KEGG   PATHWAY: mni04150
Entry
mni04150                    Pathway                                
Name
mTOR signaling pathway - Macaca nemestrina (pig-tailed macaque)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mni04150  mTOR signaling pathway
mni04150

Organism
Macaca nemestrina (pig-tailed macaque) [GN:mni]
Gene
105463925  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
105464069  TSC1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
105464299  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
105464966  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
105465235  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
105465416  SOS1; son of sevenless homolog 1 [KO:K03099]
105465645  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
105465834  RRAGB; LOW QUALITY PROTEIN: ras-related GTP-binding protein B [KO:K16185]
105466044  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105466358  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
105467084  WNT8A; protein Wnt-8a [KO:K00714]
105467191  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
105468003  FZD5; frizzled-5 [KO:K02375]
105468085  FZD7; frizzled-7 [KO:K02432]
105468099  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
105468256  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105468523  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
105468692  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
105468775  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
105468880  FZD4; frizzled-4 isoform X1 [KO:K02354]
105468999  FZD2; frizzled-2 [KO:K02235]
105469029  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105469160  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105469284  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
105469470  SLC3A2; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
105469589  WNT9B; protein Wnt-9b [KO:K01064]
105469679  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
105469707  LRP5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
105469786  INS; insulin isoform X1 [KO:K04526]
105469947  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105470323  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105470428  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
105471274  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105471421  [KO:K02151]
105471570  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
105472859  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
105473080  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
105473107  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
105473151  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105473235  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105473911  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
105473949  CAB39; calcium-binding protein 39 [KO:K08272]
105473988  IRS1; insulin receptor substrate 1 [KO:K16172]
105474393  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
105474669  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105474923  RHEB; GTP-binding protein Rheb [KO:K07208]
105475205  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105475297  WNT16; protein Wnt-16 [KO:K01558]
105475481  FZD1; frizzled-1 [KO:K02432]
105475541  WNT2; protein Wnt-2 [KO:K00182]
105475567  MIOS; GATOR complex protein MIOS isoform X1 [KO:K20407]
105476018  FZD6; frizzled-6 isoform X1 [KO:K02376]
105476022  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
105476527  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105476575  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105476846  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105477021  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
105477226  [KO:K02145] [EC:7.1.2.2]
105477695  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
105477727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105477747  WNT7A; protein Wnt-7a [KO:K00572]
105478207  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
105478396  WNT8B; protein Wnt-8b [KO:K00714]
105478402  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105478818  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
105478936  SEH1L; nucleoporin SEH1 [KO:K14299]
105478978  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105479146  NRAS; GTPase NRas [KO:K07828]
105479182  WNT2B; protein Wnt-2b [KO:K00182]
105479238  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
105479398  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
105480120  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
105480439  RHOA; transforming protein RhoA [KO:K04513]
105480490  NPRL2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
105480585  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
105480656  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105480754  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
105480917  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105480946  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
105481233  WNT10A; protein Wnt-10a [KO:K01357]
105481234  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
105481847  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
105482118  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
105482143  FZD3; LOW QUALITY PROTEIN: frizzled-3 [KO:K02329]
105482300  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
105482314  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
105482435  [KO:K20396]
105482882  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105483035  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
105483642  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105484103  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
105484176  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105484230  [KO:K03258]
105484672  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
105485029  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105485357  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105485792  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
105485809  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
105485816  TSC2; tuberin isoform X13 [KO:K07207]
105485849  TELO2; telomere length regulation protein TEL2 homolog isoform X2 [KO:K11137]
105485898  WDR24; GATOR complex protein WDR24 [KO:K20408]
105485931  NPRL3; LOW QUALITY PROTEIN: GATOR complex protein NPRL3 [KO:K20406]
105486273  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
105486360  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
105486387  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
105486474  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
105486488  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
105487005  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
105487083  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
105487241  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
105487290  DEPDC5; LOW QUALITY PROTEIN: GATOR complex protein DEPDC5 [KO:K20404]
105487437  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
105487633  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
105487991  [KO:K02991]
105488082  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105488275  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105488644  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
105488823  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
105489061  RRAGA; ras-related GTP-binding protein A [KO:K16185]
105489172  RPS6; LOW QUALITY PROTEIN: 40S ribosomal protein S6 [KO:K02991]
105489807  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
105489842  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105489973  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105490525  FZD10; frizzled-10 [KO:K02842]
105490544  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
105490706  CAB39L; calcium-binding protein 39-like [KO:K08272]
105491074  FLCN; folliculin isoform X1 [KO:K09594]
105492133  KRAS; GTPase KRas isoform X1 [KO:K07827]
105492378  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
105492890  WNT10B; protein Wnt-10b [KO:K01357]
105492891  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105493332  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
105493817  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
105494134  HRAS; GTPase HRas isoform X1 [KO:K02833]
105494335  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
105494399  WNT4; protein Wnt-4 isoform X2 [KO:K00408]
105494511  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105494561  SESN2; sestrin-2 isoform X1 [KO:K20394]
105494771  RRAGC; ras-related GTP-binding protein C [KO:K16186]
105494953  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105495129  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105495155  [KO:K16344]
105495343  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105495957  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
105496320  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
105496363  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
105496426  RRAGD; ras-related GTP-binding protein D [KO:K16186]
105496750  FZD9; frizzled-9 [KO:K02842]
105497021  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105497176  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
105497210  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
105497639  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
105497642  TNF; tumor necrosis factor isoform X2 [KO:K03156]
105498031  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
105498314  DVL1; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
105499392  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
105499659  WNT9A; protein Wnt-9a [KO:K01064]
105499661  WNT3A; protein Wnt-3a [KO:K00312]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mni00561  Glycerolipid metabolism
mni04010  MAPK signaling pathway
mni04140  Autophagy - animal
mni04151  PI3K-Akt signaling pathway
mni04152  AMPK signaling pathway
mni04810  Regulation of actin cytoskeleton
mni04910  Insulin signaling pathway
KO pathway
ko04150   

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