KEGG   PATHWAY: mmma04530
Entry
mmma04530                   Pathway                                
Name
Tight junction - Marmota marmota marmota (Alpine marmot)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mmma04530  Tight junction
mmma04530

Other DBs
GO: 0005923
Organism
Marmota marmota marmota (Alpine marmot) [GN:mmma]
Gene
107133923  [KO:K06087]
107134036  [KO:K06448]
107134064  [KO:K06448]
107134361  [KO:K06099]
107134536  [KO:K07374]
107134690  [KO:K05754]
107135457  Dlg2; disks large homolog 2 isoform X4 [KO:K12075]
107135580  [KO:K04345] [EC:2.7.11.11]
107135766  [KO:K05692]
107136114  Jam2; junctional adhesion molecule B [KO:K06735]
107136135  Tiam1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
107136194  [KO:K05763]
107136242  Cldn17; claudin-17 [KO:K06087]
107136243  Cldn8; claudin-8 [KO:K06087]
107136457  Runx1; runt-related transcription factor 1 isoform X2 [KO:K08367]
107136467  Cldn14; claudin-14 [KO:K06087]
107136488  Igsf5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
107137207  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
107137232  Actr2; actin-related protein 2 isoform X2 [KO:K17260]
107137311  Prkce; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
107137496  Rock2; rho-associated protein kinase 2 isoform X6 [KO:K17388] [EC:2.7.11.39]
107137806  [KO:K04382] [EC:3.1.3.16]
107138044  Rab8b; ras-related protein Rab-8B [KO:K07902]
107138069  Cgnl1; cingulin-like protein 1 isoform X1 [KO:K21110]
107138078  Nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X2 [KO:K10591] [EC:2.3.2.26]
107138363  Mpp4; MAGUK p55 subfamily member 4 [KO:K21109]
107138444  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
107138688  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
107138705  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
107138719  [KO:K07374]
107138722  [KO:K07374]
107138910  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
107139425  Ocln; occludin [KO:K06088]
107139426  Marveld2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
107139483  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X2 [KO:K13305] [EC:2.3.2.26]
107139600  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
107139615  [KO:K12757]
107139616  [KO:K12757]
107139815  Pcna; proliferating cell nuclear antigen [KO:K04802]
107139898  Myh9; myosin-9 isoform X3 [KO:K10352]
107140113  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
107140181  Myl6b; myosin light chain 6B [KO:K12751]
107140182  Myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
107140411  Pard3; partitioning defective 3 homolog isoform X2 [KO:K04237]
107140415  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
107140681  [KO:K07374]
107140943  Cldn10; claudin-10 isoform X1 [KO:K06087]
107141298  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
107141439  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
107141635  Cldn19; claudin-19 [KO:K06087]
107141702  Patj; inaD-like protein isoform X4 [KO:K06092]
107141712  Jun; transcription factor Jun [KO:K04448]
107141892  [KO:K07374]
107142153  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
107142324  [KO:K04513]
107142603  Cldn23; claudin-23 [KO:K06087]
107142690  [KO:K06087]
107142691  [KO:K06087]
107142797  Synpo; LOW QUALITY PROTEIN: synaptopodin [KO:K21112]
107142812  Scrib; protein scribble homolog [KO:K16175]
107143219  Dlg1; disks large homolog 1 isoform X13 [KO:K12076]
107143255  Hcls1; hematopoietic lineage cell-specific protein isoform X1 [KO:K06106]
107143379  Amotl2; angiomotin-like protein 2 [KO:K06104]
107143431  Pals1; protein PALS1 [KO:K06091]
107143485  Rhoa; transforming protein RhoA [KO:K04513]
107143564  Cldn18; claudin-18 isoform X1 [KO:K06087]
107143942  Tjap1; tight junction-associated protein 1 isoform X1 [KO:K06105]
107144171  [KO:K04440] [EC:2.7.11.24]
107144405  Cftr; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
107144974  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107145041  Rab8a; ras-related protein Rab-8A [KO:K07901]
107145569  Ybx3; Y-box-binding protein 3 isoform X1 [KO:K06099]
107145801  [KO:K07839]
107145870  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
107145878  Rdx; radixin isoform X1 [KO:K05762]
107145926  Amotl1; angiomotin-like protein 1 isoform X2 [KO:K06104]
107145989  Cldn25; putative claudin-25 [KO:K06087]
107146329  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
107146396  Actn1; alpha-actinin-1 isoform X2 [KO:K05699]
107146526  Myh11; LOW QUALITY PROTEIN: myosin-11 [KO:K10352]
107146874  Arhgap17; rho GTPase-activating protein 17 isoform X2 [KO:K20638]
107147033  Cldn4; claudin-4 [KO:K06087]
107147034  Cldn3; claudin-3 [KO:K06087]
107147070  Cldn15; claudin-15 isoform X1 [KO:K06087]
107147126  Cldn6; claudin-6 [KO:K06087]
107147127  Cldn9; claudin-9 [KO:K06087]
107147487  F11r; junctional adhesion molecule A [KO:K06089]
107147571  [KO:K05756]
107147611  Epb41l4b; band 4.1-like protein 4B [KO:K21111]
107148110  Rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
107148126  Hspa4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
107148131  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
107148201  Tjp2; tight junction protein ZO-2 [KO:K06098]
107148389  Whamm; LOW QUALITY PROTEIN: WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
107148479  Tjp1; tight junction protein ZO-1 isoform X3 [KO:K05701]
107148597  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
107148600  Tuba1a; tubulin alpha-1A chain [KO:K07374]
107148601  [KO:K07374]
107148916  Actr3b; actin-related protein 3B [KO:K18584]
107148919  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
107149492  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
107149562  Cldn11; claudin-11 [KO:K06087]
107149619  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
107149675  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2 [KO:K05631]
107149958  [KO:K05692]
107150064  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
107150280  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
107150926  Marveld3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
107151096  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
107151220  Myh14; myosin-14 isoform X7 [KO:K10352]
107151337  Sympk; symplekin isoform X1 [KO:K06100]
107151439  [KO:K07200]
107151490  Actn4; alpha-actinin-4 isoform X3 [KO:K05699]
107151608  [KO:K06274]
107151930  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
107152096  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
107152397  Amot; angiomotin isoform X1 [KO:K16819]
107152412  Cldn2; claudin-2 [KO:K06087]
107152929  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
107153096  Afdn; afadin isoform X20 [KO:K05702]
107153130  Ezr; ezrin [KO:K08007]
107153146  Cldn20; claudin-20 [KO:K06087]
107153326  [KO:K04513]
107153372  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107153555  Jam3; junctional adhesion molecule C isoform X1 [KO:K06785]
107153644  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107153732  [KO:K04354]
107153859  Gata4; LOW QUALITY PROTEIN: transcription factor GATA-4 [KO:K09183]
107153907  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
107154109  Bves; blood vessel epicardial substance isoform X2 [KO:K21108]
107154378  Cldn16; claudin-16 [KO:K06087]
107154379  Cldn1; claudin-1 [KO:K06087]
107154502  Nf2; merlin [KO:K16684]
107154571  [KO:K07374]
107154572  Cldn5; claudin-5 [KO:K06087]
107154692  [KO:K07374]
107154696  [KO:K07374]
107155040  Tuba8; tubulin alpha-8 chain isoform X1 [KO:K07374]
107155364  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
107155579  Prkcz; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
107155620  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
107155636  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
107155694  Msn; moesin [KO:K05763]
107155734  Actr3; actin-related protein 3 [KO:K18584]
107155948  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
107155949  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
107155970  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
107155983  Actb; actin, cytoplasmic 1 [KO:K05692]
107156012  Micall2; MICAL-like protein 2 isoform X1 [KO:K21068]
107156138  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
107156315  Cldn12; claudin-12 [KO:K06087]
107156428  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
107156437  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
107156478  Mpdz; LOW QUALITY PROTEIN: multiple PDZ domain protein [KO:K06095]
107156572  [KO:K06448]
107156574  [KO:K06448]
107156575  [KO:K06448]
107156661  [KO:K06448]
107156703  Arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
107156759  Rab13; ras-related protein Rab-13 [KO:K06109]
107156801  Cgn; LOW QUALITY PROTEIN: cingulin [KO:K06102]
107156886  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
107157046  Cttn; src substrate cortactin [KO:K06106]
107157175  Llgl1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
107157242  Stk11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
107157320  Crb3; protein crumbs homolog 3 [KO:K06090]
107157355  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
107157439  Tjp3; tight junction protein ZO-3 [KO:K06097]
107157474  Arhgef18; rho guanine nucleotide exchange factor 18 [KO:K21066]
107157705  Actg1; actin, cytoplasmic 2 [KO:K05692]
107157779  Llgl2; LLGL scribble cell polarity complex component 2 isoform X3 [KO:K06094]
107157809  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
107158034  Myh10; myosin-10 isoform X1 [KO:K10352]
107158085  Cldn7; claudin-7 [KO:K06087]
107158205  [KO:K05692]
107158295  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107158637  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X2 [KO:K07199]
107158690  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
107158737  Cldn34; claudin-34 [KO:K06087]
107159012  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
107159013  [KO:K05757]
107159518  [KO:K06088]
107159581  Rap2c; ras-related protein Rap-2c [KO:K07839]
107159793  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107159819  Was; wiskott-Aldrich syndrome protein [KO:K05747]
107160020  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
107160582  [KO:K06448]
107160583  [KO:K06448]
107160586  [KO:K06448]
107160587  [KO:K06448]
107160589  [KO:K06448]
107160591  [KO:K06448]
107160592  [KO:K06448]
107160593  [KO:K06448]
107160595  [KO:K06448]
107160597  [KO:K06448]
107160598  [KO:K06448]
107160599  [KO:K06448]
107160600  [KO:K06448]
107160601  [KO:K06448]
107160606  [KO:K06448]
107161116  [KO:K05763]
125616316  [KO:K06090]
125619942  [KO:K08018]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mmma04520  Adherens junction
mmma04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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