KEGG   PATHWAY: mcoc04514
Entry
mcoc04514                   Pathway                                
Name
Cell adhesion molecule (CAM) interaction - Mastomys coucha (southern multimammate mouse)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
mcoc04514  Cell adhesion molecule (CAM) interaction
mcoc04514

Other DBs
GO: 0050839
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116068209  Selplg; P-selectin glycoprotein ligand 1 [KO:K06544]
116068514  [KO:K06087]
116068516  Cldn4; claudin-4 [KO:K06087]
116068520  Cldn3; claudin-3 [KO:K06087]
116069258  Cldn22; claudin-22 [KO:K06087]
116069259  Cd34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
116069260  [KO:K06087]
116069999  Cdh5; cadherin-5 [KO:K06533]
116070103  Cdh3; cadherin-3 isoform X1 [KO:K06796]
116070104  Cdh1; cadherin-1 [KO:K05689]
116070194  Glg1; Golgi apparatus protein 1 [KO:K06816]
116070345  Cdh15; cadherin-15 [KO:K06809]
116070458  Itgb1; integrin beta-1 [KO:K05719]
116070836  Sele; E-selectin [KO:K06494]
116070957  Cldn15; claudin-15 [KO:K06087]
116071342  Cldn23; claudin-23 [KO:K06087]
116071911  Nectin1; nectin-1 [KO:K06081]
116072206  Jam3; junctional adhesion molecule C isoform X1 [KO:K06785]
116072890  Neo1; neogenin isoform X1 [KO:K06766]
116072929  Cldn18; claudin-18 isoform X1 [KO:K06087]
116072932  Cd276; LOW QUALITY PROTEIN: CD276 antigen [KO:K06746]
116073076  Icam1; intercellular adhesion molecule 1 [KO:K06490]
116073287  Cldn25; putative claudin-25 [KO:K06087]
116073335  Cadm1; cell adhesion molecule 1 isoform X1 [KO:K06781]
116073431  Jaml; junctional adhesion molecule-like isoform X1 [KO:K28137]
116073468  Esam; endothelial cell-selective adhesion molecule [KO:K06787]
116073780  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
116073852  Ncam1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
116074277  [KO:K06752]
116074338  [KO:K06751]
116074434  [KO:K06752]
116074448  [KO:K06751]
116074449  [KO:K06751]
116074450  [KO:K06751]
116074451  [KO:K06751]
116074620  [KO:K06751]
116074623  [KO:K06751]
116074625  [KO:K06751]
116074627  [KO:K06751]
116074637  [KO:K06751]
116074638  [KO:K06751]
116074642  [KO:K06751]
116074645  [KO:K06751]
116074664  [KO:K06751]
116074843  [KO:K06752]
116074875  Itgb2; integrin beta-2 [KO:K06464]
116074939  [KO:K06752]
116074952  [KO:K06752]
116074953  [KO:K06752]
116074954  [KO:K06752]
116075017  [KO:K06751]
116075057  Vsir; V-type immunoglobulin domain-containing suppressor of T-cell activation isoform X1 [KO:K23268]
116075078  [KO:K06751]
116075117  [KO:K06752]
116075136  [KO:K06752]
116075170  [KO:K06752]
116075182  Icoslg; ICOS ligand isoform X1 [KO:K06710]
116075360  Ptprs; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
116075380  [KO:K06751]
116075381  [KO:K06751]
116076384  Madcam1; mucosal addressin cell adhesion molecule 1 isoform X1 [KO:K06779]
116076904  Pecam1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
116076992  Cntnap1; contactin-associated protein 1 isoform X1 [KO:K07379]
116077103  Cldn7; claudin-7 [KO:K06087]
116077309  Nlgn2; neuroligin-2 isoform X1 [KO:K07378]
116077675  Cldn6; claudin-6 [KO:K06087]
116077676  Cldn9; claudin-9 [KO:K06087]
116078098  Cldn20; claudin-20 [KO:K06087]
116078157  Icam2; intercellular adhesion molecule 2 [KO:K06523]
116078219  Cntn1; contactin-1 isoform X1 [KO:K06759]
116078761  [KO:K06087]
116079852  Nrxn3; neurexin 3 isoform X1 [KO:K07377]
116080200  Sdc1; syndecan-1 [KO:K06257]
116080246  Nrxn1; neurexin-1 isoform X1 [KO:K07377]
116080371  Itgb7; integrin beta-7 isoform X1 [KO:K06590]
116080606  Nrcam; neuronal cell adhesion molecule isoform X1 [KO:K06756]
116080974  Itgb8; integrin beta-8 [KO:K06591]
116082297  [KO:K06815]
116082759  Sdc2; syndecan-2 [KO:K16336]
116083458  Ocln; occludin isoform X1 [KO:K06088]
116083609  Vcan; versican core protein isoform X1 [KO:K06793]
116084108  Cldn10; claudin-10 isoform X1 [KO:K06087]
116084142  [KO:K10784]
116084383  Slitrk5; SLIT and NTRK-like protein 5 [KO:K25836]
116084801  [KO:K10784]
116084812  Slitrk6; SLIT and NTRK-like protein 6 [KO:K25837]
116084907  Slitrk1; SLIT and NTRK-like protein 1 [KO:K25832]
116085640  Slitrk4; SLIT and NTRK-like protein 4 isoform X1 [KO:K25835]
116085766  Cd99l2; CD99 antigen-like protein 2 [KO:K06520]
116085768  Cldn1; claudin-1 [KO:K06087]
116085876  Cd86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
116085901  Cd80; T-lymphocyte activation antigen CD80 [KO:K05412]
116085907  Igsf11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
116085964  Nectin3; nectin-3 isoform X1 [KO:K06592]
116085984  Alcam; CD166 antigen isoform X1 [KO:K06547]
116086035  L1cam; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
116086073  Cxadr; coxsackievirus and adenovirus receptor isoform X1 [KO:K06788]
116086077  Ncam2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
116086082  Jam2; junctional adhesion molecule B [KO:K06735]
116086319  Cldn5; claudin-5 [KO:K06087]
116086362  Cldn16; claudin-16 [KO:K06087]
116086415  Tigit; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
116086542  Cldn8; claudin-8 [KO:K06087]
116086544  Cldn17; claudin-17 [KO:K06087]
116086619  Cldn14; claudin-14 isoform X1 [KO:K06087]
116086631  [KO:K06464]
116086875  Cdh2; cadherin-2 [KO:K06736]
116087207  Nlgn3; neuroligin-3 isoform X1 [KO:K07378]
116087445  Cd226; CD226 antigen isoform X1 [KO:K06567]
116088494  Cd28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
116088495  Icos; inducible T-cell costimulator isoform X1 [KO:K06713]
116088864  Ptprm; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
116089186  Ctla4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
116089315  Pdcd1; programmed cell death protein 1 [KO:K06744]
116089710  Itga8; integrin alpha-8 [KO:K06584]
116089916  Ntng2; netrin-G2 isoform X1 [KO:K16359]
116089917  Cldn34; claudin-34 [KO:K06087]
116090300  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
116090371  Itga4; integrin alpha-4 [KO:K06483]
116090387  Itgav; integrin alpha-V isoform X1 [KO:K06487]
116090538  Lrrc4c; leucine-rich repeat-containing protein 4C [KO:K07523]
116090951  Siglec1; sialoadhesin isoform X1 [KO:K06548]
116091362  Sdc4; syndecan-4 [KO:K16338]
116091386  Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
116091514  Cdh4; cadherin-4 isoform X1 [KO:K06797]
116092757  Cd40lg; CD40 ligand [KO:K03161]
116092997  Slitrk3; SLIT and NTRK-like protein 3 [KO:K25834]
116093297  [KO:K06087]
116093332  [KO:K06087]
116093505  Vtcn1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
116093509  Cd2; T-cell surface antigen CD2 [KO:K06449]
116093655  Ntng1; netrin-G1 isoform X1 [KO:K07522]
116093675  Vcam1; vascular cell adhesion protein 1 [KO:K06527]
116093979  Negr1; neuronal growth regulator 1 isoform X1 [KO:K06775]
116094363  [KO:K06087]
116094897  Cldn2; claudin-2 [KO:K06087]
116095005  Nlgn1; neuroligin-1 isoform X1 [KO:K07378]
116095033  Cldn11; claudin-11 [KO:K06087]
116095540  Cldn19; claudin-19 [KO:K06087]
116096165  Ptprd; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
116096518  Ptprf; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
116096735  Sdc3; syndecan-3 isoform X1 [KO:K16337]
116097459  Cldn12; claudin-12 [KO:K06087]
116097874  Slitrk2; SLIT and NTRK-like protein 2 [KO:K25833]
116098178  Cd8a; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
116098652  Lrrc4; leucine-rich repeat-containing protein 4 [KO:K16351]
116098829  Cntnap2; contactin-associated protein-like 2 isoform X1 [KO:K07380]
116099056  Cd8b; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
116099126  Cntn2; contactin-2 [KO:K06760]
116099153  Nfasc; neurofascin isoform X1 [KO:K06757]
116099586  Cd4; T-cell surface glycoprotein CD4 [KO:K06454]
116100060  Ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
116100452  Mag; myelin-associated glycoprotein isoform X1 [KO:K06771]
116101769  Nectin2; nectin-2 isoform X1 [KO:K06531]
116101776  [KO:K06539]
116101996  Cd22; B-cell receptor CD22 [KO:K06467]
116102124  Lrrc4b; leucine-rich repeat-containing protein 4B [KO:K16360]
116102660  Sell; L-selectin [KO:K06495]
116102671  Selp; P-selectin [KO:K06496]
116102997  Spn; leukosialin isoform X1 [KO:K06477]
116103005  Itgal; integrin alpha-L isoform X1 [KO:K05718]
116103050  Itgam; integrin alpha-M isoform X1 [KO:K06461]
116103329  Mpz; myelin protein P0 [KO:K06770]
116103452  Nrxn2; neurexin-2-beta isoform X1 [KO:K07377]
116103490  F11r; junctional adhesion molecule A [KO:K06089]
116103564  Cd6; T-cell differentiation antigen CD6 isoform X1 [KO:K06456]
116103713  Cd274; programmed cell death 1 ligand 1 [KO:K06745]
116103714  Pdcd1lg2; programmed cell death 1 ligand 2 [KO:K06708]
116103792  Cadm3; cell adhesion molecule 3 isoform X1 [KO:K06780]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
mcoc04520  Adherens junction
mcoc04530  Tight junction
mcoc04610  Complement and coagulation cascades
mcoc04660  T cell receptor signaling pathway
mcoc04670  Leukocyte transendothelial migration
KO pathway
ko04514   

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