KEGG   PATHWAY: ctig04512
Entry
ctig04512                   Pathway                                
Name
ECM-receptor interaction - Crotalus tigris (Tiger rattlesnake)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ctig04512  ECM-receptor interaction
ctig04512

Other DBs
GO: 0005201
Organism
Crotalus tigris (Tiger rattlesnake) [GN:ctig]
Gene
120307150  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
120303516  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
120303322  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
120311435  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
120311436  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
120300407  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
120300408  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
120310373  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
120310375  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
120304996  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
120304932  collagen alpha-6(VI) chain-like [KO:K06238]
120304995  collagen alpha-6(VI) chain-like [KO:K06238]
120300357  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
120300364  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
120300380  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
120301961  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
120314758  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
120309453  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
120299635  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
120306262  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
120301406  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
120309345  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
120311569  LAMA4; laminin subunit alpha-4 [KO:K06241]
120313018  LAMB1; laminin subunit beta-1 [KO:K05636]
120303027  laminin subunit beta-2-like [KO:K06243]
120315900  laminin subunit beta-4-like isoform X1 [KO:K06243]
120316128  LAMB3; laminin subunit beta-3 [KO:K06244]
120313019  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
120314964  LAMC1; laminin subunit gamma-1 [KO:K05635]
120314965  LAMC2; laminin subunit gamma-2 [KO:K06246]
120308717  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
120307748  CHAD; chondroadherin [KO:K06248]
120317294  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
120307674  THBS1; thrombospondin-1 [KO:K16857]
120317128  THBS3; thrombospondin-3 [KO:K04659]
120314045  THBS2; thrombospondin-2 [KO:K04659]
120303777  THBS4; thrombospondin-4 [KO:K04659]
120298118  cartilage oligomeric matrix protein [KO:K04659]
120307303  FN1; fibronectin isoform X1 [KO:K05717]
120316052  SPP1; osteopontin [KO:K06250]
120319405  VTN; vitronectin [KO:K06251]
120311449  TNC; tenascin isoform X1 [KO:K06252]
120310279  TNN; tenascin-N [KO:K06252]
120310303  TNR; tenascin-R [KO:K06252]
120308239  NPNT; nephronectin isoform X1 [KO:K06824]
120296746  FRAS1; extracellular matrix protein FRAS1 isoform X1 [KO:K23379]
120317250  FREM1; FRAS1-related extracellular matrix protein 1 isoform X1 [KO:K23380]
120296801  VWF; von Willebrand factor [KO:K03900]
120316044  bone sialoprotein 2 [KO:K06253]
120316054  DMP1; dentin matrix acidic phosphoprotein 1 [KO:K23328]
120316038  uncharacterized protein LOC120316038 [KO:K26442]
120319241  AGRN; agrin isoform X1 [KO:K06254]
120319186  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
120313756  ITGA1; integrin alpha-1 [KO:K06480]
120313761  ITGA2; integrin alpha-2 [KO:K06481]
120302614  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
120303491  ITGA3; integrin alpha-3 [KO:K06482]
120298608  ITGA4; integrin alpha-4 [KO:K06483]
120308545  ITGA5; integrin alpha-5 [KO:K06484]
120316325  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
120306220  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
120302747  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
120305284  ITGA9; integrin alpha-9 [KO:K06585]
120314886  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
120320142  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
120310958  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
120308266  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
120302667  ITGB3; integrin beta-3 [KO:K06493]
120301143  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
120299200  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
120301313  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
120302350  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
120303155  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
120311392  SDC1; syndecan-1 [KO:K06257]
120311624  SDC4; syndecan-4 [KO:K16338]
120317416  SV2C; synaptic vesicle glycoprotein 2C isoform X1 [KO:K06258]
120315202  SV2B; synaptic vesicle glycoprotein 2B [KO:K06258]
120296689  SV2A; synaptic vesicle glycoprotein 2A isoform X1 [KO:K06258]
120299801  platelet glycoprotein 4-like isoform X1 [KO:K06259]
120299802  platelet glycoprotein 4-like [KO:K06259]
120319129  platelet glycoprotein 4-like [KO:K06259]
120303157  GP1BB; platelet glycoprotein Ib beta chain [KO:K06262]
120310710  platelet glycoprotein IX-like [KO:K06263]
120310716  platelet glycoprotein IX-like [KO:K06263]
120304007  DAG1; dystroglycan isoform X1 [KO:K06265]
120308136  HMMR; hyaluronan mediated motility receptor isoform X1 [KO:K06267]
Compound
G10505  Hyaluronic acid
Reference
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
ctig04510  Focal adhesion
KO pathway
ko04512   
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