KEGG   PATHWAY: masi03013
Entry
masi03013                   Pathway                                
Name
Nucleocytoplasmic transport - Myxocyprinus asiaticus (Chinese sucker)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
masi03013  Nucleocytoplasmic transport
masi03013

Other DBs
GO: 0050658
Organism
Myxocyprinus asiaticus (Chinese sucker) [GN:masi]
Gene
127448161  aladin [KO:K14320]
127421227  LOW QUALITY PROTEIN: nucleoporin NUP42 [KO:K14321]
127414509  mRNA export factor GLE1-like isoform X1 [KO:K18723]
127423723  mRNA export factor GLE1 isoform X1 [KO:K18723]
127418792  ATP-dependent RNA helicase DDX19A-like isoform X1 [KO:K18655] [EC:5.6.2.7]
127426319  ATP-dependent RNA helicase DDX19B-like [KO:K18655] [EC:5.6.2.7]
127420501  ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
127428237  ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
127449259  mRNA export factor isoform X1 [KO:K14298]
127446054  mRNA export factor-like isoform X1 [KO:K14298]
127431348  nuclear pore complex protein Nup98-Nup96-like isoform X1 [KO:K14297]
127428512  nuclear pore complex protein Nup98-Nup96-like isoform X1 [KO:K14297]
127422635  nuclear pore complex protein Nup214-like isoform X1 [KO:K14317]
127435432  nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
127418897  nucleoporin 88 isoform X1 [KO:K14318]
127439852  nucleoporin 88 [KO:K14318]
127447742  RANBP2-like and GRIP domain-containing protein 5/6 isoform X1 [KO:K12172] [EC:2.3.2.-]
127451275  ran GTPase-activating protein 1-like isoform X1 [KO:K14319]
127427300  ran GTPase-activating protein 1b isoform X1 [KO:K14319]
127449982  SUMO-conjugating enzyme UBC9-B [KO:K10577]
127450048  SUMO-conjugating enzyme UBC9-like [KO:K10577]
127431598  SUMO-conjugating enzyme UBC9-A [KO:K10577]
127451764  SUMO-conjugating enzyme UBC9-B [KO:K10577]
127452334  SUMO-conjugating enzyme UBC9-like [KO:K10577]
127434572  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
127449510  small ubiquitin-related modifier 1 [KO:K12160]
127449917  small ubiquitin-related modifier 2 isoform X1 [KO:K12160]
127446460  small ubiquitin-related modifier 3-like [KO:K12160]
127446488  small ubiquitin-related modifier 3-like [KO:K12160]
127452022  small ubiquitin-related modifier 2 [KO:K12160]
127447205  small ubiquitin-related modifier 3 [KO:K12160]
127448377  small ubiquitin-related modifier 3 [KO:K12160]
127448947  small ubiquitin-related modifier 3-like [KO:K12160]
127437224  nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
127449834  nuclear pore complex protein Nup85 [KO:K14304]
127451478  nuclear pore complex protein Nup85-like [KO:K14304]
127438201  protein SEC13 homolog isoform X1 [KO:K14004]
127439096  protein SEC13 homolog [KO:K14004]
127436809  nuclear pore complex protein Nup107 [KO:K14301]
127435438  LOW QUALITY PROTEIN: nuclear pore complex protein Nup107-like [KO:K14301]
127444536  nuclear pore complex protein Nup133 [KO:K14300]
127424850  nucleoporin SEH1 isoform X1 [KO:K14299]
127420744  nucleoporin SEH1-like [KO:K14299]
127454274  nucleoporin SEH1-like [KO:K14299]
127409908  nucleoporin Nup43 [KO:K14305]
127435473  nucleoporin Nup37-like [KO:K14302]
127455616  protein ELYS-like isoform X1 [KO:K25129]
127411080  protein ELYS-like isoform X1 [KO:K25129]
127418227  nuclear pore glycoprotein p62-like [KO:K14306]
127412804  nucleoporin 62 like [KO:K14306]
127431951  nucleoporin p58/p45 isoform X1 [KO:K14307]
127434349  nucleoporin p58/p45-like isoform X1 [KO:K14307]
127430456  nucleoporin p54-like isoform X1 [KO:K14308]
127428536  nucleoporin p54-like isoform X1 [KO:K14308]
127456119  nuclear pore complex protein Nup205-like [KO:K14310]
127417277  nuclear pore complex protein Nup205-like isoform X1 [KO:K14310]
127431167  nucleoporin NUP188-like [KO:K14311]
127429294  nucleoporin NUP188-like isoform X1 [KO:K14311]
127433059  nuclear pore complex protein Nup155-like [KO:K14312]
127433328  nuclear pore complex protein Nup155 [KO:K14312]
127455788  nuclear pore complex protein Nup93-like [KO:K14309]
127417390  nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
127447197  nucleoporin NUP35-like [KO:K14313]
127447883  nucleoporin NUP35 [KO:K14313]
127440459  nucleoporin NDC1-like [KO:K14315]
127442291  nucleoporin NDC1-like isoform X1 [KO:K14315]
127419563  nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
127419863  nuclear pore membrane glycoprotein 210-like [KO:K14314]
127432479  nuclear envelope pore membrane protein POM 121 isoform X1 [KO:K14316]
127433758  nuclear envelope pore membrane protein POM 121-like [KO:K14316]
127413052  transmembrane protein 33 isoform X1 [KO:K20724]
127417648  transmembrane protein 33-like [KO:K20724]
127456657  nucleoprotein TPR-like isoform X1 [KO:K09291]
127440994  nucleoprotein TPR-like isoform X1 [KO:K09291]
127416381  nucleoprotein TPR-like isoform X1 [KO:K09291]
127442393  nucleoprotein TPR-like isoform X1 [KO:K09291]
127437012  nuclear pore complex protein Nup50-like isoform X1 [KO:K14295]
127435338  nuclear pore complex protein Nup50-like [KO:K14295]
127425393  nuclear pore complex protein Nup153-like isoform X1 [KO:K14296]
127421290  nuclear pore complex protein Nup153-like isoform X1 [KO:K14296]
127449153  sentrin-specific protease 2-like isoform X1 [KO:K03345] [EC:3.4.22.68]
127445839  sentrin-specific protease 2-like [KO:K03345] [EC:3.4.22.68]
127431896  importin subunit alpha-5-like [KO:K23940]
127434793  importin subunit alpha-5-like isoform X1 [KO:K23940]
127450027  importin subunit alpha-1-like [KO:K15043]
127432951  LOW QUALITY PROTEIN: importin subunit alpha-5-like [KO:K15043]
127452033  importin subunit alpha-1 [KO:K15043]
127449016  importin subunit alpha-1-like isoform X1 [KO:K15043]
127444440  importin subunit alpha-4-like isoform X1 [KO:K23583]
127445527  importin subunit alpha-4 [KO:K23583]
127421943  importin subunit alpha-3 [KO:K23583]
127429603  importin subunit alpha-3-like [KO:K23583]
127425216  importin subunit alpha-7 [KO:K15042]
127421261  importin subunit alpha-7-like [KO:K15042]
127453311  importin subunit alpha-6-like [KO:K15042]
127453626  importin subunit alpha-6 [KO:K15042]
127425138  importin subunit beta-1 [KO:K14293]
127421057  importin subunit beta-1-like isoform X1 [KO:K14293]
127438478  transportin-1-like isoform X1 [KO:K18752]
127417302  transportin-1 isoform X1 [KO:K18752]
127443603  transportin-2 [KO:K18727]
127451112  transportin-2-like isoform X1 [KO:K18727]
127445581  transportin-2-like [KO:K18727]
127434959  transportin-3-like isoform X1 [KO:K15436]
127436398  transportin-3 [KO:K15436]
127432014  importin-4-like [KO:K20221]
127434195  importin-4-like [KO:K20221]
127443834  importin-5-like isoform X1 [KO:K20222]
127444906  importin-5 [KO:K20222]
127440441  importin-7-like [KO:K20223]
127454519  importin-7 [KO:K20223]
127436805  importin-8 isoform X1 [KO:K18755]
127434904  importin-8-like isoform X1 [KO:K18755]
127426364  importin-9 isoform X1 [KO:K20224]
127428208  importin-9-like isoform X1 [KO:K20224]
127424369  importin-11 isoform X1 [KO:K25201]
127415403  LOW QUALITY PROTEIN: importin-11 [KO:K25201]
127409608  importin-13-like [KO:K25202]
127415743  importin-13-like isoform X1 [KO:K25202]
127443061  importin-13 [KO:K25202]
127435579  snurportin-1 [KO:K13151]
127455594  exportin-1 [KO:K14290]
127444243  exportin-1-like [KO:K14290]
127444555  exportin-1-like [KO:K14290]
127411069  exportin-1-like isoform X1 [KO:K14290]
127426346  exportin-2 [KO:K18423]
127427634  exportin-2-like isoform X1 [KO:K18423]
127435170  exportin-T isoform X1 [KO:K14288]
127436423  exportin-T isoform X1 [KO:K14288]
127446882  exportin-4-like [KO:K25203]
127448572  exportin-4 isoform X1 [KO:K25203]
127413604  exportin-5 isoform X1 [KO:K14289]
127450217  exportin-6 [KO:K25204]
127451972  exportin-6-like isoform X1 [KO:K25204]
127432236  exportin-7-like isoform X1 [KO:K18460]
127433637  exportin-7 [KO:K18460]
127418228  GTP-binding nuclear protein Ran [KO:K07936]
127413144  GTP-binding nuclear protein Ran [KO:K07936]
127412064  elongation factor 1-alpha 1 [KO:K03231]
127443772  elongation factor 1-alpha 1 [KO:K03231]
127419283  elongation factor 1-alpha 2-like [KO:K03231]
127425423  elongation factor 1-alpha-like [KO:K03231]
127425424  elongation factor 1-alpha-like [KO:K03231]
127431774  si:dkey-37o8.1; elongation factor 1-alpha-like [KO:K03231]
127419957  elongation factor 1-alpha 2 [KO:K03231]
127414347  elongation factor 1-alpha, somatic form [KO:K03231]
127421383  elongation factor 1-alpha [KO:K03231]
127432462  phosphorylated adapter RNA export protein isoform X1 [KO:K14291]
127412581  nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
127417597  nuclear cap-binding protein subunit 1-like [KO:K12882]
127439056  nuclear cap-binding protein subunit 2 [KO:K12883]
127421941  60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
127453233  RNA-binding protein 8A-like [KO:K12876]
127453591  RNA-binding protein 8A [KO:K12876]
127424661  protein mago nashi homolog [KO:K12877]
127415078  protein mago nashi homolog [KO:K12877]
127450629  protein CASC3 isoform X1 [KO:K14323]
127451769  protein CASC3-like isoform X1 [KO:K14323]
127426504  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
127428194  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
127450309  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
127440625  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
127440762  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
127442317  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
127446889  histone deacetylase complex subunit SAP18 [KO:K14324]
127448589  histone deacetylase complex subunit SAP18-like [KO:K14324]
127450633  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
127452007  RNA-binding protein with serine-rich domain 1 [KO:K14325]
127455301  pinin [KO:K13114]
127411058  pinin-like [KO:K13114]
127450400  THO complex subunit 4-A-like isoform X1 [KO:K12881]
127451177  THO complex subunit 4 [KO:K12881]
127441438  regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
127442678  regulator of nonsense transcripts 1-like isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
127436967  regulator of nonsense transcripts 2-like [KO:K14327]
127435166  regulator of nonsense transcripts 2-like [KO:K14327]
127413272  regulator of nonsense transcripts 3B-like [KO:K14328]
127447504  regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
127447950  regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
127417696  regulator of nonsense transcripts 3B-like [KO:K14328]
127430635  nuclear RNA export factor 1-like [KO:K14284]
127412649  nuclear RNA export factor 1-like [KO:K14284]
127429066  nuclear RNA export factor 1-like [KO:K14284]
127417544  nuclear RNA export factor 1-like [KO:K14284]
127418385  NTF2-related export protein 2-like [KO:K14285]
127413469  NTF2-related export protein 2 [KO:K14285]
127425469  spliceosome RNA helicase DDX39B-like [KO:K12812] [EC:5.6.2.7]
127420975  spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
127454933  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
127411580  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
127424361  partner of Y14 and mago B-like isoform X1 [KO:K14294]
127415163  partner of Y14 and mago B-like isoform X1 [KO:K14294]
127440939  THO complex subunit 1-like [KO:K12878]
127441996  THO complex subunit 1-like [KO:K12878]
127412787  THO complex subunit 2 [KO:K12879]
127417554  THO complex subunit 2-like isoform X1 [KO:K12879]
127437685  THO complex subunit 5 homolog isoform X1 [KO:K13174]
127436106  THO complex subunit 5 homolog [KO:K13174]
127450466  THO complex subunit 6 homolog [KO:K13175]
127451807  THO complex subunit 6 homolog isoform X1 [KO:K13175]
127426006  THO complex subunit 7 homolog isoform X1 [KO:K13176]
127428258  THO complex subunit 7 homolog isoform X1 [KO:K13176]
127418002  THO complex subunit 3 [KO:K12880]
127413299  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
masi03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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