Entry
Name
B cell receptor signaling pathway - Lipotes vexillifer (Yangtze River dolphin)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
lve04662 B cell receptor signaling pathway
Ortholog table
Other DBs
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:
lve ]
Gene
103075075 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like [KO:K06856 ]
103075361 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like [KO:K06856 ]
103090927 CD79A; B-cell antigen receptor complex-associated protein alpha chain isoform X1 [KO:K06506 ]
103077726 CD79B; B-cell antigen receptor complex-associated protein beta chain isoform X1 [KO:K06507 ]
103088484 DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X1 [KO:K12229 ]
103082841 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
103088874 VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730 ]
103074749 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
103070997 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
103088182 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
103070526 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
103090427 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
103078845 PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268 ]
103081110 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
103083433 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
103079766 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
103090968 CARD11; caspase recruitment domain-containing protein 11 isoform X1 [KO:K07367 ]
103081651 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
103068644 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
103070370 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
103078725 PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
103083960 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
103089257 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
103088756 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
103085303 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
103088736 low affinity immunoglobulin gamma Fc region receptor II-like [KO:K12560 ]
103078405 INPPL1; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909 ] [EC:3.1.3.86 ]
103087792 LILRA6; leukocyte immunoglobulin-like receptor subfamily A member 6-like [KO:K06512 ]
103069792 leukocyte immunoglobulin-like receptor subfamily B member 3-like [KO:K06512 ]
103086106 leukocyte immunoglobulin-like receptor subfamily A member 3-like [KO:K06512 ]
103086672 leukocyte immunoglobulin-like receptor subfamily B member 1-like [KO:K06512 ]
103086390 LILRB3; leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Niiro H, Clark EA.
Title
Regulation of B-cell fate by antigen-receptor signals.
Journal
Reference
Authors
Kurosaki T.
Title
Genetic analysis of B cell antigen receptor signaling.
Journal
Reference
Authors
Nitschke L.
Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal
Reference
Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title
Complement: central to innate immunity and bridging to adaptive responses.
Journal
Reference
Authors
Kurosaki T.
Title
Regulation of B-cell signal transduction by adaptor proteins.
Journal
Reference
Authors
Nitschke L, Tsubata T.
Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal
Reference
Authors
Jumaa H, Hendriks RW, Reth M.
Title
B cell signaling and tumorigenesis.
Journal
Reference
Authors
Rickert RC.
Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal
Reference
Authors
Zouali M, Sarmay G
Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal
Reference
Authors
Chiles TC.
Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal
Reference
Authors
Allam A, Marshall AJ
Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal
Reference
Authors
Gold MR
Title
To make antibodies or not: signaling by the B-cell antigen receptor.
Journal
Reference
Authors
Fu C, Turck CW, Kurosaki T, Chan AC
Title
BLNK: a central linker protein in B cell activation.
Journal
Reference
Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal
Reference
Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal
Related pathway
lve04610 Complement and coagulation cascades
lve04810 Regulation of actin cytoskeleton
KO pathway
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