KEGG   PATHWAY: eju05322
Entry
eju05322                    Pathway                                
Name
Systemic lupus erythematosus - Eumetopias jubatus (Steller sea lion)
Description
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.
Class
Human Diseases; Immune disease
Pathway map
eju05322  Systemic lupus erythematosus
eju05322

Organism
Eumetopias jubatus (Steller sea lion) [GN:eju]
Gene
114199063  C1QC; complement C1q subcomponent subunit C [KO:K03988]
114222260  C2; complement C2 [KO:K01332] [EC:3.4.21.43]
114222096  complement C4-B-like [KO:K03989]
114199796  histone H2A type 1-E [KO:K11251]
114224617  histone H2A-like [KO:K11251]
114209595  core histone macro-H2A.1 isoform X1 [KO:K11251]
114201324  histone H2A.Z [KO:K11251]
114201919  histone H2A-Bbd type 2/3 [KO:K11251]
114201931  histone H2A-Bbd type 2/3-like [KO:K11251]
114201993  histone H2A type 3 [KO:K11251]
114211336  histone H2AX [KO:K11251]
114203090  uncharacterized protein LOC114203090 [KO:K11251]
114203093  uncharacterized protein LOC114203093 [KO:K11251]
114204078  LOW QUALITY PROTEIN: histone H2A-Bbd type 1-like [KO:K11251]
114212504  histone H2A type 1-H-like [KO:K11251]
114212547  histone H2A.J-like [KO:K11251]
114212599  histone H2A type 1-C [KO:K11251]
114212600  histone H2A type 1-E-like [KO:K11251]
114212601  histone H2A type 1-B/E [KO:K11251]
114212602  histone H2A type 1-B/E-like [KO:K11251]
114197278  histone H2A type 2-B [KO:K11251]
114197279  histone H2A type 2-C [KO:K11251]
114214188  core histone macro-H2A.2 isoform X1 [KO:K11251]
114221630  histone H2A.J [KO:K11251]
114199797  histone H2B type 1-K [KO:K11252]
114201989  histone H2B type 1-F/J/L-like [KO:K11252]
114201990  histone H2B type 3-B [KO:K11252]
114202410  late histone H2B.2.1-like [KO:K11252]
114203571  late histone H2B.L4-like [KO:K11252]
114203572  late histone H2B.L4-like [KO:K11252]
114203809  late histone H2B.L4-like [KO:K11252]
114203945  late histone H2B.L4-like [KO:K11252]
114204152  histone H2B type 1 [KO:K11252]
114204153  histone H2B type 1-N-like [KO:K11252]
114204192  histone H2B type W-T-like [KO:K11252]
114204228  late histone H2B.L4-like [KO:K11252]
114212556  histone H2B type 1-A [KO:K11252]
114212596  histone H2B type 1-like [KO:K11252]
114212603  histone H2B type 1-M isoform X1 [KO:K11252]
114212604  histone H2B type 1 [KO:K11252]
114212605  histone H2B type 1-B [KO:K11252]
114212606  histone H2B type 1 [KO:K11252]
114212607  histone H2B type 1 [KO:K11252]
114212608  histone H2B type 1-F/J/L [KO:K11252]
114212628  histone H2B type 1-A-like [KO:K11252]
114197310  histone H2B type 2-E [KO:K11252]
114197995  late histone H2B.L4-like [KO:K11252]
114198240  histone H2B subacrosomal variant-like [KO:K11252]
114208476  histone H3.3-like [KO:K11253]
114216180  histone H3.3 [KO:K11253]
114216610  LOW QUALITY PROTEIN: histone H3.3 [KO:K11253]
114209607  histone H3.3-like [KO:K11253]
114203786  histone H3.1 [KO:K11253]
114204120  histone H3.1 [KO:K11253]
114212502  uncharacterized protein LOC114212502 [KO:K11253]
114212597  histone H3.1 [KO:K11253]
114212598  histone H3.1 [KO:K11253]
114212613  uncharacterized protein LOC114212613 [KO:K11253]
114204282  histone H3-like [KO:K11253]
114212893  histone H3.3C-like [KO:K11253]
114197313  histone H3 [KO:K11253]
114221180  histone H3.3-like [KO:K11253]
114205620  histone H3.3-like [KO:K11253]
114221598  histone H3.3-like [KO:K11253]
114207486  histone H3.3-like [KO:K11253]
114215547  histone H3.3 [KO:K11253]
114199799  histone H4 [KO:K11254]
114199800  histone H4 [KO:K11254]
114199801  histone H4 [KO:K11254]
114203785  histone H4 [KO:K11254]
114212609  histone H4 [KO:K11254]
114212610  histone H4 [KO:K11254]
114212611  histone H4 [KO:K11254]
114197356  histone H4 [KO:K11254]
114221629  histone H4 [KO:K11254]
114220780  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086]
114200414  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
114201482  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
114219938  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
114221701  GRIN2B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B [KO:K05210]
114218756  TRIM21; E3 ubiquitin-protein ligase TRIM21 [KO:K10651] [EC:2.3.2.27]
114210400  RO60; 60 kDa SS-A/Ro ribonucleoprotein [KO:K11089]
114224373  SSB; lupus La protein [KO:K11090]
114224643  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
114198920  ACTN4; alpha-actinin-4 [KO:K05699]
114222080  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
114222082  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
114222085  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
114222086  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
114222121  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
114222122  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
114222182  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
114222184  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
114222220  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
114222222  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
114222228  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
114222281  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
114214720  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
114214808  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
114215933  CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470]
114201455  CD40LG; CD40 ligand [KO:K03161]
114223210  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
114222242  TNF; tumor necrosis factor [KO:K03156]
114214991  IFNG; interferon gamma [KO:K04687]
114221910  IL10; interleukin-10 [KO:K05443]
114222545  C1R; complement C1r subcomponent isoform X1 [KO:K01330] [EC:3.4.21.41]
114222555  C1S; complement C1s subcomponent [KO:K01331] [EC:3.4.21.42]
114226149  C3; complement C3 [KO:K03990]
114212820  C5; complement C5 [KO:K03994]
114204832  C6; complement component C6 [KO:K03995]
114204794  C7; complement component C7 isoform X1 [KO:K03996]
114212130  C8A; complement component C8 alpha chain [KO:K03997]
114212140  C8B; complement component C8 beta chain [KO:K03998]
114201774  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
114204828  C9; complement component C9 [KO:K04000]
114217879  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
114226239  neutrophil elastase-like [KO:K01327] [EC:3.4.21.37]
114197301  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
114210408  low affinity immunoglobulin gamma Fc region receptor III-like isoform X1 [KO:K06463]
Compound
C00027  Hydrogen peroxide
C00434  Double-stranded DNA
C02737  Phosphatidylserine
Reference
PMID:18305268
  Authors
Rahman A, Isenberg DA.
  Title
Systemic lupus erythematosus.
  Journal
N Engl J Med 358:929-39 (2008)
DOI:10.1056/NEJMra071297
Reference
PMID:12835292
  Authors
Mok CC, Lau CS.
  Title
Pathogenesis of systemic lupus erythematosus.
  Journal
J Clin Pathol 56:481-90 (2003)
DOI:10.1136/jcp.56.7.481
Reference
PMID:17943287
  Authors
Clatworthy MR, Smith KG.
  Title
B cells in glomerulonephritis: focus on lupus nephritis.
  Journal
Semin Immunopathol 29:337-53 (2007)
DOI:10.1007/s00281-007-0092-1
Reference
PMID:8048228
  Authors
Couser WG.
  Title
New insights into mechanisms of immune glomerular injury.
  Journal
West J Med 160:440-6 (1994)
Reference
PMID:16932712
  Authors
Cook HT, Botto M.
  Title
Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus.
  Journal
Nat Clin Pract Rheumatol 2:330-7 (2006)
DOI:10.1038/ncprheum0191
Reference
PMID:15459673
  Authors
Carroll MC.
  Title
A protective role for innate immunity in systemic lupus erythematosus.
  Journal
Nat Rev Immunol 4:825-31 (2004)
DOI:10.1038/nri1456
Reference
PMID:15972354
  Authors
Sturfelt G, Truedsson L.
  Title
Complement and its breakdown products in SLE.
  Journal
Rheumatology (Oxford) 44:1227-32 (2005)
DOI:10.1093/rheumatology/keh719
Reference
PMID:10430616
  Authors
Lu L, Kaliyaperumal A, Boumpas DT, Datta SK.
  Title
Major peptide autoepitopes for nucleosome-specific T cells of human lupus.
  Journal
J Clin Invest 104:345-55 (1999)
DOI:10.1172/JCI6801
Reference
PMID:12965173
  Authors
Zieve GW, Khusial PR.
  Title
The anti-Sm immune response in autoimmunity and cell biology.
  Journal
Autoimmun Rev 2:235-40 (2003)
DOI:10.1016/S1568-9972(03)00018-1
Reference
PMID:10025913
  Authors
Scofield RH, Farris AD, Horsfall AC, Harley JB.
  Title
Fine specificity of the autoimmune response to the Ro/SSA and La/SSB ribonucleoproteins.
  Journal
Arthritis Rheum 42:199-209 (1999)
DOI:10.1002/1529-0131(199902)42:2<199::AID-ANR1>3.0.CO;2-1
Reference
PMID:15380523
  Authors
Hoffman RW.
  Title
T cells in the pathogenesis of systemic lupus erythematosus.
  Journal
Clin Immunol 113:4-13 (2004)
DOI:10.1016/j.clim.2004.05.001
Related
pathway
eju04060  Cytokine-cytokine receptor interaction
eju04514  Cell adhesion molecules
eju04610  Complement and coagulation cascades
eju04612  Antigen processing and presentation
eju04630  JAK-STAT signaling pathway
eju04660  T cell receptor signaling pathway
eju04662  B cell receptor signaling pathway
eju04670  Leukocyte transendothelial migration
KO pathway
ko05322   
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