KEGG   PATHWAY: mcal04010
Entry
mcal04010                   Pathway                                
Name
MAPK signaling pathway - Mus caroli (Ryukyu mouse)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcal04010  MAPK signaling pathway
mcal04010

Other DBs
GO: 0000165
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110299941  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
110289304  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X5 [KO:K04849]
110295755  voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
110309492  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110292269  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X8 [KO:K04852]
110286673  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
110304549  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
110284204  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [KO:K04855]
110310116  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X3 [KO:K04856]
110296075  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110295349  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
110301155  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
110309146  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
110295757  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
110304211  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
110290272  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
110310131  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
110308006  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
110306271  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
110310670  Cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
110298765  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
110305755  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
110305659  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
110299392  Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
110298853  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
110297342  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
110290795  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
110300173  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110304357  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110297826  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110297763  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110295092  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
110300627  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
110296551  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110309045  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110309273  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110290686  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
110304839  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
110293037  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
110308129  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X2 [KO:K12326]
110311236  Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
110285321  Rasgrp2; RAS guanyl-releasing protein 2 [KO:K12361]
110312642  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
110298815  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
110290848  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
110304532  Nf1; neurofibromin isoform X1 [KO:K08052]
110308133  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
110301714  Rasa2; ras GTPase-activating protein 2 [KO:K08053]
110290796  Rap1a; ras-related protein Rap-1A [KO:K04353]
110303320  Rap1b; ras-related protein Rap-1b [KO:K07836]
110291005  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110295684  Tgfa; protransforming growth factor alpha [KO:K08774]
110295414  Ereg; proepiregulin [KO:K09784]
110295417  Areg; amphiregulin [KO:K09782]
110284837  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110291557  Fgf2; fibroblast growth factor 2 [KO:K18497]
110300580  Fgf20; fibroblast growth factor 20 [KO:K04358]
110295342  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110285629  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110287226  Fgf16; fibroblast growth factor 16 [KO:K04358]
110305760  Fgf18; fibroblast growth factor 18 [KO:K04358]
110308847  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
110303818  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110309422  Fgf9; fibroblast growth factor 9 [KO:K04358]
110289950  Fgf7; fibroblast growth factor 7 [KO:K04358]
110296943  Fgf6; fibroblast growth factor 6 [KO:K04358]
110299316  Fgf4; fibroblast growth factor 4 [KO:K04358]
110299386  Fgf3; fibroblast growth factor 3 [KO:K04358]
110308330  Fgf10; fibroblast growth factor 10 [KO:K04358]
110299450  Fgf19; fibroblast growth factor 19 [KO:K22603]
110299358  Fgf21; fibroblast growth factor 21 [KO:K22429]
110297028  Fgf23; fibroblast growth factor 23 [KO:K22428]
110291584  Ngf; beta-nerve growth factor [KO:K02582]
110285237  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
110296798  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
110299428  Ntf4; neurotrophin-4 [KO:K12457]
110299132  insulin-2 [KO:K04526]
110286053  insulin-1 [KO:K04526]
110304009  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
110298427  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
110294651  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110310626  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110290924  Pdgfc; platelet-derived growth factor C [KO:K05450]
110301590  Pdgfd; platelet-derived growth factor D isoform X2 [KO:K05450]
110291496  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
110302981  Kitlg; kit ligand isoform X1 [KO:K05461]
110297597  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
110284402  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
110285510  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110307029  Pgf; placenta growth factor [KO:K16859]
110287326  Vegfd; vascular endothelial growth factor D [KO:K05449]
110300171  Vegfc; vascular endothelial growth factor C [KO:K05449]
110294216  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110310421  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
110300338  Angpt2; angiopoietin-2 [KO:K05466]
110290227  Angpt4; angiopoietin-4 [KO:K05467]
110303946  Efna2; ephrin-A2 [KO:K05462]
110291707  Efna1; ephrin-A1 [KO:K05462]
110283991  Efna5; ephrin-A5 isoform X1 [KO:K05462]
110291641  Efna3; ephrin-A3 isoform X1 [KO:K05462]
110291542  Efna4; ephrin-A4 isoform X2 [KO:K05462]
110310770  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
110284230  Nrtn; neurturin [KO:K25414]
110293284  Artn; artemin isoform X1 [KO:K25415]
110283764  Pspn; persephin [KO:K25416]
110304228  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110304771  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110302668  Erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
110312376  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
110299550  Fgfr1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
110299396  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110293909  Fgfr3; fibroblast growth factor receptor 3 isoform X8 [KO:K05094] [EC:2.7.10.1]
110307648  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110305182  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110290875  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110307883  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110300622  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110297825  Igf1r; insulin-like growth factor 1 receptor isoform X2 [KO:K05087] [EC:2.7.10.1]
110295292  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110284880  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
110285184  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110294693  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110294537  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
110294038  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110304471  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110294607  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110295947  Met; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
110293136  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
110292090  Epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
110295751  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
110304772  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110306968  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110312423  Sos1; son of sevenless homolog 1 [KO:K03099]
110297313  Hras; GTPase HRas isoform X2 [KO:K02833]
110296194  Kras; GTPase KRas isoform X1 [KO:K07827]
110290873  Nras; GTPase NRas [KO:K07828]
110298333  Rras; ras-related protein R-Ras [KO:K07829]
110297889  Rras2; ras-related protein R-Ras2 [KO:K07830]
110300983  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
110287540  Araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
110295945  Braf; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
110296919  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110301502  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110303196  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110291223  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
110297836  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110311382  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110303049  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
110292985  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
110283921  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
110286610  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
110286617  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
110293427  Rps6ka1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
110310868  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110286681  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
110299027  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
110310583  Myc; myc proto-oncogene protein [KO:K04377]
110284129  Srf; serum response factor isoform X1 [KO:K04378]
110307063  Fos; proto-oncogene c-Fos [KO:K04379]
110304807  Mapt; microtubule-associated protein tau isoform X8 [KO:K04380]
110292664  Stmn1; stathmin [KO:K04381]
110289370  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
110284581  Pla2g4b; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
110289583  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
110294088  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
110298861  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
110290316  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
110284110  Tnf; tumor necrosis factor [KO:K03156]
110290044  Il1a; interleukin-1 alpha [KO:K04383]
110290100  Il1b; interleukin-1 beta [KO:K04519]
110298438  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
110292955  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
110306834  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
110296205  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
110293878  Il1r1; interleukin-1 receptor type 1 isoform X2 [KO:K04386]
110311552  Il1rap; interleukin-1 receptor accessory protein isoform X4 [KO:K04723]
110292408  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110301725  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110300709  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
110285655  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
110284977  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
110293965  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110310226  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110305163  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110292517  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110300541  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
110299851  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
110289986  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110284048  Daxx; death domain-associated protein 6 [KO:K02308]
110301084  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
110286819  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
110310638  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
110290132  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
110303739  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
110296344  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
110308191  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
110310212  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
110303600  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
110301636  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
110312508  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
110297642  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X6 [KO:K04407] [EC:2.7.11.1]
110298174  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
110298300  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110311434  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
110284093  Stk4; serine/threonine-protein kinase 4 [KO:K04411]
110310568  Stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
110285263  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
110284809  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
110307741  Map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
110285431  Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
110284747  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
110305762  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
110306985  Map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
110298678  Map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
110300557  Map3k21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
110311026  Map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
110311270  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
110285269  Map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
110292889  Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
110303338  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
110292293  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
110312545  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
110295047  Taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
110298389  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
110306216  Taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
110304803  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
110299603  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
110304977  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
110304684  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
110289269  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
110310393  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
110283834  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
110287345  Flna; filamin-A isoform X1 [KO:K04437]
110305233  Crk; adapter molecule crk isoform X1 [KO:K04438]
110311596  Crkl; crk-like protein [KO:K04438]
110304234  Arrb2; beta-arrestin-2 isoform X2 [KO:K04439]
110298318  Arrb1; beta-arrestin-1 isoform X3 [KO:K04439]
110294148  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110308920  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110304169  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110312562  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110310902  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
110310903  Mapk11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
110312437  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110294137  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
110294905  Mapkapk2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
110301239  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
110306698  Rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
110285316  Rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
110287319  Cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
110284760  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
110299723  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110292423  Jun; transcription factor AP-1 [KO:K04448]
110300009  Jund; transcription factor jun-D [KO:K04449]
110286367  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110305297  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
110302857  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
110306748  Max; protein max isoform X3 [KO:K04453]
110307611  Mef2c; myocyte-specific enhancer factor 2C isoform X8 [KO:K04454]
110297609  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110294471  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110307022  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110306546  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
110288963  protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
110303204  Ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
110298575  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X3 [KO:K18018] [EC:3.1.3.48]
110294490  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
110312644  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
110301891  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110296244  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110290186  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110285728  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110299088  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110300183  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110303747  Dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
110287373  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
110302001  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
110305950  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
110298654  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
110284267  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
110312581  heat shock 70 kDa protein 1A-like [KO:K03283]
110312589  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
110312667  heat shock 70 kDa protein 1A [KO:K03283]
110301384  heat shock cognate 71 kDa protein [KO:K03283]
110290693  Mecom; histone-lysine N-methyltransferase MECOM isoform X2 [KO:K04462] [EC:2.1.1.367]
110301925  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
110305070  Mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
110310281  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
110304892  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
110285285  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110300158  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110287188  Ikbkg; NF-kappa-B essential modulator isoform X4 [KO:K07210]
110305742  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
110291231  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110285291  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
110285703  Rela; transcription factor p65 [KO:K04735]
110297403  Relb; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mcal04070  Phosphatidylinositol signaling system
mcal04110  Cell cycle
mcal04115  p53 signaling pathway
mcal04210  Apoptosis
mcal04310  Wnt signaling pathway
mcal04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

DBGET integrated database retrieval system