KEGG   PATHWAY: csab04151
Entry
csab04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Chlorocebus sabaeus (green monkey)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
csab04151  PI3K-Akt signaling pathway
csab04151

Other DBs
GO: 0043491
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103236114  EGF; epidermal growth factor [KO:K04357]
103220091  TGFA; transforming growth factor alpha [KO:K08774]
103235804  EREG; epiregulin [KO:K09784]
103235805  AREG; amphiregulin [KO:K09782]
103244714  FGF1; fibroblast growth factor 1 [KO:K18496]
103236710  FGF2; fibroblast growth factor 2 [KO:K18497]
103246179  FGF3; fibroblast growth factor 3 [KO:K04358]
103246230  FGF4; fibroblast growth factor 4 [KO:K04358]
103245650  FGF7; fibroblast growth factor 7 [KO:K04358]
103233582  FGF22; fibroblast growth factor 22 [KO:K04358]
103216414  FGF8; fibroblast growth factor 8 [KO:K04358]
103215381  FGF20; fibroblast growth factor 20 [KO:K04358]
103244968  FGF18; fibroblast growth factor 18 [KO:K04358]
103215436  FGF17; fibroblast growth factor 17 [KO:K04358]
103235869  FGF5; fibroblast growth factor 5 [KO:K04358]
103232230  FGF16; fibroblast growth factor 16 [KO:K04358]
103248989  FGF9; fibroblast growth factor 9 [KO:K04358]
103215226  FGF10; fibroblast growth factor 10 [KO:K04358]
103218416  FGF6; fibroblast growth factor 6 [KO:K04358]
103246343  FGF19; fibroblast growth factor 19 [KO:K22603]
103234997  FGF21; fibroblast growth factor 21 [KO:K22429]
103218414  FGF23; fibroblast growth factor 23 [KO:K22428]
103224160  NGF; nerve growth factor [KO:K02582]
103238537  BDNF; brain derived neurotrophic factor [KO:K04355]
103218434  NTF3; neurotrophin 3 [KO:K04356]
103235010  neurotrophin-4 [KO:K12457]
103239029  INS; insulin [KO:K04526]
103238957  IGF1; insulin like growth factor 1 [KO:K05459]
103239180  IGF2; insulin like growth factor 2 [KO:K13769]
103246906  PDGFA; platelet derived growth factor subunit A [KO:K04359]
103223339  PDGFB; platelet derived growth factor subunit B [KO:K17386]
103236438  PDGFC; platelet derived growth factor C [KO:K05450]
103248362  PDGFD; platelet derived growth factor D [KO:K05450]
103224269  CSF1; colony stimulating factor 1 [KO:K05453]
103238826  KITLG; KIT ligand [KO:K05461]
103235035  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
103221446  VEGFA; vascular endothelial growth factor A [KO:K05448]
103233363  VEGFB; vascular endothelial growth factor B [KO:K16858]
103229341  PGF; placental growth factor [KO:K16859]
103236566  VEGFC; vascular endothelial growth factor C [KO:K05449]
103231636  VEGFD; vascular endothelial growth factor D [KO:K05449]
103226643  HGF; hepatocyte growth factor [KO:K05460]
103237282  ANGPT1; angiopoietin 1 [KO:K05465]
103215294  ANGPT2; angiopoietin 2 [KO:K05466]
103215952  ANGPT4; angiopoietin 4 [KO:K05467]
103233602  EFNA2; ephrin A2 [KO:K05462]
103223896  EFNA1; ephrin A1 [KO:K05462]
103223897  EFNA3; ephrin A3 [KO:K05462]
103223911  EFNA4; ephrin A4 [KO:K05462]
103244301  EFNA5; ephrin A5 [KO:K05462]
103215153  GDNF; glial cell derived neurotrophic factor [KO:K05452]
103233749  NRTN; neurturin [KO:K25414]
103224958  ARTN; artemin [KO:K25415]
103233766  PSPN; persephin [KO:K25416]
103226055  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103243533  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
103238504  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
103217777  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
103215648  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
103216628  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103246479  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103245042  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103243642  NGFR; nerve growth factor receptor [KO:K02583]
103223823  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
103219672  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
103234346  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103231259  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103235675  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103244790  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103244788  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103235672  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
103249072  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
103249076  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
103245125  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
103235670  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
103226771  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
103219338  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
103225530  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
103215755  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
103243048  GRB2; growth factor receptor bound protein 2 [KO:K04364]
103228953  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103220440  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103246363  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103218763  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103224167  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103228031  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103245451  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103233717  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103217981  IRS1; insulin receptor substrate 1 [KO:K16172]
103236415  toll-like receptor 2 [KO:K10159]
103218937  TLR4; toll like receptor 4 [KO:K10160]
103246815  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103229828  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103224088  uncharacterized LOC103224088 [KO:K06856]
103229820  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229838  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229839  uncharacterized LOC103229839 [KO:K06856]
103229845  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229849  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229850  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229864  uncharacterized LOC103229864 [KO:K06856]
103247608  uncharacterized LOC103247608 [KO:K06856]
103229935  uncharacterized LOC103229935 [KO:K06856]
103229939  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 [KO:K06856]
103229942  uncharacterized LOC103229942 [KO:K06856]
103229943  uncharacterized LOC103229943 [KO:K06856]
103219736  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
103231655  B-lymphocyte antigen CD19 [KO:K06465]
103230281  B-lymphocyte antigen CD19-like [KO:K06465]
103216329  PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 [KO:K12230]
103243211  somatotropin [KO:K05438]
103243213  somatotropin-like [KO:K05438]
103243214  somatotropin-like [KO:K05438]
103243843  somatotropin-like [KO:K05438]
108449889  somatotropin-like [KO:K05438]
103222073  PRL; prolactin [KO:K05439]
103223157  OSM; oncostatin M [KO:K05418]
103236209  IL2; interleukin 2 [KO:K05429]
103244501  IL3; interleukin 3 [KO:K04736]
103226390  IL6; interleukin 6 [KO:K05405]
103244520  IL4; interleukin 4 [KO:K05430]
103237005  IL7; interleukin 7 [KO:K05431]
103219368  IFNA2; interferon alpha 2 [KO:K05414]
103219366  interferon alpha-1/13-like [KO:K05414]
103219367  IFNA8; interferon alpha 8 [KO:K05414]
103219370  interferon alpha-1/13 [KO:K05414]
103219372  interferon alpha-6 [KO:K05414]
103219377  interferon alpha-14 [KO:K05414]
103219378  interferon alpha-4-like [KO:K05414]
103219379  interferon alpha-4 [KO:K05414]
103219381  interferon alpha-17-like [KO:K05414]
103219383  IFNB1; interferon beta 1 [KO:K05415]
103246719  EPO; erythropoietin [KO:K05437]
103243524  CSF3; colony stimulating factor 3 [KO:K05423]
103215199  GHR; growth hormone receptor [KO:K05080]
103215118  PRLR; prolactin receptor [KO:K05081]
103215160  OSMR; oncostatin M receptor [KO:K05057]
103237839  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
103223268  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
103232148  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
103247515  IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
103223920  IL6R; interleukin 6 receptor [KO:K05055]
103230069  IL4R; interleukin 4 receptor [KO:K05071]
103215123  IL7R; interleukin 7 receptor [KO:K05072]
103216875  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
103216889  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
103233928  EPOR; erythropoietin receptor [KO:K05079]
103225104  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
103224682  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
103219496  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
103234155  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
103242943  COL1A1; collagen type I alpha 1 chain [KO:K06236]
103226536  COL1A2; collagen type I alpha 2 chain [KO:K06236]
103238216  COL2A1; collagen type II alpha 1 chain [KO:K19719]
103214793  COL4A2; collagen type IV alpha 2 chain [KO:K06237]
103214795  COL4A1; collagen type IV alpha 1 chain [KO:K06237]
103217991  COL4A3; collagen type IV alpha 3 chain [KO:K06237]
103217992  COL4A4; collagen type IV alpha 4 chain [KO:K06237]
103232468  COL4A5; collagen type IV alpha 5 chain [KO:K06237]
103232470  COL4A6; collagen type IV alpha 6 chain [KO:K06237]
103221158  COL6A1; collagen type VI alpha 1 chain [KO:K06238]
103220301  COL6A2; collagen type VI alpha 2 chain [KO:K06238]
103218151  COL6A3; collagen type VI alpha 3 chain [KO:K06238]
103241696  COL6A6; collagen type VI alpha 6 chain [KO:K06238]
103241698  COL6A5; collagen type VI alpha 5 chain [KO:K06238]
103241700  collagen alpha-4(VI) chain-like [KO:K06238]
103242965  COL9A3; collagen type IX alpha 3 chain [KO:K08131]
103243930  COL9A1; collagen type IX alpha 1 chain [KO:K08131]
103225034  COL9A2; collagen type IX alpha 2 chain [KO:K08131]
103240395  LAMA2; laminin subunit alpha 2 [KO:K05637]
103222731  LAMA1; laminin subunit alpha 1 [KO:K05637]
103243076  LAMA5; laminin subunit alpha 5 [KO:K06240]
103222632  LAMA3; laminin subunit alpha 3 [KO:K06240]
103240557  LAMA4; laminin subunit alpha 4 [KO:K06241]
103226726  LAMB1; laminin subunit beta 1 [KO:K05636]
103227619  LAMB2; laminin subunit beta 2 [KO:K06243]
103230157  LAMB3; laminin subunit beta 3 [KO:K06244]
103226727  LAMB4; laminin subunit beta 4 [KO:K06245]
103230459  LAMC1; laminin subunit gamma 1 [KO:K05635]
103230458  LAMC2; laminin subunit gamma 2 [KO:K06246]
103239930  LAMC3; laminin subunit gamma 3 [KO:K06247]
103242933  CHAD; chondroadherin [KO:K06248]
103226686  RELN; reelin [KO:K06249] [EC:3.4.21.-]
103245860  THBS1; thrombospondin 1 [KO:K16857]
103223769  THBS4; thrombospondin 4 [KO:K04659]
103234192  COMP; cartilage oligomeric matrix protein [KO:K04659]
103240966  THBS2; thrombospondin 2 [KO:K04659]
103223887  THBS3; thrombospondin 3 [KO:K04659]
103217800  FN1; fibronectin 1 [KO:K05717]
103235944  SPP1; secreted phosphoprotein 1 [KO:K06250]
103242610  VTN; vitronectin [KO:K06251]
103218953  TNC; tenascin C [KO:K06252]
103221729  TNXB; tenascin XB [KO:K06252]
103230545  TNR; tenascin R [KO:K06252]
103230548  TNN; tenascin N [KO:K06252]
103218442  VWF; von Willebrand factor [KO:K03900]
103235942  IBSP; integrin binding sialoprotein [KO:K06253]
103221277  ITGA1; integrin subunit alpha 1 [KO:K06480]
103221285  ITGA2; integrin subunit alpha 2 [KO:K06481]
103243322  ITGA2B; integrin subunit alpha 2b [KO:K06476]
103242953  ITGA3; integrin subunit alpha 3 [KO:K06482]
103217451  ITGA4; integrin subunit alpha 4 [KO:K06483]
103238438  ITGA5; integrin subunit alpha 5 [KO:K06484]
103217327  ITGA6; integrin subunit alpha 6 [KO:K06485]
103238480  integrin alpha-7 [KO:K06583]
103237941  ITGA8; integrin subunit alpha 8 [KO:K06584]
103221076  ITGA9; integrin subunit alpha 9 [KO:K06585]
103224063  ITGA10; integrin subunit alpha 10 [KO:K06586]
103245421  ITGA11; integrin subunit alpha 11 [KO:K06587]
103217487  ITGAV; integrin subunit alpha V [KO:K06487]
103238098  ITGB1; integrin subunit beta 1 [KO:K05719]
103243277  ITGB3; integrin subunit beta 3 [KO:K06493]
103243035  ITGB4; integrin subunit beta 4 [KO:K06525]
103228149  ITGB5; integrin subunit beta 5 [KO:K06588]
103217169  ITGB6; integrin subunit beta 6 [KO:K06589]
103238384  ITGB7; integrin subunit beta 7 [KO:K06590]
103226407  ITGB8; integrin subunit beta 8 [KO:K06591]
103237724  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103223358  F2R; coagulation factor II thrombin receptor [KO:K03914]
103233802  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
103226965  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
103219021  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103234222  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103224524  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
103232244  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103218464  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103214404  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
103225777  GNB1; G protein subunit beta 1 [KO:K04536]
103246723  GNB2; G protein subunit beta 2 [KO:K04537]
103218476  GNB3; G protein subunit beta 3 [KO:K07825]
103221209  GNB4; G protein subunit beta 4 [KO:K04538]
103245611  GNB5; G protein subunit beta 5 [KO:K04539]
103228983  GNG2; G protein subunit gamma 2 [KO:K07826]
103233940  GNG3; G protein subunit gamma 3 [KO:K04540]
103236336  GNG5; G protein subunit gamma 5 [KO:K04542]
103233652  GNG7; G protein subunit gamma 7 [KO:K04543]
103234920  GNG8; G protein subunit gamma 8 [KO:K04544]
103219014  GNG10; G protein subunit gamma 10 [KO:K04545]
103226542  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103224649  GNG12; G protein subunit gamma 12 [KO:K04347]
103243636  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
103226710  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
103242368  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
103242366  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6 [KO:K21290]
103247598  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103233599  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
103215177  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
103224740  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
103216026  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
103239711  TSC1; tuberous sclerosis 1 [KO:K07206]
103226584  TSC2; tuberous sclerosis 2 [KO:K07207]
103227259  RHEB; Ras homolog enriched in brain [KO:K07208]
103226678  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
103225615  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103243701  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
103215636  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
103245196  EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
103236007  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
103218088  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
103218141  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
103242820  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
103238376  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
103219399  RPS6; ribosomal protein S6 [KO:K02991]
103243171  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
103234039  PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
103224486  PKN2; protein kinase N2 [KO:K23691] [EC:2.7.11.13]
103239789  PKN3; protein kinase N3 [KO:K23692] [EC:2.7.11.13]
103240340  SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
103245773  SGK2; SGK2, serine/threonine kinase 2 [KO:K13303] [EC:2.7.11.1]
103236916  serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103227852  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
103226669  MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2 [KO:K05629]
103216211  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103224017  acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
103244545  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
103215586  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
103235167  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
103248442  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
103216725  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
103244749  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
103215510  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
103246406  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
103247478  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
103241631  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
103228818  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
103232471  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
103221482  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
103230127  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
103229722  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
103229152  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
103236665  heat shock protein HSP 90-alpha-like [KO:K04079]
103229726  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
103221436  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
103238976  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
103233899  CDC37; cell division cycle 37 [KO:K09554]
103223939  CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
103233169  PHLPP2; PH domain and leucine rich repeat protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
103244170  PHLPP1; PH domain and leucine rich repeat protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
103229636  TCL1A; T-cell leukemia/lymphoma 1A [KO:K10167]
103229634  TCL1B; T-cell leukemia/lymphoma 1B [KO:K16836]
103232854  MTCP1; mature T-cell proliferation 1 [KO:K16837]
103227233  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
103243855  BRCA1; BRCA1, DNA repair associated [KO:K10605] [EC:2.3.2.27]
103228213  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103235009  GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
103218736  GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
103228704  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
103243712  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
103243337  G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
103243379  G6PC; glucose-6-phosphatase catalytic subunit [KO:K01084] [EC:3.1.3.9]
103217259  G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
103237430  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
103246489  CCND1; cyclin D1 [KO:K04503]
103221583  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
103218647  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
103238495  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
103238589  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103226555  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103218410  CCND2; cyclin D2 [KO:K10151]
103221504  CCND3; cyclin D3 [KO:K10152]
103237156  CCNE2; cyclin E2 [KO:K06626]
103235482  CCNE1; cyclin E1 [KO:K06626]
103240621  FOXO3; forkhead box O3 [KO:K09408]
103232914  RBL2; RB transcriptional corepressor like 2 [KO:K16332]
103230577  FASLG; Fas ligand [KO:K04389]
103241244  BCL2L11; BCL2 like 11 [KO:K16341]
103237221  YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [KO:K16197]
103220843  YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
103245470  YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [KO:K16197]
103242121  YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [KO:K06630]
103223201  YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [KO:K16198]
103246662  YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [KO:K16198]
103233293  BAD; BCL2 associated agonist of cell death [KO:K02158]
103248011  BCL2L1; BCL2 like 1 [KO:K04570]
103244166  BCL2; BCL2, apoptosis regulator [KO:K02161]
103225550  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
103217717  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
103217363  ATF2; activating transcription factor 2 [KO:K04450]
103223345  ATF4; activating transcription factor 4 [KO:K04374]
103236571  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
103223942  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
103226974  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
103233716  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
103219209  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
103226299  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
103221718  ATF6B; activating transcription factor 6 beta [KO:K09049]
103247197  MCL1; BCL2 family apoptosis regulator [KO:K02539]
103239669  RXRA; retinoid X receptor alpha [KO:K08524]
103238335  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
103232832  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103216382  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103215686  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103227364  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103236047  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103240331  MYB; MYB proto-oncogene, transcription factor [KO:K09420]
103238687  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
103242323  TP53; tumor protein p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
csab00010  Glycolysis / Gluconeogenesis
csab04010  MAPK signaling pathway
csab04012  ErbB signaling pathway
csab04062  Chemokine signaling pathway
csab04064  NF-kappa B signaling pathway
csab04068  FoxO signaling pathway
csab04110  Cell cycle
csab04115  p53 signaling pathway
csab04150  mTOR signaling pathway
csab04210  Apoptosis
csab04370  VEGF signaling pathway
csab04510  Focal adhesion
csab04620  Toll-like receptor signaling pathway
csab04630  JAK-STAT signaling pathway
csab04662  B cell receptor signaling pathway
csab04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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