KEGG   PATHWAY: cjo04110
Entry
cjo04110                    Pathway                                
Name
Cell cycle - Coturnix japonica (Japanese quail)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
cjo04110  Cell cycle
cjo04110

Other DBs
GO: 0000278
Organism
Coturnix japonica (Japanese quail) [GN:cjo]
Gene
107314428  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107318017  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
107324823  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
107325825  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
107309074  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
107308151  RB1; retinoblastoma-associated protein [KO:K06618]
107322796  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
107319080  RBL2; retinoblastoma-like protein 2 [KO:K16332]
107321848  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
107311872  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
107323875  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
107322866  E2F1; transcription factor E2F1 [KO:K17454]
107324074  E2F2; transcription factor E2F2 [KO:K09389]
107309724  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
107310308  E2F5; transcription factor E2F5 [KO:K04682]
107319117  E2F4; transcription factor E2F4 [KO:K04682]
107306354  TFDP1; transcription factor Dp-1 isoform X1 [KO:K04683]
107318079  TFDP2; transcription factor Dp-2 isoform X1 [KO:K09392]
107319718  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107307103  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
107311051  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
107315120  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
107305704  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
107318915  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
107306999  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
107324374  mothers against decapentaplegic homolog 4-like [KO:K04501]
107310561  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
107323317  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
107306707  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
107317588  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
107317865  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
107314571  CDKN1C; cyclin-dependent kinase inhibitor 1C [KO:K09993]
107324690  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
107310377  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
107319346  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
107325763  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
107320209  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
107309836  CUL1; cullin-1 [KO:K03347]
107312930  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
107305844  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
107308220  CCNA1; cyclin-A1 [KO:K06627]
107313565  CCNA2; cyclin-A2 [KO:K06627]
107325289  CDC6; cell division control protein 6 homolog [KO:K02213]
107319489  CDT1; chromatin licensing and DNA replication factor 1 [KO:K10727]
107317640  ORC1; origin recognition complex subunit 1 [KO:K02603]
107316520  ORC2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
107311954  ORC3; origin recognition complex subunit 3 [KO:K02605]
107317054  ORC4; origin recognition complex subunit 4 [KO:K02606]
107325026  ORC5; origin recognition complex subunit 5 [KO:K02607]
107319281  ORC6; origin recognition complex subunit 6 [KO:K02608]
107319813  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
107312427  MCM3; DNA replication licensing factor MCM3 isoform X1 [KO:K02541] [EC:5.6.2.3]
107310154  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
107314341  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
107316873  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
107307417  MCM7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
107321035  CDC45; cell division control protein 45 homolog [KO:K06628]
107318804  TICRR; treslin [KO:K26117]
107310494  MTBP; mdm2-binding protein isoform X1 [KO:K26116]
107317548  CDC7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
107309012  DBF4; protein DBF4 homolog A isoform X1 [KO:K06629]
107325024  DBF4B; protein DBF4 homolog B isoform X1 [KO:K06629]
107315682  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
107318514  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
107312631  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
107306857  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
107322951  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
107312216  YWHAQ; 14-3-3 protein theta [KO:K16197]
107310427  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
107322429  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
107321448  YWHAH; 14-3-3 protein eta [KO:K16198]
107322673  YWHAG; 14-3-3 protein gamma [KO:K16198]
107320693  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
107315845  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
107314612  WEE1; wee1-like protein kinase isoform X1 [KO:K06632] [EC:2.7.11.1]
107306509  CCNH; cyclin-H isoform X1 [KO:K06634]
107305924  CDK7; cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
107310726  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
107321609  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
107325192  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
107313933  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
107321116  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
107306410  CDC16; cell division cycle protein 16 homolog [KO:K03353]
107321129  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
107320046  CDC23; cell division cycle protein 23 homolog [KO:K03355]
107313145  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
107322162  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
107321604  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
107317975  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
107308546  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
107315752  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
107317405  CDC20; cell division cycle protein 20 homolog [KO:K03363]
107320338  PTTG1; securin [KO:K06635]
107306949  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
107317589  SMC1B; structural maintenance of chromosomes protein 1B [KO:K06636]
107316087  SMC3; structural maintenance of chromosomes protein 3 [KO:K06669]
107310505  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
107323130  RAD21L1; double-strand-break repair protein rad21-like protein 1 [KO:K06670]
107307728  cohesin subunit SA-2-like isoform X1 [KO:K06671]
107317847  STAG1; cohesin subunit SA-1 isoform X1 [KO:K06671]
107312933  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
107312762  ATRX; transcriptional regulator ATRX isoform X1 [KO:K10779]
107315448  DDX11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
107305848  NIPBL; nipped-B-like protein isoform X1 [KO:K06672]
107325417  MAU2; LOW QUALITY PROTEIN: MAU2 chromatid cohesion factor homolog [KO:K11266]
107312522  HDAC8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
107310086  ESCO1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
107312363  ESCO2; N-acetyltransferase ESCO2 isoform X1 [KO:K11268] [EC:2.3.1.-]
107308266  PDS5B; LOW QUALITY PROTEIN: sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
107313783  PDS5A; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
107315546  WAPL; wings apart-like protein homolog isoform X1 [KO:K25163]
107307256  aurora kinase B-like [KO:K11479] [EC:2.7.11.1]
107309276  SGO1; shugoshin 1 isoform X1 [KO:K11580]
107313198  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
107320210  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
107307645  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
107315271  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2 [KO:K11584]
107315349  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
107310741  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
107311075  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
107310055  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
107314234  KNL1; kinetochore scaffold 1 isoform X1 [KO:K11542]
107312015  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
107320743  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X2 [KO:K06679]
107313563  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
107323529  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
107314246  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
107316302  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
107310732  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
107309785  TRIP13; pachytene checkpoint protein 2 homolog [KO:K22399]
107311273  MAD2L1BP; MAD2L1-binding protein [KO:K26093]
107325558  FZR1; fizzy-related protein homolog [KO:K03364]
107311593  FBXO5; F-box only protein 5 [KO:K10292]
107317513  CDC14A; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
107306271  CDC14B; dual specificity protein phosphatase CDC14B isoform X2 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
107312938  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
107320924  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
107310139  PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
107318067  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
107308373  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
107310502  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
107317806  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
107325480  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
107306297  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
107323623  PCNA; proliferating cell nuclear antigen [KO:K04802]
107323811  SFN; 14-3-3 protein sigma [KO:K06644]
107324224  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
107321227  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
107308656  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
cjo03030  DNA replication
cjo04010  MAPK signaling pathway
cjo04120  Ubiquitin mediated proteolysis
cjo04210  Apoptosis
KO pathway
ko04110   
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