KEGG   PATHWAY: bom04152
Entry
bom04152                    Pathway                                
Name
AMPK signaling pathway - Bos mutus (wild yak)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
bom04152  AMPK signaling pathway
bom04152

Other DBs
GO: 2000479
Organism
Bos mutus (wild yak) [GN:bom]
Gene
102264816  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102278863  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102269403  CAB39; calcium binding protein 39 [KO:K08272]
102287075  CAB39L; calcium binding protein 39 like [KO:K08272]
102274168  STRADA; STE20-related kinase adaptor alpha [KO:K08271]
102273173  STRADB; STE20-related kinase adaptor beta [KO:K17532]
102276736  LEP; leptin [KO:K05424]
102269476  LEPR; leptin receptor [KO:K05062]
102275357  CAMKK2; calcium/calmodulin dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
102265630  ADRA1A; adrenoceptor alpha 1A [KO:K04135]
102271886  ADIPOQ; adiponectin, C1Q and collagen domain containing [KO:K07296]
102274536  ADIPOR1; adiponectin receptor 1 [KO:K07297]
102274185  ADIPOR2; adiponectin receptor 2 [KO:K07297]
102270414  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102265959  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
102278235  PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1 [KO:K07199]
102275377  PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2 [KO:K07199]
102276048  PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3 [KO:K07200]
102277941  PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2 [KO:K07200]
102268424  PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
102284536  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
102266564  PFKFB1; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
102269141  PFKFB2; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
102276469  PFKFB3; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
102271677  PFKFB4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
102285847  FBP1; fructose-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
102270280  fructose-1,6-bisphosphatase isozyme 2-like [KO:K03841] [EC:3.1.3.11]
102269659  PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]
102285285  PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]
102268656  PFKL; phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
102273938  HNF4A; hepatocyte nuclear factor 4 alpha [KO:K07292]
102275376  G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
102288249  G6PC; glucose-6-phosphatase catalytic subunit [KO:K01084] [EC:3.1.3.9]
102276125  G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
102271756  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
102265930  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
102280934  CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
102281756  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
102281505  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
102268154  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
102264680  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
102271999  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
102277321  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
102275204  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
102275427  PPARGC1A; PPARG coactivator 1 alpha [KO:K07202]
102276434  ELAVL1; ELAV like RNA binding protein 1 [KO:K13088]
102270546  CCND1; cyclin D1 [KO:K04503]
102274455  CCNA2; cyclin A2 [KO:K06627]
102276514  CCNA1; cyclin A1 [KO:K06627]
102283488  EEF2K; eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
102271153  EEF2; eukaryotic translation elongation factor 2 [KO:K03234]
102284612  FOXO1; forkhead box O1 [KO:K07201]
102287014  FOXO3; forkhead box O3 [KO:K09408]
102276604  SIRT1; sirtuin 1 [KO:K11411] [EC:2.3.1.286]
102272151  SLC2A4; solute carrier family 2 member 4 [KO:K07191]
102272943  GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
102278988  GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
102266815  LIPE; lipase E, hormone sensitive type [KO:K07188] [EC:3.1.1.79]
102270355  HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase [KO:K00021] [EC:1.1.1.34]
102272556  SREBF1; sterol regulatory element binding transcription factor 1 [KO:K07197]
102278267  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
102284276  ACACA; acetyl-CoA carboxylase alpha [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
102280846  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
102278642  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
102275206  ACACB; acetyl-CoA carboxylase beta [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
102287264  MLYCD; malonyl-CoA decarboxylase [KO:K01578] [EC:4.1.1.9]
102265568  CPT1A; carnitine palmitoyltransferase 1A [KO:K08765] [EC:2.3.1.21]
102269192  CPT1B; carnitine palmitoyltransferase 1B [KO:K19523] [EC:2.3.1.21]
102287746  CPT1C; carnitine palmitoyltransferase 1C [KO:K19524] [EC:2.3.1.21]
102283663  CIDEA; cell death-inducing DFFA-like effector a [KO:K25893]
102266065  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
102279886  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
102282540  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
102278583  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
102285183  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
102278265  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
102287455  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
102272209  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
102287363  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
102287482  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
102282136  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
102270172  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
102271235  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
102288145  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
102279156  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
102287801  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
102286395  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
102278065  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
102281547  TBC1D1; TBC1 domain family member 1 [KO:K18341]
102282887  RAB2A; RAB2A, member RAS oncogene family [KO:K07877]
102287920  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
102286104  RAB10; RAB10, member RAS oncogene family [KO:K07903]
102274264  RAB11B; RAB11B, member RAS oncogene family [KO:K07905]
102288154  RAB14; RAB14, member RAS oncogene family [KO:K07881]
102264773  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
102266138  platelet glycoprotein 4 [KO:K06259]
102266632  platelet glycoprotein 4 [KO:K06259]
102272009  IGF1; insulin like growth factor 1 [KO:K05459]
102278105  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102274400  INS; insulin [KO:K04526]
102285317  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102284664  IRS1; insulin receptor substrate 1 [KO:K16172]
102273597  IRS4; insulin receptor substrate 4 [KO:K17446]
102274553  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102274461  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102277548  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102266922  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102280296  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102286868  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102264327  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102275199  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102265427  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102283212  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102267343  TSC2; tuberous sclerosis 2 [KO:K07207]
102280709  TSC1; tuberous sclerosis 1 [KO:K07206]
102277658  RHEB; Ras homolog enriched in brain [KO:K07208]
102267219  GTP-binding protein Rheb [KO:K07208]
102281727  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102285390  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102264796  AKT1S1; AKT1 substrate 1 [KO:K16184]
102285710  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102271079  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102278368  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
102265537  PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
102277562  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
bom00010  Glycolysis / Gluconeogenesis
bom00061  Fatty acid biosynthesis
bom00500  Starch and sucrose metabolism
bom01040  Biosynthesis of unsaturated fatty acids
bom04110  Cell cycle
bom04140  Autophagy - animal
bom04150  mTOR signaling pathway
bom04151  PI3K-Akt signaling pathway
bom04910  Insulin signaling pathway
bom04920  Adipocytokine signaling pathway
KO pathway
ko04152   
LinkDB

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