KEGG   PATHWAY: cide04530
Entry
cide04530                   Pathway                                
Name
Tight junction - Ctenopharyngodon idella (grass carp)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
cide04530  Tight junction
cide04530

Other DBs
GO: 0005923
Organism
Ctenopharyngodon idella (grass carp) [GN:cide]
Gene
127496861  claudin-12 [KO:K06087]
127505953  claudin-11b [KO:K06087]
127514252  claudin-10a [KO:K06087]
127521483  claudin-5b [KO:K06087]
127521500  claudin-7-B [KO:K06087]
127514954  claudin-34 [KO:K06087]
127521724  claudin-23 [KO:K06087]
127500217  claudin 15-like a [KO:K06087]
127515248  claudin-7-A [KO:K06087]
127500505  claudin-4 [KO:K06087]
127501026  claudin-11a [KO:K06087]
127515885  claudin-9 [KO:K06087]
127508388  claudin i [KO:K06087]
127516680  claudin-15a isoform X1 [KO:K06087]
127522840  claudin-19 isoform X1 [KO:K06087]
127523015  claudin-34-like [KO:K06087]
127523019  putative claudin-24 [KO:K06087]
127495207  claudin 15-like b isoform X1 [KO:K06087]
127495373  claudin-4 [KO:K06087]
127495374  claudin-3 isoform X1 [KO:K06087]
127495375  claudin-4-like [KO:K06087]
127495376  claudin-4-like [KO:K06087]
127495377  claudin j [KO:K06087]
127495378  claudin-4-like isoform X1 [KO:K06087]
127495379  claudin-4-like [KO:K06087]
127495380  claudin-like protein ZF-A89 [KO:K06087]
127495925  claudin-4-like [KO:K06087]
127495926  claudin-8 [KO:K06087]
127495931  LOW QUALITY PROTEIN: claudin-8-like [KO:K06087]
127502564  claudin-20 [KO:K06087]
127509985  claudin-like protein ZF-A9 [KO:K06087]
127496026  claudin-18-like [KO:K06087]
127503240  claudin-2 [KO:K06087]
127518132  claudin 5a [KO:K06087]
127503505  claudin 3d [KO:K06087]
127503506  claudin b [KO:K06087]
127503507  claudin 3c [KO:K06087]
127503508  claudin-4 [KO:K06087]
127503509  claudin-like protein ZF-A89 [KO:K06087]
127503510  LOW QUALITY PROTEIN: claudin 29 [KO:K06087]
127503511  claudin-4 [KO:K06087]
127503530  claudin-4 [KO:K06087]
127503532  claudin-4-like [KO:K06087]
127525043  claudin-18-like [KO:K06087]
127513018  claudin-15b [KO:K06087]
127519206  claudin-10 [KO:K06087]
127513297  putative claudin-24 [KO:K06087]
127498599  LOW QUALITY PROTEIN: claudin-20 [KO:K06087]
127505117  claudin-1 [KO:K06087]
127521262  occludin [KO:K06088]
127517637  si:ch73-61d6.3; occludin [KO:K06088]
127496877  zgc:154006; occludin isoform X1 [KO:K06088]
127512096  LOW QUALITY PROTEIN: occludin b [KO:K06088]
127512334  F11 receptor, tandem duplicate 2 [KO:K06089]
127512335  junctional adhesion molecule A-like isoform X1 [KO:K06089]
127512336  junctional adhesion molecule A-like [KO:K06089]
127521192  junctional adhesion molecule 2A isoform X1 [KO:K06735]
127518633  junctional adhesion molecule 2b isoform X1 [KO:K06735]
127495131  junctional adhesion molecule 3B [KO:K06785]
127503957  junctional adhesion molecule 3B [KO:K06785]
127497224  blood vessel epicardial substance isoform X1 [KO:K21108]
127522841  cell division control protein 42 homolog isoform X1 [KO:K04393]
127497067  cell division cycle 42, like [KO:K04393]
127505518  cell division cycle 42 like 2 isoform X1 [KO:K04393]
127500052  partitioning defective 6 homolog alpha [KO:K06093]
127500605  par-6 family cell polarity regulator gamma b [KO:K06093]
127496680  par-6 family cell polarity regulator gamma a [KO:K06093]
127505370  partitioning defective 6 homolog beta [KO:K06093]
127498703  protein PALS1 [KO:K06091]
127514960  MAGUK p55 subfamily member 4 [KO:K21109]
127518572  MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
127519978  tight junction protein ZO-3 isoform X1 [KO:K06097]
127519942  LOW QUALITY PROTEIN: inaD-like protein [KO:K06092]
127515854  multiple PDZ domain protein isoform X1 [KO:K06095]
127496290  si:dkey-92j12.5; multiple PDZ domain protein [KO:K06095]
127517663  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
127522116  protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
127503597  angiomotin isoform X1 [KO:K16819]
127514587  angiomotin-like 2a [KO:K06104]
127495335  angiomotin-like protein 1 isoform X1 [KO:K06104]
127502190  LOW QUALITY PROTEIN: angiomotin-like 2a [KO:K06104]
127496017  angiomotin-like 2a [KO:K06104]
127507399  rho GTPase-activating protein 17b isoform X1 [KO:K20638]
127523729  rho GTPase-activating protein 17a isoform X1 [KO:K20638]
127508687  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
127508911  ras-related C3 botulinum toxin substrate 1b [KO:K04392]
127524274  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
127505389  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
127503529  NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor b [KO:K16684]
127512778  NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor a isoform X1 [KO:K16684]
127508589  lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
127523628  LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
127506853  discs large homolog 1-like protein isoform X1 [KO:K12076]
127513977  disks large homolog 1 isoform X1 [KO:K12076]
127515516  protein scribble homolog isoform X1 [KO:K16175]
127521315  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
127494566  protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
127503213  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
127495457  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
127512623  protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
127494059  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
127494068  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
127523283  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
127518116  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
127503477  protein phosphatase 2, regulatory subunit B, beta b isoform X1 [KO:K04354]
127511898  protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
127520386  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
127495415  par-3 family cell polarity regulator alpha, b isoform X1 [KO:K04237]
127505829  partitioning defective 3 homolog isoform X1 [KO:K04237]
127521563  rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
127515277  tight junction protein ZO-1 isoform X1 [KO:K05701]
127507778  tight junction protein ZO-1 isoform X1 [KO:K05701]
127524937  tight junction-associated protein 1 [KO:K06105]
127520730  disks large homolog 2 isoform X1 [KO:K12075]
127494121  disks large homolog 3 isoform X1 [KO:K21098]
127499969  E3 ubiquitin-protein ligase NEDD4a isoform X1 [KO:K10591] [EC:2.3.2.26]
127503397  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
127524832  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
127500710  cingulin isoform X1 [KO:K06102]
127497595  cingulin [KO:K06102]
127494296  cingulin-like protein 1 [KO:K21110]
127516769  cingulin-like protein 1 [KO:K21110]
127501019  rho guanine nucleotide exchange factor 1a isoform X1 [KO:K12791]
127497293  rho guanine nucleotide exchange factor 2 [KO:K12791]
127521361  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
127514981  ras homolog family member Ca [KO:K04513]
127517741  rho-related GTP-binding protein RhoA-B [KO:K04513]
127517742  rho-related GTP-binding protein RhoA-D [KO:K04513]
127518202  rho-related GTP-binding protein RhoA-A [KO:K04513]
127505431  rho-related GTP-binding protein RhoA-C [KO:K04513]
127501956  transcription factor GATA-4-like [KO:K09183]
127502347  transcription factor GATA-4-like [KO:K09183]
127515170  MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
127502179  si:ch211-191a24.4; MARVEL domain-containing protein 3 [KO:K21099]
127520635  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
127523601  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127503188  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
127524755  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127524923  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127503882  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127513691  junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
127502688  transcription factor AP-1 [KO:K04448]
127500183  cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
127522801  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
127512793  symplekin isoform X1 [KO:K06100]
127520720  proliferating cell nuclear antigen [KO:K04802]
127516057  G1/S-specific cyclin-D1 [KO:K04503]
127523623  receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
127521140  runt-related transcription factor 1 isoform X1 [KO:K08367]
127494171  heat shock 70 kDa protein 4b [KO:K09489]
127503962  heat shock 70 kDa protein 4a [KO:K09489]
127508351  Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X1 [KO:K13365]
127523357  Na(+)/H(+) exchange regulatory cofactor NHE-RF1a [KO:K13365]
127502279  ezrin b [KO:K08007]
127498393  ezrin a isoform X1 [KO:K08007]
127514079  radixin isoform X1 [KO:K05762]
127494442  moesin b isoform X1 [KO:K05763]
127513664  moesin a isoform X1 [KO:K05763]
127523898  protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
127523910  protein kinase C epsilon type-like isoform X1 [KO:K18050] [EC:2.7.11.13]
127524763  protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
127508367  actin, cytoplasmic 2 [KO:K05692]
127509863  actin, cytoplasmic 1 [KO:K05692]
127522496  calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
127516967  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
127502840  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
127497386  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
127514659  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
127504709  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
127500007  src substrate cortactin-like isoform X1 [KO:K06106]
127510798  src substrate protein p85-like isoform X1 [KO:K06106]
127516019  zgc:101810; actin-related protein 2-A [KO:K17260]
127510666  actin-related protein 2-A [KO:K17260]
127525265  actin-related protein 2-B [KO:K17260]
127506160  actin-related protein 3B isoform X1 [KO:K18584]
127518527  actin-related protein 3 [KO:K18584]
127508539  actin-related protein 2/3 complex subunit 1A [KO:K05757]
127508540  actin-related protein 2/3 complex subunit 1B [KO:K05757]
127509820  zgc:86896; actin-related protein 2/3 complex subunit 1A [KO:K05757]
127518553  actin-related protein 2/3 complex subunit 2 [KO:K05758]
127503542  actin-related protein 2/3 complex subunit 3 [KO:K05756]
127522074  actin related protein 2/3 complex, subunit 4, like [KO:K05755]
127514036  actin-related protein 2/3 complex subunit 4 [KO:K05755]
127523669  actin-related protein 2/3 complex subunit 5-A-like [KO:K05754]
127495823  actin-related protein 2/3 complex subunit 5-A-like [KO:K05754]
127502912  actin-related protein 2/3 complex subunit 5b [KO:K05754]
127517994  actin related protein 2/3 complex, subunit 5-like, a [KO:K05754]
127512434  actin related protein 2/3 complex, subunit 5-like, b [KO:K05754]
127499766  WASP homolog-associated protein with actin, membranes and microtubules isoform X1 [KO:K20479]
127517453  actin nucleation-promoting factor WASL isoform X1 [KO:K05747]
127517476  WASP actin nucleation promoting factor b [KO:K05747]
127499671  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
127521954  vasodilator stimulated phosphoprotein a [KO:K06274]
127506489  protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
127522428  protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
127519370  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
127497936  ras-related protein Rab-13 [KO:K06109]
127502575  rho guanine nucleotide exchange factor 18a [KO:K21066]
127520655  rho guanine nucleotide exchange factor 18-like isoform X1 [KO:K21066]
127522588  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
127502798  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
127524531  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
127518134  myosin, light chain 2b, regulatory, cardiac, slow isoform X1 [KO:K10351]
127512736  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
127513170  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
127496895  band 4.1-like protein 4B isoform X1 [KO:K21111]
127501770  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
127496481  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
127502675  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
127512635  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
127521199  5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
127517870  5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
127496686  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
127518302  5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
127512766  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
127505542  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
127505739  5'-AMP-activated protein kinase subunit gamma-2a isoform X1 [KO:K07200]
127514076  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
127514374  myosin-11a isoform X1 [KO:K10352]
127509789  LOW QUALITY PROTEIN: myosin-9-like [KO:K10352]
127513960  myosin-10 isoform X1 [KO:K10352]
127513974  myosin-9a isoform X1 [KO:K10352]
127514414  myosin light polypeptide 6 isoform X1 [KO:K12751]
127505115  zgc:153867; myosin light polypeptide 6 isoform X1 [KO:K12751]
127514242  myosin regulatory light polypeptide 9b [KO:K12755]
127504795  myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
127515989  myosin, light chain 12, genome duplicate 1 [KO:K12757]
127496925  myosin, light chain 12, genome duplicate 2 [KO:K12757]
127521220  immunoglobulin superfamily member 5 [KO:K06786]
127522249  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1b isoform X1 [KO:K05631]
127494253  synaptopodin 2-like protein isoform X1 [KO:K21112]
127494941  alpha-actinin-4 isoform X1 [KO:K05699]
127524703  alpha-actinin-1 isoform X1 [KO:K05699]
127509734  MICAL-like protein 2a [KO:K21068]
127509857  protein-methionine sulfoxide oxidase mical2b isoform X1 [KO:K21068]
127494153  ras-related protein Rab-8A [KO:K07901]
127507005  ras-related protein Rab-8B-like [KO:K07902]
127516048  ras-related protein Rab-8B isoform X1 [KO:K07902]
127503338  rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
127522029  ras-related protein rap1ab isoform X1 [KO:K04353]
127517991  RAP1A, member of RAS oncogene family a [KO:K04353]
127495450  integrin beta-1-like isoform X1 [KO:K05719]
127505736  integrin beta-1a isoform X1 [KO:K05719]
127502311  afadin isoform X1 [KO:K05702]
127517995  tight junction protein ZO-2-like isoform X1 [KO:K06098]
127520920  tight junction protein ZO-2a isoform X1 [KO:K06098]
127510384  rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
127525669  rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
127494890  ras-related protein Rap-2c [KO:K07839]
127521260  MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
127512094  MARVEL domain-containing protein 2b [KO:K17291]
127514626  tubulin, alpha 8 like 4 [KO:K07374]
127522680  tubulin alpha-1A chain-like [KO:K07374]
127522681  tubulin alpha-1B chain [KO:K07374]
127517989  tubulin alpha 5 [KO:K07374]
127524479  tubulin alpha-8 chain-like [KO:K07374]
127524480  tubulin alpha-8 chain-like [KO:K07374]
127519004  tubulin alpha chain-like [KO:K07374]
127504593  tubulin alpha-1A chain isoform X1 [KO:K07374]
127504594  tubulin alpha-1C chain [KO:K07374]
127519155  tubulin alpha chain-like [KO:K07374]
127520112  tubulin, alpha 8 like 2 [KO:K07374]
127520196  tubulin, alpha 7 like [KO:K07374]
127505313  tubulin alpha-1B chain-like [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
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Related
pathway
cide04520  Adherens junction
cide04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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