KEGG   PATHWAY: lve04810
Entry
lve04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Lipotes vexillifer (Yangtze River dolphin)
Class
Cellular Processes; Cell motility
Pathway map
lve04810  Regulation of actin cytoskeleton
lve04810

Other DBs
GO: 0030036
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103068396  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103068454  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
103068478  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
103068672  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
103068734  NRAS; GTPase NRas [KO:K07828]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103069069  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103069126  [KO:K18584]
103069136  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103069138  [KO:K04131]
103069171  PFN2; profilin-2 [KO:K05759]
103069327  FGF5; fibroblast growth factor 5 [KO:K04358]
103069348  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
103069371  ABI2; abl interactor 2 isoform X1 [KO:K05751]
103069477  C8A; complement component C8 alpha chain [KO:K03997]
103069562  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
103069609  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
103069755  C8B; complement component C8 beta chain [KO:K03998]
103069854  EZR; ezrin isoform X1 [KO:K08007]
103069902  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103069913  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103070292  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103070405  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
103070546  ITGAE; integrin alpha-E [KO:K06524]
103070593  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
103070656  CHRM1; muscarinic acetylcholine receptor M1 isoform X1 [KO:K04129]
103070662  RRAS; ras-related protein R-Ras [KO:K07829]
103070717  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
103070821  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
103070964  MYH11; myosin-11 isoform X1 [KO:K10352]
103071141  ITGA11; integrin alpha-11 [KO:K06587]
103071252  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
103071284  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
103071473  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103071476  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
103071546  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103071564  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
103071630  [KO:K05745]
103071727  FAM49A; protein FAM49A [KO:K27976]
103071840  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
103071879  FGF18; fibroblast growth factor 18 [KO:K04358]
103071897  [KO:K10031]
103071962  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103071997  PPP1R12A; protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K06270]
103072122  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
103072153  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
103072342  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103072869  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103072971  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
103072981  FGF16; fibroblast growth factor 16 [KO:K04358]
103072994  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103073013  CXCR4; c-X-C chemokine receptor type 4 [KO:K04189]
103073184  RGCC; regulator of cell cycle RGCC [KO:K26108]
103073252  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
103073297  ITGAX; integrin alpha-X [KO:K06462]
103073449  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
103073477  C6; complement component C6 [KO:K03995]
103073578  ITGAM; integrin alpha-M [KO:K06461]
103073751  C7; complement component C7 [KO:K03996]
103073860  PFN4; profilin-4 [KO:K05759]
103073883  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103074002  NCKAP1L; nck-associated protein 1-like [KO:K05750]
103074387  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103074388  FGF23; fibroblast growth factor 23 [KO:K22428]
103074405  RDX; radixin isoform X1 [KO:K05762]
103074553  ITGA5; integrin alpha-5 [KO:K06484]
103074641  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
103074732  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
103074749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103074802  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103075356  ITGA2B; integrin alpha-IIb [KO:K06476]
103075385  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103075701  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103075920  MYH10; myosin-10 [KO:K10352]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103076075  [KO:K05764]
103076082  ARPC4; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 4 [KO:K05755]
103076279  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076387  PDGFC; platelet-derived growth factor C [KO:K05450]
103076541  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
103076611  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
103076856  [KO:K05765]
103076963  KNG1; kininogen-1 isoform X1 [KO:K03898]
103077059  ACTR3B; actin-related protein 3B-like isoform X1 [KO:K18584]
103077106  ITGA4; integrin alpha-4 [KO:K06483]
103077180  ITGB4; integrin beta-4 [KO:K06525]
103077223  ACTB; actin, cytoplasmic 1 [KO:K05692]
103077228  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
103077310  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
103077393  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
103077422  FGF6; fibroblast growth factor 6 [KO:K04358]
103077564  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103077568  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
103077579  KRAS; GTPase KRas [KO:K07827]
103077653  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
103077706  PAK7; serine/threonine-protein kinase PAK 7 isoform X1 [KO:K05736] [EC:2.7.11.1]
103077707  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103077775  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103077822  [KO:K05759]
103077891  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
103078013  F2R; proteinase-activated receptor 1 [KO:K03914]
103078023  LPAR4; lysophosphatidic acid receptor 4 isoform X1 [KO:K04275]
103078061  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
103078101  ITGA6; integrin alpha-6 [KO:K06485]
103078406  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
103078515  PXN; paxillin-like isoform X1 [KO:K05760]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103078775  IQGAP2; LOW QUALITY PROTEIN: ras GTPase-activating-like protein IQGAP2 [KO:K05767]
103078949  C8G; complement component C8 gamma chain [KO:K03999]
103078952  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103079256  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103079280  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
103079491  ENAH; protein enabled homolog [KO:K05746]
103079514  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103079755  ITGB2; integrin beta-2 [KO:K06464]
103079981  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
103080087  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
103080281  [KO:K05752]
103080471  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103080596  WASF2; wiskott-Aldrich syndrome protein family member 2 isoform X1 [KO:K05748]
103080867  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
103080890  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103081170  [KO:K22603]
103081244  C9; complement component C9 [KO:K04000]
103081453  ITGB7; integrin beta-7 [KO:K06590]
103081507  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
103081640  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
103081872  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
103081969  FGF21; fibroblast growth factor 21 [KO:K22429]
103082067  PFN3; profilin-3 [KO:K05759]
103082256  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103082310  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
103082311  TMSB4X; thymosin beta-4 [KO:K05764]
103082363  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103082406  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
103082438  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
103082455  [KO:K04514] [EC:2.7.11.39]
103082660  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103082841  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
103083014  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103083053  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
103083293  GSN; gelsolin isoform X1 [KO:K05768]
103083467  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
103083551  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103083833  ARHGEF12; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12 [KO:K07532]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103083967  FGF10; fibroblast growth factor 10 [KO:K04358]
103084224  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
103084474  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
103084511  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
103084638  FAM49B; protein FAM49B isoform X1 [KO:K27976]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103084983  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
103084985  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
103085046  PDGFD; platelet-derived growth factor D-like isoform X1 [KO:K05450]
103085070  CFL1; cofilin-1 [KO:K05765]
103085145  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103085204  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103085543  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
103085597  C5; LOW QUALITY PROTEIN: complement C5 [KO:K03994]
103085742  INS; insulin [KO:K04526]
103085840  BDKRB2; B2 bradykinin receptor [KO:K03916]
103085980  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
103085988  ITGA2; integrin alpha-2 [KO:K06481]
103086084  [KO:K06269] [EC:3.1.3.16]
103086124  BDKRB1; B1 bradykinin receptor [KO:K03915]
103086254  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
103086359  FGF7; fibroblast growth factor 7 [KO:K04358]
103086383  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103086424  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103086500  MSN; moesin [KO:K05763]
103086550  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
103086903  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
103087072  ITGAV; integrin alpha-V [KO:K06487]
103087242  [KO:K05759]
103087310  MYH14; myosin-14 [KO:K10352]
103087313  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
103087751  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
103087761  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
103087898  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
103087905  CRK; adapter molecule crk isoform X1 [KO:K04438]
103087933  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103088257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
103088294  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103088449  [KO:K12758]
103088620  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103088628  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103088639  [KO:K12757]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103088851  CFL2; cofilin-2 isoform X1 [KO:K05765]
103088874  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
103089007  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
103089053  ITGB5; integrin beta-5 [KO:K06588]
103089055  MYL10; myosin regulatory light chain 10 [KO:K12756]
103089216  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103089268  MYL12B; myosin regulatory light chain 12B isoform X1 [KO:K12757]
103089522  [KO:K05769]
103089640  ITGA9; integrin alpha-9 [KO:K06585]
103089758  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
103089923  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
103089953  ITGAD; LOW QUALITY PROTEIN: integrin alpha-D [KO:K06594]
103090018  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
103090085  FGF4; fibroblast growth factor 4 [KO:K04358]
103090095  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103090157  ITGA8; integrin alpha-8 [KO:K06584]
103090223  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
103090456  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
103090463  CRKL; crk-like protein [KO:K04438]
103090769  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103090812  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103090898  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
103091027  FGF20; fibroblast growth factor 20 [KO:K04358]
103091045  FGF9; fibroblast growth factor 9 [KO:K04358]
103091078  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103091249  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
103091388  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
103091417  MYH9; myosin-9 isoform X1 [KO:K10352]
103091477  NCKAP1; nck-associated protein 1 [KO:K05750]
103091487  PFN1; profilin-1 [KO:K05759]
103091518  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
103091591  SCIN; adseverin [KO:K05768]
103091613  VCL; vinculin isoform X1 [KO:K05700]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
lve04010  MAPK signaling pathway
lve04510  Focal adhesion
lve04520  Adherens junction
KO pathway
ko04810   

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