KEGG   PATHWAY: csab04152
Entry
csab04152                   Pathway                                
Name
AMPK signaling pathway - Chlorocebus sabaeus (green monkey)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
csab04152  AMPK signaling pathway
csab04152

Other DBs
GO: 2000479
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103240115  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
103233599  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
103214421  CAB39L; calcium binding protein 39 like [KO:K08272]
103218041  CAB39; calcium binding protein 39 [KO:K08272]
103243220  STRADA; STE20-related kinase adaptor alpha [KO:K08271]
103217644  STRADB; STE20-related kinase adaptor beta [KO:K17532]
103226854  LEP; leptin [KO:K05424]
103224669  LEPR; leptin receptor [KO:K05062]
103239530  CAMKK2; calcium/calmodulin dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
103215521  ADRA1A; adrenoceptor alpha 1A [KO:K04135]
103241875  ADIPOQ; adiponectin, C1Q and collagen domain containing [KO:K07296]
103230296  ADIPOR1; adiponectin receptor 1 [KO:K07297]
103218374  ADIPOR2; adiponectin receptor 2 [KO:K07297]
103215177  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
103224740  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
103247234  PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2 [KO:K07199]
103239238  PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1 [KO:K07199]
103227261  PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2 [KO:K07200]
103238254  PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
103217881  PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3 [KO:K07200]
103232032  PFKFB1; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
103230179  PFKFB2; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
103237841  PFKFB3; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
103227591  PFKFB4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
103219839  FBP1; fructose-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
103219840  FBP2; fructose-bisphosphatase 2 [KO:K03841] [EC:3.1.3.11]
103237780  PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]
103219799  PFKL; phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
103238217  PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]
103245646  HNF4A; hepatocyte nuclear factor 4 alpha [KO:K07292]
103243337  G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
103243379  G6PC; glucose-6-phosphatase catalytic subunit [KO:K01084] [EC:3.1.3.9]
103217259  G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
103228704  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
103243712  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
103223939  CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
103217717  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
103236571  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
103223942  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
103226974  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
103233716  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
103219209  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
103226299  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
103246278  PPARGC1A; PPARG coactivator 1 alpha [KO:K07202]
103233830  ELAVL1; ELAV like RNA binding protein 1 [KO:K13088]
103246489  CCND1; cyclin D1 [KO:K04503]
103214281  CCNA1; cyclin A1 [KO:K06627]
103236201  CCNA2; cyclin A2 [KO:K06627]
103229593  EEF2K; eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
103233719  EEF2; eukaryotic translation elongation factor 2 [KO:K03234]
103214322  FOXO1; forkhead box O1 [KO:K07201]
103240621  FOXO3; forkhead box O3 [KO:K09408]
103216104  SIRT1; sirtuin 1 [KO:K11411] [EC:2.3.1.286]
103242286  SLC2A4; solute carrier family 2 member 4 [KO:K07191]
103235009  GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
103218736  GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
103234777  LIPE; lipase E, hormone sensitive type [KO:K07188] [EC:3.1.1.79]
103223243  HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase [KO:K00021] [EC:1.1.1.34]
103242479  SREBF1; sterol regulatory element binding transcription factor 1 [KO:K07197]
103243754  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
103242788  ACACA; acetyl-CoA carboxylase alpha [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
103216387  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
103235891  stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
103239081  ACACB; acetyl-CoA carboxylase beta [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
103233379  MLYCD; malonyl-CoA decarboxylase [KO:K01578] [EC:4.1.1.9]
103248480  CPT1A; carnitine palmitoyltransferase 1A [KO:K08765] [EC:2.3.1.21]
103223575  CPT1B; carnitine palmitoyltransferase 1B [KO:K19523] [EC:2.3.1.21]
103235051  CPT1C; carnitine palmitoyltransferase 1C [KO:K19524] [EC:2.3.1.21]
103222860  CIDEA; cell death-inducing DFFA-like effector a [KO:K25893]
103244545  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
103215586  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
103235167  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
103248442  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
103216725  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
103244749  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
103215510  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
103246406  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
103247478  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
103241631  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
103228818  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
103232471  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
103221482  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
103230127  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
103229722  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
103229152  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
103246222  TBC1D1; TBC1 domain family member 1 [KO:K18341]
103236857  RAB2A; RAB2A, member RAS oncogene family [KO:K07877]
103234098  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
103220645  RAB10; RAB10, member RAS oncogene family [KO:K07903]
103233840  RAB11B; RAB11B, member RAS oncogene family [KO:K07905]
103218911  RAB14; RAB14, member RAS oncogene family [KO:K07881]
103226777  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
103226648  CD36; CD36 molecule [KO:K06259]
103238957  IGF1; insulin like growth factor 1 [KO:K05459]
103231259  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103239029  INS; insulin [KO:K04526]
103234346  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103217981  IRS1; insulin receptor substrate 1 [KO:K16172]
103214788  IRS2; insulin receptor substrate 2 [KO:K07187]
103232472  IRS4; insulin receptor substrate 4 [KO:K17446]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103247598  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103226584  TSC2; tuberous sclerosis 2 [KO:K07207]
103239711  TSC1; tuberous sclerosis 1 [KO:K07206]
103227259  RHEB; Ras homolog enriched in brain [KO:K07208]
103225615  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103243701  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
103235060  AKT1S1; AKT1 substrate 1 [KO:K16184]
103218141  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
103242820  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
103215636  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
103228027  PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
103239428  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
csab00010  Glycolysis / Gluconeogenesis
csab00061  Fatty acid biosynthesis
csab00500  Starch and sucrose metabolism
csab01040  Biosynthesis of unsaturated fatty acids
csab04110  Cell cycle
csab04140  Autophagy - animal
csab04150  mTOR signaling pathway
csab04151  PI3K-Akt signaling pathway
csab04910  Insulin signaling pathway
csab04920  Adipocytokine signaling pathway
KO pathway
ko04152   
LinkDB

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