KEGG   PATHWAY: omm04625
Entry
omm04625                    Pathway                                
Name
C-type lectin receptor signaling pathway - Oncorhynchus masou masou (cherry salmon)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
omm04625  C-type lectin receptor signaling pathway
omm04625

Organism
Oncorhynchus masou masou (cherry salmon) [GN:omm]
Gene
135503829  [KO:K07210]
135503955  [KO:K04441] [EC:2.7.11.24]
135504011  [KO:K04513]
135504098  [KO:K05704] [EC:2.7.10.2]
135504099  [KO:K17332]
135504355  [KO:K04513]
135504359  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
135504404  [KO:K04960]
135504499  [KO:K07293] [EC:3.1.3.48]
135504504  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
135504569  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
135504659  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
135504695  [KO:K04443] [EC:2.7.11.1]
135504732  [KO:K04467] [EC:2.7.11.10]
135504995  [KO:K04467] [EC:2.7.11.10]
135505085  [KO:K04440] [EC:2.7.11.24]
135505231  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
135505819  [KO:K02183]
135505894  [KO:K04456] [EC:2.7.11.1]
135506121  [KO:K04734]
135507019  [KO:K07368]
135507112  [KO:K04371] [EC:2.7.11.24]
135507829  fcer1gl; Fc receptor, IgE, high affinity I, gamma polypeptide like isoform X1 [KO:K07983]
135508031  [KO:K02183]
135508034  [KO:K04734]
135508265  [KO:K04456] [EC:2.7.11.1]
135509074  [KO:K17333]
135509177  [KO:K04441] [EC:2.7.11.24]
135509197  [KO:K04959]
135509201  kras; GTPase KRas isoform X1 [KO:K07827]
135509252  [KO:K02833]
135509334  malt3; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
135509652  calml4b; calmodulin-like protein 4 [KO:K02183]
135510374  cyld3; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
135510643  [KO:K04348] [EC:3.1.3.16]
135510693  [KO:K04735]
135510803  [KO:K04440] [EC:2.7.11.24]
135510885  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
135510926  [KO:K04469]
135511098  [KO:K12496]
135511144  [KO:K04398] [EC:3.4.22.61]
135511389  [KO:K12496]
135511699  [KO:K02649]
135511704  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
135511959  [KO:K02649]
135512037  [KO:K04448]
135512115  bcl10; B-cell lymphoma/leukemia 10 [KO:K07368]
135512389  [KO:K04469]
135512429  [KO:K02183]
135512508  [KO:K04440] [EC:2.7.11.24]
135512704  malt2; MALT paracaspase 2 [KO:K07369] [EC:3.4.22.-]
135512712  [KO:K21083]
135512926  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
135512958  [KO:K04448]
135513124  cyldl; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
135513189  [KO:K02649]
135513208  ptgs2b; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
135513776  [KO:K04519]
135513887  [KO:K04348] [EC:3.1.3.16]
135513966  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
135514108  [KO:K08862] [EC:2.7.11.21]
135514124  egr3; early growth response protein 3 [KO:K12497]
135514371  [KO:K12794]
135514664  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
135514932  [KO:K04441] [EC:2.7.11.24]
135515567  [KO:K06643] [EC:2.3.2.27]
135515725  [KO:K11987] [EC:1.14.99.1]
135515865  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
135515866  [KO:K04441] [EC:2.7.11.24]
135516146  [KO:K02649]
135516293  [KO:K07983]
135516346  [KO:K04348] [EC:3.1.3.16]
135516396  [KO:K04735]
135516529  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
135516918  il1b; LOW QUALITY PROTEIN: interleukin-1 beta [KO:K04519]
135517151  [KO:K12799]
135517190  [KO:K00922] [EC:2.7.1.153]
135517256  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
135517580  [KO:K04440] [EC:2.7.11.24]
135517722  [KO:K07293] [EC:3.1.3.48]
135517743  [KO:K04348] [EC:3.1.3.16]
135518066  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
135518385  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
135518445  [KO:K04448]
135519373  [KO:K07831]
135519470  [KO:K04398] [EC:3.4.22.61]
135519723  [KO:K11220]
135520030  [KO:K04446]
135520162  [KO:K12799]
135520520  [KO:K09258]
135521250  [KO:K03156]
135521979  [KO:K09258]
135522208  [KO:K06268]
135522335  [KO:K12799]
135522408  [KO:K04456] [EC:2.7.11.1]
135522448  [KO:K10059]
135522463  [KO:K04446]
135523356  [KO:K06268]
135523536  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
135523884  [KO:K04440] [EC:2.7.11.24]
135523890  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
135524022  [KO:K04467] [EC:2.7.11.10]
135524143  [KO:K17333]
135524224  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
135524242  [KO:K04959]
135524248  [KO:K07827]
135524285  [KO:K02833]
135524312  [KO:K06563]
135524354  [KO:K12799]
135524469  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
135524650  [KO:K02649]
135525308  [KO:K21083]
135525697  [KO:K04734]
135525702  [KO:K02183]
135525926  [KO:K04456] [EC:2.7.11.1]
135526217  [KO:K04440] [EC:2.7.11.24]
135526301  [KO:K02580]
135526589  [KO:K04348] [EC:3.1.3.16]
135527281  [KO:K05425]
135527406  [KO:K07293] [EC:3.1.3.48]
135527673  [KO:K07210]
135527795  [KO:K04960]
135527928  [KO:K04443] [EC:2.7.11.1]
135527979  [KO:K04366] [EC:2.7.11.1]
135528079  [KO:K04513]
135528124  [KO:K04513]
135528170  [KO:K05443]
135528394  [KO:K17332]
135528398  [KO:K05704] [EC:2.7.10.2]
135528540  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
135528548  [KO:K04441] [EC:2.7.11.24]
135529147  [KO:K06643] [EC:2.3.2.27]
135529409  [KO:K12496]
135532818  [KO:K07827]
135532908  [KO:K07827]
135533006  [KO:K07827]
135534936  [KO:K14957]
135536209  [KO:K04441] [EC:2.7.11.24]
135536565  [KO:K04441] [EC:2.7.11.24]
135536884  [KO:K07369] [EC:3.4.22.-]
135537717  [KO:K02183]
135537719  [KO:K02183]
135538814  [KO:K05406]
135538815  [KO:K05406]
135539368  [KO:K04456] [EC:2.7.11.1]
135539388  [KO:K06268]
135539549  [KO:K05704] [EC:2.7.10.2]
135539687  [KO:K04513]
135539913  [KO:K04958]
135539966  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
135539986  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
135540185  cyld2; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
135540212  [KO:K04958]
135540240  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
135540373  [KO:K04441] [EC:2.7.11.24]
135541272  [KO:K04443] [EC:2.7.11.1]
135541275  il10; interleukin-10 [KO:K05443]
135541363  [KO:K05704] [EC:2.7.10.2]
135541365  [KO:K12497]
135541366  [KO:K17332]
135541547  [KO:K04513]
135541627  [KO:K02183]
135541678  [KO:K11220]
135541877  [KO:K04958]
135541920  [KO:K06068] [EC:2.7.11.13]
135542088  [KO:K06068] [EC:2.7.11.13]
135542133  [KO:K08601] [EC:3.4.19.12]
135542154  [KO:K04958]
135542263  [KO:K04513]
135542316  [KO:K04441] [EC:2.7.11.24]
135542511  [KO:K11220]
135542537  [KO:K07831]
135543546  [KO:K07831]
135543566  [KO:K11220]
135543917  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
135544085  [KO:K04456] [EC:2.7.11.1]
135544088  [KO:K04440] [EC:2.7.11.24]
135544163  [KO:K04348] [EC:3.1.3.16]
135544317  [KO:K02183]
135544655  [KO:K02649]
135544705  [KO:K04519]
135544946  [KO:K05425]
135545263  [KO:K05406]
135545264  [KO:K05406]
135545602  [KO:K04348] [EC:3.1.3.16]
135545623  [KO:K04519]
135545799  [KO:K02580]
135546061  [KO:K07532]
135546095  [KO:K09253]
135546100  [KO:K02183]
135546237  [KO:K02649]
135546337  [KO:K01370] [EC:3.4.22.36]
135546340  [KO:K01370] [EC:3.4.22.36]
135546367  [KO:K04409] [EC:2.7.11.1]
135546565  [KO:K14958]
135546622  [KO:K00922] [EC:2.7.1.153]
135546631  [KO:K04456] [EC:2.7.11.1]
135546966  il17d; interleukin-17D [KO:K05492]
135547140  stat1b; signal transducer and activator of transcription 1b [KO:K11220]
135547641  mrasa; ras-related protein M-Ras [KO:K07831]
135547684  [KO:K04398] [EC:3.4.22.61]
135548046  [KO:K04448]
135548084  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
135548248  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
135548266  [KO:K04348] [EC:3.1.3.16]
135548388  [KO:K14958]
135548782  [KO:K05425]
135548825  [KO:K09444]
135549026  [KO:K03156]
135549561  [KO:K05405]
135550150  [KO:K04446]
135550226  [KO:K04456] [EC:2.7.11.1]
135550307  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
135550426  [KO:K02183]
135550494  ksr1a; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
135550513  [KO:K07830]
135550889  arhgef12b; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12 [KO:K07532]
135550953  [KO:K09444]
135551001  [KO:K05425]
135551021  [KO:K08601] [EC:3.4.19.12]
135551344  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
135551362  [KO:K17333]
135551516  [KO:K05406]
135551931  il6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
135552285  [KO:K10059]
135552361  [KO:K04446]
135552532  [KO:K07532]
135552568  [KO:K09253]
135552574  [KO:K02183]
135552815  [KO:K01370] [EC:3.4.22.36]
135552832  [KO:K04409] [EC:2.7.11.1]
135553049  [KO:K14958]
135553111  [KO:K00922] [EC:2.7.1.153]
135553129  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
135554071  [KO:K04466] [EC:2.7.11.25]
135555214  il12b2; interleukin-12 subunit beta isoform X1 [KO:K05425]
135555684  [KO:K04466] [EC:2.7.11.25]
135555983  [KO:K04371] [EC:2.7.11.24]
135556019  [KO:K07830]
135556084  [KO:K07830]
135556099  [KO:K04371] [EC:2.7.11.24]
135556149  [KO:K11987] [EC:1.14.99.1]
135556158  [KO:K02649]
135556362  jun; transcription factor AP-1 isoform X1 [KO:K04448]
135556996  [KO:K17333]
135557230  [KO:K08601] [EC:3.4.19.12]
135557457  [KO:K04734]
135557668  [KO:K04456] [EC:2.7.11.1]
135557798  [KO:K07830]
135557915  [KO:K02183]
135558441  [KO:K00922] [EC:2.7.1.153]
135558527  [KO:K02649]
135558554  zmp:0000001127; interleukin-12 subunit alpha [KO:K05406]
135558564  [KO:K11987] [EC:1.14.99.1]
135558695  [KO:K08862] [EC:2.7.11.21]
135558878  [KO:K07368]
135558884  [KO:K04448]
135558891  [KO:K04448]
135558893  [KO:K02649]
135558971  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
135559008  [KO:K17334]
135559403  [KO:K04466] [EC:2.7.11.25]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
KO pathway
ko04625   

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