Entry Name B cell receptor signaling pathway - Eumetopias jubatus (Steller sea lion)
Description B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map eju04662 B cell receptor signaling pathway
Other DBs Organism Eumetopias jubatus (Steller sea lion) [GN:
eju ]
Gene 114196753 CD79B; B-cell antigen receptor complex-associated protein beta chain isoform X1 [KO:K06507 ]
114197099 CD79A; B-cell antigen receptor complex-associated protein alpha chain [KO:K06506 ]
114198925 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
114199321 BANK1; B-cell scaffold protein with ankyrin repeats isoform X1 [KO:K26239 ]
114199341 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
114199922 CARD11; caspase recruitment domain-containing protein 11 [KO:K07367 ]
114201319 DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229 ]
114201320 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114202334 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
114202451 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
114205178 PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230 ]
114205617 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
114206954 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
114207903 VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730 ]
114208802 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369 ] [EC:3.4.22.-]
114210517 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560 ]
114213130 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
114214123 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114216204 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
114217489 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114218556 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
114224631 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
114225505 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
114226659 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Niiro H, Clark EA.
Title Regulation of B-cell fate by antigen-receptor signals.
Journal Reference Authors Kurosaki T.
Title Genetic analysis of B cell antigen receptor signaling.
Journal Reference Authors Nitschke L.
Title The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal Reference Authors Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title Complement: central to innate immunity and bridging to adaptive responses.
Journal Reference Authors Kurosaki T.
Title Regulation of B-cell signal transduction by adaptor proteins.
Journal Reference Authors Nitschke L, Tsubata T.
Title Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal Reference Authors Jumaa H, Hendriks RW, Reth M.
Title B cell signaling and tumorigenesis.
Journal Reference Authors Rickert RC.
Title Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal Reference Authors Zouali M, Sarmay G
Title B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal Reference Authors Chiles TC.
Title Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal Reference Authors Allam A, Marshall AJ
Title Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal Reference Authors Gold MR
Title To make antibodies or not: signaling by the B-cell antigen receptor.
Journal Reference Authors Fu C, Turck CW, Kurosaki T, Chan AC
Title BLNK: a central linker protein in B cell activation.
Journal Reference Authors Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal Reference Authors Shinohara H, Maeda S, Watarai H, Kurosaki T
Title IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
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