KEGG   PATHWAY: alat04110
Entry
alat04110                   Pathway                                
Name
Cell cycle - Acanthopagrus latus (yellowfin seabream)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
alat04110  Cell cycle
alat04110

Other DBs
GO: 0000278
Organism
Acanthopagrus latus (yellowfin seabream) [GN:alat]
Gene
119004341  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
119004427  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
119004476  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
119004478  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
119004647  [KO:K16197]
119004824  [KO:K04402]
119004841  orc3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
119004848  stag1a; cohesin subunit SA-1a [KO:K06671]
119004901  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
119004977  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
119005063  pds5a; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
119005498  dbf4; protein DBF4 homolog A [KO:K06629]
119005875  [KO:K16197]
119005886  [KO:K06620]
119005921  [KO:K06670]
119006026  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
119006144  [KO:K04501]
119006267  ttk; dual specificity protein kinase Ttk [KO:K08866] [EC:2.7.12.1]
119006316  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
119006571  trip13; pachytene checkpoint protein 2 homolog isoform X1 [KO:K22399]
119006701  [KO:K26116]
119006720  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
119006914  pttg1; securin [KO:K06635]
119007066  stag2b; cohesin subunit SA-2 isoform X1 [KO:K06671]
119007071  [KO:K06671]
119007182  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
119007210  atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
119007217  [KO:K04382] [EC:3.1.3.16]
119007805  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
119007921  ccna2; cyclin-A2 [KO:K06627]
119008099  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
119008696  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
119008730  myca; transcriptional regulator Myc-A [KO:K04377]
119009067  [KO:K03347]
119009263  tgfb1a; transforming growth factor, beta 1a isoform X1 [KO:K13375]
119009409  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
119009531  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
119009668  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
119009677  dbf4b; protein DBF4 homolog B isoform X1 [KO:K06629]
119009684  [KO:K25163]
119010292  bub3; mitotic checkpoint protein BUB3 [KO:K02180]
119010664  [KO:K04377]
119010756  fzr1b; fizzy-related protein homolog [KO:K03364]
119010879  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
119010889  [KO:K03364]
119011007  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
119011011  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
119011238  cdc14aa; cell division cycle 14Aa [KO:K06639] [EC:3.1.3.16 3.1.3.48]
119011245  orc2; origin recognition complex subunit 2 [KO:K02604]
119011510  mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
119011670  e2f5; transcription factor E2F5 [KO:K04682]
119011683  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
119011852  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
119011886  cdc20; cell division cycle protein 20 homolog [KO:K03363]
119012044  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
119012184  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
119012203  esco2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
119012391  knl1; kinetochore scaffold 1 isoform X1 [KO:K11542]
119012560  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
119012588  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
119012715  [KO:K13377]
119013337  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
119013546  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
119013730  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
119013794  ccndx; cyclin Dx [KO:K10151]
119014113  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
119014366  cdk21; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
119014400  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
119014615  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
119015104  [KO:K16197]
119015252  orc4; origin recognition complex subunit 4 [KO:K02606]
119016513  e2f3; transcription factor E2F3 isoform X1 [KO:K06620]
119016518  [KO:K06626]
119016666  [KO:K06067] [EC:3.5.1.98]
119016796  sgo1; shugoshin 1 isoform X1 [KO:K11580]
119016803  cdca5; sororin [KO:K17390]
119016868  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119017111  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
119017208  si:dkey-222b8.1; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
119017440  [KO:K06670]
119017612  [KO:K21770]
119017665  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119017679  anapc11; anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
119017850  [KO:K21770]
119017891  [KO:K04682]
119018224  [KO:K23605]
119018235  cdkn1ca; cyclin-dependent kinase inhibitor 1Ca [KO:K09993]
119018548  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
119018817  [KO:K04681]
119018859  cdc45; cell division control protein 45 homolog [KO:K06628]
119019013  pcna; proliferating cell nuclear antigen [KO:K04802]
119019015  cdc14b; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
119019026  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
119019135  [KO:K04500]
119019146  nipbla; nipped-B-like protein A isoform X1 [KO:K06672]
119019147  ndc80; kinetochore protein NDC80 homolog isoform X1 [KO:K11547]
119019185  [KO:K04382] [EC:3.1.3.16]
119019348  ccnh; cyclin-H [KO:K06634]
119019438  anapc7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
119019615  [KO:K04501]
119020009  [KO:K03363]
119020097  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
119020249  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
119020292  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
119020391  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
119020831  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119020857  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119020881  ywhaba; 14-3-3 protein beta/alpha-A [KO:K16197]
119021164  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
119021256  espl1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
119021282  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
119021405  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
119021652  mych; myelocytomatosis oncogene homolog [KO:K04377]
119021737  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
119021806  cdc6; cell division control protein 6 homolog [KO:K02213]
119021974  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
119022676  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
119022719  rad21l1; double-strand-break repair protein rad21-like protein 1 [KO:K06670]
119022849  zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
119022881  e2f1; transcription factor E2F1 [KO:K17454]
119023478  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
119023623  [KO:K16197]
119023781  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
119023842  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
119023845  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
119023886  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
119023891  ddx11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
119024188  smc1b; structural maintenance of chromosomes protein 1B isoform X1 [KO:K06636]
119024238  wee2; wee1-like protein kinase 2 isoform X1 [KO:K06632] [EC:2.7.11.1]
119024274  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
119024552  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
119024603  ticrr; treslin [KO:K26117]
119024850  e2f4; transcription factor E2F4 [KO:K04682]
119025008  [KO:K04503]
119025025  cdkn1cb; cyclin-dependent kinase inhibitor 1C [KO:K09993]
119025321  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
119025333  cdkn2d; cyclin-dependent kinase 4 inhibitor D isoform X1 [KO:K06623]
119025414  si:ch211-269e2.1; cohesin subunit SA-2 isoform X1 [KO:K06671]
119025775  cdc16; cell division cycle protein 16 homolog [KO:K03353]
119026483  tfdp1a; transcription factor Dp-1a [KO:K04683]
119026908  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
119027328  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
119027521  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
119027553  hdac8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
119027882  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
119027927  plk1; serine/threonine-protein kinase PLK1 isoform X1 [KO:K06631] [EC:2.7.11.21]
119028048  cdkn2c; cyclin-dependent kinase 4 inhibitor C isoform X1 [KO:K06622]
119028302  [KO:K04402]
119028438  cdc14ab; dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
119028465  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
119028541  [KO:K11266]
119028597  aurkb; aurora kinase B [KO:K11479] [EC:2.7.11.1]
119028639  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
119029173  [KO:K03364]
119029295  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
119029557  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
119029646  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
119029939  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
119029955  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
119029983  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
119030028  [KO:K06672]
119030068  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
119030106  [KO:K04402]
119030467  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
119031011  pds5b; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
119031051  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 [KO:K06630]
119031071  ccna1; cyclin-A1 [KO:K06627]
119031215  rb1; retinoblastoma-associated protein [KO:K06618]
119031226  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
119031384  ywhag2; 14-3-3 protein gamma-B [KO:K16198]
119031399  [KO:K10779]
119031413  cdc23; cell division cycle protein 23 homolog [KO:K03355]
119031422  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
119031471  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
119031508  [KO:K06630]
119031719  skp1; S-phase kinase-associated protein 1 [KO:K03094]
119031863  stag2a; cohesin subunit SA-2a [KO:K06671]
119032268  [KO:K21770]
119032317  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
119032385  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
119032388  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
119032712  [KO:K10151]
119032886  orc5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
119033161  [KO:K26093]
119033272  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
119033446  cdt1; DNA replication factor Cdt1 [KO:K10727]
119033464  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
119033660  wapla; wings apart-like protein homolog [KO:K25163]
119033846  anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
119034162  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
119034183  fbxo5; F-box only protein 5 [KO:K10292]
119034492  [KO:K06067] [EC:3.5.1.98]
119034505  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
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Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
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Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
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J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
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Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
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Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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EMBO J 16:343-54 (1997)
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Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
alat03030  DNA replication
alat04010  MAPK signaling pathway
alat04120  Ubiquitin mediated proteolysis
alat04210  Apoptosis
KO pathway
ko04110   

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