KEGG   PATHWAY: afor00230
Entry
afor00230                   Pathway                                
Name
Purine metabolism - Aptenodytes forsteri (emperor penguin)
Class
Metabolism; Nucleotide metabolism
Pathway map
afor00230  Purine metabolism
afor00230

Module
afor_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:afor00230]
afor_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:afor00230]
afor_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:afor00230]
afor_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:afor00230]
afor_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:afor00230]
afor_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:afor00230]
Other DBs
GO: 0006163 0042278
Organism
Aptenodytes forsteri (emperor penguin) [GN:afor]
Gene
103899717  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
103899677  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
103904125  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
103905679  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
103899646  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
103904777  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
103898289  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
103897434  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
103901972  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
103902070  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
103897396  trihelix transcription factor GT-2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
103897432  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
103907879  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
103903852  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
103893837  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
103903625  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
103897710  NT5C2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
103904902  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
103899255  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
103893232  cytosolic purine 5'-nucleotidase-like [KO:K01081] [EC:3.1.3.5]
103906704  cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
103908352  cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
103901765  NT5E; LOW QUALITY PROTEIN: 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
103908465  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
103897181  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
103897317  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
103905853  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
103903336  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
103898119  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
103898273  nucleoside diphosphate kinase, mitochondrial-like [KO:K00940] [EC:2.7.4.6]
103899247  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
103899278  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
103907588  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
103895286  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
103907064  AK9; LOW QUALITY PROTEIN: adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
103902394  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
103902413  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
103902414  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
103902503  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
103897679  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
103896887  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
103893808  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
103893478  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
103900106  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
103894017  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
103904176  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
103906351  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
103899108  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
103894350  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
103903956  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
103896171  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
103908490  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
103895882  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
103897160  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
103907021  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
103894432  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
103904400  deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
103906883  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
103900524  PRUNE1; protein prune homolog [KO:K01514] [EC:3.6.1.11]
103904001  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103898441  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
103902407  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103895406  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103903427  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103896863  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103894564  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103897456  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
103902290  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
103897011  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
103902291  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
103905104  guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
103907898  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
103904626  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
103893467  NPR1; LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
103903928  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
103904749  atrial natriuretic peptide receptor 1 [KO:K12324] [EC:4.6.1.2]
103894152  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
103907390  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
103896987  uncharacterized protein LOC103896987 [KO:K18283] [EC:3.1.4.17]
103898676  PDE3A; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
103906839  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
103907234  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
103895128  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
103897662  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
103901480  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
103902450  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
103907839  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
103902014  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
103898228  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
103898412  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
103896478  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
103900335  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
103893553  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
103906769  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
103908279  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
103897590  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
103901350  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
103898650  CECR1; adenosine deaminase CECR1 [KO:K19572] [EC:3.5.4.4]
103898463  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
103903563  AK2; adenylate kinase 2, mitochondrial isoform X2 [KO:K00939] [EC:2.7.4.3]
103905559  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
103905386  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
103900309  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
103900356  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
103894801  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
103908285  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
103901022  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
103900814  ENPP3; LOW QUALITY PROTEIN: ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103900755  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
103893427  cAMP-specific 3',5'-cyclic phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
103899356  cAMP-specific 3',5'-cyclic phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
103898464  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
103904035  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
103900738  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
103896639  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
103899776  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
103903233  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
103906911  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
103895506  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103894231  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
103894871  uricase [KO:K00365] [EC:1.7.3.3]
103907314  5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
afor00030  Pentose phosphate pathway
afor00220  Arginine biosynthesis
afor00250  Alanine, aspartate and glutamate metabolism
afor00260  Glycine, serine and threonine metabolism
afor00340  Histidine metabolism
afor00630  Glyoxylate and dicarboxylate metabolism
afor00730  Thiamine metabolism
afor00740  Riboflavin metabolism
afor00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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