KEGG   PATHWAY: els04144
Entry
els04144                    Pathway                                
Name
Endocytosis - Esox lucius (northern pike)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
els04144  Endocytosis
els04144

Other DBs
GO: 0006897
Organism
Esox lucius (northern pike) [GN:els]
Gene
105017547  ADP-ribosylation factor 6 [KO:K07941]
105026457  ADP-ribosylation factor 6 [KO:K07941]
105008609  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
105011662  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
105029228  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [KO:K00889] [EC:2.7.1.68]
105022262  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
105015056  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X3 [KO:K00889] [EC:2.7.1.68]
105014287  phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
105014163  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
105030829  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
105019794  phospholipase D1 [KO:K01115] [EC:3.1.4.4]
105023918  phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
105022017  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
105011722  dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
105015079  dnm1; dynamin-1 isoform X2 [KO:K01528] [EC:3.6.5.5]
105022146  dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
105008713  dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
105007676  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
105013082  dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
105022903  clta; clathrin light chain A isoform X1 [KO:K04644]
105027890  cltb; clathrin light chain B isoform X1 [KO:K04645]
105006438  clathrin heavy chain 1 isoform X1 [KO:K04646]
105010991  cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
105014295  clathrin heavy chain 1 isoform X1 [KO:K04646]
105029098  AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
105011096  ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
105021137  AP-2 complex subunit mu-A [KO:K11826]
105029770  AP-2 complex subunit mu-B isoform X1 [KO:K11826]
105012140  ap2s1; AP-2 complex subunit sigma isoform X1 [KO:K11827]
105010863  EH domain-containing protein 2 [KO:K12469]
105029599  ehd2; EH domain-containing protein 2 isoform X1 [KO:K12469]
105019479  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105024259  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105012782  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
105023521  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
105030836  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
105006096  zinc finger FYVE domain-containing protein 16 isoform X3 [KO:K04679]
105031234  zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
105028158  zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
105014505  mothers against decapentaplegic homolog 2 [KO:K04500]
105005850  smad3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
105013596  mothers against decapentaplegic homolog 3 [KO:K23605]
105021980  transferrin receptor protein 1 isoform X1 [KO:K06503]
105024999  tfrc; transferrin receptor protein 1 [KO:K06503]
105027310  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
105019998  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105011836  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105010630  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105015916  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105011125  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105016672  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105023472  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105011087  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
105012434  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
105028781  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
105024282  cblc; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
105021977  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
105018400  endophilin-A3 isoform X1 [KO:K11247]
105020449  endophilin-A2 isoform X1 [KO:K11247]
105020978  endophilin-A1 isoform X1 [KO:K11247]
105014658  endophilin-A3 isoform X1 [KO:K11247]
105031522  endophilin-A1 [KO:K11247]
105011609  sh3gl1; endophilin-A2 isoform X1 [KO:K11247]
105022607  endophilin-B1 [KO:K11248]
105028407  sh3glb2; endophilin-B2 isoform X1 [KO:K21269]
105014161  endophilin-B2 isoform X1 [KO:K21269]
105023173  myc box-dependent-interacting protein 1 isoform X7 [KO:K12562]
105023428  amph; amphiphysin isoform X1 [KO:K12562]
105027291  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
105006167  epsin-3 isoform X1 [KO:K12471]
105019032  epsin-1 isoform X1 [KO:K12471]
105009039  epsin-3 [KO:K12471]
105025884  epsin-1 isoform X1 [KO:K12471]
105008324  epsin-2 isoform X1 [KO:K12471]
105011464  eps15l1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
105026373  eps15; epidermal growth factor receptor substrate 15 isoform X5 [KO:K12472]
105007164  uncharacterized protein LOC105007164 isoform X2 [KO:K12472]
105022526  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
105010781  spartin isoform X1 [KO:K19366]
105029984  spart; spartin isoform X1 [KO:K19366]
105016386  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X3 [KO:K10591] [EC:2.3.2.26]
105006395  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
105017801  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
105025313  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
105022304  E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
105017089  E3 ubiquitin-protein ligase NRDP1-like isoform X1 [KO:K11981] [EC:2.3.2.27]
105030547  E3 ubiquitin-protein ligase Itchy isoform X1 [KO:K05632] [EC:2.3.2.26]
105022768  E3 ubiquitin-protein ligase Itchy isoform X1 [KO:K05632] [EC:2.3.2.26]
105021636  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
105009663  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
105013159  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
105031534  wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
105012136  low-density lipoprotein receptor isoform X1 [KO:K12473]
105013183  ldlr; low-density lipoprotein receptor [KO:K12473]
105010796  uncharacterized protein LOC105010796 isoform X1 [KO:K12474]
105031479  uncharacterized protein LOC105031479 [KO:K12474]
105015824  ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
105028631  low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
105030235  low density lipoprotein receptor adapter protein 1-A-like isoform X1 [KO:K12474]
114839978  low density lipoprotein receptor adapter protein 1-A-like [KO:K12474]
105029307  disabled homolog 2 isoform X1 [KO:K12475]
105029626  dab2; disabled homolog 2 isoform X1 [KO:K12475]
105023730  C-X-C chemokine receptor type 2 [KO:K05050]
105026540  C-X-C chemokine receptor type 2-like [KO:K05050]
105018736  C-X-C chemokine receptor type 1 [KO:K05050]
105021320  C-X-C chemokine receptor type 4 [KO:K04189]
105022415  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
105012608  rhodopsin kinase 1 [KO:K00909] [EC:2.7.11.14]
105024979  rhodopsin kinase 1 [KO:K00909] [EC:2.7.11.14]
105016570  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
105020061  grk1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
105029565  rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
105015221  grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
105011133  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
105015238  G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
105020825  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
105014098  G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
105027656  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
105027032  beta-arrestin-1 [KO:K04439]
105023937  arrestin red cell isoform X1 [KO:K04439]
105020146  neural Wiskott-Aldrich syndrome protein [KO:K23612]
105017184  neural Wiskott-Aldrich syndrome protein [KO:K23612]
105018628  neural Wiskott-Aldrich syndrome protein-like isoform X2 [KO:K23612]
105008543  actin-related protein 2-A [KO:K17260]
105026763  actin-related protein 2-B [KO:K17260]
105021597  actin-related protein 2-A [KO:K17260]
105016099  actr3; actin-related protein 3 [KO:K18584]
105019550  actin-related protein 3B isoform X1 [KO:K18584]
105012802  actin-related protein 2/3 complex subunit 1A-A-like [KO:K05757]
105007304  actin-related protein 2/3 complex subunit 1A [KO:K05757]
105007298  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
105023731  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
105014827  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
105017188  arpc4; actin related protein 2/3 complex, subunit 4, 20kDa [KO:K05755]
105017318  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
105006807  arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
105010147  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
105028803  actin-related protein 2/3 complex subunit 5 [KO:K05754]
105021479  WAS/WASL-interacting protein family member 2 [KO:K19475]
105020070  wipf1; WAS/WASL-interacting protein family member 1 [KO:K19475]
105013271  WAS/WASL-interacting protein family member 2 isoform X1 [KO:K19475]
105029202  heat shock 70 kDa protein [KO:K03283]
105019107  heat shock cognate 71 kDa protein [KO:K03283]
106024497  heat shock 70 kDa protein-like [KO:K03283]
105012826  heat shock 70 kDa protein [KO:K03283]
105023216  heat shock cognate 70 kDa protein [KO:K03283]
105006577  heat shock cognate 70 kDa protein-like [KO:K03283]
114840508  heat shock 70 kDa protein-like [KO:K03283]
114828708  heat shock 70 kDa protein-like [KO:K03283]
105028966  heat shock cognate 70 kDa protein [KO:K03283]
105011920  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
105018607  washc4; WASH complex subunit 4 [KO:K18465]
105023504  washc5; WASH complex subunit 5 [KO:K18464]
105010604  washc2c; WASH complex subunit 2 isoform X1 [KO:K18462]
105022212  washc1; WASH complex subunit 1 isoform X1 [KO:K18461]
105030157  washc3; WASH complex subunit 3 [KO:K18463]
105013990  F-actin-capping protein subunit alpha-1 isoform X1 [KO:K10364]
105023680  F-actin-capping protein subunit alpha-1 [KO:K10364]
105029521  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
105017119  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
105014829  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
105021335  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
105023209  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
105024202  vacuolar protein sorting-associated protein 26B-like isoform X1 [KO:K18466]
105026352  vps35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
105029271  snx12; sorting nexin-12 [KO:K17918]
105017481  snx3; sorting nexin-3 [KO:K17918]
105024666  sorting nexin-12 [KO:K17918]
105025342  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
105006510  stambp; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
105015198  ras-related protein Rab-7a-like isoform X1 [KO:K07897]
105017191  ras-related protein rab7 [KO:K07897]
105017315  ras-related protein rab7 [KO:K07897]
105029614  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X3 [KO:K12182]
105030193  stam; signal transducing adapter molecule 1 [KO:K04705]
105016119  stam2; signal transducing adapter molecule 2 [KO:K04705]
105009210  tsg101; tumor susceptibility gene 101 protein [KO:K12183]
105024006  mvb12b; multivesicular body subunit 12B isoform X2 [KO:K12186]
105007773  multivesicular body subunit 12A isoform X1 [KO:K12186]
105012594  vps28; vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
105011081  vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
105015228  vacuolar protein sorting-associated protein 37B [KO:K12185]
105021025  vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
105022895  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
105006199  vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
105007182  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
105011209  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
105021188  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
105030414  chmp6; charged multivesicular body protein 6 [KO:K12195]
105012856  charged multivesicular body protein 6-like [KO:K12195]
105026337  charged multivesicular body protein 4b [KO:K12194]
105029527  charged multivesicular body protein 4b [KO:K12194]
105029440  charged multivesicular body protein 4c [KO:K24782]
105015585  chmp3; charged multivesicular body protein 3 [KO:K12193]
105007158  chmp2a; charged multivesicular body protein 2a [KO:K12191]
105016369  charged multivesicular body protein 2b isoform X1 [KO:K12192]
105020089  charged multivesicular body protein 2b [KO:K12192]
105014028  chmp7; charged multivesicular body protein 7 [KO:K15053]
105018959  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
105018559  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
105017735  vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
105018561  chmp1a; charged multivesicular body protein 1a [KO:K12197]
105026971  chmp1b; charged multivesicular body protein 1b [KO:K12197]
105010316  charged multivesicular body protein 1b [KO:K12197]
105008242  chmp5; charged multivesicular body protein 5 [KO:K12198]
105007712  chmp5; charged multivesicular body protein 5 [KO:K12198]
105030770  ist1; IST1 homolog isoform X1 [KO:K19476]
105012523  pdcd6ip; programmed cell death 6-interacting protein isoform X3 [KO:K12200]
105014739  spg21; maspardin [KO:K19367]
105017707  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
105013784  snx1; sorting nexin-1 [KO:K17917]
105025390  snx2; sorting nexin-2 isoform X1 [KO:K17917]
105018674  sorting nexin-1 [KO:K17917]
105010075  snx5; sorting nexin-5 [KO:K17920]
105023614  snx6; sorting nexin-6 [KO:K17920]
105017003  sorting nexin-6 isoform X1 [KO:K17920]
105013575  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105016680  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105018344  hras; GTPase HRas [KO:K02833]
105009012  il2rb; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
105029657  interleukin-2 receptor subunit beta [KO:K05069]
105010007  cytokine receptor common subunit gamma isoform X1 [KO:K05070]
105024667  cytokine receptor common subunit gamma [KO:K05070]
114828756  cytokine receptor common subunit gamma-like [KO:K05070]
105016855  rhoa; ras homolog family member A [KO:K04513]
105006799  rho-related GTP-binding protein RhoA-A [KO:K04513]
105026930  rho-related GTP-binding protein RhoA-C [KO:K04513]
105023679  rho-related GTP-binding protein RhoA-D [KO:K04513]
105025252  transforming protein RhoA [KO:K04513]
105009518  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
105010034  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
105028584  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X2 [KO:K06751]
114839964  major histocompatibility complex class I-related gene protein-like [KO:K06751]
105028062  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
114839965  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
105028052  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X1 [KO:K06751]
105009516  major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751]
114828637  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
105023574  major histocompatibility complex class I-related gene protein-like [KO:K06751]
105028342  riboflavin-binding protein [KO:K13649]
105024055  folr3; folate receptor gamma [KO:K13649]
105018292  cav1; caveolin-1 isoform X2 [KO:K06278]
106024720  caveolin-2-like [KO:K12958]
105018294  cav2; caveolin-2 [KO:K12958]
105026476  caveolin-2 [KO:K12958]
114828880  caveolin-2-like [KO:K12958]
114828881  LOW QUALITY PROTEIN: caveolin-2-like [KO:K12958]
105017029  cav3; caveolin-3 [KO:K12959]
105026474  caveolin-3 [KO:K12959]
105017749  EH domain-containing protein 3 isoform X1 [KO:K12476]
105023592  EH domain-containing protein 4-like [KO:K12477]
105022143  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
105012610  ras-related protein Rab-5A [KO:K07887]
105021874  ras-related protein Rab-5A [KO:K07887]
105016952  ras-related protein Rab-5B-like [KO:K07888]
105016271  ras-related protein Rab-5B [KO:K07888]
105027630  ras-related protein Rab-5C-like [KO:K07889]
105013346  rab5c; ras-related protein Rab-5C [KO:K07889]
105011083  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
105024944  rbsn; rabenosyn-5 [KO:K12481]
105021202  rab4a; ras-related protein Rab-4A isoform X1 [KO:K07879]
105026272  RUN and FYVE domain-containing protein 1 [KO:K12482]
105021328  rufy2; RUN and FYVE domain-containing protein 2 isoform X2 [KO:K12482]
105010940  EH domain-containing protein 1 [KO:K12483]
105026715  EH domain-containing protein 1 isoform X2 [KO:K12483]
105012695  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
105023132  sorting nexin-4-like [KO:K17919]
105030835  sorting nexin-4 [KO:K17919]
105016685  rab22a; ras-related protein Rab-22A [KO:K07891]
105025295  rab31; ras-related protein Rab-31 [KO:K07891]
105018052  rab10; ras-related protein Rab-10 [KO:K07903]
105011476  rab8a; ras-related protein Rab-8A [KO:K07901]
105022474  ras-related protein Rab-8A [KO:K07901]
105014197  rab35; ras-related protein Rab-35 [KO:K07876]
105030390  ras-related protein Rab-35 [KO:K07876]
105026501  ras-related protein Rab-11A [KO:K07904]
105007892  ras-related protein Rab-11A [KO:K07904]
105031461  ras-related protein Rab-11A [KO:K07904]
105011497  ras-related protein Rab-11B-like [KO:K07905]
105011499  ras-related protein Rab-11B [KO:K07905]
105024484  ras-related protein Rab-11B isoform X1 [KO:K07905]
105015855  uncharacterized threonine-rich GPI-anchored glycoprotein PJ4664.02 isoform X1 [KO:K12484]
105014878  uncharacterized protein KIAA1211 homolog isoform X1 [KO:K12484]
105028281  uncharacterized protein LOC105028281 isoform X1 [KO:K12484]
105014253  rab11 family-interacting protein 1 isoform X1 [KO:K12484]
105026564  rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
105006854  zfyve27; protrudin isoform X1 [KO:K19368]
105024560  kinesin-1 heavy chain isoform X1 [KO:K10396]
105019408  kinesin-1 heavy chain [KO:K10396]
105026326  kinesin heavy chain isoform X2 [KO:K10396]
105022551  kinesin heavy chain [KO:K10396]
105016244  kinesin heavy chain [KO:K10396]
105007363  kif5a; kinesin heavy chain isoform X1 [KO:K10396]
105012258  rab11 family-interacting protein 4B isoform X1 [KO:K12485]
105021268  rab11fip3; rab11 family-interacting protein 3 isoform X2 [KO:K12485]
105031642  rab11 family-interacting protein 4A isoform X1 [KO:K12485]
105019433  partitioning defective 3 homolog isoform X1 [KO:K04237]
105017776  partitioning defective 3 homolog isoform X1 [KO:K04237]
105012742  pard6g; partitioning defective 6 homolog gamma [KO:K06093]
105006217  partitioning defective 6 homolog gamma-like isoform X1 [KO:K06093]
105013754  pard6b; partitioning defective 6 homolog beta [KO:K06093]
105018449  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
105023788  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
105022740  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
105013744  cdc42; uncharacterized protein LOC105013744 [KO:K04393]
105029961  cell division control protein 42 homolog [KO:K04393]
105025850  cell division control protein 42 homolog [KO:K04393]
105025458  cell division control protein 42 homolog isoform X1 [KO:K04393]
105012243  stromal membrane-associated protein 1 [KO:K12486]
105010637  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
105012363  stromal membrane-associated protein 2 [KO:K12486]
105024092  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
105014444  git2; ARF GTPase-activating protein GIT2 isoform X3 [KO:K12487]
105027056  ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
105005697  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
105006543  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
105019382  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
105024511  asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
105026581  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
105006207  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
105013664  acap3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X3 [KO:K12489]
105029825  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K12489]
105020631  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
105025348  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
105029110  arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
105024637  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
105025986  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
105020781  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
105007474  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
105023125  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X6 [KO:K12491]
105019589  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
105013611  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K17848]
105017076  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
105020406  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
105025326  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
105006897  PH and SEC7 domain-containing protein 1 isoform X1 [KO:K12494]
105010700  uncharacterized protein LOC105010700 isoform X1 [KO:K12494]
105015028  uncharacterized protein LOC105015028 [KO:K12494]
105021728  PH and SEC7 domain-containing protein 2 isoform X2 [KO:K12494]
105026743  PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
105013163  IQ motif and SEC7 domain-containing protein 1 isoform X4 [KO:K12495]
105022235  IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
105020425  iqsec3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
105022406  IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
105029144  IQ motif and SEC7 domain-containing protein 1 isoform X2 [KO:K12495]
105013053  cytohesin-1 isoform X1 [KO:K18441]
105018993  cyth2; cytohesin-2 [KO:K18441]
105021321  cytohesin-1 isoform X3 [KO:K18441]
105031186  cytohesin-2 isoform X1 [KO:K18441]
105026136  cytohesin-3 [KO:K18441]
105031472  cyth3; cytohesin-3 [KO:K18441]
105022953  cytohesin-3 [KO:K18441]
105013755  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
105019582  brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X3 [KO:K18442]
105018391  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
105010729  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
105007649  ADP-ribosylation factor 1 [KO:K07937]
105013206  ADP-ribosylation factor 2 [KO:K07937]
105019712  arf1; ADP-ribosylation factor 1 [KO:K07937]
105013557  arf3; ADP-ribosylation factor 3 [KO:K07938]
105013246  arf4; ADP-ribosylation factor 4 [KO:K07939]
105020167  ADP-ribosylation factor 4 [KO:K07939]
105028709  ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
els04060  Cytokine-cytokine receptor interaction
els04070  Phosphatidylinositol signaling system
els04130  SNARE interactions in vesicular transport
els04142  Lysosome
els04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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