]
105647413  importin subunit alpha-4 isoform X1 [KO:K15042]
105642189  importin subunit alpha-9 [KO:K15042]
105642588  importin subunit alpha [KO:K15042]
105629337  importin subunit beta-1 [KO:K14293]
105629338  importin subunit beta-1 [KO:K14293]
105648108  importin subunit beta-1 [KO:K14293]
105638511  transportin-1 [KO:K18752]
105630256  transportin MOS14 isoform X4 [KO:K15436]
105640459  transportin MOS14 [KO:K15436]
105646465  importin-4 [KO:K20221]
105630016  importin-5 [KO:K20222]
105632615  importin-5 [KO:K20222]
105645467  importin subunit beta-3 isoform X1 [KO:K20222]
105629308  importin beta-like SAD2 [KO:K20223]
105641940  importin-9 [KO:K20224]
105640199  snurportin-1 [KO:K13151]
105649014  LOW QUALITY PROTEIN: protein EXPORTIN 1A [KO:K14290]
105642834  exportin-2 [KO:K18423]
105631387  exportin-T [KO:K14288]
105647741  exportin-4 [KO:K25203]
105647628  protein HASTY 1 [KO:K14289]
105631289  exportin-7 [KO:K18460]
105639313  GTP-binding nuclear protein Ran1A [KO:K07936]
105637667  GTP-binding nuclear protein Ran-3 [KO:K07936]
105642186  LOW QUALITY PROTEIN: elongation factor 1-alpha [KO:K03231]
105638175  uncharacterized protein LOC105638175 isoform X1 [KO:K14291]
105648321  nuclear cap-binding protein subunit 1 [KO:K12882]
105646896  nuclear cap-binding protein subunit 2 [KO:K12883]
105645459  60S ribosomal export protein NMD3 [KO:K07562]
105648305  RNA-binding protein Y14 [KO:K12876]
105643230  protein mago nashi homolog [KO:K12877]
105628920  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
105627963  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
105643078  histone deacetylase complex subunit SAP18 [KO:K14324]
105645899  histone deacetylase complex subunit SAP18 isoform X1 [KO:K14324]
105646209  serine/arginine-rich splicing factor SR45 isoform X1 [KO:K14325]
105628779  pinin [KO:K13114]
105628230  LOW QUALITY PROTEIN: THO complex subunit 4A [KO:K12881]
105636460  regulator of nonsense transcripts 1 homolog [KO:K14326] [EC:5.6.2.5 5.6.2.3]
105635232  regulator of nonsense transcripts UPF2 [KO:K14327]
105635129  regulator of nonsense transcripts UPF3 isoform X1 [KO:K14328]
105629679  regulator of nonsense transcripts UPF3 isoform X3 [KO:K14328]
105637649  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
105634868  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
105629923  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
105628787  partner of Y14 and mago [KO:K14294]
105631259  THO complex subunit 1 [KO:K12878]
105634157  THO complex subunit 2 [KO:K12879]
105633637  THO complex subunit 5B isoform X1 [KO:K13174]
105632458  THO complex subunit 7A [KO:K13176]
105629302  THO complex subunit 3 isoform X1 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
jcu03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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