KEGG   PATHWAY: mpah04151
Entry
mpah04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Mus pahari (shrew mouse)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
mpah04151  PI3K-Akt signaling pathway
mpah04151

Other DBs
GO: 0043491
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110312793  Ywhag; 14-3-3 protein gamma [KO:K16198]
110312812  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110312881  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110312926  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
110313227  Epo; erythropoietin isoform X1 [KO:K05437]
110313307  Col4a5; collagen alpha-5(IV) chain [KO:K06237]
110313365  Col4a6; collagen alpha-6(IV) chain [KO:K06237]
110313464  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
110313491  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
110313584  [KO:K16197]
110313800  Mtcp1; protein p13 MTCP-1 [KO:K16837]
110313900  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
110313918  Il2rg; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
110314005  Fgf16; fibroblast growth factor 16 [KO:K04358]
110314464  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110314893  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110315110  Nos3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
110315179  [KO:K05414]
110315688  [KO:K05414]
110315801  Ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
110315929  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
110315943  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
110315992  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
110315994  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
110316104  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110316106  Vwf; von Willebrand factor [KO:K03900]
110316152  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
110316202  Col1a2; collagen alpha-2(I) chain [KO:K06236]
110316203  Reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
110316221  Kras; GTPase KRas isoform X1 [KO:K07827]
110316234  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110316300  Rheb; GTP-binding protein Rheb [KO:K07208]
110316402  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
110316409  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
110316496  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
110316535  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
110316545  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
110316560  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
110316577  Tgfa; protransforming growth factor alpha [KO:K08774]
110316700  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
110316713  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
110316808  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
110317041  Rela; transcription factor p65 [KO:K04735]
110317128  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
110317140  Il6; interleukin-6 [KO:K05405]
110317154  Fgf6; fibroblast growth factor 6 [KO:K04358]
110317162  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
110317196  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
110317258  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110317286  Fgf23; fibroblast growth factor 23 [KO:K22428]
110317477  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
110317492  Rxra; retinoic acid receptor RXR-alpha [KO:K08524]
110317788  Pkn3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
110317810  Itga8; integrin alpha-8 isoform X1 [KO:K06584]
110317821  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110317910  Itga4; integrin alpha-4 [KO:K06483]
110318089  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
110318223  Lamc3; laminin subunit gamma-3 [KO:K06247]
110318229  Itgav; integrin alpha-V isoform X1 [KO:K06487]
110318250  Sgk2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
110318270  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
110318278  Bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
110318313  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
110318364  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
110318370  [KO:K03258]
110318603  Fgf7; fibroblast growth factor 7 [KO:K04358]
110318630  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
110318637  Tsc1; hamartin isoform X1 [KO:K07206]
110318923  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
110318967  [KO:K02833]
110319023  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
110319095  Itgb6; integrin beta-6 [KO:K06589]
110319257  G6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
110319289  Angpt4; angiopoietin-4 [KO:K05467]
110319307  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
110319567  Hras; GTPase HRas [KO:K02833]
110319686  Lama5; laminin subunit alpha-5 [KO:K06240]
110319750  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110319787  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110319789  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110319825  Thbs3; thrombospondin-3 isoform X1 [KO:K04659]
110319917  Pkn2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
110319942  Gnb4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
110319957  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
110319975  Eif4e; eukaryotic translation initiation factor 4E [KO:K03259]
110320006  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110320020  Mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
110320038  Crtc2; CREB-regulated transcription coactivator 2 [KO:K16333]
110320052  Csf1; macrophage colony-stimulating factor 1 [KO:K05453]
110320340  Nras; GTPase NRas [KO:K07828]
110320381  Efna3; ephrin-A3 [KO:K05462]
110320476  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
110320485  Efna1; ephrin-A1 isoform X1 [KO:K05462]
110320512  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
110320552  Efna4; ephrin-A4 [KO:K05462]
110320556  Il2; interleukin-2 [KO:K05429]
110320585  Ngf; beta-nerve growth factor [KO:K02582]
110320586  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
110320589  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
110320648  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
110320649  Them4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
110320673  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
110320678  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
110320682  Il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
110320724  Tlr2; toll-like receptor 2 [KO:K10159]
110321006  Il7; interleukin-7 isoform X1 [KO:K05431]
110321059  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
110321144  Lamc1; laminin subunit gamma-1 [KO:K05635]
110321151  Fn1; fibronectin isoform X1 [KO:K05717]
110321248  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
110321270  Irs1; insulin receptor substrate 1 [KO:K16172]
110321532  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
110321572  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
110321591  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
110321617  Col4a4; LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237]
110321626  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
110321667  Phlpp1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
110321772  Lamc2; laminin subunit gamma-2 [KO:K06246]
110321780  Tnr; tenascin-R isoform X1 [KO:K06252]
110322035  Tnn; tenascin-N [KO:K06252]
110322146  Lamb3; laminin subunit beta-3 [KO:K06244]
110322215  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
110322284  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110322321  Col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
110322378  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
110322391  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
110322564  Col9a1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
110322758  Tnc; tenascin isoform X1 [KO:K06252]
110322865  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110322872  Lpar1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
110322884  Tek; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
110322912  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
110322972  Rps6; 40S ribosomal protein S6 [KO:K02991]
110322992  Il4r; interleukin-4 receptor subunit alpha [KO:K05071]
110322994  [KO:K05414]
110323049  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
110323053  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
110323060  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
110323165  [KO:K05414]
110323303  [KO:K05414]
110323338  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
110323342  [KO:K05414]
110323346  Ifnb1; interferon beta [KO:K05415]
110323363  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
110323382  [KO:K05414]
110323390  [KO:K05414]
110323408  [KO:K05414]
110323416  [KO:K05414]
110323424  [KO:K05414]
110323427  [KO:K05414]
110323448  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110323564  Artn; artemin isoform X1 [KO:K25415]
110323586  Tlr4; toll-like receptor 4 [KO:K10160]
110323626  Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
110323696  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
110323886  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
110324083  Ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
110324089  [KO:K16836]
110324187  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
110324236  Ywhaq; LOW QUALITY PROTEIN: 14-3-3 protein theta [KO:K16197]
110324283  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
110324292  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
110324300  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
110324314  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110324355  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
110324386  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110324417  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
110324731  Pgf; placenta growth factor isoform X1 [KO:K16859]
110324840  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
110324946  [KO:K16836]
110324954  Lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
110324970  [KO:K16836]
110324988  [KO:K10167]
110324992  [KO:K16836]
110325021  [KO:K04737]
110325228  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
110325234  Lpar6; lysophosphatidic acid receptor 6 [KO:K04273]
110325248  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
110325313  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
110325518  Fgf9; fibroblast growth factor 9 [KO:K04358]
110325648  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
110326056  Hsp90b1; endoplasmin [KO:K09487]
110326077  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
110326140  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
110326196  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110326220  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
110326225  Kitlg; kit ligand isoform X1 [KO:K05461]
110326250  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110326255  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
110326286  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
110326297  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
110326321  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110326410  [KO:K04526]
110326421  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
110326428  Foxo3; forkhead box protein O3 [KO:K09408]
110326449  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110326473  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
110326486  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110326602  Efna2; ephrin-A2 [KO:K05462]
110326660  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
110326668  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
110326936  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
110327081  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110327130  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
110327244  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110327251  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110327315  Itga11; integrin alpha-11 [KO:K06587]
110327357  Lamb2; laminin subunit beta-2 [KO:K06243]
110327390  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
110327434  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
110327494  Cdc37; hsp90 co-chaperone Cdc37 [KO:K09554]
110327826  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
110327901  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
110327924  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
110327962  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110328130  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
110328273  [KO:K06238]
110328279  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
110328285  Epor; erythropoietin receptor [KO:K05079]
110328669  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
110328784  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
110328811  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110328813  Ghr; growth hormone receptor isoform X1 [KO:K05080]
110328853  Itga1; integrin alpha-1 [KO:K06480]
110328981  Prlr; prolactin receptor isoform X1 [KO:K05081]
110328985  F2r; proteinase-activated receptor 1 [KO:K03914]
110329030  Itga2; integrin alpha-2 [KO:K06481]
110329042  Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
110329057  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
110329060  Fgf10; fibroblast growth factor 10 [KO:K04358]
110329173  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
110329282  Thbs4; thrombospondin-4 [KO:K04659]
110329343  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110329345  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
110329614  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110329735  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
110329827  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
110330230  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110330275  Ywhah; 14-3-3 protein eta [KO:K16198]
110330369  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
110330463  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110330480  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110330752  Spp1; osteopontin [KO:K06250]
110330786  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110330788  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110330859  Ibsp; bone sialoprotein 2 [KO:K06253]
110330966  Areg; amphiregulin [KO:K09782]
110330998  Osm; oncostatin-M [KO:K05418]
110331017  Ereg; proepiregulin [KO:K09784]
110331028  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
110331180  Brca1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
110331195  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110331339  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110331368  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
110331422  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
110331448  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110331504  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
110331550  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110331575  Ywhae; 14-3-3 protein epsilon [KO:K06630]
110331582  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
110331607  Chad; chondroadherin [KO:K06248]
110331696  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
110331731  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
110331831  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
110331902  Itga2b; integrin alpha-IIb [KO:K06476]
110331904  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110331915  Itgb3; integrin beta-3 [KO:K06493]
110331970  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
110332000  Fgf18; fibroblast growth factor 18 [KO:K04358]
110332042  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
110332069  Vtn; vitronectin [KO:K06251]
110332154  G6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
110332223  [KO:K05438]
110332429  G6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
110332445  Gys1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
110332508  Col1a1; collagen alpha-1(I) chain [KO:K06236]
110332564  Csf3; granulocyte colony-stimulating factor [KO:K05423]
110332714  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
110332758  [KO:K04736]
110332760  Il4; interleukin-4 [KO:K05430]
110332769  Itgb4; integrin beta-4 isoform X1 [KO:K06525]
110332843  Ppp2r2b; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
110333065  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
110333309  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110333327  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110333346  [KO:K02833]
110333420  [KO:K04526]
110333444  Lama3; laminin subunit alpha-3 [KO:K06240]
110333583  [KO:K05439]
110333600  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110333852  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
110333863  [KO:K05439]
110333918  [KO:K05439]
110333990  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
110333996  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110334033  Eif4e1b; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
110334116  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
110334155  [KO:K05439]
110334192  [KO:K05439]
110334478  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
110334489  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
110334491  Itgb7; integrin beta-7 [KO:K06590]
110334538  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
110334621  Itga5; integrin alpha-5 isoform X1 [KO:K06484]
110334651  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110334656  Myc; myc proto-oncogene protein [KO:K04377]
110334786  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
110334893  Eif4b; eukaryotic translation initiation factor 4B [KO:K03258]
110334904  Fgf19; fibroblast growth factor 19 [KO:K22603]
110334927  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
110335025  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
110335075  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
110335320  Ntf4; neurotrophin-4 [KO:K12457]
110335402  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110335407  Lama1; laminin subunit alpha-1 [KO:K05637]
110335444  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
110335526  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
110335603  Efna5; ephrin-A5 isoform X1 [KO:K05462]
110335613  Tnxb; tenascin-X isoform X1 [KO:K06252]
110335699  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
110335780  Sos1; son of sevenless homolog 1 [KO:K03099]
110335852  Pspn; persephin [KO:K25416]
110335936  Nrtn; neurturin [KO:K25414]
110336182  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110336304  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
110336317  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110336420  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110336428  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
110336430  Comp; cartilage oligomeric matrix protein [KO:K04659]
110336606  Fgf4; fibroblast growth factor 4 [KO:K04358]
110336732  Vegfc; vascular endothelial growth factor C [KO:K05449]
110336761  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
110336807  Fgf20; fibroblast growth factor 20 [KO:K04358]
110336809  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
110336830  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
110336982  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
110337003  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110337115  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
110337116  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
110337191  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
110337225  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
110337414  Phlpp2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
110337711  Gng14; uncharacterized LOC105372280 homolog [KO:K04347]
110337766  Fgf3; fibroblast growth factor 3 [KO:K04358]
110337776  Pkn1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
110337886  Mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
110337888  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
110337932  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
110337950  Myb; transcriptional activator Myb isoform X1 [KO:K09420]
110337991  Lama2; laminin subunit alpha-2 [KO:K05637]
110338062  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
110338098  Thbs2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
110338236  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
110338315  Tsc2; tuberin isoform X1 [KO:K07207]
110338459  Cd19; B-lymphocyte antigen CD19 [KO:K06465]
110338480  [KO:K02833]
110338537  Sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
110338619  [KO:K13304] [EC:2.7.11.1]
110338839  Fgf21; fibroblast growth factor 21 [KO:K22429]
110338930  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
110338975  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
110339030  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110339066  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
110339167  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
mpah00010  Glycolysis / Gluconeogenesis
mpah04010  MAPK signaling pathway
mpah04012  ErbB signaling pathway
mpah04062  Chemokine signaling pathway
mpah04064  NF-kappa B signaling pathway
mpah04068  FoxO signaling pathway
mpah04110  Cell cycle
mpah04115  p53 signaling pathway
mpah04150  mTOR signaling pathway
mpah04210  Apoptosis
mpah04370  VEGF signaling pathway
mpah04510  Focal adhesion
mpah04620  Toll-like receptor signaling pathway
mpah04630  JAK-STAT signaling pathway
mpah04662  B cell receptor signaling pathway
mpah04910  Insulin signaling pathway
KO pathway
ko04151   

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