KEGG   PATHWAY: leri00310
Entry
leri00310                   Pathway                                
Name
Lysine degradation - Leucoraja erinacea (little skate)
Class
Metabolism; Amino acid metabolism
Pathway map
leri00310  Lysine degradation
leri00310

Module
leri_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:leri00310]
Other DBs
GO: 0006554
Organism
Leucoraja erinacea (little skate) [GN:leri]
Gene
129706180  aass; alpha-aminoadipic semialdehyde synthase, mitochondrial [KO:K14157] [EC:1.5.1.8 1.5.1.9]
129695789  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
129695409  aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [KO:K00825] [EC:2.6.1.7 2.6.1.39]
129707957  dhtkd1; 2-oxoadipate dehydrogenase complex component E1 [KO:K15791] [EC:1.2.4.-]
129699995  dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1 [KO:K00658] [EC:2.3.1.61]
129707622  dldh; dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
129714353  glutaryl-CoA dehydrogenase, mitochondrial-like [KO:K00252] [EC:1.3.8.6]
129697175  trifunctional enzyme subunit alpha, mitochondrial-like isoform X1 [KO:K07515] [EC:4.2.1.17 1.1.1.211]
129712872  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
129701011  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
129698132  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
129699588  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
129713553  hydroxylysine kinase-like isoform X1 [KO:K18201] [EC:2.7.1.81]
129713554  hydroxylysine kinase-like isoform X1 [KO:K18201] [EC:2.7.1.81]
129713556  LOW QUALITY PROTEIN: hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
129713559  hydroxylysine kinase-like [KO:K18201] [EC:2.7.1.81]
129701744  phykpl; 5-phosphohydroxy-L-lysine phospho-lyase [KO:K18202] [EC:4.2.3.134]
129710860  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
129699653  camkmt; calmodulin-lysine N-methyltransferase isoform X1 [KO:K18826] [EC:2.1.1.60]
129712254  kmt2a; histone-lysine N-methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
129714725  kmt2d; histone-lysine N-methyltransferase 2D isoform X1 [KO:K09187] [EC:2.1.1.354]
129714455  kmt2ca; histone-lysine N-methyltransferase 2C isoform X1 [KO:K09188] [EC:2.1.1.354]
129707817  kmt2e; inactive histone-lysine N-methyltransferase 2E isoform X1 [KO:K09189] [EC:2.1.1.354]
129709397  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase SETD1B-like [KO:K11422] [EC:2.1.1.354]
129693732  histone-lysine N-methyltransferase PRDM7-like isoform X1 [KO:K20796] [EC:2.1.1.354]
129715786  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase ASH1L-like [KO:K06101] [EC:2.1.1.354]
129699466  smyd3; histone-lysine N-methyltransferase SMYD3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
129699728  N-lysine methyltransferase SMYD2-like isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
129700638  histone-lysine N-methyltransferase Smyd1-like [KO:K11426] [EC:2.1.1.354 2.1.1.357]
129707975  histone-lysine N-methyltransferase SUV39H2-like [KO:K11419] [EC:2.1.1.355]
129711920  histone-lysine N-methyltransferase EHMT1-like isoform X1 [KO:K11420] [EC:2.1.1.355]
129716250  ehmt2; histone-lysine N-methyltransferase EHMT2 [KO:K11420] [EC:2.1.1.355]
129715984  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase SETDB1-like [KO:K11421] [EC:2.1.1.366]
129702836  histone-lysine N-methyltransferase SETDB2-like [KO:K18494] [EC:2.1.1.355]
129711463  PR domain zinc finger protein 2-like [KO:K11432] [EC:2.1.1.355]
129710221  ezh2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
129704555  setmar; histone-lysine N-methyltransferase SETMAR isoform X1 [KO:K11433] [EC:2.1.1.357]
129701609  histone-lysine N-methyltransferase NSD2-like isoform X1 [KO:K15588] [EC:2.1.1.357]
129707813  nsd2; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
129713203  nsd3; histone-lysine N-methyltransferase NSD3 isoform X1 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
129714861  setd2; histone-lysine N-methyltransferase SETD2 isoform X1 [KO:K11423] [EC:2.1.1.359]
129711131  dot1l; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
129709245  N-lysine methyltransferase KMT5A-like isoform X1 [KO:K11428] [EC:2.1.1.361]
129695800  prdm6; putative histone-lysine N-methyltransferase PRDM6 [KO:K20795] [EC:2.1.1.361]
129705710  kmt5b; histone-lysine N-methyltransferase KMT5B isoform X1 [KO:K11429] [EC:2.1.1.362]
129713956  uncharacterized protein LOC129713956 isoform X1 [KO:K11429] [EC:2.1.1.362]
129703274  histone-lysine N-methyltransferase MECOM-like [KO:K04462] [EC:2.1.1.367]
129711763  prdm16; histone-lysine N-methyltransferase PRDM16 isoform X1 [KO:K22410] [EC:2.1.1.367]
129702189  tmlhe; trimethyllysine dioxygenase, mitochondrial [KO:K00474] [EC:1.14.11.8]
129709155  aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
129713971  aldehyde dehydrogenase family 16 member A1-like isoform X1 [KO:K00128] [EC:1.2.1.3]
129710558  aldehyde dehydrogenase family 3 member A2-like [KO:K00128] [EC:1.2.1.3]
129710561  aldehyde dehydrogenase family 3 member A2-like [KO:K00128] [EC:1.2.1.3]
129701198  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
129705553  bbox1; LOW QUALITY PROTEIN: gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
129711559  plod1a; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform X1 [KO:K00473] [EC:1.14.11.4]
129703322  plod2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1 [KO:K13645] [EC:1.14.11.4]
129701273  procollagen galactosyltransferase 2-like isoform X1 [KO:K11703] [EC:2.4.1.50]
129711999  cercam; procollagen galactosyltransferase 1 isoform X1 [KO:K11703] [EC:2.4.1.50]
129714365  procollagen galactosyltransferase 1-like [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
leri00020  Citrate cycle (TCA cycle)
leri00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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