KEGG   PATHWAY: mcal04150
Entry
mcal04150                   Pathway                                
Name
mTOR signaling pathway - Mus caroli (Ryukyu mouse)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcal04150  mTOR signaling pathway
mcal04150

Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110299835  Slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
110285746  Slc3a2; 4F2 cell-surface antigen heavy chain [KO:K06519]
110307960  Slc38a9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
110311958  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
110300753  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
110296652  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform isoform X2 [KO:K02147]
110310247  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
110306754  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X3 [KO:K02148]
110306911  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
110284052  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
110295768  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
110296591  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
110290013  V-type proton ATPase subunit G 1 [KO:K02152]
110292685  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
110304817  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
110312623  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
110305043  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
110297468  Lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
110291286  Lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
110291223  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
110293985  Lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
110291399  Lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
110305887  Flcn; LOW QUALITY PROTEIN: folliculin [KO:K09594]
110304184  Fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
110290929  Fnip2; folliculin-interacting protein 2 isoform X4 [KO:K20401]
110286521  Rragb; ras-related GTP-binding protein B isoform X1 [KO:K16185]
110292623  Rraga; ras-related GTP-binding protein A [KO:K16185]
110293088  Rragc; ras-related GTP-binding protein C [KO:K16186]
110293099  Rragd; ras-related GTP-binding protein D [KO:K16186]
110292989  Sesn2; sestrin-2 [KO:K20394]
110305016  Castor1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
110294431  Castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
110296873  Mios; GATOR complex protein MIOS [KO:K20407]
115029031  Seh1l; nucleoporin SEH1 isoform X2 [KO:K14299]
110283899  Wdr24; GATOR complex protein WDR24 [KO:K20408]
110300393  Wdr59; GATOR complex protein WDR59 isoform X2 [KO:K20409]
110296061  Sec13; protein SEC13 homolog [KO:K14004]
110307094  protein SEC13 homolog [KO:K14004]
110294180  Depdc5; GATOR complex protein DEPDC5 [KO:K20404]
110302016  Nprl2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
110304982  Nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
110310405  Skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
110298373  Rnf152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
110304213  Rptor; regulatory-associated protein of mTOR [KO:K07204]
110299208  Akt1s1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
110292680  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
110310650  Deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
110312417  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
110312641  Telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
110290203  Tti1; TELO2-interacting protein 1 homolog [KO:K20403]
110295161  Clip1; CAP-Gly domain-containing linker protein 1 isoform X3 [KO:K10421]
110305653  Grb10; growth factor receptor-bound protein 10 isoform X3 [KO:K20064]
110312521  Lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
110290456  Lpin3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
110307500  Lpin1; phosphatidate phosphatase LPIN1 isoform X3 [KO:K15728] [EC:3.1.3.4]
110294005  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
110304290  Ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
110305658  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
110300284  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
110292210  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
110291348  Eif4e; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
110308348  Eif4e1b; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
110285417  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
110304919  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110309992  Eif4b; eukaryotic translation initiation factor 4B [KO:K03258]
110292653  Rps6; 40S ribosomal protein S6 [KO:K02991]
110305764  Strada; STE20-related kinase adapter protein alpha isoform X3 [KO:K08271]
110297528  Stradb; STE20-related kinase adapter protein beta [KO:K17532]
110303223  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
110294829  Cab39; calcium-binding protein 39 [KO:K08272]
110308909  Cab39l; calcium-binding protein 39-like [KO:K08272]
110310318  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
110292593  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
110312162  Tsc1; hamartin isoform X2 [KO:K07206]
110284338  Tsc2; tuberin isoform X1 [KO:K07207]
110308048  Tbc1d7; TBC1 domain family member 7 isoform X1 [KO:K20396]
110294321  Rheb; GTP-binding protein Rheb [KO:K07208]
110303598  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
110310964  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
110296313  Wnt2; protein Wnt-2 [KO:K00182]
110291476  Wnt2b; protein Wnt-2b [KO:K00182]
110305853  Wnt3a; protein Wnt-3a [KO:K00312]
110304911  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
110293218  Wnt4; protein Wnt-4 isoform X1 [KO:K00408]
110295760  Wnt5b; protein Wnt-5b [KO:K00444]
110309360  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
110299810  Wnt6; protein Wnt-6 [KO:K00445]
110310689  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
110296669  Wnt7a; protein Wnt-7a isoform X1 [KO:K00572]
110285759  Wnt8b; protein Wnt-8b [KO:K00714]
110285093  Wnt8a; protein Wnt-8a [KO:K00714]
110306039  Wnt9a; protein Wnt-9a [KO:K01064]
110305968  Wnt9b; protein Wnt-9b [KO:K01064]
110310912  Wnt10b; protein Wnt-10b isoform X1 [KO:K01357]
110300434  Wnt10a; protein Wnt-10a [KO:K01357]
110298907  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
110296883  Wnt16; protein Wnt-16 [KO:K01558]
110301431  Fzd7; frizzled-7 [KO:K02432]
110294363  Fzd1; frizzled-1 [KO:K02432]
110305336  Fzd2; frizzled-2 [KO:K02235]
110309352  Fzd3; frizzled-3 [KO:K02329]
110298417  Fzd4; frizzled-4 [KO:K02354]
110294401  Fzd5; frizzled-5 [KO:K02375]
110284745  Fzd8; frizzled-8 [KO:K02375]
110310580  Fzd6; frizzled-6 [KO:K02376]
110295350  Fzd9; frizzled-9 [KO:K02842]
110295197  Fzd10; frizzled-10 [KO:K02842]
110286073  Lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
110297114  Lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
110292264  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
110304161  Dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
110311604  Dvl3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
110311365  Gsk3b; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
110284110  Tnf; tumor necrosis factor [KO:K03156]
110296205  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
110300158  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110299132  insulin-2 [KO:K04526]
110286053  insulin-1 [KO:K04526]
110304009  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
110300622  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110297825  Igf1r; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
110304772  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110306968  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110312423  Sos1; son of sevenless homolog 1 [KO:K03099]
110297313  Hras; GTPase HRas isoform X2 [KO:K02833]
110296194  Kras; GTPase KRas isoform X1 [KO:K07827]
110290873  Nras; GTPase NRas [KO:K07828]
110295945  Braf; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
110296919  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110301502  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110303196  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110297836  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110311382  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110283921  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
110286610  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
110286617  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
110293427  Rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
110292727  Irs1; insulin receptor substrate 1 [KO:K16172]
110308009  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110299855  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110292624  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110290798  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110292183  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110301355  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110285202  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110312395  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
110297609  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110294471  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110307022  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110285285  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110310884  Mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X2 [KO:K20410]
110310249  Rictor; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
110310245  Prr5; proline-rich protein 5 isoform X1 [KO:K20411]
110290098  Prr5l; proline-rich protein 5-like isoform X1 [KO:K20411]
110292411  transforming protein RhoA [KO:K04513]
110302438  Rhoa; transforming protein RhoA [KO:K04513]
110304357  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110297826  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110297763  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110302862  Sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mcal00561  Glycerolipid metabolism
mcal04010  MAPK signaling pathway
mcal04140  Autophagy - animal
mcal04151  PI3K-Akt signaling pathway
mcal04152  AMPK signaling pathway
mcal04810  Regulation of actin cytoskeleton
mcal04910  Insulin signaling pathway
KO pathway
ko04150   
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