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Entry Name Pancreatic secretion - Mus musculus (house mouse)
Description The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Other DBs Organism Mus musculus (house mouse) [GN:
mmu ]
Gene 11931 Atp1b1; ATPase, Na+/K+ transporting, beta 1 polypeptide [KO:K01540 ]
11932 Atp1b2; ATPase, Na+/K+ transporting, beta 2 polypeptide [KO:K01540 ]
11933 Atp1b3; ATPase, Na+/K+ transporting, beta 3 polypeptide [KO:K01540 ]
11936 Fxyd2; FXYD domain-containing ion transport regulator 2 [KO:K01538 ]
11937 Atp2a1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [KO:K05853 ] [EC:7.2.2.10 ]
11938 Atp2a2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 [KO:K05853 ] [EC:7.2.2.10 ]
12671 Chrm3; cholinergic receptor, muscarinic 3, cardiac [KO:K04131 ]
12722 Clca3a1; chloride channel accessory 3A1 [KO:K05030 ]
13487 Slc26a3; solute carrier family 26, member 3 [KO:K14078 ]
14682 Gnaq; guanine nucleotide binding protein, alpha q polypeptide [KO:K04634 ]
16438 Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958 ]
16439 Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959 ]
16440 Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960 ]
16531 Kcnma1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1 [KO:K04936 ]
16535 Kcnq1; potassium voltage-gated channel, subfamily Q, member 1 [KO:K04926 ]
17274 Rab8a; RAB8A, member RAS oncogene family [KO:K07901 ]
18780 Pla2g2a; phospholipase A2, group IIA (platelets, synovial fluid) [KO:K01047 ] [EC:3.1.1.4 ]
19340 Rab3d; RAB3D, member RAS oncogene family [KO:K07884 ]
20496 Slc12a2; solute carrier family 12, member 2 [KO:K10951 ]
20535 Slc4a2; solute carrier family 4 (anion exchanger), member 2 [KO:K13855 ]
20544 Slc9a1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 [KO:K05742 ]
22063 Trpc1; transient receptor potential cation channel, subfamily C, member 1 [KO:K04964 ]
53869 Rab11a; RAB11A, member RAS oncogene family [KO:K07904 ]
54403 Slc4a4; solute carrier family 4 (anion exchanger), member 4 [KO:K13575 ]
67653 4930544G11Rik; RIKEN cDNA 4930544G11 gene [KO:K04513 ]
67821 Atp1b4; ATPase Na+/K+ transporting, beta 4 polypeptide [KO:K01540 ]
80718 Rab27b; RAB27B, member RAS oncogene family [KO:K07886 ]
80797 Clca3a2; chloride channel accessory 3A2 [KO:K05030 ]
99663 Clca4a; chloride channel accessory 4A [KO:K05030 ]
99709 Clca4b; chloride channel accessory 4B [KO:K05030 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C13051 Nicotinic acid adenine dinucleotide phosphate
Reference Authors Petersen OH, Tepikin AV
Title Polarized calcium signaling in exocrine gland cells.
Journal Reference Authors Williams JA
Title Regulation of acinar cell function in the pancreas.
Journal Reference Authors Williams JA
Title Regulation of pancreatic acinar cell function.
Journal Reference Authors Bi Y, Williams JA
Title Receptor biology and signal transduction in pancreatic acinar cells.
Journal Reference Authors Yamasaki M, Masgrau R, Morgan AJ, Churchill GC, Patel S, Ashcroft SJ, Galione A
Title Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
Journal Reference Authors Kanno T
Title Ca2+ signaling in the pancreatic acinus.
Journal Pancreas 16:273-6 (1998)
Reference Authors Heitzmann D, Warth R
Title Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal Reference Authors Konturek SJ, Zabielski R, Konturek JW, Czarnecki J
Title Neuroendocrinology of the pancreas; role of brain-gut axis in pancreatic secretion.
Journal Reference Authors Chu JY, Yung WH, Chow BK
Title Secretin: a pleiotrophic hormone.
Journal Reference Authors Siu FK, Lam IP, Chu JY, Chow BK
Title Signaling mechanisms of secretin receptor.
Journal Reference Authors Steward MC, Ishiguro H, Case RM
Title Mechanisms of bicarbonate secretion in the pancreatic duct.
Journal Reference Authors Kim D, Steward MC
Title The role of CFTR in bicarbonate secretion by pancreatic duct and airway epithelia.
Journal Reference Authors Whitcomb DC, Lowe ME
Title Human pancreatic digestive enzymes.
Journal Reference Authors Cancela JM, Gerasimenko OV, Gerasimenko JV, Tepikin AV, Petersen OH
Title Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
Journal Reference Authors Cancela JM, Churchill GC, Galione A
Title Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
Journal Reference Authors Parekh AB
Title Calcium signaling and acute pancreatitis: specific response to a promiscuous messenger.
Journal Reference Authors Williams JA, Chen X, Sabbatini ME
Title Small G proteins as key regulators of pancreatic digestive enzyme secretion.
Journal Related mmu04973 Carbohydrate digestion and absorption
mmu04974 Protein digestion and absorption
mmu04977 Vitamin digestion and absorption
KO pathway
