KEGG   PATHWAY: hrt00230
Entry
hrt00230                    Pathway                                
Name
Purine metabolism - Hirundo rustica (Barn swallow)
Class
Metabolism; Nucleotide metabolism
Pathway map
hrt00230  Purine metabolism
hrt00230

Module
hrt_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:hrt00230]
hrt_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:hrt00230]
hrt_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:hrt00230]
hrt_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:hrt00230]
hrt_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:hrt00230]
hrt_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:hrt00230]
Other DBs
GO: 0006163 0042278
Organism
Hirundo rustica (Barn swallow) [GN:hrt]
Gene
120753034  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
120760956  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
120751622  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
120756770  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
120753419  PGM2; phosphopentomutase [KO:K15779] [EC:5.4.2.2 5.4.2.7]
120748579  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
120762001  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
120752709  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
120748479  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
120748480  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
120752708  PAICS; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
120751401  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
120755187  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
120757740  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
120763212  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
120763991  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
120759856  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
120754769  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
120761089  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [KO:K01081] [EC:3.1.3.5]
120755633  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
120750242  NT5C1B; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
120750821  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
120757947  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
120748024  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
120748753  LACC1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
120764925  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
120765296  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
120757951  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
120758451  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
120752430  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
120759566  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
120759567  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
120765932  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
120760902  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
120760903  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
120749825  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
120757238  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
120755876  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
120761803  LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
120761830  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
120761874  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
120760967  CANT1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
120747936  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X2 [KO:K12305] [EC:3.6.1.6]
120754425  ENTPD5; nucleoside diphosphate phosphatase ENTPD5 isoform X1 [KO:K01511] [EC:3.6.1.6]
120751300  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
120756426  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
120750839  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120765751  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1 [KO:K01518] [EC:3.6.1.17]
120757177  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
120756922  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
120765894  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
120763005  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
120747859  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
120750270  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
120756553  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
120750977  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
120764026  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
120752885  DCK; deoxycytidine kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
120759179  deoxycytidine kinase 2 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
120758831  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
120764215  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
120758617  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
120758559  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
120754848  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120764420  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
120757744  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
120751558  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120759456  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
120753479  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
120748529  GUCY1A2; LOW QUALITY PROTEIN: guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
120757399  guanylate cyclase soluble subunit beta-2-like isoform X1 [KO:K12319] [EC:4.6.1.2]
120753480  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
120751674  GUCY2C; guanylyl cyclase C [KO:K12320] [EC:4.6.1.2]
120748605  retinal guanylyl cyclase 2-like [KO:K12322] [EC:4.6.1.2]
120764173  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
120765621  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
120761860  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
120755495  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755] [EC:3.1.4.17]
120748540  PDE2A; LOW QUALITY PROTEIN: cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
120751793  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
120754372  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
120752595  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
120765877  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
120755952  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
120756945  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
120760938  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
120751813  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
120748664  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
120749851  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
120755015  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
120753932  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
120750160  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X2 [KO:K01939] [EC:6.3.4.4]
120753703  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
120762840  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
120762931  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
120755553  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
120760316  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
120751831  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
120763026  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
120754063  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
120761818  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
120761857  AK8; adenylate kinase 8 isoform X3 [KO:K00939] [EC:2.7.4.3]
120756635  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
120756819  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
120765411  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
120765647  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
120761809  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
120751323  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
120751063  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120751062  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120763370  cAMP-specific 3',5'-cyclic phosphodiesterase 4C-like isoform X1 [KO:K13293] [EC:3.1.4.53]
120764716  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
120765143  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
120756359  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
120749843  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
120747559  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
120758682  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
120765026  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
120758491  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
120750921  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
120752987  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120756076  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120756556  uricase-like [KO:K00365] [EC:1.7.3.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
hrt00030  Pentose phosphate pathway
hrt00220  Arginine biosynthesis
hrt00250  Alanine, aspartate and glutamate metabolism
hrt00260  Glycine, serine and threonine metabolism
hrt00340  Histidine metabolism
hrt00630  Glyoxylate and dicarboxylate metabolism
hrt00730  Thiamine metabolism
hrt00740  Riboflavin metabolism
hrt00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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