KEGG   PATHWAY: alat04115
Entry
alat04115                   Pathway                                
Name
p53 signaling pathway - Acanthopagrus latus (yellowfin seabream)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
alat04115  p53 signaling pathway
alat04115

Organism
Acanthopagrus latus (yellowfin seabream) [GN:alat]
Gene
119011683  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
119019026  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
119004478  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
119031422  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
119028986  gorab; RAB6-interacting golgin [KO:K19748]
119032385  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
119021207  mdm4; protein Mdm4 isoform X1 [KO:K10127]
119027521  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
119007055  ppp1r13l; relA-associated inhibitor [KO:K27356]
119021974  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
119032388  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
119017665  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119025008  G1/S-specific cyclin-D1-like [KO:K04503]
119023886  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
119032712  G1/S-specific cyclin-D2-like [KO:K10151]
119013794  ccndx; cyclin Dx [KO:K10151]
119020831  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119020857  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119014366  cdk21; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
119016868  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119006026  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
119016518  G1/S-specific cyclin-E2-like [KO:K06626]
119018548  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
119021737  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
119025880  rprma; protein reprimo A [KO:K10128]
119013410  rprml; reprimo-like protein [KO:K10128]
119030467  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
119017612  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
119017850  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
119032268  cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
119034162  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
119004824  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
119028302  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
119029295  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
119030068  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
119030106  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
119011852  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
119020292  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
119024019  gtse1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
119023603  znf385a; zinc finger protein 385A isoform X1 [KO:K26543]
119020456  zinc finger protein 385A-like isoform X1 [KO:K26543]
119034075  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119024375  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
119030076  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
119019251  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
119010726  caspase-8-like [KO:K04398] [EC:3.4.22.61]
119011511  caspase-8-like [KO:K04398] [EC:3.4.22.61]
119026092  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
119024241  bida; BH3 interacting domain death agonist isoform X1 [KO:K04726]
119013666  apoptosis regulator BAX-like [KO:K02159]
119017934  zgc:153993; apoptosis regulator BAX [KO:K02159]
119014265  apoptosis regulator BAX-like [KO:K02159]
119005090  siva1; apoptosis regulatory protein Siva [KO:K22744]
119022663  bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
119021192  bcl-2-like protein 1 [KO:K04570]
119011053  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
119031221  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
119021365  protein shisa-5-like [KO:K10135]
119033532  p53 apoptosis effector related to PMP-22 isoform X1 [KO:K10136]
119028003  zmat3; zinc finger matrin-type protein 3 [KO:K10137]
119024721  siah1; E3 ubiquitin-protein ligase Siah1 [KO:K04506] [EC:2.3.2.27]
119016417  cytochrome c-like [KO:K08738]
119026341  cytochrome c-b-like [KO:K08738]
119033999  cytochrome c [KO:K08738]
119032660  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
119023405  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119007045  caspase-3-like [KO:K02187] [EC:3.4.22.56]
119010646  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
119033491  aifm2; apoptosis-inducing factor 2 [KO:K22745]
119028604  igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
119010995  insulin-like growth factor-binding protein 3 [KO:K10138]
119022093  insulin-like growth factor I [KO:K05459]
119032208  igf1; insulin-like growth factor I [KO:K05459]
119027844  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
119006526  adgrb1a; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
119006006  si:ch73-139j3.4; tetraspanin-19 isoform X1 [KO:K06509]
119024724  CD82 antigen-like [KO:K06509]
119018545  CD82 antigen-like isoform X1 [KO:K06509]
119004792  thrombospondin-1-like [KO:K16857]
119012924  thbs1b; thrombospondin-1 [KO:K16857]
119024438  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
119017446  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
119012785  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
119012786  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
119007703  si:zfos-80g12.1; sestrin-3 isoform X1 [KO:K10141]
119012247  sesn1; sestrin-1 isoform X1 [KO:K10141]
119016920  sesn2; sestrin-2 isoform X1 [KO:K20394]
119010300  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119033631  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119024301  tsc2; tuberin isoform X1 [KO:K07207]
119015479  metalloreductase STEAP3-like [KO:K10142] [EC:1.16.1.-]
119026355  metalloreductase STEAP3-like [KO:K10142] [EC:1.16.1.-]
119011407  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
119020194  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
119007050  ccng1; cyclin-G1 [KO:K10145]
119030152  ccng2; cyclin-G2 [KO:K10146]
119019710  cyclin-G2-like [KO:K10146]
119004826  ppm1da; protein phosphatase, Mg2+/Mn2+ dependent, 1Da [KO:K10147] [EC:3.1.3.16]
119031020  protein phosphatase 1D-like isoform X1 [KO:K10147] [EC:3.1.3.16]
119022317  tp73; tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
alat04110  Cell cycle
alat04210  Apoptosis
alat04218  Cellular senescence
KO pathway
ko04115   
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