KEGG   PATHWAY: jcu03015
Entry
jcu03015                    Pathway                                
Name
mRNA surveillance pathway - Jatropha curcas (Barbados nut)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
jcu03015  mRNA surveillance pathway
jcu03015

Other DBs
GO: 0071028
Organism
Jatropha curcas (Barbados nut) [GN:jcu]
Gene
105648321  nuclear cap-binding protein subunit 1 [KO:K12882]
105646896  nuclear cap-binding protein subunit 2 [KO:K12883]
105635129  regulator of nonsense transcripts UPF3 isoform X1 [KO:K14328]
105629679  regulator of nonsense transcripts UPF3 isoform X3 [KO:K14328]
105648305  RNA-binding protein Y14 [KO:K12876]
105643230  protein mago nashi homolog [KO:K12877]
105628920  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
105643078  histone deacetylase complex subunit SAP18 [KO:K14324]
105645899  histone deacetylase complex subunit SAP18 isoform X1 [KO:K14324]
105628779  pinin [KO:K13114]
105627963  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
105646209  serine/arginine-rich splicing factor SR45 isoform X1 [KO:K14325]
105628230  LOW QUALITY PROTEIN: THO complex subunit 4A [KO:K12881]
105642304  DEAD-box ATP-dependent RNA helicase 38 [KO:K18655] [EC:5.6.2.7]
105644675  protein GLE1 isoform X1 [KO:K18723]
105637649  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
105634868  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
105628787  partner of Y14 and mago [KO:K14294]
105629923  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
105646640  mRNA-capping enzyme [KO:K13917] [EC:2.7.7.50 3.6.1.74]
105648376  mRNA cap guanine-N7 methyltransferase 2 isoform X1 [KO:K00565] [EC:2.1.1.56]
105639549  transcription initiation factor TFIID subunit 15b isoform X1 [KO:K13098]
105631591  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
105648675  polyadenylate-binding protein 1 [KO:K14396]
105641635  polyadenylate-binding protein 3 isoform X2 [KO:K14396]
105648478  pre-mRNA cleavage factor Im 25 kDa subunit 2 [KO:K14397]
105637920  pre-mRNA cleavage factor Im 25 kDa subunit 1 [KO:K14397]
105644707  cleavage and polyadenylation specificity factor subunit 6 [KO:K14398]
105636696  LOW QUALITY PROTEIN: nuclear poly(A) polymerase 1 [KO:K14376] [EC:2.7.7.19]
105631534  nuclear poly(A) polymerase 4 [KO:K14376] [EC:2.7.7.19]
105638230  nuclear poly(A) polymerase 4 isoform X2 [KO:K14376] [EC:2.7.7.19]
105642601  protein CLP1 homolog [KO:K14399] [EC:2.7.1.78]
105629451  LOW QUALITY PROTEIN: uncharacterized protein LOC105629451 [KO:K14400]
105649373  polyadenylation and cleavage factor homolog 4 [KO:K14400]
105648570  cleavage and polyadenylation specificity factor subunit 1 isoform X1 [KO:K14401]
105646924  cleavage and polyadenylation specificity factor subunit 2 isoform X3 [KO:K14402]
105633321  cleavage and polyadenylation specificity factor subunit 3-I [KO:K14403] [EC:3.1.27.-]
105636862  LOW QUALITY PROTEIN: 30-kDa cleavage and polyadenylation specificity factor 30 [KO:K14404]
105631110  uncharacterized protein LOC105631110 isoform X1 [KO:K14404]
105643542  FIP1[V]-like protein [KO:K14405]
105631219  flowering time control protein FY isoform X1 [KO:K15542]
105628902  protein ANTHESIS POMOTING FACTOR 1 isoform X1 [KO:K14962]
105634162  protein ANTHESIS POMOTING FACTOR 1 [KO:K14962]
105629912  serine/threonine-protein phosphatase PP1 isozyme 2 [KO:K06269] [EC:3.1.3.16]
105632126  serine/threonine-protein phosphatase PP1 isozyme 2 isoform X1 [KO:K06269] [EC:3.1.3.16]
105649055  serine/threonine-protein phosphatase PP1 isozyme 1 [KO:K06269] [EC:3.1.3.16]
105647030  serine/threonine-protein phosphatase PP1 isozyme 4 [KO:K06269] [EC:3.1.3.16]
105647733  serine/threonine-protein phosphatase PP1 isoform X1 [KO:K06269] [EC:3.1.3.16]
105645743  serine/threonine-protein phosphatase PP1 [KO:K06269] [EC:3.1.3.16]
105647484  serine/threonine-protein phosphatase PP1 isozyme 9 [KO:K06269] [EC:3.1.3.16]
105636420  RNA polymerase II subunit A C-terminal domain phosphatase SSU72 isoform X1 [KO:K15544] [EC:3.1.3.16]
105640652  cleavage stimulation factor subunit 50 isoform X1 [KO:K14406]
105635764  cleavage stimulation factor subunit 77 isoform X2 [KO:K14408]
105630767  uncharacterized protein LOC105630767 [KO:K06100]
105646588  uncharacterized protein LOC105646588 isoform X2 [KO:K06100]
105635564  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
105630809  RNA-binding protein 1 [KO:K14411]
105633054  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
105639711  RNA-binding protein Musashi homolog 1 isoform X4 [KO:K14411]
105639877  RNA-binding protein 1 [KO:K14411]
105644493  heterogeneous nuclear ribonucleoprotein 1 [KO:K14411]
105641477  heterogeneous nuclear ribonucleoprotein 1 isoform X2 [KO:K14411]
105635923  polyadenylate-binding protein 3 [KO:K13126]
105631520  polyadenylate-binding protein 6 isoform X1 [KO:K13126]
105642321  polyadenylate-binding protein 7 [KO:K13126]
105630930  LOW QUALITY PROTEIN: polyadenylate-binding protein 2 [KO:K13126]
105639743  polyadenylate-binding protein 4 [KO:K13126]
105639744  polyadenylate-binding protein 4 [KO:K13126]
105630255  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
105647259  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
105634327  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
105636460  regulator of nonsense transcripts 1 homolog [KO:K14326] [EC:5.6.2.5 5.6.2.3]
105635232  regulator of nonsense transcripts UPF2 [KO:K14327]
105631693  uncharacterized protein LOC105631693 isoform X1 [KO:K08873] [EC:2.7.11.1]
105628990  protein SMG7 isoform X1 [KO:K14409]
105640463  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
105648947  serine/threonine-protein phosphatase PP2A-4 catalytic subunit [KO:K04382] [EC:3.1.3.16]
105644337  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
105649811  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
105650665  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
105642001  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
105631493  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105638165  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105640354  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
105631809  probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 [KO:K11583]
105632152  serine/threonine protein phosphatase 2A regulatory subunit B''beta isoform X1 [KO:K11583]
105647748  serine/threonine protein phosphatase 2A regulatory subunit B''beta [KO:K11583]
105644514  serine/threonine protein phosphatase 2A regulatory subunit B''alpha isoform X1 [KO:K11583]
105633250  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
105638524  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform [KO:K11584]
105642281  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform [KO:K11584]
105639286  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform isoform X2 [KO:K11584]
105644749  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
105644750  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform [KO:K11584]
105637470  elongation factor 1-alpha isoform X1 [KO:K14416]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
jcu03013  Nucleocytoplasmic transport
jcu03018  RNA degradation
jcu03040  Spliceosome
KO pathway
ko03015   
LinkDB

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