KEGG   PATHWAY: csab04150
Entry
csab04150                   Pathway                                
Name
mTOR signaling pathway - Chlorocebus sabaeus (green monkey)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
csab04150  mTOR signaling pathway
csab04150

Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103233435  SLC7A5; solute carrier family 7 member 5 [KO:K13780]
103233824  SLC3A2; solute carrier family 3 member 2 [KO:K06519]
103221535  SLC38A9; solute carrier family 38 member 9 [KO:K14995]
103228299  ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:7.1.2.2]
103215418  ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
103220084  ATP6V1B1; ATPase H+ transporting V1 subunit B1 [KO:K02147]
103220817  ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
103237247  ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
103229206  ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
103222872  ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
103220345  ATP6V1E2; ATPase H+ transporting V1 subunit E2 [KO:K02150]
103226868  ATP6V1F; ATPase H+ transporting V1 subunit F [KO:K02151]
103221764  ATP6V1G2; ATPase H+ transporting V1 subunit G2 [KO:K02152]
103230366  ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
103218965  ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
103236797  ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
103247983  LAMTOR1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 [KO:K20397]
103223861  LAMTOR2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [KO:K20398]
103236031  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
103232026  ragulator complex protein LAMTOR3 [KO:K04370]
103246750  LAMTOR4; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 [KO:K20399]
103224248  LAMTOR5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [KO:K16344]
103242467  FLCN; folliculin [KO:K09594]
103244496  FNIP1; folliculin interacting protein 1 [KO:K20400]
103236455  FNIP2; folliculin interacting protein 2 [KO:K20401]
103232050  RRAGB; Ras related GTP binding B [KO:K16185]
103219403  RRAGA; Ras related GTP binding A [KO:K16185]
103225068  RRAGC; Ras related GTP binding C [KO:K16186]
103240102  RRAGD; Ras related GTP binding D [KO:K16186]
103225266  SESN2; sestrin 2 [KO:K20394]
103223159  GATSL3; GATS protein like 3 [KO:K23080]
103246611  GATSL2; GATS protein like 2 [KO:K23081]
103226499  MIOS; meiosis regulator for oocyte development [KO:K20407]
103222823  SEH1L; SEH1 like nucleoporin [KO:K14299]
103225607  WDR24; WD repeat domain 24 [KO:K20408]
103233141  WDR59; WD repeat domain 59 [KO:K20409]
103228003  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
103223197  DEPDC5; DEP domain containing 5 [KO:K20404]
103227680  NPRL2; NPR2-like, GATOR1 complex subunit [KO:K20405]
103225313  NPRL3; NPR3 like, GATOR1 complex subunit [KO:K20406]
103215131  SKP2; S-phase kinase associated protein 2 [KO:K03875]
103244181  RNF152; ring finger protein 152 [KO:K15705] [EC:2.3.2.27]
103243701  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
103235060  AKT1S1; AKT1 substrate 1 [KO:K16184]
103225615  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103237349  DEPTOR; DEP domain containing MTOR interacting protein [KO:K20402]
103226678  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
103226141  TELO2; telomere maintenance 2 [KO:K11137]
103246312  TTI1; TELO2 interacting protein 1 [KO:K20403]
103239307  CLIP1; CAP-Gly domain containing linker protein 1 [KO:K10421]
103226075  GRB10; growth factor receptor bound protein 10 [KO:K20064]
103222696  LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
103220794  LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
103245943  LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
103239428  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
103242520  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
103215636  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
103245196  EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
103236007  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
103218088  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
103218141  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
103242820  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
103238376  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
103219399  RPS6; ribosomal protein S6 [KO:K02991]
103243220  STRADA; STE20-related kinase adaptor alpha [KO:K08271]
103217644  STRADB; STE20-related kinase adaptor beta [KO:K17532]
103233599  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
103214421  CAB39L; calcium binding protein 39 like [KO:K08272]
103218041  CAB39; calcium binding protein 39 [KO:K08272]
103215177  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
103224740  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
103239711  TSC1; tuberous sclerosis 1 [KO:K07206]
103226584  TSC2; tuberous sclerosis 2 [KO:K07207]
103222152  TBC1D7; TBC1 domain family member 7 [KO:K20396]
103227259  RHEB; Ras homolog enriched in brain [KO:K07208]
103216026  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
103238251  WNT1; Wnt family member 1 [KO:K03209]
103224207  WNT2B; Wnt family member 2B [KO:K00182]
103226775  WNT2; Wnt family member 2 [KO:K00182]
103229967  WNT3A; Wnt family member 3A [KO:K00312]
103243255  WNT3; Wnt family member 3 [KO:K00312]
103225420  WNT4; Wnt family member 4 [KO:K00408]
103227777  WNT5A; Wnt family member 5A [KO:K00444]
103218369  WNT5B; Wnt family member 5B [KO:K00444]
103217884  WNT6; Wnt family member 6 [KO:K00445]
103223483  WNT7B; Wnt family member 7B [KO:K00572]
103228043  WNT7A; Wnt family member 7A [KO:K00572]
103216388  WNT8B; Wnt family member 8B [KO:K00714]
103244620  WNT8A; Wnt family member 8A [KO:K00714]
103229968  WNT9A; Wnt family member 9A [KO:K01064]
103243254  WNT9B; Wnt family member 9B [KO:K01064]
103238252  WNT10B; Wnt family member 10B [KO:K01357]
103217886  WNT10A; Wnt family member 10A [KO:K01357]
103248071  WNT11; Wnt family member 11 [KO:K01384]
103226795  WNT16; Wnt family member 16 [KO:K01558]
103226575  FZD1; frizzled class receptor 1 [KO:K02432]
103217660  FZD7; frizzled class receptor 7 [KO:K02432]
103243320  FZD2; frizzled class receptor 2 [KO:K02235]
103215545  FZD3; frizzled class receptor 3 [KO:K02329]
103248178  FZD4; frizzled class receptor 4 [KO:K02354]
103238123  FZD8; frizzled class receptor 8 [KO:K02375]
103217720  FZD5; frizzled class receptor 5 [KO:K02375]
103237249  FZD6; frizzled class receptor 6 [KO:K02376]
103246638  FZD9; frizzled class receptor 9 [KO:K02842]
103239400  FZD10; frizzled class receptor 10 [KO:K02842]
103214791  LRP5; LDL receptor related protein 5 [KO:K03068]
103218639  LRP6; LDL receptor related protein 6 [KO:K03068]
103242279  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
103221145  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
103225806  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
103228213  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103218446  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
103215686  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103239029  INS; insulin [KO:K04526]
103238957  IGF1; insulin like growth factor 1 [KO:K05459]
103234346  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103231259  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103243048  GRB2; growth factor receptor bound protein 2 [KO:K04364]
103228953  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103220440  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103246363  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103218763  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103224167  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103227022  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103228031  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103245451  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103233717  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103240913  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
103225318  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
103231690  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
103232278  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
103217981  IRS1; insulin receptor substrate 1 [KO:K16172]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103216211  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103247598  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103216382  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103239868  MAPKAP1; mitogen-activated protein kinase associated protein 1 [KO:K20410]
103215161  RICTOR; RPTOR independent companion of MTOR complex 2 [KO:K08267]
103223462  PRR5; proline rich 5 [KO:K20411]
103237558  PRR5L; proline rich 5 like [KO:K20411]
103227629  RHOA; ras homolog family member A [KO:K04513]
103243171  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103229829  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
103235232  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
103240340  SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
csab00561  Glycerolipid metabolism
csab04010  MAPK signaling pathway
csab04140  Autophagy - animal
csab04151  PI3K-Akt signaling pathway
csab04152  AMPK signaling pathway
csab04810  Regulation of actin cytoskeleton
csab04910  Insulin signaling pathway
KO pathway
ko04150   
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