KEGG   PATHWAY: bbub04060
Entry
bbub04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Bubalus bubalis (water buffalo)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
bbub04060  Cytokine-cytokine receptor interaction
bbub04060

Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102388960  EDA; ectodysplasin-A isoform X1 [KO:K05480]
102389048  IL26; interleukin-26 [KO:K05446]
102389105  [KO:K16596]
102389179  [KO:K05439]
102389318  IL36RN; interleukin-36 receptor antagonist protein [KO:K05483]
102389386  IL22; interleukin-22 [KO:K05445]
102389416  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102389589  [KO:K21092]
102389630  CCR4; C-C chemokine receptor type 4 [KO:K04179]
102389633  [KO:K05440]
102389636  IL1F10; interleukin-1 family member 10 [KO:K05488]
102389662  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
102389875  CCL1; C-C motif chemokine 1 [KO:K05514]
102389922  CCL16; C-C motif chemokine 16 [KO:K21093]
102389972  [KO:K05440]
102389974  IL1RN; interleukin-1 receptor antagonist protein isoform X4 [KO:K05481]
102390185  BMP8B; bone morphogenetic protein 8B isoform X1 [KO:K16622]
102390241  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
102390331  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
102390397  [KO:K05436]
102390524  [KO:K16622]
102390598  OSM; oncostatin-M isoform X1 [KO:K05418]
102390629  TGFB2; transforming growth factor beta-2 proprotein isoform X3 [KO:K13376]
102390637  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
102390853  [KO:K05440]
102390924  LIF; leukemia inhibitory factor isoform X1 [KO:K05419]
102391064  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
102391191  [KO:K05440]
102391247  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
102391294  ACKR4; atypical chemokine receptor 4 [KO:K04186]
102391532  [KO:K05440]
102391609  [KO:K05440]
102391610  XCR1; chemokine XC receptor 1 [KO:K04193]
102391778  LTA; lymphotoxin-alpha [KO:K05468]
102391865  [KO:K05440]
102391873  [KO:K05069]
102391908  IL11; interleukin-11 [KO:K05417]
102391941  [KO:K04176]
102392112  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102392130  GDF2; growth/differentiation factor 2 [KO:K05503]
102392192  [KO:K05069]
102392202  CCL17; C-C motif chemokine 17 [KO:K21083]
102392270  CCR1; C-C chemokine receptor type 1 [KO:K04176]
102392310  CCL5; C-C motif chemokine 5 isoform X1 [KO:K12499]
102392529  CX3CL1; fractalkine [KO:K05508]
102392659  LTB; lymphotoxin-beta isoform X1 [KO:K03157]
102392777  GDF10; growth/differentiation factor 10 isoform X2 [KO:K22674]
102392809  CCR3; C-C chemokine receptor type 3 [KO:K04178]
102392870  [KO:K22632]
102393062  IL9; interleukin-9 [KO:K05432]
102393071  CCL22; C-C motif chemokine 22 [KO:K21095]
102393187  CCL21; C-C motif chemokine 21 [KO:K16062]
102393220  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
102393260  TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473]
102393323  CCR8; C-C chemokine receptor type 8 [KO:K04183]
102393345  IL7; interleukin-7 isoform X1 [KO:K05431]
102393447  IL21R; interleukin-21 receptor [KO:K05075]
102393452  CCR2; C-C chemokine receptor type 2 [KO:K04177]
102393454  GDF9; growth/differentiation factor 9 [KO:K22673]
102393500  BMP15; bone morphogenetic protein 15 [KO:K05498]
102393503  CCL19; C-C motif chemokine 19 isoform X2 [KO:K05512]
102393529  IL10RA; interleukin-10 receptor subunit alpha isoform X2 [KO:K05134]
102393535  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
102393548  BMP5; bone morphogenetic protein 5 [KO:K04663]
102393701  [KO:K05414]
102393717  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
102393764  IFNGR2; interferon gamma receptor 2 [KO:K05133]
102393815  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
102393818  [KO:K05414]
102393840  OSMR; oncostatin-M-specific receptor subunit beta isoform X8 [KO:K05057]
102393859  CX3CR1; CX3C chemokine receptor 1 isoform X4 [KO:K04192]
102394028  [KO:K05440]
102394049  [KO:K16598]
102394092  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X2 [KO:K05150]
102394204  IL4R; interleukin-4 receptor subunit alpha isoform X4 [KO:K05071]
102394317  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102394321  TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X6 [KO:K05160]
102394323  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102394361  ACVRL1; serine/threonine-protein kinase receptor R3 isoform X1 [KO:K13594] [EC:2.7.11.30]
102394461  IL17A; interleukin-17A [KO:K05489]
102394558  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
102394618  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
102394692  [KO:K05474]
102394708  ACKR3; atypical chemokine receptor 3 [KO:K04304]
102394782  IL17F; interleukin-17F [KO:K05494]
102394946  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102395034  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X2 [KO:K05147]
102395107  IL21; interleukin-21 [KO:K05434]
102395229  CSF1; macrophage colony-stimulating factor 1 isoform X3 [KO:K05453]
102395421  IL2; interleukin-2 precursor [KO:K05429]
102395463  CCR6; C-C chemokine receptor type 6 [KO:K04181]
102395794  [KO:K22669]
102395805  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
102395900  EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X3 [KO:K05163]
102396194  [KO:K05475]
102396243  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
102396262  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
102396373  [KO:K04667]
102396479  [KO:K22632]
102396581  [KO:K04723]
102396760  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
102396812  TGFBR1; TGF-beta receptor type-1 precursor [KO:K04674] [EC:2.7.11.30]
102396964  IL16; pro-interleukin-16 isoform X2 [KO:K22628]
102397096  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
102397131  IL4; interleukin-4 precursor [KO:K05430]
102397453  IL13; interleukin-13 precursor [KO:K05435]
102397573  IFNK; interferon kappa [KO:K05441]
102397778  EPO; erythropoietin [KO:K05437]
102397936  TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X2 [KO:K05476]
102398115  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
102398200  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102398263  INHBB; inhibin beta B chain [KO:K22687]
102398308  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
102398309  IL5; interleukin-5 precursor [KO:K05428]
102398464  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
102398646  CD40LG; CD40 ligand [KO:K03161]
102398743  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
102398788  BMP4; bone morphogenetic protein 4 isoform X4 [KO:K04662]
102399141  [KO:K05440]
102399265  EBI3; interleukin-27 subunit beta isoform X1 [KO:K24476]
102399388  TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X2 [KO:K05154]
102399524  BMPR1B; bone morphogenetic protein receptor type-1B isoform X2 [KO:K13578] [EC:2.7.11.30]
102399583  IL9R; interleukin-9 receptor isoform X1 [KO:K05073]
102399807  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
102399832  BMP7; bone morphogenetic protein 7 [KO:K16621]
102400650  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
102400684  LTBR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159]
102400790  IL10; interleukin-10 precursor [KO:K05443]
102400849  IL23R; interleukin-23 receptor [KO:K05065]
102400952  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
102401012  CD27; CD27 antigen isoform X1 [KO:K05144]
102401266  CXCL17; C-X-C motif chemokine 17 [KO:K22627]
102401396  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
102401432  IL18; interleukin-18 isoform X1 [KO:K05482]
102401526  IL17B; interleukin-17B isoform X1 [KO:K05490]
102401594  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
102401642  LEP; leptin isoform X1 [KO:K05424]
102401655  IL24; interleukin-24 [KO:K22668]
102401716  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
102401761  [KO:K04175]
102401824  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
102402056  [KO:K05415]
102402145  CCL26; C-C motif chemokine 26 [KO:K21096]
102402159  LEPR; leptin receptor isoform X2 [KO:K05062]
102402216  IFNL3; interferon lambda-3 [KO:K22669]
102402301  IL20; interleukin-20 [KO:K22667]
102402346  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102402367  [KO:K05415]
102402460  CCL24; C-C motif chemokine 24 [KO:K21097]
102402566  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
102402570  TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145]
102402621  IL19; interleukin-19 isoform X1 [KO:K05444]
102402634  CCL25; C-C motif chemokine 25 isoform X2 [KO:K13072]
102402697  [KO:K05415]
102402789  [KO:K05414]
102403008  INHBC; inhibin beta C chain [KO:K22688]
102403011  CNTF; ciliary neurotrophic factor [KO:K05420]
102403331  INHBE; inhibin beta E chain [KO:K22689]
102403474  TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X1 [KO:K05469]
102403541  IL17RB; interleukin-17 receptor B isoform X7 [KO:K05165]
102403761  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X2 [KO:K05064]
102403765  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
102403790  TNFSF18; tumor necrosis factor ligand superfamily member 18 isoform X3 [KO:K05479]
102403831  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
102403858  IL33; interleukin-33 [KO:K12967]
102403960  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102404404  GDF11; growth/differentiation factor 11 [KO:K22679]
102404535  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
102404721  NODAL; nodal homolog [KO:K04666]
102404929  GDF7; growth/differentiation factor 7 [KO:K20013]
102405003  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
102405131  TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X2 [KO:K05155]
102405178  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
102405218  AMH; muellerian-inhibiting factor [KO:K04665]
102405590  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
102405747  [KO:K05474]
102405922  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
102405937  ACVR2B; activin receptor type-2B isoform X2 [KO:K13596] [EC:2.7.11.30]
102406002  CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423]
102406107  GDF3; growth/differentiation factor 3 [KO:K22672]
102406204  BMP3; bone morphogenetic protein 3 [KO:K05496]
102406287  GH; somatotropin isoform X1 [KO:K05438]
102406514  [KO:K05439]
102406980  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
102406982  IL17D; interleukin-17D [KO:K05492]
102407174  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
102407360  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
102407436  IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]
102407630  [KO:K05439]
102407643  CCR10; C-C chemokine receptor type 10 [KO:K04185]
102407739  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
102407921  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
102408026  CRLF2; cytokine receptor-like factor 2 isoform X1 [KO:K05078]
102408304  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
102408349  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
102408388  BMP2; bone morphogenetic protein 2 [KO:K21283]
102408406  RELL1; RELT-like protein 1 [KO:K26541]
102408434  [KO:K05415]
102408655  [KO:K16597]
102408664  [KO:K05174]
102408691  CD70; CD70 antigen [KO:K05470]
102408756  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102408812  IL27; interleukin-27 subunit alpha [KO:K22629]
102408963  [KO:K14624]
102409007  TNFSF9; tumor necrosis factor ligand superfamily member 9 isoform X1 [KO:K05472]
102409271  THPO; thrombopoietin isoform X1 [KO:K06854]
102409460  GDF5; growth/differentiation factor 5 [KO:K04664]
102409466  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
102409545  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
102409559  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
102409760  IL34; interleukin-34 isoform X3 [KO:K22633]
102410135  IFNGR1; interferon gamma receptor 1 [KO:K05132]
102410211  GHR; growth hormone receptor isoform X2 [KO:K05080]
102410273  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
102410411  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
102410416  [KO:K05440]
102410529  BMP6; bone morphogenetic protein 6 precursor [KO:K16620]
102410967  [KO:K05440]
102411074  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
102411076  IL1RL2; interleukin-1 receptor-like 2 isoform X1 [KO:K05172]
102411137  CLCF1; cardiotrophin-like cytokine factor 1 isoform X4 [KO:K05421]
102411220  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
102411318  MPL; thrombopoietin receptor [KO:K05082]
102411482  IFNE; interferon epsilon [KO:K05442]
102411580  [KO:K05439]
102411639  IL6R; interleukin-6 receptor subunit alpha isoform X3 [KO:K05055]
102411913  [KO:K05439]
102411949  [KO:K05440]
102412157  GDF15; growth/differentiation factor 15 [KO:K05504]
102412179  RELL2; RELT-like protein 2 [KO:K26541]
102412228  [KO:K05439]
102412286  EPOR; erythropoietin receptor [KO:K05079]
102412530  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
102412560  [KO:K05439]
102412694  CCL28; C-C motif chemokine 28 [KO:K05513]
102412840  IL25; interleukin-25 [KO:K05493]
102412882  [KO:K05439]
102412933  CXCL8; interleukin-8 precursor [KO:K10030]
102413125  IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X2 [KO:K05077]
102413271  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
102413348  IL23A; interleukin-23 subunit alpha [KO:K05426]
102413371  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
102413467  [KO:K05440]
102413537  [KO:K05408]
102413568  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
102413651  IL17RE; interleukin-17 receptor E isoform X6 [KO:K05168]
102413660  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
102413678  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
102413723  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
102413779  [KO:K05440]
102413808  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102413882  IL3; interleukin-3 precursor [KO:K04736]
102414042  MSTN; growth/differentiation factor 8 precursor [KO:K05497]
102414145  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
102414238  [KO:K05506]
102414333  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
102414434  [KO:K05414]
102414580  GDF6; growth/differentiation factor 6 [KO:K20012]
102414637  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
102414669  IL37; interleukin-37 isoform X2 [KO:K05485]
102414674  CXCL11; C-X-C motif chemokine 11 isoform X2 [KO:K12672]
102414734  [KO:K12964]
102414739  IL17RC; interleukin-17 receptor C isoform X7 [KO:K05166]
102414778  [KO:K05440]
102414909  [KO:K05407]
102415007  [KO:K05484]
102415013  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
102415065  CCL3; C-C motif chemokine 3 precursor [KO:K05408]
102415101  IL6; interleukin-6 isoform X1 [KO:K05405]
102415114  [KO:K05414]
102415138  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
102415212  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
102415247  [KO:K05505]
102415303  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102415351  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
102415400  [KO:K05408]
102415410  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
102415426  [KO:K05507]
102415704  LIFR; leukemia inhibitory factor receptor isoform X2 [KO:K05058]
102415727  [KO:K05408]
102415743  PRLR; prolactin receptor isoform X1 [KO:K05081]
102415761  [KO:K05507]
102415781  IL36G; interleukin-36 gamma isoform X1 [KO:K05487]
102415803  INHA; inhibin alpha chain [KO:K05500]
102415899  [KO:K05505]
102415969  [KO:K05439]
102416057  [KO:K05511]
102416204  [KO:K05414]
102416225  [KO:K05505]
102416431  CCR9; C-C chemokine receptor type 9 [KO:K04184]
102416472  IL17C; interleukin-17C [KO:K05491]
102416494  IFNG; interferon gamma precursor [KO:K04687]
102416530  IL36B; interleukin-36 beta [KO:K05486]
102416605  CCR7; C-C chemokine receptor type 7 [KO:K04182]
102416621  [KO:K05439]
112577611  [KO:K05408]
112577675  CCL27; C-C motif chemokine 27 [KO:K16598]
112577736  [KO:K05414]
112577752  [KO:K05439]
112579588  [KO:K05439]
112581848  CTF1; cardiotrophin-1 isoform X2 [KO:K05422]
112583541  [KO:K05414]
112583542  [KO:K05440]
112583543  [KO:K05440]
112583544  [KO:K05414]
112583545  [KO:K05414]
112583546  [KO:K05414]
112583547  [KO:K05440]
112583548  [KO:K05414]
112583865  [KO:K05440]
112583867  [KO:K05414]
112583871  [KO:K05440]
112583872  [KO:K05440]
112583874  [KO:K05440]
112583876  [KO:K05414]
112583880  [KO:K05414]
112583883  [KO:K05415]
112583884  [KO:K05415]
112583885  [KO:K05415]
112583886  [KO:K05415]
123327493  [KO:K04180]
123331640  [KO:K24382]
123332407  [KO:K05440]
123332776  [KO:K05440]
123332785  [KO:K05415]
123332932  [KO:K04722]
123464797  BMP10; bone morphogenetic protein 10 [KO:K22670]
123465533  [KO:K05440]
123465588  [KO:K05415]
123465589  [KO:K05415]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
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