KEGG   PATHWAY: mpah04070
Entry
mpah04070                   Pathway                                
Name
Phosphatidylinositol signaling system - Mus pahari (shrew mouse)
Class
Environmental Information Processing; Signal transduction
Pathway map
mpah04070  Phosphatidylinositol signaling system
mpah04070

Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110312812  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110313431  Mtm1; myotubularin isoform X1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
110313466  Mtmr1; myotubularin-related protein 1 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
110313510  Ocrl; inositol polyphosphate 5-phosphatase OCRL-1 isoform X1 [KO:K01099] [EC:3.1.3.36]
110314050  Dgkk; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
110314623  Mtmr14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
110316028  Dgki; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
110316115  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
110316706  Pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
110317052  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
110317210  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
110317251  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
110317555  Ppip5k1; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1 [KO:K13024] [EC:2.7.4.24]
110317815  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
110318143  Cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
110318289  Pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
110318415  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
110318558  Inpp5e; 72 kDa inositol polyphosphate 5-phosphatase isoform X1 [KO:K20278] [EC:3.1.3.36]
110319038  Dgkz; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
110319506  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
110319646  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
110319649  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
110319750  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110319827  Pi4k2a; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
110320075  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110320177  Inpp5a; type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01106] [EC:3.1.3.56]
110320241  Impa1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
110320362  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
110320392  Pi4kb; phosphatidylinositol 4-kinase beta isoform X1 [KO:K19801] [EC:2.7.1.67]
110320411  Cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
110320843  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
110321148  Pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
110321244  Inpp4a; type I inositol 3,4-bisphosphate 4-phosphatase isoform X1 [KO:K01109] [EC:3.1.3.66]
110321516  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
110321564  Inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1 [KO:K03084] [EC:3.1.3.86]
110322135  Pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
110322195  Inpp1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
110322268  Dgkd; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
110322377  Ppip5k2; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
110322413  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
110322865  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110322930  Inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01099] [EC:3.1.3.36]
110323448  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110324186  Dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
110324261  Calm1; calmodulin [KO:K02183]
110324479  Itpk1; LOW QUALITY PROTEIN: inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
110324799  Pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
110325282  Dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
110325348  Tmem55b; type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1 [KO:K13084] [EC:3.1.3.78]
110325485  Mtmr6; myotubularin-related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
110326224  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
110326235  Pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
110326436  Dgka; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
110326626  Ipmk; inositol polyphosphate multikinase isoform X1 [KO:K00915] [EC:2.7.1.140 2.7.1.151]
110327212  Sacm1l; phosphatidylinositide phosphatase SAC1 isoform X1 [KO:K21797] [EC:3.1.3.-]
110327213  Mtmr2; myotubularin-related protein 2 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
110327251  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110327328  Ip6k1; inositol hexakisphosphate kinase 1 isoform X1 [KO:K07756] [EC:2.7.4.21]
110327877  Ip6k2; inositol hexakisphosphate kinase 2 isoform X1 [KO:K07756] [EC:2.7.4.21]
110328293  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
110328461  Inpp5f; phosphatidylinositide phosphatase SAC2 [KO:K21798] [EC:3.1.3.-]
110328624  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
110328811  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110329076  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
110329476  Pi4ka; LOW QUALITY PROTEIN: phosphatidylinositol 4-kinase alpha [KO:K00888] [EC:2.7.1.67]
110329525  Dgkg; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
110329565  Synj1; synaptojanin-1 isoform X1 [KO:K20279] [EC:3.1.3.36]
110329610  Inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
110330391  Mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
110330508  Dgkq; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
110330647  Pi4k2b; phosphatidylinositol 4-kinase type 2-beta isoform X1 [KO:K13711] [EC:2.7.1.67]
110330763  Cds1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
110331200  Mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
110331704  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
110331896  Pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
110331977  Dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
110332714  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
110332837  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
110333216  Impa2; inositol monophosphatase 2 [KO:K01092] [EC:3.1.3.25]
110334164  Ippk; inositol-pentakisphosphate 2-kinase isoform X1 [KO:K10572] [EC:2.7.1.158]
110334170  Calml3; calmodulin-like protein 3 [KO:K02183]
110334182  [KO:K02183]
110336102  Calm2; calmodulin isoform X1 [KO:K02183]
110336350  Mtmr7; myotubularin-related protein 7 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
110336366  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
110336420  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110336466  Calm3; calmodulin [KO:K02183]
110336671  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
110337280  Inpp4b; type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [KO:K01109] [EC:3.1.3.66]
110337392  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
110338229  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
110338334  Ip6k3; inositol hexakisphosphate kinase 3 [KO:K07756] [EC:2.7.4.21]
110338390  Synj2; synaptojanin-2 isoform X1 [KO:K20279] [EC:3.1.3.36]
110338742  Tmem55a; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [KO:K13084] [EC:3.1.3.78]
110338776  Impad1; inositol monophosphatase 3 [KO:K15759] [EC:3.1.3.7]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
mpah04020  Calcium signaling pathway
mpah04144  Endocytosis
mpah04151  PI3K-Akt signaling pathway
mpah04510  Focal adhesion
KO pathway
ko04070   

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