KEGG   PATHWAY: crg00230
Entry
crg00230                    Pathway                                
Name
Purine metabolism - Magallana gigas (Pacific oyster)
Class
Metabolism; Nucleotide metabolism
Pathway map
crg00230  Purine metabolism
crg00230

Module
crg_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:crg00230]
crg_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:crg00230]
crg_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:crg00230]
crg_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:crg00230]
crg_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:crg00230]
crg_M00546  Purine degradation, xanthine => urea [PATH:crg00230]
crg_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:crg00230]
crg_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:crg00230]
Other DBs
GO: 0006163 0042278
Organism
Magallana gigas (Pacific oyster) [GN:crg]
Gene
105339074  ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
105341087  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X2 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
117683170  ADP-sugar pyrophosphatase-like isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
105348082  LOW QUALITY PROTEIN: phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
117684867  phosphoglucomutase-like isoform X1 [KO:K01835] [EC:5.4.2.2]
105325277  phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
105329847  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
105333393  amidophosphoribosyltransferase isoform X2 [KO:K00764] [EC:2.4.2.14]
105346659  trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
105346301  phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
105333392  multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
105324978  adenylosuccinate lyase-like [KO:K01756] [EC:4.3.2.2]
117689741  bifunctional purine biosynthesis protein PURH-like [KO:K00602] [EC:2.1.2.3 3.5.4.10]
105346146  bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
105348875  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
105325061  cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
105338653  cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
105345957  5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [KO:K01081] [EC:3.1.3.5]
105337745  trifunctional nucleotide phosphoesterase protein YfkN isoform X1 [KO:K01081] [EC:3.1.3.5]
117692106  snake venom 5'-nucleotidase-like [KO:K19970] [EC:3.1.3.5]
105348905  snake venom 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
105324749  snake venom 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
105343050  snake venom 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
105321089  purine nucleoside phosphorylase isoform X1 [KO:K03783] [EC:2.4.2.1]
105330190  purine nucleoside phosphorylase-like isoform X2 [KO:K03783] [EC:2.4.2.1]
105335030  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
105319329  laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
105345279  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
105330403  inosine-5'-monophosphate dehydrogenase 1b isoform X4 [KO:K00088] [EC:1.1.1.205]
105341901  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
105343795  LOW QUALITY PROTEIN: nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
105346431  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
117686725  nucleoside diphosphate kinase 7-like [KO:K00940] [EC:2.7.4.6]
105318231  adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
105337763  ectonucleoside triphosphate diphosphohydrolase 8 isoform X4 [KO:K01510] [EC:3.6.1.5]
105347053  soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
105341080  ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
109618305  U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
105347412  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
105320492  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105322104  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105338956  xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105320852  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105320513  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105345601  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
105329768  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
105329398  GMP reductase 2 isoform X2 [KO:K00364] [EC:1.7.1.7]
105345833  guanine deaminase [KO:K01487] [EC:3.5.4.3]
117685650  guanylate kinase-like [KO:K00942] [EC:2.7.4.8]
105338667  guanylate kinase-like [KO:K00942] [EC:2.7.4.8]
105348744  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
105336299  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
105330524  5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
105342918  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
105340585  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105336030  adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
105328828  uncharacterized protein LOC105328828 [KO:K08043] [EC:4.6.1.1]
105346394  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105335675  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
105344201  adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
105333172  guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
105329901  soluble guanylate cyclase gcy-35 [KO:K12319] [EC:4.6.1.2]
105333171  guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
105333624  soluble guanylate cyclase 88E isoform X1 [KO:K12319] [EC:4.6.1.2]
105344579  guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
105318117  speract receptor [KO:K12321] [EC:4.6.1.2]
105337771  retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
117683284  atrial natriuretic peptide receptor 2-like [KO:K22600] [EC:4.6.1.2]
117680576  uncharacterized protein LOC117680576 [KO:K22600] [EC:4.6.1.2]
105331235  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105333054  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105328111  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105346626  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105337690  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105333894  receptor-type guanylate cyclase Gyc76C [KO:K12323] [EC:4.6.1.2]
105347204  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105328431  atrial natriuretic peptide receptor 1-like [KO:K12323] [EC:4.6.1.2]
105338096  LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105331903  atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
105324420  atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
105331377  atrial natriuretic peptide receptor 1 [KO:K12324] [EC:4.6.1.2]
105346387  atrial natriuretic peptide receptor 1 [KO:K12324] [EC:4.6.1.2]
105319035  soluble guanylate cyclase 88E isoform X1 [KO:K01769] [EC:4.6.1.2]
105330040  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
105336267  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X8 [KO:K18283] [EC:3.1.4.17]
105335488  cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X4 [KO:K19021] [EC:3.1.4.17]
105333594  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
105342903  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13763] [EC:3.1.4.35]
105321830  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3 [KO:K13761] [EC:3.1.4.35]
105342253  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
105324662  probable 3',5'-cyclic phosphodiesterase pde-5 isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
105328273  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
105344624  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
105347202  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
105319827  adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
105326550  AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
105339395  adenosine kinase [KO:K00856] [EC:2.7.1.20]
105347364  adenosine kinase 2 isoform X1 [KO:K00856] [EC:2.7.1.20]
105325902  adenosine deaminase isoform X4 [KO:K01488] [EC:3.5.4.4]
105336152  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
105343616  adenosine deaminase AGSA isoform X1 [KO:K19572] [EC:3.5.4.4]
105334635  adenosine deaminase 2-like [KO:K19572] [EC:3.5.4.4]
105348777  adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
105348169  adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
105347819  adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
105319542  adenylate kinase 2, mitochondrial [KO:K00939] [EC:2.7.4.3]
105317172  adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
105330382  GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
105321370  cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
105324649  cAMP-specific 3',5'-cyclic phosphodiesterase 4C-like isoform X1 [KO:K13293] [EC:3.1.4.53]
105318499  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
117684245  uncharacterized protein LOC117684245 [KO:K18436] [EC:3.1.4.53]
105347718  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
105336483  LOW QUALITY PROTEIN: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase [KO:K13811] [EC:2.7.7.4 2.7.1.25]
105344267  uricase-like [KO:K00365] [EC:1.7.3.3]
105338742  5-hydroxyisourate hydrolase isoform X2 [KO:K07127] [EC:3.5.2.17]
105325831  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
105330147  allantoinase, mitochondrial isoform X1 [KO:K01466] [EC:3.5.2.5]
105338720  allantoicase isoform X1 [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
crg00030  Pentose phosphate pathway
crg00220  Arginine biosynthesis
crg00250  Alanine, aspartate and glutamate metabolism
crg00260  Glycine, serine and threonine metabolism
crg00340  Histidine metabolism
crg00630  Glyoxylate and dicarboxylate metabolism
crg00730  Thiamine metabolism
crg00740  Riboflavin metabolism
crg00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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