KEGG   PATHWAY: hhv04728
Entry
hhv04728                    Pathway                                
Name
Dopaminergic synapse - Hyaena hyaena (striped hyena)
Description
Dopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning and memory, and endocrine regulation. Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. In addition, D1Rs and D2Rs modulate intracellular Ca2+ levels and a number of Ca2+ -dependent intracellular signaling processes. Through diverse cAMP- and Ca2+-dependent and - independent mechanisms, DA influences neuronal activity, synaptic plasticity, and behavior. Presynaptically localized D2Rs regulate synthesis and release of DA as the main autoreceptor of the dopaminergic system.
Class
Organismal Systems; Nervous system
Pathway map
hhv04728  Dopaminergic synapse
hhv04728

Other DBs
GO: 0001963
Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120226898  TH; tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
120234040  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
120234024  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
120235149  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
120236750  DRD1; D(1A) dopamine receptor [KO:K04144]
120242993  DRD5; D(1B) dopamine receptor [KO:K05840]
120245390  CALY; neuron-specific vesicular protein calcyon [KO:K15493]
120238451  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
120232253  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
120226357  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
120226638  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
120240178  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
120237135  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120237482  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
120238181  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
120232098  CALM1; calmodulin-1 [KO:K02183]
120237182  calmodulin-like [KO:K02183]
120237195  calmodulin-like protein 3 [KO:K02183]
120241014  CALM2; calmodulin-2 [KO:K02183]
120221982  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
120241987  CALM3; calmodulin-3 isoform X1 [KO:K02183]
120242524  CALML6; calmodulin-like protein 6 [KO:K02183]
120233726  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
120238899  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
120222252  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
120236563  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
120225617  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
120233735  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120239494  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120234190  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120233260  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120239766  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
120231952  FOS; proto-oncogene c-Fos [KO:K04379]
120234858  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
120234860  neuroendocrine secretory protein 55 [KO:K04632]
120220192  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
120237362  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
120241649  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120245321  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
120220409  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
120243894  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
120235229  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
120232978  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
120228497  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
120221289  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
120221513  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
120242085  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
120230339  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
120221927  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
120233796  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
120233829  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
120234701  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
120235253  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
120244180  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120232781  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120245677  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120229084  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
120233909  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
120239251  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
120235890  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
120243913  sodium channel protein type 1 subunit alpha [KO:K04833]
120243774  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
120239388  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
120245276  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
120222772  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
120223709  KCNJ3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
120230240  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
120241356  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
120237106  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
120226664  DRD3; D(3) dopamine receptor isoform X1 [KO:K04146]
120223421  DRD4; D(4) dopamine receptor isoform X1 [KO:K04147]
120229291  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
120244506  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
120245414  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
120232146  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
120242569  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
120223690  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
120220432  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
120246690  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
120235024  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
120247989  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
120249175  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
120241831  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
120241642  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
120244574  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
120242329  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
120237008  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
120234397  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
120220331  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
120245305  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
120241598  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
120234413  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
120229112  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
120229898  DRD2; D(2) dopamine receptor [KO:K04145]
120226697  ARRB2; beta-arrestin-2 [KO:K04439]
120229571  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
120238508  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
120223033  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
120229915  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
120222367  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
120244090  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
120221673  uncharacterized protein LOC120221673 [KO:K04354]
120231861  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
120245371  PPP2R2D; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
120248361  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
120240557  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
120248228  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
120248601  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
120238408  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
120240155  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
120230498  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
120231211  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
120244579  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
120235277  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120244696  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120247774  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120240891  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
120242922  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120239836  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
120236891  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
120226547  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
120248504  GRIA2; glutamate receptor 2 [KO:K05198]
120236181  GRIA3; glutamate receptor 3 [KO:K05199]
120244229  GRIA4; glutamate receptor 4 [KO:K05200]
120240008  KIF5C; kinesin heavy chain [KO:K10396]
120242748  KIF5B; kinesin-1 heavy chain [KO:K10396]
120248003  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
120243027  CLOCK; circadian locomoter output cycles protein kaput isoform X1 [KO:K02223] [EC:2.3.1.48]
120237519  ARNTL; aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1 [KO:K02296]
120235641  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
120245055  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
120245059  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
120238857  COMT; catechol O-methyltransferase [KO:K00545] [EC:2.1.1.6]
120245113  transmembrane O-methyltransferase [KO:K00545] [EC:2.1.1.6]
Compound
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00238  Potassium cation
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C01161  3,4-Dihydroxyphenylacetate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C03758  Dopamine
C05582  Homovanillate
C05587  3-Methoxytyramine
Reference
PMID:21303898
  Authors
Beaulieu JM, Gainetdinov RR
  Title
The physiology, signaling, and pharmacology of dopamine receptors.
  Journal
Pharmacol Rev 63:182-217 (2011)
DOI:10.1124/pr.110.002642
Reference
PMID:15521361
  Authors
Neve KA, Seamans JK, Trantham-Davidson H
  Title
Dopamine receptor signaling.
  Journal
J Recept Signal Transduct Res 24:165-205 (2004)
DOI:10.1081/RRS-200029981
Reference
PMID:17408758
  Authors
Surmeier DJ, Ding J, Day M, Wang Z, Shen W
  Title
D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.
  Journal
Trends Neurosci 30:228-35 (2007)
DOI:10.1016/j.tins.2007.03.008
Reference
PMID:20224735
  Authors
Knab AM, Lightfoot JT
  Title
Does the difference between physically active and couch potato lie in the dopamine system?
  Journal
Int J Biol Sci 6:133-50 (2010)
DOI:10.7150/ijbs.6.133
Reference
PMID:10433257
  Authors
Greengard P, Allen PB, Nairn AC
  Title
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.
  Journal
Neuron 23:435-47 (1999)
DOI:10.1016/S0896-6273(00)80798-9
Reference
PMID:15590733
  Authors
Hu XT, Dong Y, Zhang XF, White FJ
  Title
Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons.
  Journal
J Neurophysiol 93:1406-17 (2005)
DOI:10.1152/jn.00771.2004
Reference
PMID:17349698
  Authors
Beaulieu JM, Gainetdinov RR, Caron MG
  Title
The Akt-GSK-3 signaling cascade in the actions of dopamine.
  Journal
Trends Pharmacol Sci 28:166-72 (2007)
DOI:10.1016/j.tips.2007.02.006
Reference
PMID:19138563
  Authors
De Mei C, Ramos M, Iitaka C, Borrelli E
  Title
Getting specialized: presynaptic and postsynaptic dopamine D2 receptors.
  Journal
Curr Opin Pharmacol 9:53-8 (2009)
DOI:10.1016/j.coph.2008.12.002
Reference
PMID:15381316
  Authors
Seamans JK, Yang CR
  Title
The principal features and mechanisms of dopamine modulation in the prefrontal cortex.
  Journal
Prog Neurobiol 74:1-58 (2004)
DOI:10.1016/j.pneurobio.2004.05.006
Reference
PMID:18353279
  Authors
Yao WD, Spealman RD, Zhang J
  Title
Dopaminergic signaling in dendritic spines.
  Journal
Biochem Pharmacol 75:2055-69 (2008)
DOI:10.1016/j.bcp.2008.01.018
Reference
PMID:20727368
  Authors
Li YC, Gao WJ
  Title
GSK-3beta activity and hyperdopamine-dependent behaviors.
  Journal
Neurosci Biobehav Rev 35:645-54 (2011)
DOI:10.1016/j.neubiorev.2010.08.001
Reference
PMID:15292232
  Authors
Tang TS, Bezprozvanny I
  Title
Dopamine receptor-mediated Ca(2+) signaling in striatal medium spiny neurons.
  Journal
J Biol Chem 279:42082-94 (2004)
DOI:10.1074/jbc.M407389200
Reference
PMID:12967774
  Authors
Bergson C, Levenson R, Goldman-Rakic PS, Lidow MS
  Title
Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
  Journal
Trends Pharmacol Sci 24:486-92 (2003)
DOI:10.1016/S0165-6147(03)00232-3
Reference
PMID:9457173
  Authors
Missale C, Nash SR, Robinson SW, Jaber M, Caron MG
  Title
Dopamine receptors: from structure to function.
  Journal
Physiol Rev 78:189-225 (1998)
DOI:10.1152/physrev.1998.78.1.189
Reference
PMID:19251795
  Authors
Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ
  Title
Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?
  Journal
Eur Respir J 33:468-80 (2009)
DOI:10.1183/09031936.00056908
Related
pathway
hhv00350  Tyrosine metabolism
hhv04020  Calcium signaling pathway
hhv04721  Synaptic vesicle cycle
hhv04724  Glutamatergic synapse
hhv05012  Parkinson disease
KO pathway
ko04728   
LinkDB

DBGET integrated database retrieval system