KEGG   PATHWAY: lve04151
Entry
lve04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Lipotes vexillifer (Yangtze River dolphin)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
lve04151  PI3K-Akt signaling pathway
lve04151

Other DBs
GO: 0043491
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103068298  [KO:K05439]
103068413  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
103068442  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
103068450  HSP90AB1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
103068454  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
103068554  AREG; amphiregulin isoform X1 [KO:K09782]
103068617  [KO:K05414]
103068644  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103068686  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103068734  NRAS; GTPase NRas [KO:K07828]
103068746  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
103068747  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
103068842  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103068905  THBS3; thrombospondin-3 [KO:K04659]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103069012  IL4; interleukin-4 [KO:K05430]
103069069  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103069101  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
103069127  IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
103069161  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
103069181  [KO:K05414]
103069202  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103069204  EREG; proepiregulin [KO:K09784]
103069235  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
103069249  [KO:K06236]
103069327  FGF5; fibroblast growth factor 5 [KO:K04358]
103069406  CHAD; chondroadherin isoform X1 [KO:K06248]
103069416  GHR; growth hormone receptor isoform X1 [KO:K05080]
103069455  PIK3CG; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
103069500  [KO:K04542]
103069560  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
103069563  EFNA2; ephrin-A2 [KO:K05462]
103069618  [KO:K07208]
103069638  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
103069739  [KO:K05414]
103069787  [KO:K04360] [EC:2.7.10.1]
103069902  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103070284  G6PC3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
103070292  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
103070306  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103070557  EFNA1; ephrin-A1 [KO:K05462]
103070575  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
103070593  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
103070656  CHRM1; muscarinic acetylcholine receptor M1 isoform X1 [KO:K04129]
103070701  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
103070821  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
103070825  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
103070834  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
103070931  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
103070944  PPP2R2C; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform [KO:K04354]
103071005  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
103071106  LAMC3; laminin subunit gamma-3 [KO:K06247]
103071141  ITGA11; integrin alpha-11 [KO:K06587]
103071175  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
103071252  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
103071263  EPO; erythropoietin [KO:K05437]
103071281  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
103071415  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
103071469  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
103071473  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103071477  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
103071508  IL2; interleukin-2 [KO:K05429]
103071546  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103071696  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103071744  LAMB1; laminin subunit beta-1 [KO:K05636]
103071756  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
103071879  FGF18; fibroblast growth factor 18 [KO:K04358]
103071883  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
103071928  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
103071944  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
103071962  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103071970  LAMB2; laminin subunit beta-2 [KO:K06243]
103071971  [KO:K06236]
103072092  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103072118  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
103072184  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
103072382  PKN3; serine/threonine-protein kinase N3 [KO:K23692]
103072416  OSM; oncostatin-M [KO:K05418]
103072433  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
103072491  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103072598  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
103072682  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103072981  FGF16; fibroblast growth factor 16 [KO:K04358]
103073004  VWF; von Willebrand factor [KO:K03900]
103073028  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
103073033  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
103073066  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103073219  [KO:K05414]
103073252  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
103073424  LAMA5; laminin subunit alpha-5 [KO:K06240]
103073470  [KO:K10605] [EC:2.3.2.27]
103073645  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
103073772  [KO:K05415]
103073883  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103074001  [KO:K16197]
103074278  IRS1; insulin receptor substrate 1 [KO:K16172]
103074298  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103074358  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
103074388  FGF23; fibroblast growth factor 23 [KO:K22428]
103074426  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
103074553  ITGA5; integrin alpha-5 [KO:K06484]
103074623  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
103074659  TLR4; toll-like receptor 4 [KO:K10160]
103074714  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
103074746  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103074749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103074757  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
103074802  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103074827  VEGFC; vascular endothelial growth factor C [KO:K05449]
103074830  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
103074848  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
103074882  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103074944  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
103075075  [KO:K06856]
103075247  NTF3; neurotrophin-3 [KO:K04356]
103075275  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
103075350  TSC2; tuberin [KO:K07207]
103075356  ITGA2B; integrin alpha-IIb [KO:K06476]
103075361  [KO:K06856]
103075444  IL7; interleukin-7 isoform X1 [KO:K05431]
103075492  [KO:K04542]
103075527  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103075672  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
103075748  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
103075939  MAGI1; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
103075969  ANGPT2; angiopoietin-2 [KO:K05466]
103075978  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076387  PDGFC; platelet-derived growth factor C [KO:K05450]
103076642  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
103076750  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103076801  VTN; vitronectin isoform X1 [KO:K06251]
103076804  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
103076917  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
103076982  TGFA; protransforming growth factor alpha [KO:K08774]
103077071  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
103077106  ITGA4; integrin alpha-4 [KO:K06483]
103077162  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
103077180  ITGB4; integrin beta-4 [KO:K06525]
103077238  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
103077256  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
103077294  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
103077329  TNC; tenascin isoform X1 [KO:K06252]
103077422  FGF6; fibroblast growth factor 6 [KO:K04358]
103077460  GH1; somatotropin [KO:K05438]
103077552  PSPN; persephin [KO:K25416]
103077579  KRAS; GTPase KRas [KO:K07827]
103077876  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
103077901  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
103077970  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103077986  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
103078013  F2R; proteinase-activated receptor 1 [KO:K03914]
103078023  LPAR4; lysophosphatidic acid receptor 4 isoform X1 [KO:K04275]
103078095  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
103078101  ITGA6; integrin alpha-6 [KO:K06485]
103078168  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
103078286  NRTN; neurturin [KO:K25414]
103078299  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
103078303  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
103078350  ERBB4; receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
103078406  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
103078532  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103078728  SPP1; osteopontin isoform X1 [KO:K06250]
103078804  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
103078877  CSF3; granulocyte colony-stimulating factor [KO:K05423]
103078928  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103079037  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
103079072  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103079754  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103079796  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103079910  PRLR; prolactin receptor isoform X1 [KO:K05081]
103079925  RPS6; 40S ribosomal protein S6 [KO:K02991]
103079968  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
103080002  IBSP; bone sialoprotein 2 [KO:K06253]
103080206  EFNA5; ephrin-A5 [KO:K05462]
103080271  RHEB; GTP-binding protein Rheb [KO:K07208]
103080479  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103080643  KITLG; kit ligand isoform X1 [KO:K05461]
103080694  THBS1; thrombospondin-1 [KO:K16857]
103080733  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103080887  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
103080890  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103081109  BRCA1; breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
103081131  HSP90B1; endoplasmin [KO:K09487]
103081170  [KO:K22603]
103081180  [KO:K05057]
103081291  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103081338  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103081431  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
103081453  ITGB7; integrin beta-7 [KO:K06590]
103081519  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
103081545  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
103081594  LAMA1; laminin subunit alpha-1 [KO:K05637]
103081604  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
103081765  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103081811  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
103081969  FGF21; fibroblast growth factor 21 [KO:K22429]
103081992  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
103082053  PGF; placenta growth factor isoform X1 [KO:K16859]
103082213  [KO:K03456]
103082303  YWHAH; 14-3-3 protein eta [KO:K16198]
103082310  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
103082363  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103082417  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
103082438  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
103082546  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
103082763  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103082839  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
103082904  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
103082933  CD19; B-lymphocyte antigen CD19 [KO:K06465]
103083306  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
103083417  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
103083485  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
103083608  BAD; bcl2 antagonist of cell death [KO:K02158]
103083668  THBS4; thrombospondin-4 [KO:K04659]
103083851  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
103083889  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103083967  FGF10; fibroblast growth factor 10 [KO:K04358]
103084220  NGF; beta-nerve growth factor [KO:K02582]
103084224  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
103084253  [KO:K16198]
103084467  FOXO3; forkhead box protein O3 [KO:K09408]
103084472  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
103084737  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
103084753  LAMA3; laminin subunit alpha-3 [KO:K06240]
103084826  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103084836  YWHAG; LOW QUALITY PROTEIN: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma [KO:K16198]
103084946  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103084996  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
103085046  PDGFD; platelet-derived growth factor D-like isoform X1 [KO:K05450]
103085069  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
103085145  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103085220  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103085298  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103085446  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
103085500  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
103085559  YWHAZ; 14-3-3 protein zeta/delta isoform X1 [KO:K16197]
103085622  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
103085711  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
103085727  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
103085742  INS; insulin [KO:K04526]
103085988  ITGA2; integrin alpha-2 [KO:K06481]
103086163  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
103086171  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
103086266  YWHAQ; 14-3-3 protein theta [KO:K16197]
103086359  FGF7; fibroblast growth factor 7 [KO:K04358]
103086387  NTF4; neurotrophin-4 [KO:K12457]
103086398  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
103086424  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103086550  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
103086552  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
103086573  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
103086651  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
103086689  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
103086745  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
103086967  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
103087008  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103087072  ITGAV; integrin alpha-V [KO:K06487]
103087133  FIGF; vascular endothelial growth factor D [KO:K05449]
103087166  LAMB3; laminin subunit beta-3 [KO:K06244]
103087241  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
103087259  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
103087304  RELA; transcription factor p65 isoform X1 [KO:K04735]
103087530  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
103087546  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
103087641  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
103087655  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
103087751  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
103087752  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
103087802  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
103087914  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103088257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103088278  TSC1; hamartin isoform X1 [KO:K07206]
103088362  YWHAE; 14-3-3 protein epsilon [KO:K06630]
103088369  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
103088616  [KO:K06238]
103088633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103088660  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103088802  TNR; tenascin-R [KO:K06252]
103088885  [KO:K06238]
103088921  IL3; interleukin-3 [KO:K04736]
103088923  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
103088926  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
103089053  ITGB5; integrin beta-5 [KO:K06588]
103089070  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103089095  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
103089138  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
103089216  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103089226  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103089331  TNN; tenascin-N [KO:K06252]
103089375  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
103089400  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
103089406  MTCP1; protein p13 MTCP-1 [KO:K16837]
103089438  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
103089640  ITGA9; integrin alpha-9 [KO:K06585]
103089643  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
103089724  [KO:K04548]
103089745  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
103089752  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
103089875  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103089912  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
103089962  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
103090009  LAMC1; LOW QUALITY PROTEIN: laminin subunit gamma-1 [KO:K05635]
103090085  FGF4; fibroblast growth factor 4 [KO:K04358]
103090095  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103090157  ITGA8; integrin alpha-8 [KO:K06584]
103090179  [KO:K10159]
103090223  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
103090256  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
103090274  LAMC2; laminin subunit gamma-2 [KO:K06246]
103090358  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103090378  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
103090480  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
103090518  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
103090612  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103090661  [KO:K05414]
103090694  ANGPT4; angiopoietin-4 [KO:K05467]
103090714  ARTN; artemin [KO:K25415]
103090769  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103090812  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103090844  EPOR; erythropoietin receptor [KO:K05079]
103090870  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
103090898  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
103090939  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
103090946  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog isoform X1 [KO:K02539]
103090984  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
103091027  FGF20; fibroblast growth factor 20 [KO:K04358]
103091030  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
103091045  FGF9; fibroblast growth factor 9 [KO:K04358]
103091078  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103091114  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
103091152  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
103091202  [KO:K05414]
103091506  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
103091662  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
103091674  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
lve00010  Glycolysis / Gluconeogenesis
lve04010  MAPK signaling pathway
lve04012  ErbB signaling pathway
lve04062  Chemokine signaling pathway
lve04064  NF-kappa B signaling pathway
lve04068  FoxO signaling pathway
lve04110  Cell cycle
lve04115  p53 signaling pathway
lve04150  mTOR signaling pathway
lve04210  Apoptosis
lve04370  VEGF signaling pathway
lve04510  Focal adhesion
lve04620  Toll-like receptor signaling pathway
lve04630  JAK-STAT signaling pathway
lve04662  B cell receptor signaling pathway
lve04910  Insulin signaling pathway
KO pathway
ko04151   

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