KEGG   PATHWAY: manu04144
Entry
manu04144                   Pathway                                
Name
Endocytosis - Misgurnus anguillicaudatus (oriental weatherfish)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
manu04144  Endocytosis
manu04144

Other DBs
GO: 0006897
Organism
Misgurnus anguillicaudatus (oriental weatherfish) [GN:manu]
Gene
129417595  arf6b; ADP-ribosylation factor 6b [KO:K07941]
129428971  arf6a; ADP-ribosylation factor 6a [KO:K07941]
129414633  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
129443214  pip5k1cb; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b isoform X1 [KO:K00889] [EC:2.7.1.68]
129453762  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
129455425  pip5k1aa; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a isoform X1 [KO:K00889] [EC:2.7.1.68]
129447375  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a [KO:K00889] [EC:2.7.1.68]
129447760  pip5k1ab; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
129414130  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
129440237  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
129440446  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
129442237  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
129426114  pld1b; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
129440981  dnm1b; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
129441446  dnm3b; dynamin-3 [KO:K01528] [EC:3.6.5.5]
129439576  dnm1a; dynamin-1a [KO:K01528] [EC:3.6.5.5]
129445303  dnm2b; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
129429611  dnm2a; dynamin-3 isoform X1 [KO:K23484] [EC:3.6.5.5]
129444856  clta; clathrin light chain A isoform X1 [KO:K04644]
129422309  cltb; clathrin light chain B isoform X1 [KO:K04645]
129413722  cltcl1; clathrin heavy chain 1 isoform X1 [KO:K04646]
129437867  cltcb; clathrin, heavy chain b (Hc) isoform X1 [KO:K04646]
129446889  cltca; clathrin, heavy chain a (Hc) [KO:K04646]
129436055  ap2a1; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
129440891  ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
129442725  ap2m1a; AP-2 complex subunit mu-A [KO:K11826]
129419291  ap2m1b; AP-2 complex subunit mu-B [KO:K11826]
129437710  ap2s1; AP-2 complex subunit sigma [KO:K11827]
129419863  ehd2b; EH domain-containing protein 2b [KO:K12469]
129442288  tgfbr1a; TGF-beta receptor type-1a [KO:K04674] [EC:2.7.11.30]
129425572  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
129451707  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
129448464  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
129442459  zfyve9a; LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 9 [KO:K04679]
129446432  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
129428226  zfyve9b; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
129447399  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
129444055  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
129419215  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
129442563  tfr1a; transferrin receptor 1a [KO:K06503]
129425533  tfr1b; transferrin receptor 1b [KO:K06503]
129442582  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
129426034  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
129428961  pdgfra; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
129415896  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129423828  fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
129418564  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129420648  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
129437995  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
129448038  cblc; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
129425554  sh3kbp1; SH3 domain-containing kinase-binding protein 1 [KO:K12470]
129431120  sh3gl2b; SH3 domain containing GRB2 like 2b, endophilin A1 [KO:K11247]
129441645  sh3gl1a; SH3-domain GRB2-like 1a [KO:K11247]
129414003  sh3gl1b; SH3-domain GRB2-like 1b isoform X1 [KO:K11247]
129433810  sh3gl3b; endophilin-A3b isoform X1 [KO:K11247]
129425841  sh3gl3a; endophilin-A3a isoform X1 [KO:K11247]
129444560  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 isoform X1 [KO:K11247]
129442410  sh3glb1b; endophilin-B1b isoform X1 [KO:K11248]
129442426  endophilin-B1-like isoform X1 [KO:K11248]
129425494  sh3glb1a; endophilin-B1a isoform X1 [KO:K11248]
129414131  sh3glb2a; endophilin-B2a isoform X1 [KO:K21269]
129440238  sh3glb2b; endophilin-B2b isoform X1 [KO:K21269]
129442071  amph; amphiphysin isoform X1 [KO:K12562]
129451090  bin1b; myc box-dependent-interacting protein 1b isoform X1 [KO:K12562]
129452222  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
129432935  epn2; epsin-2 isoform X1 [KO:K12471]
129443839  epn3b; epsin-3 [KO:K12471]
129455702  epn1b; epsin-1 isoform X1 [KO:K12471]
129429262  epn3a; epsin-3 isoform X1 [KO:K12471]
129447855  epn1a; epsin-1 isoform X1 [KO:K12471]
129413713  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
129443056  eps15l1b; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
129453196  eps15l1a; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
129446784  sparta; spartin a isoform X1 [KO:K19366]
129438279  spartb; spartin b isoform X1 [KO:K19366]
129419775  nedd4a; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
129423156  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
129431747  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
129447218  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
129430822  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
129431044  itchb; itchy E3 ubiquitin protein ligase b isoform X1 [KO:K05632] [EC:2.3.2.26]
129450320  itcha; itchy E3 ubiquitin protein ligase a [KO:K05632] [EC:2.3.2.26]
129432635  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
129436484  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
129426374  NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
129436506  ldlra; low density lipoprotein receptor a [KO:K12473]
129416113  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
129455018  ldlrap1a; low density lipoprotein receptor adapter protein 1a isoform X1 [KO:K12474]
129429020  si:dkey-71h2.2; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
129440624  si:ch211-204c21.1; LOW QUALITY PROTEIN: disabled homolog 2 [KO:K12475]
129440266  dab2; disabled homolog 2 isoform X1 [KO:K12475]
129449094  C-C chemokine receptor type 5-like [KO:K04180]
129422644  C-C chemokine receptor type 5-like [KO:K04180]
129422645  C-C chemokine receptor type 2-like [KO:K04180]
129447719  C-C chemokine receptor type 5-like [KO:K04180]
129447720  C-C chemokine receptor type 5-like [KO:K04180]
129447721  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
129447727  C-C chemokine receptor type 5-like [KO:K04180]
129451961  C-X-C chemokine receptor type 1-like [KO:K05050]
129452157  C-X-C chemokine receptor type 1-like [KO:K05050]
129452240  C-X-C chemokine receptor type 1-like [KO:K05050]
129452251  C-X-C chemokine receptor type 1-like [KO:K05050]
129452252  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
129450184  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
129452158  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
129441190  grk1b; rhodopsin kinase GRK1b [KO:K00909] [EC:2.7.11.14]
129442422  rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
129442436  grk7a; rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
129445156  grk1a; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
129446520  grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
129414876  grk5l; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
129423655  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
129444872  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
129446419  grk5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
129441072  arrb2b; arrestin, beta 2b [KO:K04439]
129437477  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
129447037  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
129432427  actin nucleation-promoting factor WASL-like isoform X1 [KO:K23612]
129434336  wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612]
129415944  actr2b; actin-related protein 2-B [KO:K17260]
129444078  actr2a; actin-related protein 2-A [KO:K17260]
129437174  zgc:101810; actin-related protein 2-B [KO:K17260]
129451909  actr3; actin-related protein 3 [KO:K18584]
129432616  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
129432623  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
129434014  zgc:86896; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-B [KO:K05757]
129451848  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
129423509  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
129450546  arpc4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
129428152  arpc4l; actin related protein 2/3 complex, subunit 4, like [KO:K05755]
129442369  arpc5a; actin-related protein 2/3 complex subunit 5a [KO:K05754]
129414749  arpc5la; actin related protein 2/3 complex, subunit 5-like, a [KO:K05754]
129429880  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
129440249  arpc5lb; actin related protein 2/3 complex, subunit 5-like, b [KO:K05754]
129451134  wipf1b; WAS/WASL-interacting protein family member 1 [KO:K19475]
129451992  wipf1a; WAS/WASL-interacting protein family member 1a isoform X1 [KO:K19475]
129454854  wipf3; WAS/WASL-interacting protein family member 3 [KO:K19475]
129428140  wipf2a; WAS/WASL-interacting protein family member 2 [KO:K19475]
129455419  wipf2b; WAS/WASL-interacting protein family member 2b [KO:K19475]
129413983  hspa1b; heat shock 70 kDa protein-like [KO:K03283]
129436229  heat shock 70 kDa protein-like [KO:K03283]
129436230  heat shock 70 kDa protein-like isoform X1 [KO:K03283]
129436231  heat shock 70 kDa protein [KO:K03283]
129436311  heat shock 70 kDa protein-like [KO:K03283]
129437905  hspa8b; heat shock protein family A (Hsp70) member 8b isoform X1 [KO:K03283]
129446869  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
129438436  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
129450112  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
129433119  washc4; WASH complex subunit 4 [KO:K18465]
129448584  washc5; WASH complex subunit 5 [KO:K18464]
129415494  washc2c; WASH complex subunit 2 isoform X1 [KO:K18462]
129418905  wash1; WASH complex subunit 1 [KO:K18461]
129432201  washc3; WASH complex subunit 3 [KO:K18463]
129413805  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
129450780  capza1a; F-actin-capping protein subunit alpha-1a [KO:K10364]
129453245  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
129423508  vps29; vacuolar protein sorting-associated protein 29 [KO:K18467]
129416301  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
129437899  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
129446847  vps26bl; vacuolar protein sorting-associated protein 26B-like [KO:K18466]
129446489  vps35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
129423582  snx12; sorting nexin-12 isoform X1 [KO:K17918]
129429345  snx3; sorting nexin-3 [KO:K17918]
129419221  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
129413941  stambpb; STAM binding protein b isoform X1 [KO:K11866] [EC:3.4.19.12]
129446572  stambpa; STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
129413809  rab7b; ras-related protein Rab-7b [KO:K07897]
129427062  rab7a; ras-related protein Rab-7a [KO:K07897]
129446553  zgc:100918; ras-related protein rab7-like [KO:K07897]
129429224  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
129451618  stam2; signal transducing adapter molecule 2 [KO:K04705]
129434002  tsg101a; tumor susceptibility 101a [KO:K12183]
129447440  tsg101b; tumor susceptibility gene 101 protein [KO:K12183]
129414293  mvb12bb; multivesicular body subunit 12Bb isoform X1 [KO:K12186]
129443808  mvb12a; multivesicular body subunit 12A [KO:K12186]
129439485  mvb12ba; multivesicular body subunit 12Ba isoform X1 [KO:K12186]
129455294  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
129440937  vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
129444307  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
129444802  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
129446476  vps37bb; VPS37B subunit of ESCRT-I b [KO:K12185]
129437790  vacuolar protein sorting-associated protein 37B-like isoform X1 [KO:K12185]
129440113  vps37ba; VPS37B subunit of ESCRT-I a [KO:K12185]
129420383  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
129446988  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
129420359  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
129420610  chmp6b; charged multivesicular body protein 6 [KO:K12195]
129450269  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
129413551  chmp4bb; charged multivesicular body protein 4c [KO:K12194]
129425639  charged multivesicular body protein 4c-like [KO:K24782]
129426092  chmp4c; charged multivesicular body protein 4c [KO:K24782]
129417133  chmp3; charged multivesicular body protein 3 [KO:K12193]
129421285  chmp2a; charged multivesicular body protein 2a [KO:K12191]
129452041  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
129444489  chmp2bb; charged multivesicular body protein 2b [KO:K12192]
129413864  chmp7; charged multivesicular body protein 7 [KO:K15053]
129433126  vps4a; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
129442739  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
129454321  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
129429670  vta1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
129429743  vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
129434275  chmp1a; charged multivesicular body protein 1a [KO:K12197]
129439957  chmp1b; charged multivesicular body protein 1b [KO:K12197]
129442121  chmp5a; charged multivesicular body protein 5 [KO:K12198]
129453121  chmp5b; charged multivesicular body protein 5 [KO:K12198]
129452487  ist1; IST1 homolog [KO:K19476]
129455145  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
129427441  spg21; maspardin [KO:K19367]
129429152  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
129414346  snx2; sorting nexin-2 isoform X1 [KO:K17917]
129433796  snx1a; sorting nexin-1a [KO:K17917]
129445575  snx1b; sorting nexin-1 isoform X1 [KO:K17917]
129450543  si:dkey-28n18.9; uncharacterized protein si:dkey-28n18.9 [KO:K17920]
129415812  snx5; sorting nexin-5 [KO:K17920]
129417512  snx6; sorting nexin-6 [KO:K17920]
129430577  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
129434004  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
129447448  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
129436470  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
129422472  il2rgb; interleukin 2 receptor, gamma b [KO:K05070]
129446805  il2rga; interleukin 2 receptor, gamma a [KO:K05070]
129431475  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
129450350  rhoca; ras homolog family member Ca [KO:K04513]
129413969  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
129413970  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
129414387  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
129453223  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
129454452  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
129427764  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
129454623  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129455412  major histocompatibility complex class I-related gene protein isoform X1 [KO:K06751]
129455638  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
129447692  zinc-alpha-2-glycoprotein-like [KO:K06751]
129436800  rtbdn; retbindin [KO:K13649]
129438759  folr; folate receptor [KO:K13649]
129433141  cav1; caveolin-1 [KO:K06278]
129431082  cav4b; caveolin-2 [KO:K12958]
129434128  cav2; caveolin-2 [KO:K12958]
129427754  cav4a; caveolin-2 [KO:K12958]
129450613  cav3; caveolin-3 [KO:K12959]
129429447  ehd3; EH domain-containing protein 3 [KO:K12476]
129416902  ehd4; EH domain-containing protein 4 [KO:K12477]
129419030  eea1; early endosome antigen 1 [KO:K12478]
129455445  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
129448779  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
129451602  rab5b; ras-related protein Rab-5B [KO:K07888]
129436244  rab5c; ras-related protein Rab-5C [KO:K07889]
129440939  rabep1; rab GTPase-binding effector protein 1 [KO:K12480]
129414152  rabenosyn-5 [KO:K12481]
129415770  rab4a; ras-related protein Rab-4A [KO:K07879]
129422039  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
129416813  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
129422538  ehd1a; EH domain-containing protein 1a [KO:K12483]
129446907  ehd1b; LOW QUALITY PROTEIN: EH domain-containing protein 1b [KO:K12483]
129455235  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
129451708  snx4; sorting nexin-4 [KO:K17919]
129449986  rab22a; ras-related protein Rab-22A [KO:K07891]
129443152  rab31; ras-related protein Rab-31 [KO:K07891]
129429444  rab10; ras-related protein Rab-10 [KO:K07903]
129443182  rab8a; ras-related protein Rab-8A [KO:K07901]
129413721  rab35b; ras-related protein Rab-35b [KO:K07876]
129436034  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
129439561  rab35a; ras-related protein Rab-35 [KO:K07876]
129419152  rab11a; ras-related protein Rab-11A [KO:K07904]
129448712  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
129443229  rab11bb; RAB11B, member RAS oncogene family, b [KO:K07905]
129453765  rab11ba; RAB11B, member RAS oncogene family, a [KO:K07905]
129422404  uncharacterized protein LOC129422404 [KO:K12484]
129413388  rab11fip1a; rab11 family-interacting protein 1 [KO:K12484]
129416764  rab11 family-interacting protein 2 [KO:K12484]
129416826  rab11fip5a; uncharacterized protein rab11fip5a isoform X1 [KO:K12484]
129446593  rab11fip1b; titin homolog isoform X1 [KO:K12484]
129443939  zfyve27; protrudin isoform X1 [KO:K19368]
129450900  kif5ab; kinesin heavy chain [KO:K10396]
129442971  kif5ba; kinesin-1 heavy chain isoform X1 [KO:K10396]
129452005  kif5c; kinesin heavy chain [KO:K10396]
129452044  kif5aa; kinesin family member 5Aa [KO:K10396]
129420990  kif5bb; kinesin-1 heavy chain isoform X1 [KO:K10396]
129434096  rab11fip4a; rab11 family-interacting protein 4A [KO:K12485]
129425933  rab11fip3; LOW QUALITY PROTEIN: rab11 family-interacting protein 3 [KO:K12485]
129442954  pard3ab; par-3 family cell polarity regulator alpha, b isoform X1 [KO:K04237]
129426443  pard3aa; partitioning defective 3 homolog isoform X1 [KO:K04237]
129430821  pard6b; partitioning defective 6 homolog beta [KO:K06093]
129418894  pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
129455393  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
129448022  pard6ga; par-6 family cell polarity regulator gamma a [KO:K06093]
129413470  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
129441888  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
129427500  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
129430245  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
129448204  cdc42l; cell division cycle 42, like [KO:K04393]
129415442  smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
129455198  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
129438129  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
129446636  git2b; ARF GTPase-activating protein GIT2b isoform X1 [KO:K12487]
129439834  git2a; ARF GTPase-activating protein GIT2a isoform X1 [KO:K12487]
129442065  asap1a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a isoform X1 [KO:K12488]
129425607  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
129417324  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a isoform X1 [KO:K12488]
129417550  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
129427632  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
129429479  asap2b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b [KO:K12488]
129430880  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
129431276  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
129441785  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like [KO:K12489]
129441807  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like [KO:K12489]
129453137  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12489]
129428235  acap3b; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3b isoform X1 [KO:K12489]
129438703  zgc:162872; BAR_ACAPs and ArfGap_ACAP domain-containing protein [KO:K12489]
129438778  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
129423511  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
129438752  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
129439981  arap1a; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
129448607  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
129422321  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
129451142  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
129426196  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
129431088  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
129430380  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2-like [KO:K17848]
129427613  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
129432005  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
129419359  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
129440734  PH and SEC7 domain-containing protein 1 [KO:K12494]
129422059  psd2; LOW QUALITY PROTEIN: PH and SEC7 domain-containing protein 2 [KO:K12494]
129415627  psda; uncharacterized protein psda isoform X1 [KO:K12494]
129445828  psd3l; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
129420716  uncharacterized protein LOC129420716 isoform X1 [KO:K12494]
129431249  iqsec1a; IQ motif and Sec7 domain ArfGEF 1a isoform X1 [KO:K12495]
129432085  iqsec3a; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
129414046  IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
129414613  iqsec2b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
129418908  iqsec3b; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
129428023  iqsec1b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
129449075  cyth2; cytohesin-2 [KO:K18441]
129450663  cyth4b; cytohesin 4b isoform X1 [KO:K18441]
129426786  cyth1a; cytohesin-1a [KO:K18441]
129436161  cyth4a; cytohesin-3 isoform X1 [KO:K18441]
129427171  cyth3b; cytohesin-3 isoform X1 [KO:K18441]
129421305  cyth3a; cytohesin-3 [KO:K18441]
129421402  cyth1b; cytohesin-1b isoform X1 [KO:K18441]
129426453  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
129430722  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
129416509  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
129442805  arf1; ADP-ribosylation factor 1 [KO:K07937]
129433458  arf2a; ADP-ribosylation factor 2a [KO:K07937]
129426503  arf2b; ADP-ribosylation factor 2b [KO:K07937]
129431422  arf3a; ADP-ribosylation factor 3a [KO:K07938]
129450203  arf3b; ADP-ribosylation factor 3b [KO:K07938]
129427545  ADP-ribosylation factor 4 [KO:K07939]
129427547  ADP-ribosylation factor 4-like isoform X1 [KO:K07939]
129418861  zgc:77650; ADP-ribosylation factor 4 [KO:K07939]
129418862  arf5; ADP-ribosylation factor 5 [KO:K07939]
129427983  ADP-ribosylation factor 1-like [KO:K07939]
129427984  ADP-ribosylation factor 4-like isoform X1 [KO:K07939]
129427985  ADP-ribosylation factor 4-like [KO:K07939]
129427986  ADP-ribosylation factor 4-like [KO:K07939]
129427987  ADP-ribosylation factor 4-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
manu04060  Cytokine-cytokine receptor interaction
manu04070  Phosphatidylinositol signaling system
manu04130  SNARE interactions in vesicular transport
manu04142  Lysosome
manu04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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