KEGG   PATHWAY: npd04218
Entry
npd04218                    Pathway                                
Name
Cellular senescence - Nothoprocta perdicaria (Chilean tinamou)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
npd04218  Cellular senescence
npd04218

Other DBs
GO: 0090398
Organism
Nothoprocta perdicaria (Chilean tinamou) [GN:npd]
Gene
112942339  [KO:K06625]
112942428  IL6; interleukin-6 [KO:K05405]
112942604  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
112942696  [KO:K02649]
112942701  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
112942703  HUS1; checkpoint protein HUS1 isoform X1 [KO:K10903]
112942805  LIN9; protein lin-9 homolog [KO:K21773]
112942883  CCNA1; cyclin-A1 [KO:K06627]
112942902  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
112943487  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
112943529  HRAS; GTPase HRas [KO:K02833]
112943569  RRAS2; ras-related protein R-Ras2 [KO:K07830]
112943669  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
112943759  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
112943951  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112944015  SLC25A6; ADP/ATP translocase 3 isoform X1 [KO:K05863]
112944112  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
112944317  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
112944352  RAD1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
112944410  [KO:K04685]
112944417  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
112944579  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
112944638  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112944651  RASSF5; ras association domain-containing protein 5 [KO:K08015]
112944968  RBL2; retinoblastoma-like protein 2 [KO:K16332]
112945115  [KO:K09408]
112945183  TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
112945202  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
112945237  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112945540  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112945662  RBL1; retinoblastoma-like protein 1 [KO:K04681]
112945932  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112946392  ZFP36L1; mRNA decay activator protein ZFP36L1 [KO:K18753]
112946619  HIPK2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
112947033  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
112947058  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
112947286  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
112947301  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
112947358  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112947678  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
112947898  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
112947911  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112948263  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112948290  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
112948387  CALML4; calmodulin-like protein 4 [KO:K02183]
112948417  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112948468  TRAF3IP2; adapter protein CIKS [KO:K21124]
112948550  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
112948774  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112948817  HIPK3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
112948970  LIN54; protein lin-54 homolog isoform X1 [KO:K21776]
112949082  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112949088  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112949307  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
112949378  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112949405  RAD9B; cell cycle checkpoint control protein RAD9B [KO:K10995]
112949513  MYBL2; myb-related protein B isoform X1 [KO:K21769]
112949627  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
112949923  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
112950026  E2F1; transcription factor E2F1 [KO:K17454]
112950070  [KO:K10030]
112950072  [KO:K10030]
112950088  [KO:K10030]
112950210  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
112950229  CCNA2; cyclin-A2 [KO:K06627]
112950459  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
112950524  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
112950663  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
112950669  KRAS; GTPase KRas [KO:K07827]
112950756  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112950940  RBBP4; histone-binding protein RBBP4 [KO:K10752]
112951314  [KO:K09408]
112951378  [KO:K04685]
112951455  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
112951487  NRAS; GTPase NRas [KO:K07828]
112951489  HIPK1; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
112951551  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
112951558  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
112952227  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
112952245  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112952569  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112952606  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112952774  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
112952833  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
112952880  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
112952996  RAD50; DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
112953017  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112953071  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
112953156  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
112953186  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112953209  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112953257  CALM2; calmodulin-2 isoform X1 [KO:K02183]
112953351  CALM1; LOW QUALITY PROTEIN: calmodulin-1 [KO:K02183]
112953655  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
112953844  FOXM1; forkhead box protein M1 isoform X1 [KO:K09406]
112953854  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
112953909  E2F3; transcription factor E2F3 [KO:K06620]
112954301  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
112954803  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
112954963  [KO:K04388] [EC:2.7.11.30]
112954975  [KO:K06751]
112955150  TGFB2; transforming growth factor beta-2 [KO:K13376]
112955299  E2F4; transcription factor E2F4 [KO:K04682]
112955351  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112955484  HIPK4; homeodomain-interacting protein kinase 4 [KO:K08826] [EC:2.7.11.1]
112955491  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112955595  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
112955817  TSC1; hamartin [KO:K07206]
112956485  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
112957014  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
112957292  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
112957315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112957522  CAPN11; calpain-11 [KO:K01367] [EC:3.4.22.52]
112957825  RAD9A; LOW QUALITY PROTEIN: cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
112957826  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112957983  LIN52; protein lin-52 homolog [KO:K21775]
112958062  TGFB3; transforming growth factor beta-3 [KO:K13377]
112958103  RHEB; GTP-binding protein Rheb [KO:K07208]
112958162  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
112958826  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
112959001  MRE11; double-strand break repair protein MRE11 [KO:K10865]
112959174  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112959195  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
112959234  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112959267  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112959296  RB1; retinoblastoma-associated protein [KO:K06618]
112959314  FOXO1; forkhead box protein O1 [KO:K07201]
112959404  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112959422  MYC; myc proto-oncogene protein [KO:K04377]
112959567  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112959596  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112959724  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112959727  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112959825  MRAS; ras-related protein M-Ras [KO:K07831]
112959892  TSC2; tuberin isoform X1 [KO:K07207]
112960040  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
112960333  E2F5; transcription factor E2F5 [KO:K04682]
112960339  NBN; nibrin [KO:K10867]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
npd04020  Calcium signaling pathway
npd04068  FoxO signaling pathway
npd04110  Cell cycle
npd04115  p53 signaling pathway
npd04150  mTOR signaling pathway
KO pathway
ko04218   

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