KEGG   PATHWAY: bbub04540
Entry
bbub04540                   Pathway                                
Name
Gap junction - Bubalus bubalis (water buffalo)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
bbub04540  Gap junction
bbub04540

Other DBs
GO: 0005921
Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102394767  GJA1; gap junction alpha-1 protein [KO:K07372]
102402303  GJD2; gap junction delta-2 protein [KO:K07373]
102406108  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
102413668  GNAI2; guanine nucleotide-binding protein G(I) subunit alpha-2 [KO:K04630]
102401306  GNAI1; guanine nucleotide-binding protein G(I) subunit alpha-1 [KO:K04630]
102409247  GNAI3; guanine nucleotide-binding protein G(I) subunit alpha-3 [KO:K04630]
102396940  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102392849  PDGFC; platelet-derived growth factor C isoform X3 [KO:K05450]
102411002  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
102416325  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
102409620  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102392216  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102398103  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102394713  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102412823  SOS2; son of sevenless homolog 2 [KO:K03099]
102392913  SOS1; son of sevenless homolog 1 isoform X3 [KO:K03099]
112587129  GTPase HRas-like [KO:K02833]
102392995  KRAS; GTPase KRas isoform X2 [KO:K07827]
102399487  NRAS; GTPase NRas isoform X2 [KO:K07828]
102412922  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102396842  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102401744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102396206  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
102403296  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102410133  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
102406531  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102392821  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X7 [KO:K04463] [EC:2.7.12.2]
102401035  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
102414462  tubulin alpha-1A chain [KO:K07374]
102405836  tubulin alpha-1C chain [KO:K07374]
112584592  tubulin alpha-1C chain [KO:K07374]
102405981  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102397197  tubulin alpha-1D chain isoform X1 [KO:K07374]
102397626  tubulin alpha-4A chain [KO:K07374]
102394738  TUBA8; tubulin alpha-8 chain [KO:K07374]
112579865  tubulin alpha-3 chain [KO:K07374]
102415619  tubulin alpha-1A chain [KO:K07374]
102412090  tubulin alpha-1A chain-like [KO:K07374]
102399969  tubulin alpha-1B chain [KO:K07374]
102407148  TUBB4B; tubulin beta-4B chain [KO:K07375]
102398816  TUBB2A; tubulin beta-2A chain [KO:K07375]
102411164  tubulin beta-2B chain [KO:K07375]
102403160  TUBB3; tubulin beta-3 chain [KO:K07375]
102396504  TUBB6; tubulin beta-6 chain [KO:K07375]
102412866  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
102410657  TUBB4A; tubulin beta-4A chain [KO:K07375]
102413762  TUBB; tubulin beta chain [KO:K07375]
102410087  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
102405957  CDK1; cyclin-dependent kinase 1 isoform X3 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102402627  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
102399704  ADRB1; beta-1 adrenergic receptor [KO:K04141]
102399173  DRD1; D(1A) dopamine receptor [KO:K04144]
102408597  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
112577614  neuroendocrine secretory protein 55 [KO:K04632]
102395376  DRD2; D(2) dopamine receptor [KO:K04145]
102415323  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102412622  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102407976  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
102408103  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
102405387  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102407637  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102410456  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102395302  ADCY8; adenylate cyclase type 8 isoform X3 [KO:K08048] [EC:4.6.1.1]
102404282  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102392366  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102413383  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X4 [KO:K04345] [EC:2.7.11.11]
102396941  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
102395490  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
102406013  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
102414394  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
102399934  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
102391819  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102409250  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102412320  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
102405830  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
102413748  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
102389945  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102412452  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X8 [KO:K04958]
102401062  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X2 [KO:K04959]
102409793  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
102415611  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
102407189  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
102397646  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102394541  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
102390736  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
102400461  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
102394244  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
102407722  PRKG1; cGMP-dependent protein kinase 1 isoform X2 [KO:K07376] [EC:2.7.11.12]
102405676  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
bbub04010  MAPK signaling pathway
bbub04020  Calcium signaling pathway
bbub04060  Cytokine-cytokine receptor interaction
bbub04070  Phosphatidylinositol signaling system
bbub04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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