Entry Name Serotonergic synapse
Description Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class Organismal Systems; Nervous systemBRITE hierarchy
Pathway map Ortholog table Other DBs Orthology K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
K04850 voltage-dependent calcium channel L type alpha-1C
K04851 voltage-dependent calcium channel L type alpha-1D
K04853 voltage-dependent calcium channel L type alpha-1F
K04857 voltage-dependent calcium channel L type alpha-1S
K04157 5-hydroxytryptamine receptor 2
K04634 guanine nucleotide-binding protein G(q) subunit alpha
K04958 inositol 1,4,5-triphosphate receptor type 1
K04959 inositol 1,4,5-triphosphate receptor type 2
K04960 inositol 1,4,5-triphosphate receptor type 3
K08021 arachidonate 12-lipoxygenase (R-type) [EC:1.13.11.-]
K08022 arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type) [EC:1.13.11.33 1.13.11.-]
K04819 5-hydroxytryptamine receptor 3
K04160 5-hydroxytryptamine receptor 4
K04162 5-hydroxytryptamine receptor 6
K04163 5-hydroxytryptamine receptor 7
K04632 guanine nucleotide-binding protein G(s) subunit alpha
K04943 potassium intermediate/small conductance calcium-activated channel subfamily N member 2
K04892 potassium voltage-gated channel Shal-related subfamily D member 2
K05181 gamma-aminobutyric acid receptor subunit beta
K08014 Rap guanine nucleotide exchange factor 3
K04520 amyloid beta A4 protein
K04153 5-hydroxytryptamine receptor 1
K04161 5-hydroxytryptamine receptor 5
K04630 guanine nucleotide-binding protein G(i) subunit alpha
K04534 guanine nucleotide-binding protein G(o) subunit alpha
K04536 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
K04537 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
K07825 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
K04538 guanine nucleotide-binding protein subunit beta-4
K04539 guanine nucleotide-binding protein subunit beta-5
K07826 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
K04540 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
K04541 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
K04542 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
K04543 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
K04544 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
K04545 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
K04546 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
K04347 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
K04547 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
K04548 guanine nucleotide-binding protein G(T) subunit gamma-T1
K04549 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
K08845 A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04365 B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04366 RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04344 voltage-dependent calcium channel P/Q type alpha-1A
K04849 voltage-dependent calcium channel N type alpha-1B
K04997 potassium inwardly-rectifying channel subfamily J member 3
K05000 potassium inwardly-rectifying channel subfamily J member 6
K05002 potassium inwardly-rectifying channel subfamily J member 9
K04999 potassium inwardly-rectifying channel subfamily J member 5
K04964 transient receptor potential cation channel subfamily C member 1
K05037 solute carrier family 6 (neurotransmitter transporter, serotonin) member 4
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05964 11-Dehydro-thromboxane B2
Reference Authors Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
Title Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
Journal Reference Authors Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
Title Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
Journal Reference Authors Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
Title Multiplicity of mechanisms of serotonin receptor signal transduction.
Journal Reference Authors Noda M, Higashida H, Aoki S, Wada K
Title Multiple signal transduction pathways mediated by 5-HT receptors.
Journal Reference Authors Daubert EA, Condron BG
Title Serotonin: a regulator of neuronal morphology and circuitry.
Journal Reference Authors Chameau P, van Hooft JA
Title Serotonin 5-HT(3) receptors in the central nervous system.
Journal Reference Authors Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
Title Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
Journal Reference Authors Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
Title Epoxyeicosanoid signaling in CNS function and disease.
Journal Reference Authors Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
Title The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
Journal Reference Authors Albert PR, Tiberi M
Title Receptor signaling and structure: insights from serotonin-1 receptors.
Journal Reference Authors Durham PL, Russo AF
Title Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
Journal Reference Authors Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
Title Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
Journal Reference Authors Lezoualc'h F, Robert SJ
Title The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
Journal Reference Authors Durham PL, Russo AF
Title Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
Journal Reference Authors Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
Title Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
Journal Reference Authors Nestler EJ, Hyman SE, Malenka RC.
Title Molecular neuropharmacology: A foundation for clinical neuroscience
Journal The McGraw-Hill Companies, Inc. (2001)
Related ko00590 Arachidonic acid metabolism
LinkDB All DBs
