KEGG   PATHWAY: ccar04141
Entry
ccar04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Cyprinus carpio (common carp)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ccar04141  Protein processing in endoplasmic reticulum
ccar04141

Other DBs
GO: 0030433 0034976
Organism
Cyprinus carpio (common carp) [GN:ccar]
Gene
109067675  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
109091081  sec61a1; protein transport protein Sec61 subunit alpha [KO:K10956]
109091101  protein transport protein Sec61 subunit alpha-like [KO:K10956]
109105977  protein transport protein Sec61 subunit beta-like isoform X1 [KO:K09481]
109106006  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
109054089  protein transport protein Sec61 subunit gamma [KO:K07342]
109113600  LOW QUALITY PROTEIN: protein transport protein Sec61 subunit gamma-like [KO:K07342]
109091044  LOW QUALITY PROTEIN: translocation protein SEC62-like [KO:K12275]
109069566  translocation protein SEC62-like isoform X1 [KO:K12275]
109069916  translocation protein SEC63 homolog [KO:K09540]
109057073  LOW QUALITY PROTEIN: translocation protein SEC63 homolog [KO:K09540]
109056956  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
109090847  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
109059463  LOW QUALITY PROTEIN: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667]
109098747  LOW QUALITY PROTEIN: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like [KO:K12667]
109055462  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1-like [KO:K12668]
109084863  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 isoform X1 [KO:K12668]
109047982  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
109047987  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
109110318  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1 [KO:K07151] [EC:2.4.99.18]
109098020  LOW QUALITY PROTEIN: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
109097658  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
109106616  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
109072816  magnesium transporter protein 1-like [KO:K19478]
109072819  magnesium transporter protein 1-like [KO:K19478]
109075823  magnesium transporter protein 1 [KO:K19478]
109093849  tusc3; tumor suppressor candidate 3 [KO:K19478]
109095341  ostc; oligosaccharyltransferase complex subunit OSTC isoform X1 [KO:K26501]
109051056  transmembrane protein 258 isoform X1 [KO:K26502]
109051058  LOW QUALITY PROTEIN: transmembrane protein 258-like [KO:K26502]
109076645  mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
109067866  mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
109068405  mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
109062600  putative leucine-rich repeat-containing protein DDB_G0290503 [KO:K13999]
109064557  rrbp1; LOW QUALITY PROTEIN: ribosome-binding protein 1 [KO:K14000]
109056714  nucleotide exchange factor SIL1-like [KO:K14001]
109087938  nucleotide exchange factor SIL1-like [KO:K14001]
109097193  hypoxia up-regulated protein 1-like [KO:K09486]
109097196  LOW QUALITY PROTEIN: hypoxia up-regulated protein 1-like [KO:K09486]
109076076  78 kDa glucose-regulated protein-like [KO:K09490] [EC:3.6.4.10]
109080967  LOW QUALITY PROTEIN: 78 kDa glucose-regulated protein-like [KO:K09490] [EC:3.6.4.10]
109078454  dnaJ homolog subfamily B member 11-like [KO:K09517]
109087116  dnaJ homolog subfamily B member 11 [KO:K09517]
109103475  dnaJ homolog subfamily C member 1-like [KO:K09521]
109059642  dnaJ homolog subfamily C member 1-like isoform X1 [KO:K09521]
109062692  dnajc3; dnaJ homolog subfamily C member 3 isoform X1 [KO:K09523]
109066055  dnaJ homolog subfamily C member 3-like isoform X1 [KO:K09523]
109095037  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
109063884  LOW QUALITY PROTEIN: endoplasmin-like [KO:K09487]
109077907  LOW QUALITY PROTEIN: neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
109110667  glucosidase 2 subunit beta-like [KO:K08288]
109110670  glucosidase 2 subunit beta-like [KO:K08288]
109106522  calnexin-like [KO:K08054]
109102540  calnexin-like [KO:K08054]
109110836  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
109091631  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
109066466  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
109104774  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
109084505  calreticulin-like [KO:K08057]
109079961  calreticulin-like [KO:K08057]
109102759  calreticulin-like [KO:K08057]
109102461  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
109105475  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC-like [KO:K01230] [EC:3.2.1.113]
109113619  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
109074708  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB [KO:K01230] [EC:3.2.1.113]
109074253  LOW QUALITY PROTEIN: mannosyl-oligosaccharide 1,2-alpha-mannosidase IB-like [KO:K01230] [EC:3.2.1.113]
109063135  mannosyl-oligosaccharide 1,2-alpha-mannosidase IC-like [KO:K01230] [EC:3.2.1.113]
109060144  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
109052759  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like isoform X1 [KO:K23741] [EC:3.2.1.209]
109045768  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
109081650  LOW QUALITY PROTEIN: endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
109109633  vesicular integral-membrane protein VIP36-like [KO:K10082]
109095988  lman2; vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
109045124  lman1; protein ERGIC-53 [KO:K10080]
109087115  LOW QUALITY PROTEIN: protein ERGIC-53-like [KO:K10080]
109061724  LOW QUALITY PROTEIN: prolactin regulatory element-binding protein-like [KO:K14003]
109090727  prolactin regulatory element-binding protein-like isoform X1 [KO:K14003]
109066115  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
109059038  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
109113113  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
109053826  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
109053835  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
109100811  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
109096135  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
109052170  protein SEC13 homolog [KO:K14004]
109064648  sec13; protein SEC13 homolog [KO:K14004]
109084442  sec31a; protein transport protein Sec31A isoform X1 [KO:K14005]
109107139  LOW QUALITY PROTEIN: protein transport protein Sec31A-like [KO:K14005]
109048572  LOW QUALITY PROTEIN: protein transport protein Sec23A-like [KO:K14006]
109048577  protein transport protein Sec23A [KO:K14006]
109105117  protein transport protein Sec23A [KO:K14006]
109105490  protein transport protein Sec23A-like [KO:K14006]
109087229  protein transport protein Sec24A-like [KO:K14007]
109088645  LOW QUALITY PROTEIN: protein transport protein Sec24A-like [KO:K14007]
109108049  LOW QUALITY PROTEIN: protein transport protein Sec24D-like [KO:K14007]
109063798  LOW QUALITY PROTEIN: protein transport protein Sec24B-like [KO:K14007]
109102204  protein transport protein Sec24C-like [KO:K14007]
109079780  protein transport protein Sec24C-like isoform X1 [KO:K14007]
109060990  protein transport protein Sec24B-like isoform X1 [KO:K14007]
109106025  protein transport protein Sec24A-like [KO:K14007]
109113646  LOW QUALITY PROTEIN: protein transport protein Sec24C-like [KO:K14007]
109108430  protein transport protein Sec24D-like [KO:K14007]
109060127  LOW QUALITY PROTEIN: protein transport protein Sec24D-like [KO:K14007]
109045481  UDP-glucose:glycoprotein glucosyltransferase 2-like [KO:K11718] [EC:2.4.1.-]
109092717  UDP-glucose:glycoprotein glucosyltransferase 1-like [KO:K11718] [EC:2.4.1.-]
109097936  UDP-glucose:glycoprotein glucosyltransferase 1-like isoform X1 [KO:K11718] [EC:2.4.1.-]
109091492  LOW QUALITY PROTEIN: ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
109091493  LOW QUALITY PROTEIN: ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
109054834  ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1 [KO:K10085]
109095362  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
109046006  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
109095466  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
109074898  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
109113801  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
109081070  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
109092066  p4hb; protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
109074702  pdia4; protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
109112637  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
109112643  protein disulfide-isomerase A6-like isoform X1 [KO:K09584] [EC:5.3.4.1]
109112647  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
109099578  thioredoxin domain-containing protein 5-like [KO:K13984] [EC:5.3.4.1]
109106889  LOW QUALITY PROTEIN: ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
109046228  LOW QUALITY PROTEIN: ERO1-like protein beta [KO:K10976] [EC:1.8.4.-]
109079589  protein OS-9-like isoform X1 [KO:K10088]
109062770  LOW QUALITY PROTEIN: protein OS-9-like [KO:K10088]
109052890  LOW QUALITY PROTEIN: endoplasmic reticulum lectin 1-like [KO:K14008]
109095800  endoplasmic reticulum lectin 1-like [KO:K14008]
109092096  LOW QUALITY PROTEIN: translocon-associated protein subunit alpha-like [KO:K13249]
109111046  translocon-associated protein subunit beta [KO:K13250]
109107021  translocon-associated protein subunit beta-like [KO:K13250]
109109142  translocon-associated protein subunit gamma [KO:K13251]
109109144  translocon-associated protein subunit gamma [KO:K13251]
109088585  translocon-associated protein subunit delta-like [KO:K04571]
109088225  translocon-associated protein subunit delta-like [KO:K04571]
109111022  B-cell receptor-associated protein 31-like [KO:K14009]
109073465  bcap31; B-cell receptor-associated protein 31 [KO:K14009]
109108297  B-cell receptor-associated protein 31-like [KO:K14009]
109073850  translocating chain-associated membrane protein 1-like [KO:K14010]
109086114  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
109049015  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
109049018  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
109089230  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
109089236  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
109105957  derlin-1-like [KO:K11519]
109104783  derl1; derlin-1 [KO:K11519]
109071482  LOW QUALITY PROTEIN: derlin-2-like [KO:K13989]
109108744  derlin-2-like [KO:K13989]
109098883  derlin-2-like [KO:K13989]
109104925  derlin-2-like [KO:K13989]
109105702  ubxn4; UBX domain-containing protein 4 [KO:K24348]
109079406  UBX domain-containing protein 1-like [KO:K24348]
109101543  LOW QUALITY PROTEIN: UBX domain-containing protein 1-like [KO:K24348]
109045472  UBX domain-containing protein 2A-like isoform X1 [KO:K24349]
109100998  UBX domain-containing protein 2A-like isoform X1 [KO:K24349]
109110257  UBX domain-containing protein 6-like [KO:K14011]
109065873  UBX domain-containing protein 6-like [KO:K14011]
109054652  ubxn8; UBX domain-containing protein 8 [KO:K24351]
109094524  NSFL1 cofactor p47-like [KO:K14012]
109088210  nsfl1c; NSFL1 cofactor p47 isoform X1 [KO:K14012]
109074930  svip; small VCP/p97-interacting protein isoform X1 [KO:K14014]
109106880  small VCP/p97-interacting protein-like [KO:K14014]
109105177  LOW QUALITY PROTEIN: nuclear protein localization protein 4 homolog [KO:K14015]
109105185  nuclear protein localization protein 4 homolog [KO:K14015]
109095092  LOW QUALITY PROTEIN: ubiquitin fusion degradation protein 1 homolog [KO:K14016]
109104579  LOW QUALITY PROTEIN: ubiquitin fusion degradation protein 1 homolog [KO:K14016]
109097342  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
109057161  heat shock 70 kDa protein [KO:K03283]
109094113  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
109103533  heat shock cognate 71 kDa protein-like [KO:K03283]
109097744  dnaJ homolog subfamily A member 1-like [KO:K09502]
109055495  dnaJ homolog subfamily A member 1-like [KO:K09502]
109078278  dnaJ homolog subfamily A member 2-like [KO:K09503]
109056300  dnaJ homolog subfamily A member 2-like [KO:K09503]
109056306  LOW QUALITY PROTEIN: dnaJ homolog subfamily A member 2-like [KO:K09503]
109109418  dnaJ homolog subfamily A member 2-like [KO:K09503]
109063836  dnaJ homolog subfamily B member 1-like [KO:K09507]
109097783  LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 1-like [KO:K09507]
109103827  LOW QUALITY PROTEIN: dnaJ homolog subfamily B member 1-like [KO:K09507]
109090690  dnaJ homolog subfamily B member 2-like [KO:K09508]
109066093  dnaJ homolog subfamily B member 12-like [KO:K09518]
109101155  dnaJ homolog subfamily B member 12-like [KO:K09518]
109068771  dnaJ homolog subfamily C member 5B-like [KO:K09525]
109091274  dnaJ homolog subfamily C member 5B-like [KO:K09525]
109054367  dnaJ homolog subfamily C member 5-like [KO:K09525]
109053910  dnajc5; dnaJ homolog subfamily C member 5 [KO:K09525]
109094879  dnaJ homolog subfamily C member 5-like [KO:K09525]
109094875  dnaJ homolog subfamily C member 5-like [KO:K09525]
109053681  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
109110373  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
109110404  heat shock protein HSP 90-beta-like [KO:K04079]
109104102  LOW QUALITY PROTEIN: heat shock protein 105 kDa-like [KO:K09485]
109107635  heat shock 70 kDa protein 4L-like [KO:K09485]
109107222  heat shock 70 kDa protein 4L-like [KO:K09485]
109066591  LOW QUALITY PROTEIN: BAG family molecular chaperone regulator 1-like [KO:K09555]
109110081  BAG family molecular chaperone regulator 1-like [KO:K09555]
109100372  bag2; BAG family molecular chaperone regulator 2 [KO:K09556]
109111915  BAG family molecular chaperone regulator 2-like isoform X1 [KO:K09556]
109048103  alpha-crystallin A chain [KO:K09541]
109075799  alpha-crystallin A chain-like [KO:K09541]
109088826  alpha-crystallin A chain-like [KO:K09542]
109063073  alpha-crystallin A chain-like isoform X1 [KO:K09542]
109090897  alpha-crystallin B chain-like [KO:K09542]
109088095  alpha-crystallin B chain-like [KO:K09542]
109080416  alpha-crystallin B chain-like isoform X1 [KO:K09542]
109103690  alpha-crystallin B chain-like [KO:K09542]
109099046  ubiquitin thioesterase OTU1 isoform X1 [KO:K13719] [EC:3.1.2.-]
109099052  ubiquitin thioesterase OTU1-like [KO:K13719] [EC:3.1.2.-]
109067414  phospholipase A-2-activating protein-like isoform X1 [KO:K14018]
109088272  phospholipase A-2-activating protein-like [KO:K14018]
109084464  UV excision repair protein RAD23 homolog B-like isoform X1 [KO:K10839]
109085264  UV excision repair protein RAD23 homolog B-like [KO:K10839]
109076120  UV excision repair protein RAD23 homolog A-like [KO:K10839]
109076121  UV excision repair protein RAD23 homolog A-like [KO:K10839]
109084414  UV excision repair protein RAD23 homolog B-like [KO:K10839]
109078483  ubiquilin-4-like [KO:K04523]
109066324  ngly1; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
109066243  LOW QUALITY PROTEIN: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase-like [KO:K01456] [EC:3.5.1.52]
109054691  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
109073717  ataxin-3-like isoform X1 [KO:K11863] [EC:3.4.22.-]
109060938  ube4b; LOW QUALITY PROTEIN: ubiquitin conjugation factor E4 B [KO:K10597] [EC:2.3.2.27]
109074538  ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
109045292  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2-alpha kinase 3-like [KO:K08860] [EC:2.7.11.1]
109089599  eukaryotic translation initiation factor 2-alpha kinase 3-like [KO:K08860] [EC:2.7.11.1]
109109849  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
109048356  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
109063362  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
109110372  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
109088618  nuclear factor erythroid 2-related factor 2-like [KO:K05638]
109102552  nuclear factor erythroid 2-related factor 2-like isoform X1 [KO:K05638]
109102559  transcription factor NF-E2 45 kDa subunit-like [KO:K05638]
109081369  transcription factor NF-E2 45 kDa subunit-like [KO:K05638]
109068603  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
109072454  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
109071389  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
109060201  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
109079321  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
109072577  DNA damage-inducible transcript 3 protein-like [KO:K04452]
109072578  DNA damage-inducible transcript 3 protein-like [KO:K04452]
109049771  apoptosis regulator Bcl-2-like [KO:K02161]
109050096  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
109112752  cyclic AMP-dependent transcription factor ATF-6 alpha-like isoform X1 [KO:K09054]
109111390  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
109049829  LOW QUALITY PROTEIN: wolframin-like [KO:K14020]
109068651  LOW QUALITY PROTEIN: membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
109065773  LOW QUALITY PROTEIN: membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
109108692  LOW QUALITY PROTEIN: membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
109049930  membrane-bound transcription factor site-2 protease-like isoform X1 [KO:K07765] [EC:3.4.24.85]
109077056  membrane-bound transcription factor site-2 protease-like [KO:K07765] [EC:3.4.24.85]
109047261  LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
109113237  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
109068012  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
109066138  LOW QUALITY PROTEIN: TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109088491  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109103466  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109063179  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
109092120  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
109048836  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
109066210  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
109096556  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
109110870  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
109078258  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
109084935  mitogen-activated protein kinase 8A isoform X1 [KO:K04440] [EC:2.7.11.24]
109099355  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109094263  LOW QUALITY PROTEIN: mitogen-activated protein kinase 8B-like [KO:K04440] [EC:2.7.11.24]
109101277  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
109047252  apoptosis regulator BAX-like [KO:K02159]
109054953  apoptosis regulator BAX-like [KO:K02159]
109077429  apoptosis regulator BAX-like [KO:K02159]
109058994  apoptosis regulator BAX-like isoform X1 [KO:K02159]
109061123  apoptosis regulator BAX-like isoform X1 [KO:K02159]
109070275  apoptosis regulator BAX-like isoform X1 [KO:K02159]
109063226  apoptosis regulator BAX-like [KO:K02159]
109054919  uncharacterized protein LOC109054919 [KO:K02159]
109052449  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
109047016  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
109052878  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
109052956  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
109062019  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
109106269  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
109100539  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
109046872  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
109046967  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
109046972  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
109047015  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
109100541  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
109076939  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
109106274  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
109081032  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
109070306  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
109055232  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase MARCH6-like [KO:K10661] [EC:2.3.2.27]
109088939  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase MARCH6-like [KO:K10661] [EC:2.3.2.27]
109074339  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
109099533  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
109060230  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
109086140  ubiquitin-conjugating enzyme E2 J2-like isoform X1 [KO:K04554] [EC:2.3.2.23]
109054829  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
109089659  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
109081798  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
109045177  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
109045178  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
109090503  ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
109052862  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
109091809  ubiquitin-conjugating enzyme E2 G2-like isoform X1 [KO:K04555] [EC:2.3.2.23]
109109631  E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
109069395  rnf5; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
109066192  E3 ubiquitin-protein ligase RNF185-like isoform X1 [KO:K10666] [EC:2.3.2.27]
109088692  selenoprotein S-like isoform X1 [KO:K14025]
109056736  selenoprotein S-like [KO:K14025]
109101828  protein sel-1 homolog 1-like [KO:K14026]
109113443  protein sel-1 homolog 1-like [KO:K14026]
109080608  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
109109946  LOW QUALITY PROTEIN: homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
109053324  amfr; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase AMFR [KO:K10636] [EC:2.3.2.36]
109055263  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
109101593  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
109059597  LOW QUALITY PROTEIN: STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
109068413  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
109101622  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
109107084  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
109101948  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
109046807  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
109094451  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
109070422  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
109099712  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
109094574  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
109094581  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
109086991  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
109076363  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
109081461  park2; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
109076699  rbx1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
109062788  LOW QUALITY PROTEIN: cullin-1-like [KO:K03347]
109062782  cullin-1-like isoform X1 [KO:K03347]
109048021  skp1; S-phase kinase-associated protein 1 [KO:K03094]
109067897  S-phase kinase-associated protein 1-like [KO:K03094]
109051952  F-box only protein 2-like [KO:K10099]
109085080  F-box only protein 2-like [KO:K10099]
109097432  LOW QUALITY PROTEIN: F-box only protein 2-like [KO:K10099]
109097434  F-box only protein 2-like [KO:K10099]
109049273  F-box only protein 6-like [KO:K10100]
109077545  F-box only protein 6-like [KO:K10100]
109049048  LOW QUALITY PROTEIN: F-box only protein 44-like [KO:K10100]
109079807  F-box only protein 44-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
ccar00510  N-Glycan biosynthesis
ccar03050  Proteasome
ccar03060  Protein export
ccar04210  Apoptosis
KO pathway
ko04141   
LinkDB

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