KEGG   PATHWAY: gaf04540
Entry
gaf04540                    Pathway                                
Name
Gap junction - Gambusia affinis (western mosquitofish)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
gaf04540  Gap junction
gaf04540

Other DBs
GO: 0005921
Organism
Gambusia affinis (western mosquitofish) [GN:gaf]
Gene
122819404  [KO:K07374]
122819588  lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
122819930  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 isoform X1 [KO:K04157]
122820302  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
122821288  csnk1da; casein kinase I [KO:K08959] [EC:2.7.11.1]
122821683  [KO:K08049] [EC:4.6.1.1]
122821901  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
122821906  [KO:K07375]
122821961  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122821978  tjp1a; tight junction protein ZO-1 isoform X1 [KO:K05701]
122822113  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
122822281  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122822359  zgc:55558; GTPase KRas [KO:K07827]
122822550  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
122822576  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122823102  adrb1; beta-1 adrenergic receptor [KO:K04141]
122823578  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
122824379  [KO:K04361] [EC:2.7.10.1]
122824859  gja1b; gap junction alpha-1 protein [KO:K07372]
122825001  [KO:K05858] [EC:3.1.4.11]
122825010  [KO:K05858] [EC:3.1.4.11]
122825037  [KO:K08043] [EC:4.6.1.1]
122825208  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
122825293  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122825526  prkg3; cGMP-dependent protein kinase 1 [KO:K19477] [EC:2.7.11.12]
122825690  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
122826038  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
122826942  map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
122826954  [KO:K07374]
122826983  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
122827376  [KO:K07374]
122827714  [KO:K07375]
122828197  [KO:K04634]
122828371  [KO:K07375]
122828661  prkg2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
122828763  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122829319  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
122829343  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
122829426  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
122829427  gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
122829694  [KO:K07375]
122829699  [KO:K04345] [EC:2.7.11.11]
122829859  [KO:K19662] [EC:2.7.11.13]
122829977  [KO:K03099]
122830142  [KO:K04359]
122830175  [KO:K04144]
122830307  si:ch211-79m20.1; bromodomain-containing protein DDB_G0280777 isoform X1 [KO:K17386]
122830524  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
122830732  drd2l; dopamine receptor D2 like isoform X1 [KO:K04145]
122830827  gnai3; guanine nucleotide-binding protein G(i) subunit alpha isoform X1 [KO:K04630]
122830972  tubb5; tubulin beta-5 chain [KO:K07375]
122831106  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
122831188  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
122832246  [KO:K07373]
122832630  grm5b; metabotropic glutamate receptor 5b [KO:K04604]
122832669  [KO:K07375]
122832670  [KO:K07375]
122832687  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
122832700  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
122832939  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
122833202  drd2a; dopamine receptor D2a isoform X1 [KO:K04145]
122833419  [KO:K05704] [EC:2.7.10.2]
122833599  gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630]
122833721  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122833870  [KO:K04958]
122833939  [KO:K07374]
122833968  tubb1; tubulin beta-1 chain [KO:K07375]
122833970  [KO:K04632]
122834380  [KO:K07375]
122834681  [KO:K04630]
122834903  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
122834977  tjp1b; tight junction protein ZO-1 isoform X1 [KO:K05701]
122835026  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122835154  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
122835445  [KO:K04145]
122835505  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
122835662  [KO:K07374]
122835670  tuba1c; tubulin alpha-1C chain [KO:K07374]
122835677  [KO:K07374]
122835992  [KO:K04630]
122836263  kras; GTPase KRas isoform X1 [KO:K07827]
122837108  pdgfc; platelet-derived growth factor C [KO:K05450]
122837113  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
122837534  [KO:K04144]
122837578  [KO:K08046] [EC:4.6.1.1]
122837604  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122838005  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
122838016  [KO:K08041] [EC:4.6.1.1]
122838694  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
122838713  tuba5; tubulin alpha 5 [KO:K07374]
122838723  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
122838816  [KO:K04635]
122838832  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
122838885  [KO:K07374]
122839029  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
122839097  [KO:K08046] [EC:4.6.1.1]
122839106  [KO:K07374]
122839130  [KO:K07374]
122839131  [KO:K07374]
122839132  [KO:K07374]
122840015  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
122840171  [KO:K07374]
122840191  htr2aa; 5-hydroxytryptamine receptor 2A [KO:K04157]
122840340  [KO:K07374]
122840341  [KO:K07374]
122840426  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
122841048  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122841227  [KO:K07375]
122841230  [KO:K08041] [EC:4.6.1.1]
122841257  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
122841436  [KO:K07375]
122841663  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122841676  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
122842723  [KO:K05858] [EC:3.1.4.11]
122842740  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
122842979  [KO:K07376] [EC:2.7.11.12]
122844085  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
122844282  [KO:K07375]
122844635  [KO:K07373]
122844817  [KO:K05089] [EC:2.7.10.1]
122844986  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
122845146  drd1b; dopamine receptor D1b [KO:K04144]
122845454  gjd6; gap junction protein delta 6 [KO:K07373]
122845940  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122846125  [KO:K07375]
122846253  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04635]
122846362  gjd2b; gap junction protein delta 2b [KO:K07373]
122846438  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
122846559  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
122846825  [KO:K04634]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
gaf04010  MAPK signaling pathway
gaf04020  Calcium signaling pathway
gaf04060  Cytokine-cytokine receptor interaction
gaf04070  Phosphatidylinositol signaling system
gaf04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   

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