KEGG   PATHWAY: csab04140
Entry
csab04140                   Pathway                                
Name
Autophagy - animal - Chlorocebus sabaeus (green monkey)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
csab04140  Autophagy - animal
csab04140

Other DBs
GO: 0006914
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103239029  INS; insulin [KO:K04526]
103231259  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103217981  IRS1; insulin receptor substrate 1 [KO:K16172]
103214788  IRS2; insulin receptor substrate 2 [KO:K07187]
103232472  IRS4; insulin receptor substrate 4 [KO:K17446]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103247598  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103216211  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103246363  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103218763  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103224167  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103241604  MRAS; muscle RAS oncogene homolog [KO:K07831]
103235048  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
103239843  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
103228031  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103245451  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103233717  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103229134  HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
103216026  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
103226584  TSC2; tuberous sclerosis 2 [KO:K07207]
103239711  TSC1; tuberous sclerosis 1 [KO:K07206]
103216726  BNIP3; BCL2 interacting protein 3 [KO:K15464]
103227259  RHEB; Ras homolog enriched in brain [KO:K07208]
103243701  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
103237349  DEPTOR; DEP domain containing MTOR interacting protein [KO:K20402]
103225615  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103235060  AKT1S1; AKT1 substrate 1 [KO:K16184]
103226678  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
103218141  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
103242820  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
103232126  IGBP1; immunoglobulin binding protein 1 [KO:K17606]
103235886  immunoglobulin-binding protein 1-like [KO:K17606]
103244545  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
103215586  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
103239428  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
103242520  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
103236386  ATG13; autophagy related 13 [KO:K08331]
103238337  ATG101; autophagy related 101 [KO:K19730]
103236790  RB1CC1; RB1 inducible coiled-coil 1 [KO:K17589]
103232842  ATG2A; autophagy related 2A [KO:K17906]
103229646  ATG2B; autophagy related 2B [KO:K17906]
103243149  WIPI1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
103246841  WIPI2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
103243780  WDR45B; WD repeat domain 45B [KO:K22991]
103231956  WDR45; WD repeat domain 45 [KO:K22991]
103227235  ATG9B; autophagy related 9B [KO:K17907]
103217902  ATG9A; autophagy related 9A [KO:K17907]
103231725  putative transcription factor SPT20 homolog-like 2 [KO:K21245]
103231726  putative transcription factor SPT20 homolog-like 2 [KO:K21245]
103214287  SUPT20H; SPT20 homolog, SAGA complex component [KO:K21245]
103242490  SMCR8; Smith-Magenis syndrome chromosome region, candidate 8 [KO:K23611]
103223459  WDR41; WD repeat domain 41 [KO:K23610]
103219325  C12H9orf72; chromosome 12 open reading frame, human C9orf72 [KO:K23609]
103234098  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
103232859  RAB39B; RAB39B, member RAS oncogene family [KO:K07925]
103245112  SQSTM1; sequestosome 1 [KO:K14381]
103238638  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
103217178  TANK; TRAF family member associated NFKB activator [KO:K12650]
103220152  RAB1A; RAB1A, member RAS oncogene family [KO:K07874]
103232050  RRAGB; Ras related GTP binding B [KO:K16185]
103219403  RRAGA; Ras related GTP binding A [KO:K16185]
103225068  RRAGC; Ras related GTP binding C [KO:K16186]
103240102  RRAGD; Ras related GTP binding D [KO:K16186]
103233599  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
103215177  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
103224740  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
103219549  PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
103224540  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103234377  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
103227755  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
103245120  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103215844  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103235918  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
103244166  BCL2; BCL2, apoptosis regulator [KO:K02161]
103248011  BCL2L1; BCL2 like 1 [KO:K04570]
103233293  BAD; BCL2 associated agonist of cell death [KO:K02158]
103243387  BECN1; beclin 1 [KO:K08334]
103230857  beclin-2 [KO:K08334]
103216125  NRBF2; nuclear receptor binding factor 2 [KO:K21246]
103241695  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
103222505  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
103229035  ATG14; autophagy related 14 [KO:K17889]
103236448  AMBRA1; autophagy and beclin 1 regulator 1 [KO:K17985]
103237554  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
103248795  TP53INP2; tumor protein p53 inducible nuclear protein 2 [KO:K21247]
103242822  VMP1; vacuole membrane protein 1 [KO:K21248]
103219134  STX17; syntaxin 17 [KO:K08491]
103248068  UVRAG; UV radiation resistance associated [KO:K21249]
103224496  SH3GLB1; SH3 domain containing GRB2 like endophilin B1 [KO:K11248]
103242017  RUBCN; RUN and cysteine rich domain containing beclin 1 interacting protein [KO:K19330]
103239530  CAMKK2; calcium/calmodulin dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
103240115  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
103243204  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
103227941  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103233720  DAPK3; death associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
103219698  DAPK1; death associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
103245501  death-associated protein kinase 3-like [KO:K08803] [EC:2.7.11.1]
103245502  DAPK2; death associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
103237177  high mobility group protein B1 [KO:K10802]
103245968  PRAP1; proline rich acidic protein 1 [KO:K21250]
103241350  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
103245851  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
103229205  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
103223153  MTMR3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
103242843  MTMR4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
103227971  MTMR14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
103229301  ZFYVE1; zinc finger FYVE-type containing 1 [KO:K17603]
103244369  ATG12; autophagy related 12 [KO:K08336]
103240649  ATG5; autophagy related 5 [KO:K08339]
103218104  ATG16L1; autophagy related 16 like 1 [KO:K17890]
103248007  ATG16L2; autophagy related 16 like 2 [KO:K20868]
103228012  ATG7; autophagy related 7 [KO:K08337]
103224003  ATG10; autophagy related 10 [KO:K17888]
103228318  ATG3; autophagy related 3 [KO:K08343]
103217632  CFLAR; CASP8 and FADD like apoptosis regulator [KO:K04724]
103236279  RAB33B; RAB33B, member RAS oncogene family [KO:K07920]
103237845  PRKCQ; protein kinase C theta [KO:K18052] [EC:2.7.11.13]
103231198  gamma-aminobutyric acid receptor-associated protein-like 3 [KO:K08341]
103233317  GABARAPL2; GABA type A receptor associated protein like 2 [KO:K08341]
103242281  GABARAP; GABA type A receptor-associated protein [KO:K08341]
103218578  GABARAPL1; GABA type A receptor associated protein like 1 [KO:K08341]
103233426  MAP1LC3B; microtubule associated protein 1 light chain 3 beta [KO:K10435]
103230861  MAP1LC3C; microtubule associated protein 1 light chain 3 gamma [KO:K10435]
103248775  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha [KO:K10435]
103219881  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
103224699  ATG4C; autophagy related 4C cysteine peptidase [KO:K08342] [EC:3.4.22.-]
103233906  ATG4D; autophagy related 4D cysteine peptidase [KO:K08342] [EC:3.4.22.-]
103232466  ATG4A; autophagy related 4A cysteine peptidase [KO:K08342] [EC:3.4.22.-]
103218245  ATG4B; autophagy related 4B cysteine peptidase [KO:K08342] [EC:3.4.22.-]
103243366  NBR1; NBR1, autophagy cargo receptor [KO:K17987]
103237899  OPTN; optineurin [KO:K19946]
103243627  CALCOCO2; calcium binding and coiled-coil domain 2 [KO:K21348]
103226301  TAX1BP1; Tax1 binding protein 1 [KO:K21347]
103235912  WDFY3; WD repeat and FYVE domain containing 3 [KO:K22262]
103226351  ubiquitin-like [KO:K02927]
103234186  UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1 [KO:K02927]
103241789  ubiquitin-like [KO:K02927]
103237381  ubiquitin-like [KO:K02927]
103220242  RPS27A; ribosomal protein S27a [KO:K02977]
103242447  UBB; ubiquitin B [KO:K04551]
103239352  UBC; ubiquitin C [KO:K04551]
103222954  SNAP29; synaptosome associated protein 29 [KO:K08509]
103219942  VAMP8; vesicle associated membrane protein 8 [KO:K08512]
103226137  YKT6; YKT6 v-SNARE homolog (S. cerevisiae) [KO:K08516]
103240361  STX7; syntaxin 7 [KO:K08488]
103222480  EPG5; ectopic P-granules autophagy protein 5 homolog [KO:K23883]
103243285  PLEKHM1; pleckstrin homology and RUN domain containing M1 [KO:K23282]
103248617  VPS11; VPS11, CORVET/HOPS core subunit [KO:K20179]
103247047  VPS16; VPS16, CORVET/HOPS core subunit [KO:K20180]
103245809  VPS18; VPS18, CORVET/HOPS core subunit [KO:K20181]
103239305  VPS33A; VPS33A, CORVET/HOPS core subunit [KO:K20182]
103246099  VPS39; VPS39, HOPS complex subunit [KO:K20183]
103226195  VPS41; VPS41, HOPS complex subunit [KO:K20184]
103220526  BIRC6; baculoviral IAP repeat containing 6 [KO:K10586] [EC:2.3.2.23]
103217299  GORASP2; golgi reassembly stacking protein 2 [KO:K26797]
103221045  GORASP1; golgi reassembly stacking protein 1 [KO:K26797]
103228088  RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
103230208  RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
103247358  LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
103214841  LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
103236841  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
103219700  CTSL; cathepsin L [KO:K01365] [EC:3.4.22.15]
103247618  putative cathepsin L-like protein 6 [KO:K01365] [EC:3.4.22.15]
103215319  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
csab04010  MAPK signaling pathway
csab04141  Protein processing in endoplasmic reticulum
csab04142  Lysosome
csab04150  mTOR signaling pathway
csab04152  AMPK signaling pathway
csab04910  Insulin signaling pathway
KO pathway
ko04140   
LinkDB

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