KEGG PATHWAY: myd04662

KEGG

PATHWAY: myd04662

Entry

myd04662                    Pathway

Name

B cell receptor signaling pathway - Myotis davidii (David's myotis)

Description

B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.

Class

Organismal Systems; Immune system

Pathway map

B cell receptor signaling pathway

Other DBs

GO:

Organism

Myotis davidii (David's myotis) [GN:myd]

Gene

GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]

CD22; CD22 molecule [KO:K06467]

MALT1; MALT1 paracaspase [KO:K07369] [EC:3.4.22.-]

JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]

PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]

PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]

BCL10; B-cell CLL/lymphoma 10 [KO:K07368]

RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]

PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]

GRB2; growth factor receptor bound protein 2 [KO:K04364]

LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]

PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]

INPPL1; inositol polyphosphate phosphatase like 1 [KO:K15909] [EC:3.1.3.86]

PTPN6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:3.1.3.48]

PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]

MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]

CD81; CD81 molecule [KO:K06508]

VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]

BTK; Bruton tyrosine kinase [KO:K07370] [EC:2.7.10.2]

PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]

RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]

VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]

PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]

RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]

PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]

CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]

LILRB3; leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]

NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]

KRAS; KRAS proto-oncogene, GTPase [KO:K07827]

HRAS; HRas proto-oncogene, GTPase [KO:K02833]

NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]

VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]

NFKBIA; NFKB inhibitor alpha [KO:K04734]

CD79A; CD79a molecule [KO:K06506]

NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]

SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]

CD19; CD19 molecule [KO:K06465]

CARD11; caspase recruitment domain family member 11 [KO:K07367]

LILRA6; leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]

PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]

MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]

FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]

PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]

NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]

PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]

SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]

RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]

NFKBIB; NFKB inhibitor beta [KO:K02581]

MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]

BLNK; B-cell linker [KO:K07371]

INPP5D; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]

BLK; BLK proto-oncogene, Src family tyrosine kinase [KO:K08890] [EC:2.7.10.2]

RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]

NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]

BANK1; B-cell scaffold protein with ankyrin repeats 1 [KO:K26239]

IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]

AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]

SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]

RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]

CD72; CD72 molecule [KO:K06504]

AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]

PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]

IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]

DAPP1; dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [KO:K12229]

NFKBIE; NFKB inhibitor epsilon [KO:K05872]

CD79B; CD79b molecule [KO:K06507]

PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]

PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 [KO:K12230]

MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]

JUNB; JunB proto-oncogene, AP-1 transcription factor subunit [KO:K04448]

Compound

Calcium cation

Diacylglycerol

D-myo-Inositol 1,4,5-trisphosphate

Phosphatidylinositol-3,4,5-trisphosphate

Reference

Authors

Niiro H, Clark EA.

Title

Regulation of B-cell fate by antigen-receptor signals.

Journal

Nat Rev Immunol 2:945-56 (2002)
DOI:10.1038/nri955

Reference

Authors

Kurosaki T.

Title

Genetic analysis of B cell antigen receptor signaling.

Journal

Annu Rev Immunol 17:555-92 (1999)
DOI:10.1146/annurev.immunol.17.1.555

Reference

Authors

Nitschke L.

Title

The role of CD22 and other inhibitory co-receptors in B-cell activation.

Journal

Curr Opin Immunol 17:290-7 (2005)
DOI:10.1016/j.coi.2005.03.005

Reference

Authors

Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.

Title

Complement: central to innate immunity and bridging to adaptive responses.

Journal

Immunol Lett 97:171-9 (2005)
DOI:10.1016/j.imlet.2004.11.010

Reference

Authors

Kurosaki T.

Title

Regulation of B-cell signal transduction by adaptor proteins.

Journal

Nat Rev Immunol 2:354-63 (2002)
DOI:10.1038/nri801

Reference

Authors

Nitschke L, Tsubata T.

Title

Molecular interactions regulate BCR signal inhibition by CD22 and CD72.

Journal

Trends Immunol 25:543-50 (2004)
DOI:10.1016/j.it.2004.08.002

Reference

Authors

Jumaa H, Hendriks RW, Reth M.

Title

B cell signaling and tumorigenesis.

Journal

Annu Rev Immunol 23:415-45 (2005)
DOI:10.1146/annurev.immunol.23.021704.115606

Reference

Authors

Rickert RC.

Title

Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.

Journal

Curr Opin Immunol 17:237-43 (2005)
DOI:10.1016/j.coi.2005.03.001

Reference

Authors

Zouali M, Sarmay G

Title

B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.

Journal

Arthritis Rheum 50:2730-41 (2004)
DOI:10.1002/art.20487

Reference

Authors

Chiles TC.

Title

Regulation and function of cyclin D2 in B lymphocyte subsets.

Journal

J Immunol 173:2901-7 (2004)
DOI:10.4049/jimmunol.173.5.2901

Reference

Authors

Allam A, Marshall AJ

Title

Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.

Journal

Immunol Lett 97:7-17 (2005)
DOI:10.1016/j.imlet.2004.09.019

Reference

Authors

Gold MR

Title

To make antibodies or not: signaling by the B-cell antigen receptor.

Journal

Trends Pharmacol Sci 23:316-24 (2002)
DOI:10.1016/S0165-6147(02)02045-X

Reference

Authors

Fu C, Turck CW, Kurosaki T, Chan AC

Title

BLNK: a central linker protein in B cell activation.

Journal

Immunity 9:93-103 (1998)
DOI:10.1016/S1074-7613(00)80591-9

Reference

Authors

Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T

Title

BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.

Journal

Immunity 13:817-27 (2000)
DOI:10.1016/S1074-7613(00)00079-0

Reference

Authors

Shinohara H, Maeda S, Watarai H, Kurosaki T

Title

IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.

Journal

J Exp Med 204:3285-93 (2007)
DOI:10.1084/jem.20070379

Related
pathway

MAPK signaling pathway

Calcium signaling pathway

NF-kappa B signaling pathway

Ubiquitin mediated proteolysis

PI3K-Akt signaling pathway

Complement and coagulation cascades

Regulation of actin cytoskeleton

KO pathway

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