KEGG   PATHWAY: dro04820
Entry
dro04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Desmodus rotundus (common vampire bat)
Class
Cellular Processes; Cell motility
Pathway map
dro04820  Cytoskeleton in muscle cells
dro04820

Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112319841  COL1A2; collagen alpha-2(I) chain [KO:K06236]
112316389  COL1A1; collagen alpha-1(I) chain [KO:K06236]
112307967  COL3A1; collagen alpha-1(III) chain [KO:K19720]
112313513  COL11A1; collagen alpha-1(XI) chain isoform X1 [KO:K19721]
112301560  COL5A3; collagen alpha-3(V) chain [KO:K19721]
112302139  COL11A2; collagen alpha-2(XI) chain isoform X1 [KO:K19721]
112306267  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
112306307  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
112309138  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
112307813  COL5A2; collagen alpha-2(V) chain [KO:K19721]
112299197  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
112319309  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
112303890  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
112314445  DCN; decorin [KO:K04660]
112307555  VCAN; versican core protein isoform X1 [KO:K06793]
112308001  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
112309881  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
112309556  collagen alpha-4(VI) chain-like [KO:K06238]
112309687  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
112306524  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
112306535  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
112311111  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
112307475  THBS4; thrombospondin-4 [KO:K04659]
112316816  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
112305111  COMP; cartilage oligomeric matrix protein [KO:K04659]
112297305  THBS2; thrombospondin-2 [KO:K04659]
112311047  FBN1; fibrillin-1 [KO:K06825]
112314865  FBN2; fibrillin-2 [KO:K23342]
112321420  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
112321451  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
112296845  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
112296867  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
112307731  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
112307910  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
112320590  FBLN2; fibulin-2 isoform X1 [KO:K17307]
112322039  FBLN1; fibulin-1 [KO:K17307]
112299193  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
112306042  NID1; nidogen-1 [KO:K06826]
112310990  NID2; LOW QUALITY PROTEIN: nidogen-2 [KO:K06826]
112307828  FN1; fibronectin isoform X1 [KO:K05717]
112297736  SDC1; syndecan-1 isoform X1 [KO:K06257]
112315472  SDC2; syndecan-2 [KO:K16336]
112299292  SDC3; syndecan-3 [KO:K16337]
112303758  SDC4; syndecan-4 [KO:K16338]
112299598  AGRN; agrin [KO:K06254]
112296315  BGN; biglycan [KO:K08118]
112322876  desmocollin-2-like [KO:K07601]
112322738  desmoglein-2-like [KO:K07597]
112318308  PKP2; plakophilin-2 [KO:K12642]
112298551  JUP; junction plakoglobin [KO:K10056]
112297537  DSP; LOW QUALITY PROTEIN: desmoplakin [KO:K10381]
112318828  VIM; vimentin [KO:K07606]
112307751  DES; desmin [KO:K07610]
112322610  LAMA1; laminin subunit alpha-1 [KO:K05637]
112297058  LAMA2; laminin subunit alpha-2 [KO:K05637]
112315280  ITGA1; integrin alpha-1 [KO:K06480]
112315265  ITGA2; integrin alpha-2 [KO:K06481]
112298771  ITGA2B; integrin alpha-IIb [KO:K06476]
112316285  ITGA3; integrin alpha-3 [KO:K06482]
112305817  ITGA4; integrin alpha-4 [KO:K06483]
112318448  ITGA5; integrin alpha-5 [KO:K06484]
112305805  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
112319154  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
112320534  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
112309728  ITGA9; integrin alpha-9 [KO:K06585]
112314615  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
112311545  ITGA11; integrin alpha-11 [KO:K06587]
112305765  ITGAV; integrin alpha-V [KO:K06487]
112317701  ITGB1; integrin beta-1 [KO:K05719]
112316322  ITGB3; integrin beta-3 [KO:K06493]
112298656  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
112320641  ITGB5; integrin beta-5 [KO:K06588]
112322244  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
112318624  ITGB7; integrin beta-7 [KO:K06590]
112306853  ITGB8; integrin beta-8 [KO:K06591]
112311282  TLN2; talin-2 [KO:K06271]
112304416  TLN1; talin-1 isoform X1 [KO:K06271]
112305432  VCL; vinculin isoform X1 [KO:K05700]
112317105  ACTN3; alpha-actinin-3 [KO:K21073]
112306045  ACTN2; alpha-actinin-2 [KO:K21073]
112298712  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112319437  ACTB; actin, cytoplasmic 1 [KO:K05692]
112302953  ACTG2; actin, gamma-enteric smooth muscle isoform X1 [KO:K12315]
112309526  DAG1; dystroglycan [KO:K06265]
112316406  SGCA; alpha-sarcoglycan [KO:K12565]
112319844  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
112316861  SGCB; beta-sarcoglycan [KO:K12566]
112319475  SGCD; delta-sarcoglycan [KO:K12563]
112310667  SGCG; gamma-sarcoglycan [KO:K12564]
112306776  SGCZ; zeta-sarcoglycan [KO:K27062]
112318371  SSPN; sarcospan [KO:K22194]
112302011  DMD; dystrophin [KO:K10366]
112303936  SNTA1; alpha-1-syntrophin isoform X1 [KO:K24063]
112300609  SNTB2; beta-2-syntrophin [KO:K24064]
112315350  SNTB1; beta-1-syntrophin [KO:K24064]
112322718  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
112299880  FLNC; filamin-C isoform X1 [KO:K27393]
112315807  sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
112320186  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
112313776  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
112317734  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
112310823  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
112308526  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
112301115  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
112298654  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
112305441  ANK3; ankyrin-3 isoform X1 [KO:K09259]
112306217  SPTAN1; spectrin alpha chain, non-erythrocytic 1 [KO:K06114]
112297918  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
112320015  spectrin beta chain, non-erythrocytic 4-like [KO:K06115]
112311061  SPTBN5; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 5 [KO:K06115]
112317150  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
112303375  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
112322141  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
112318837  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
112308904  LOW QUALITY PROTEIN: myosin-1-like [KO:K24220]
112308902  myosin-2 [KO:K24220]
112308491  myosin-3 [KO:K24220]
112304244  MYH7B; myosin-7B [KO:K24220]
112320449  MYH15; LOW QUALITY PROTEIN: myosin-15 [KO:K24220]
112308903  myosin-4 [KO:K24220]
112308470  MYH13; myosin-13 [KO:K24220]
112308404  MYH8; LOW QUALITY PROTEIN: myosin-8 [KO:K24220]
112301295  myosin-6 isoform X1 [KO:K17751]
112300691  MYH7; myosin-7 [KO:K17751]
112308727  MYH10; myosin-10 isoform X1 [KO:K10352]
112310058  MYH14; myosin-14 isoform X1 [KO:K10352]
112315043  MYH11; myosin-11 [KO:K10352]
112321857  MYH9; myosin-9 [KO:K10352]
112307807  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
112309882  MYL3; myosin light chain 3 [KO:K12749]
112316415  MYL4; myosin light chain 4 [KO:K12750]
112310708  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
112310679  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
112316654  MYL5; myosin light chain 5 [KO:K12753]
112306911  MYL7; LOW QUALITY PROTEIN: myosin regulatory light chain 2, atrial isoform [KO:K12754]
112303838  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
112304819  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
112321886  MYBPC1; myosin-binding protein C, slow-type [KO:K12557]
112310207  MYBPC2; LOW QUALITY PROTEIN: myosin-binding protein C, fast-type [KO:K12558]
112303174  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
112318850  MYBPH; myosin-binding protein H isoform X1 [KO:K24494]
112313963  MYBPHL; myosin-binding protein H-like [KO:K24494]
112306113  ACTA1; LOW QUALITY PROTEIN: actin, alpha skeletal muscle [KO:K10354]
112311247  ACTC1; actin, alpha cardiac muscle 1 isoform X1 [KO:K12314]
112307128  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
112318873  LOW QUALITY PROTEIN: troponin I, slow skeletal muscle-like [KO:K10371]
112318847  troponin I, slow skeletal muscle [KO:K10371]
112313851  TNNT1; troponin T, slow skeletal muscle [KO:K10372]
112304012  TNNC2; troponin C, skeletal muscle [KO:K12042]
112317350  troponin I, fast skeletal muscle-like [KO:K12043]
112317169  troponin I, fast skeletal muscle [KO:K12043]
112317085  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
112313852  TNNI3; troponin I, cardiac muscle [KO:K12044]
112318844  TNNT2; troponin T, cardiac muscle [KO:K12045]
112311121  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
112304557  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
112316450  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
112305157  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
112305716  TTN; titin [KO:K12567] [EC:2.7.11.1]
112318196  MYOT; myotilin isoform X1 [KO:K19875]
112316404  TCAP; telethonin [KO:K19879]
112312634  SYNPO2; synaptopodin-2 isoform X1 [KO:K24066]
112312992  NEB; nebulin [KO:K18267]
112318932  LIM zinc-binding domain-containing Nebulette [KO:K25865]
112318921  nebulette-like [KO:K25865]
112305528  MYOZ1; myozenin-1 [KO:K26050]
112312684  MYOZ2; myozenin-2 [KO:K26050]
112319741  MYOZ3; myozenin-3 [KO:K26050]
112307082  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
112305179  PDLIM2; PDZ and LIM domain protein 2 isoform X1 [KO:K23353]
112318117  PDLIM4; PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
112306722  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
112313527  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
112318636  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
112300416  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
112299161  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
112309896  XIRP1; LOW QUALITY PROTEIN: xin actin-binding repeat-containing protein 1 [KO:K27381]
112322286  XIRP2; xin actin-binding repeat-containing protein 2 isoform X1 [KO:K27381]
112300311  NRAP; nebulin-related-anchoring protein isoform X1 [KO:K24421]
112305465  MYPN; myopalladin isoform X1 [KO:K22028]
112305491  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
112317750  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
112320373  PDLIM7; PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
112304581  TMOD1; tropomodulin-1 [KO:K10370]
112313806  TMOD4; tropomodulin-4 isoform X1 [KO:K10370]
112311381  TMOD3; tropomodulin-3 [KO:K10370]
112311881  TMOD2; tropomodulin-2 [KO:K10370]
112316164  ZYX; zyxin [KO:K06273]
112311479  four and a half LIM domains protein 1-like [KO:K14365]
112307305  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
112315155  FHL2; four and a half LIM domains protein 2 [KO:K14380]
112299530  FHL3; four and a half LIM domains protein 3 [KO:K24414]
112301267  LMOD3; leiomodin-3 isoform X1 [KO:K22030]
112299723  LMOD2; leiomodin-2 [KO:K22030]
112318854  LMOD1; leiomodin-1 [KO:K22030]
112307385  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
112307096  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
112315221  ANKRD23; ankyrin repeat domain-containing protein 23 [KO:K21438]
112322300  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
112298776  FMNL1; LOW QUALITY PROTEIN: formin-like protein 1 [KO:K23957]
112318401  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
112311660  INF2; inverted formin-2 [KO:K23958]
112311455  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
112302208  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
112318195  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
112321377  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
112310979  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
112306117  FMN2; formin-2 [KO:K02184]
112322779  MYOM1; myomesin-1 [KO:K24495]
112321299  MYOM2; myomesin-2 [KO:K24495]
112299547  MYOM3; myomesin-3 [KO:K24495]
112299074  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
112308591  ENO3; beta-enolase [KO:K01689] [EC:4.2.1.11]
112321917  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
112312513  ANK2; ankyrin-2 [KO:K09255]
112312878  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
112298031  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
112315542  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
112299486  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
112303265  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
112313709  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
112313712  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
112311921  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
112315647  PLEC; LOW QUALITY PROTEIN: plectin [KO:K10388]
112311514  SYNE3; nesprin-3 [KO:K21761]
112297128  SYNE1; nesprin-1 [KO:K19326]
112311599  SYNE2; nesprin-2 isoform X1 [KO:K19346]
112321723  SUN2; SUN domain-containing protein 2 [KO:K19347]
112319540  SUN1; SUN domain-containing protein 1 [KO:K19347]
112301289  TMEM43; transmembrane protein 43 [KO:K27488]
112296318  EMD; emerin [KO:K12569]
112318856  LBR; lamin-B receptor [KO:K19532] [EC:1.3.1.70]
112317116  LMNA; lamin [KO:K12641]
112312400  LMNB2; lamin-B2 [KO:K07611]
112314999  LMNB1; lamin-B1 isoform X1 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
dro04512  ECM-receptor interaction
dro04814  Motor proteins
KO pathway
ko04820   
LinkDB

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